Novel myosin-based therapies for congenital cardiac and skeletal myopathies
Research output: Contribution to journal › Journal article › Research › peer-review
The dysfunction in a number of inherited cardiac and skeletal myopathies is primarily due to an altered ability of myofilaments to generate force and motion. Despite this crucial knowledge, there are, currently, no effective therapeutic interventions for these diseases. In this short review, we discuss recent findings giving strong evidence that genetically or pharmacologically modulating one of the myofilament proteins, myosin, could alleviate the muscle pathology. This should constitute a research and clinical priority.
Original language | English |
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Journal | Journal of Medical Genetics |
Volume | 53 |
Issue number | 10 |
Pages (from-to) | 651-654 |
Number of pages | 4 |
ISSN | 0022-2593 |
DOIs | |
Publication status | Published - 1 Oct 2016 |
- Cardiomyopathy, Congenital heart disease, Muscle disease
Research areas
ID: 245662454