Adrenergic effects on secretion of epidermal growth factor from Brunner's glands

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Standard

Adrenergic effects on secretion of epidermal growth factor from Brunner's glands. / Poulsen, Steen Seier.

I: Gut, Bind 26, Nr. 9, 09.1985, s. 920-7.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Poulsen, SS 1985, 'Adrenergic effects on secretion of epidermal growth factor from Brunner's glands', Gut, bind 26, nr. 9, s. 920-7.

APA

Poulsen, S. S. (1985). Adrenergic effects on secretion of epidermal growth factor from Brunner's glands. Gut, 26(9), 920-7.

Vancouver

Poulsen SS. Adrenergic effects on secretion of epidermal growth factor from Brunner's glands. Gut. 1985 sep.;26(9):920-7.

Author

Poulsen, Steen Seier. / Adrenergic effects on secretion of epidermal growth factor from Brunner's glands. I: Gut. 1985 ; Bind 26, Nr. 9. s. 920-7.

Bibtex

@article{d30d640caab44c05acf07835fe1a7482,
title = "Adrenergic effects on secretion of epidermal growth factor from Brunner's glands",
abstract = "The influence of the sympathetic nervous system and adrenergic agonists on flow rate and secretion of epidermal growth factor (EGF) from Brunner's glands has been investigated in the rat. Chemical sympathectomy by administration of 6-hydroxydopamine increased volume secretion and output of EGF from Brunner's glands but depleted the glands of EGF. Infusion of noradrenaline, an alpha-adrenergic agonist, inhibited basal and vasoactive intestinal polypeptide (VIP) stimulated flow rate and output of EGF from Brunner's glands and increased the amount of EGF in the tissue. Vasoactive intestinal polypeptide also increased the amount of EGF in Brunner's gland tissue and this was unchanged after simultaneous infusion of VIP and noradrenaline as well as VIP and isoproterenol, a beta-adrenergic agonist. Isoproterenol had no effect on basal and VIP stimulated secretion of EGF from Brunner's glands. The presence of PAS-positive mucus in Brunner's glands was unchanged during infusion of noradrenaline whereas VIP induced a depletion of Brunner's gland mucus which in turn was prevented by simultaneous infusion of noradrenaline. This study indicates that the sympathetic nervous system influence the volume secretion, output of EGF and mucus content in Brunner's glands probably by activation of alpha-adrenergic pathways.",
keywords = "Adrenergic Agonists, Animals, Brunner Glands, Duodenum, Epidermal Growth Factor, Hydroxydopamines, Isoproterenol, Male, Mucus, Norepinephrine, Rats, Rats, Inbred Strains, Secretory Rate, Vasoactive Intestinal Peptide",
author = "Poulsen, {Steen Seier}",
year = "1985",
month = sep,
language = "English",
volume = "26",
pages = "920--7",
journal = "Gut",
issn = "0017-5749",
publisher = "B M J Group",
number = "9",

}

RIS

TY - JOUR

T1 - Adrenergic effects on secretion of epidermal growth factor from Brunner's glands

AU - Poulsen, Steen Seier

PY - 1985/9

Y1 - 1985/9

N2 - The influence of the sympathetic nervous system and adrenergic agonists on flow rate and secretion of epidermal growth factor (EGF) from Brunner's glands has been investigated in the rat. Chemical sympathectomy by administration of 6-hydroxydopamine increased volume secretion and output of EGF from Brunner's glands but depleted the glands of EGF. Infusion of noradrenaline, an alpha-adrenergic agonist, inhibited basal and vasoactive intestinal polypeptide (VIP) stimulated flow rate and output of EGF from Brunner's glands and increased the amount of EGF in the tissue. Vasoactive intestinal polypeptide also increased the amount of EGF in Brunner's gland tissue and this was unchanged after simultaneous infusion of VIP and noradrenaline as well as VIP and isoproterenol, a beta-adrenergic agonist. Isoproterenol had no effect on basal and VIP stimulated secretion of EGF from Brunner's glands. The presence of PAS-positive mucus in Brunner's glands was unchanged during infusion of noradrenaline whereas VIP induced a depletion of Brunner's gland mucus which in turn was prevented by simultaneous infusion of noradrenaline. This study indicates that the sympathetic nervous system influence the volume secretion, output of EGF and mucus content in Brunner's glands probably by activation of alpha-adrenergic pathways.

AB - The influence of the sympathetic nervous system and adrenergic agonists on flow rate and secretion of epidermal growth factor (EGF) from Brunner's glands has been investigated in the rat. Chemical sympathectomy by administration of 6-hydroxydopamine increased volume secretion and output of EGF from Brunner's glands but depleted the glands of EGF. Infusion of noradrenaline, an alpha-adrenergic agonist, inhibited basal and vasoactive intestinal polypeptide (VIP) stimulated flow rate and output of EGF from Brunner's glands and increased the amount of EGF in the tissue. Vasoactive intestinal polypeptide also increased the amount of EGF in Brunner's gland tissue and this was unchanged after simultaneous infusion of VIP and noradrenaline as well as VIP and isoproterenol, a beta-adrenergic agonist. Isoproterenol had no effect on basal and VIP stimulated secretion of EGF from Brunner's glands. The presence of PAS-positive mucus in Brunner's glands was unchanged during infusion of noradrenaline whereas VIP induced a depletion of Brunner's gland mucus which in turn was prevented by simultaneous infusion of noradrenaline. This study indicates that the sympathetic nervous system influence the volume secretion, output of EGF and mucus content in Brunner's glands probably by activation of alpha-adrenergic pathways.

KW - Adrenergic Agonists

KW - Animals

KW - Brunner Glands

KW - Duodenum

KW - Epidermal Growth Factor

KW - Hydroxydopamines

KW - Isoproterenol

KW - Male

KW - Mucus

KW - Norepinephrine

KW - Rats

KW - Rats, Inbred Strains

KW - Secretory Rate

KW - Vasoactive Intestinal Peptide

M3 - Journal article

C2 - 2863199

VL - 26

SP - 920

EP - 927

JO - Gut

JF - Gut

SN - 0017-5749

IS - 9

ER -

ID: 47488995