[18F]FLT and [18F]FDG PET for non-invasive treatment monitoring of the nicotinamide phosphoribosyltransferase inhibitor APO866 in human xenografts
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[18F]FLT and [18F]FDG PET for non-invasive treatment monitoring of the nicotinamide phosphoribosyltransferase inhibitor APO866 in human xenografts. / Erichsen, Kamille Dumong; Johnbeck, Camilla Bardram; Björkling, Fredrik; Madsen, Jacob; Bzorek, Michael; Jensen, Peter Buhl; Højgaard, Liselotte; Sehested, Maxwell; Kjær, Andreas; Jensen, Mette Munk.
I: P L o S One, Bind 8, Nr. 1, e53410, 2013, s. 1-8.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - [18F]FLT and [18F]FDG PET for non-invasive treatment monitoring of the nicotinamide phosphoribosyltransferase inhibitor APO866 in human xenografts
AU - Erichsen, Kamille Dumong
AU - Johnbeck, Camilla Bardram
AU - Björkling, Fredrik
AU - Madsen, Jacob
AU - Bzorek, Michael
AU - Jensen, Peter Buhl
AU - Højgaard, Liselotte
AU - Sehested, Maxwell
AU - Kjær, Andreas
AU - Jensen, Mette Munk
PY - 2013
Y1 - 2013
N2 - APO866 is a new anti-tumor compound inhibiting nicotinamide phosphoribosyltransferase (NAMPT). APO866 has an anti-tumor effect in several pre-clinical tumor models and is currently in several clinical phase II studies. 3'-deoxy-3'-[18F]fluorothymidine ([18F]FLT) is a tracer used to assess cell proliferation in vivo. The aim of this study was non-invasively to study effect of APO866 treatment on [18F]FLT and 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) uptake.
AB - APO866 is a new anti-tumor compound inhibiting nicotinamide phosphoribosyltransferase (NAMPT). APO866 has an anti-tumor effect in several pre-clinical tumor models and is currently in several clinical phase II studies. 3'-deoxy-3'-[18F]fluorothymidine ([18F]FLT) is a tracer used to assess cell proliferation in vivo. The aim of this study was non-invasively to study effect of APO866 treatment on [18F]FLT and 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) uptake.
U2 - 10.1371/journal.pone.0053410
DO - 10.1371/journal.pone.0053410
M3 - Journal article
C2 - 23308217
VL - 8
SP - 1
EP - 8
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 1
M1 - e53410
ER -
ID: 45864162