List of publications
Unterweger, I.A. Klepstad, J., Hannezo, E., Lundegaard, P. R., Trusina, A. and Ober, E.A. Lineage tracing identifies heterogenous hepatoblast contribution to cell lineages and organ growth dynamics bioRxiv 2023.01.18.524321; doi: https://doi.org/10.1101/2023.01.18.524321
Morgan K.J., Doggett K., Geng F., Mieruszynski S., Whitehead L., Smith K.A., Hogan B.M., Simons C., Baillie G.J., Molania R., Papenfuss A.T., Hall T.E., Ober E.A., Stainier D.Y.R., Gong Z. and Heath J.K. (2023) ahctf1and kras mutations combine to amplify oncogenic stress and restrict liver overgrowth in a zebrafish model of hepatocellular carcinoma. Elife 2023 Jan 17;12:e73407. doi:10.7554/eLife.73407
Caviglia S*, Unterweger I.A.*, Gasiunaite A,. Vanoosthuyse, A.E., Cutrale, F., Trinh, L.A., Fraser S.E., Neuhauss S.C.F., and Ober E.A.§. (2022) FRaeppli, a multispectral imaging toolbox for lineage tracing and dense tissue analysis. Development 149(16):dev199615. doi: 10.1242/dev.199615
Dzementsei, A., Barooji, Y., Ober, E. A.& and Oddershede, L.B.& (2022) Foregut organ progenitors and their niche display distinct viscoelastic properties in vivo during early morphogenesis stages. Communications Biology 5(1):402. doi: 10.1038/s42003-022-03349-1
Ellman, D. G., Slaiman, I. M., Mathiesen, S. B., Andersen, K. S., Hofmeister, W., Ober, E. A., & Andersen, D.C. (2021) Apex Resection in Zebrafish (Danio rerio) as a Model of Heart Regeneration: A Video-Assisted Guide. International Journal of Molecular Sciences, 22. doi: 10.3390/ijms22115865.
Thestrup, M.I., Caviglia, S., Cayuso, J., Heyne, R. L. S., Ahmad, R., Hofmeister, W., Satriano, L., Wilkinson, D. G., Andersen, J. B., and Ober, E. A. (2019) A morphogenetic EphB/EphrinB code controls hepatopancreatic duct formation. Nature Communications 10, 5220. doi: 10.1038/s41467-019-13149-7
Caviglia, S. and Ober, E. A. (2018). Non-conventional protrusions: the diversity of cell interactions at short and long distance. Current Opinion in Cell Biology, 54, 106-113. doi: 10.1016/j.ceb.2018.05.013.
Ober, E. A. and Lemaigre, F.P. (2018). Development of the liver: insights into organ and tissue morphogenesis. Journal of Hepatology 68, 1049-1062, doi:10.1016/j.jhep.2018.01.005.
Lonowski, L.A., Narimatsu, Y., Riaz, A., Delay, C.E., Yang, Z., Niola, F., Duda, K., Ober, E.A., Clausen, H., Wandall, H., Hansen, S.H., Bennett, E.P., and Frödin, M. (2017). Genome editing using FACS enrichment of nuclease-expressing cells and indel detection by amplicon analysis. Nature Protocols, 12, 581-603. doi:10.1038/nprot.2016.165.
Wang, S., Miller, S.R., Ober, E.A. and Sadler, K.C. (2017). Making it new again: Insight into liver development, regeneration, and disease from zebrafish research. Current Topics in Developmental Biology, 124, 161-195. doi:10.1016/bs.ctdb.2016.11.012.
Cayuso, J., Dzementsei, A., Fischer, J.C., Karemore, G., Caviglia, S., Bartholdson, J., Wright, G.J. and Ober E.A. (2016). EphrinB1/EphB3b Coordinate Bidirectional Epithelial-Mesenchymal Interactions Controlling Liver Morphogenesis and Laterality. Developmental Cell, 39, 316-328. doi:10.1016/j.devcel.2016.10.009. Recommended by the faculty of 1000.
Koltowska, K., Lagendijk, A.K., Pichol-Thievend, C., Fischer, J.C., Francois, M., Ober, E.A, Yap, A.S. and Hogan, B.M. (2015). Vegfc Regulates Bipotential Precursor Division and Prox1 Expression to Promote Lymphatic Identity in Zebrafish. Cell Reports 13, 1828-1841, doi:10.1016/j.celrep.2015.10.055.
Ober, E.A. and Grapin-Botton, A. (2015). At new heights - endodermal lineages in development and disease. Development, 142, 1912-1917. doi:10.1242/dev.121095.
Dunworth, W.P., Cardona-Costa, J., Bozkulak, E.C., Kim, J.-D., Meadows, S., Fischer, J.C., Wang, Y., Cleaver, O., Qyang, Y., Ober, E.A., and Jin, S.-W. (2014). Bone Morphogenetic Protein 2 Signaling Negatively Modulates Lymphatic Development in Vertebrate Embryos. Circulation Research, 114, 56-66. doi:10.1161/circresaha.114.302452.
van Impel, A., Zhao, Z., Hermkens, D.M., Roukens, M.G., Fischer, J.C., Peterson-Maduro, J., Duckers, H., Ober, E.A., Ingham, P.W. and Schulte-Merker, S. (2014). Divergence of zebrafish and mouse lymphatic cell fate specification pathways. Development, 141, 1228-U1101. doi:10.1242/dev.105031.
Markmiller, S., Cloonan, N., Lardelli, R.M., Doggett, K., Keightley, M.C., Boglev, Y., Trotter, A.J., Ng, A.Y., Wilkins, S.J., Verkade, H., Ober, E.A., Field, H.A., Grimmond, S.M., Lieschke, G.J., Stainier, D.Y., Heath, J.K. (2014). Minor class splicing shapes the zebrafish transcriptome during development. Proceedings of the National Academy of Sciences of the United States of America 111, 3062-3067, doi:10.1073/pnas.1305536111.
Boglev, Y., Badrock, A.P., Trotter, A.J., Du, Q., Richardson, E.J., Parslow, A.C., Markmiller, S.J., Hall, N.E., de Jong-Curtain, T.A., Ng, A.Y., Verkade, H., Ober, E.A., Field, H.A., Shin, D., Shin, C.H., Hannan, K.M., Hannan, R.D., Pearson, R.B., Kim, S.H., Ess, K.C., Lieschke, G.J., Stainier, D.Y. and Heath, J.K. (2013). Autophagy Induction Is a Tor- and Tp53-Independent Cell Survival Response in a Zebrafish Model of Disrupted Ribosome Biogenesis. Plos Genetics, 9. doi:10.1371/journal.pgen.1003279.
Koltowska, K., Apitz, H., Stamataki, D., Hirst, E.M.A., Verkade, H., Salecker, I. and Ober, E.A. (2013). Ssrp1a controls organogenesis by promoting cell cycle progression and RNA synthesis. Development, 140, 1912-1918. doi:10.1242/dev.093583.
Schaub, M., Nussbaum, J., Verkade, H., Ober, E.A., Stainier, D.Y.R. and Sakaguchi, T.F. (2012). Mutation of zebrafish Snapc4 is associated with loss of the intrahepatic biliary network. Developmental Biology, 363, 128-137. doi:10.1016/j.ydbio.2011.12.025.
Poulain, M. and Ober, E.A. (2011). Interplay between Wnt2 and Wnt2bb controls multiple steps of early foregut-derived organ development. Development, 138, 3557-3568. doi:10.1242/dev.055921.
Mas, J. C., Noel, E. S., & Ober, E. A. (2011). Chromatin Modification in Zebrafish Development. Zebrafish: Genetics, Genomics and Informatics, 3rd Edition. H. W. Detrich, M. Westerfield and L. I. Zon. San Diego, Elsevier Academic Press Inc. 104, 401-428.
Curado, S., Ober, E.A., Walsh, S., Cortes-Hernandez, P., Verkade, H., Koehler, C.M. and Stainier, D.Y.R. (2010). The mitochondrial import gene tomm22 is specifically required for hepatocyte survival and provides a liver regeneration model. Disease Models & Mechanisms, 3, 486-495. doi:10.1242/dmm.004390.
Noël, E.S., dos Reis, M., Arain, Z. and Ober, E.A. (2010). Analysis of the Albumin/alpha-Fetoprotein/Afamin/Group specific component gene family in the context of zebrafish liver differentiation. Gene Expression Patterns 10, 237-243, doi:10.1016/j.gep.2010.05.002.
Munson, C., Huisken, J., Bit-Avragim, N., Kuo, T., Dong, P.D., Ober, E.A., Verkade, H., Abdelilah-Seyfried, S. and Stainier, D.Y.R. (2008). Regulation of neurocoel morphogenesis by Pard6 gamma b. Developmental Biology, 324, 41-54. doi:10.1016/j.ydbio.2008.08.033.
Noël, Emily S., Antonio Casal-Sueiro, Elisabeth Busch-Nentwich, Heather Verkade, P. Duc Si Dong, Derek L. Stemple & Elke A. Ober (2008). Organ-specific requirements for Hdac1 in liver and pancreas formation. Developmental Biology, 322, 237-250. doi:10.1016/j.ydbio.2008.06.040.
Osborne, N., Brand-Arzamendi, K., Ober, E.A., Jin, S.-W., Verkade, H., Holtzman, N.G., Yelon, D. and Stainier, D.Y.R. (2008). The Spinster Homolog, Two of Hearts, Is Required for Sphingosine 1-Phosphate Signaling in Zebrafish. Current Biology 18, 1882-1888, doi:10.1016/j.cub.2008.10.061.
Shin, C.H., Chung, W.-S., Hong, S.-K., Ober, E.A., Verkade, H., Field, H.A., Huisken, J. and Stainier, D.Y.R. (2008). Multiple roles for Med12 in vertebrate endoderm development. Developmental Biology, 317, 467-479. doi:10.1016/j.ydbio.2008.02.031.
Shin, D., Shin, C.H., Tucker, J., Ober, E.A., Rentzsch, F., Poss, K.D., Hammerschmidt, M., Mullins, M.C. and Stainier, D.Y.R. (2007). Bmp and Fgf signaling are essential for liver specification in zebrafish. Development 134, 2041-2050, doi: 10.1242/dev.000281.
Geisler, R., Rauch, G.J, Geiger-Rudolph, S., Albrecht, A., van Bebber, F., Berger, A., Busch-Nentwich, E., Dahm, R., Dekens, M.P., Dooley, C., Elli, A.F., Gehring, I., Geiger, H., Geisler, M., Glaser, S., Holley, S., M., Kerr, A., Kirn, A., Knirsch, M., Konantz, M., Küchler, A.M., Maderspacher, F., Neuhauss, S.C., Nicolson, T., Ober, E.A., Praeg, E., Ray, R., Rentzsch, B., Rick, J.M., Rief, E., Schauerte, H.E., Schepp, C.P., Schönberger, U., Schonthaler, H.B., Seiler, C., Sidi, S., Söllner, C., Wehner, A., Weiler, C. and Nüsslein-Volhard, C. (2007). Large-scale mapping of mutations affecting zebrafish development. Bmc Genomics, 89. doi:10.1186/1471-2164-8-11.
Jin, S.W., Herzog, W., Santoro, M.M., Mitchell, T.S., Frantsve, J., Jungblut, B., Beis, D., Scott, I.C., D'Amico, L.A., Ober, E.A., Verkade, H., Field, H.A., Chi, N.C., Wehman, A.M., Baier, H. and Stainier, D.Y. (2007). A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryos. Developmental Biology, 307, 29-42. doi:10.1016/j.ydbio.2007.03.526.
Ober, E.A., Verkade, H., Field, H.A. and Stainier, D.Y.R. (2006). Mesodermal Wnt2b signalling positively regulates liver specification. Nature, 442, 688-691. doi:10.1038/nature04888.
Beis, D., Bartman, T., Jin, S.-W., Scott, I.C., D'Amico, L.A., Ober, E.A., Verkade, H., Frantsve, J., Field, H.A., Wehman, A., Baier, H., Tallafuss, A., Bally-Cuif, L., Chen, J.-N., Stainier, D.Y.R. and Jungblut, B. (2005). Genetic and cellular analyses of zebrafish atrioventricular cushion and valve development. Development, 132, 4193-4204. doi:10.1242/dev.01970.
Ober, E.A., Olofsson, B., Mäkinen, T., Jin, S.-W., Shoji, W., Koh, G.Y., Alitalo, K. and Stainier, D.Y.R. (2004). Vegfc is required for vascular development and endoderm morphogenesis in zebrafish. Embo Reports, 5, 78-84. doi:10.1038/sj.embor.7400047.
Loosli, F. , Staub, W., Finger-Baier, K., Ober, E.A., Verkade, H., Wittbrodt, J. and Baier, H. (2003). Loss of eyes in zebrafish caused by mutation of chokh/rx3. Embo Reports, 4, 894-899. doi:10.1038/sj.embor.embor919.
Field, H.A., Ober, E.A., Roeser, T. and Stainier, D.Y.R. (2003). Formation of the digestive system in zebrafish. I. Liver morphogenesis. Developmental Biology, 253, 279-290. doi:10.1016/s0012-1606(02)00017-9.
Ober, E.A., Field, H.A. and Stainier, D.Y.R. (2003). From endoderm formation to liver and pancreas development in zebrafish. Mechanisms of Development, 120, 5-18. doi:10.1016/s0925-4773(02)00327-1.
Ober, E.A. & Schulte-Merker, S. (1999). Signals from the yolk cell induce mesoderm, neuroectoderm, the trunk organizer, and the notochord in zebrafish. Developmental Biology, 215, 167-181. doi:10.1006/dbio.1999.9455.
Münchberg, S.R., Ober, E.A. and Steinbeisser, H. (1999). Expression of the Ets transcription factors erm and pea3 in early zebrafish development. Mechanisms of Development, 88, 233-236. doi:10.1016/s0925-4773(99)00179-3.