Novel myosin-based therapies for congenital cardiac and skeletal myopathies

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Novel myosin-based therapies for congenital cardiac and skeletal myopathies. / Ochala, Julien; Sun, Yin Biao.

In: Journal of Medical Genetics, Vol. 53, No. 10, 01.10.2016, p. 651-654.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Ochala, J & Sun, YB 2016, 'Novel myosin-based therapies for congenital cardiac and skeletal myopathies', Journal of Medical Genetics, vol. 53, no. 10, pp. 651-654. https://doi.org/10.1136/jmedgenet-2016-103881

APA

Ochala, J., & Sun, Y. B. (2016). Novel myosin-based therapies for congenital cardiac and skeletal myopathies. Journal of Medical Genetics, 53(10), 651-654. https://doi.org/10.1136/jmedgenet-2016-103881

Vancouver

Ochala J, Sun YB. Novel myosin-based therapies for congenital cardiac and skeletal myopathies. Journal of Medical Genetics. 2016 Oct 1;53(10):651-654. https://doi.org/10.1136/jmedgenet-2016-103881

Author

Ochala, Julien ; Sun, Yin Biao. / Novel myosin-based therapies for congenital cardiac and skeletal myopathies. In: Journal of Medical Genetics. 2016 ; Vol. 53, No. 10. pp. 651-654.

Bibtex

@article{6d76e835f6b149f89f7d235ab22a1e53,
title = "Novel myosin-based therapies for congenital cardiac and skeletal myopathies",
abstract = "The dysfunction in a number of inherited cardiac and skeletal myopathies is primarily due to an altered ability of myofilaments to generate force and motion. Despite this crucial knowledge, there are, currently, no effective therapeutic interventions for these diseases. In this short review, we discuss recent findings giving strong evidence that genetically or pharmacologically modulating one of the myofilament proteins, myosin, could alleviate the muscle pathology. This should constitute a research and clinical priority.",
keywords = "Cardiomyopathy, Congenital heart disease, Muscle disease",
author = "Julien Ochala and Sun, {Yin Biao}",
year = "2016",
month = oct,
day = "1",
doi = "10.1136/jmedgenet-2016-103881",
language = "English",
volume = "53",
pages = "651--654",
journal = "Journal of Medical Genetics",
issn = "0022-2593",
publisher = "B M J Group",
number = "10",

}

RIS

TY - JOUR

T1 - Novel myosin-based therapies for congenital cardiac and skeletal myopathies

AU - Ochala, Julien

AU - Sun, Yin Biao

PY - 2016/10/1

Y1 - 2016/10/1

N2 - The dysfunction in a number of inherited cardiac and skeletal myopathies is primarily due to an altered ability of myofilaments to generate force and motion. Despite this crucial knowledge, there are, currently, no effective therapeutic interventions for these diseases. In this short review, we discuss recent findings giving strong evidence that genetically or pharmacologically modulating one of the myofilament proteins, myosin, could alleviate the muscle pathology. This should constitute a research and clinical priority.

AB - The dysfunction in a number of inherited cardiac and skeletal myopathies is primarily due to an altered ability of myofilaments to generate force and motion. Despite this crucial knowledge, there are, currently, no effective therapeutic interventions for these diseases. In this short review, we discuss recent findings giving strong evidence that genetically or pharmacologically modulating one of the myofilament proteins, myosin, could alleviate the muscle pathology. This should constitute a research and clinical priority.

KW - Cardiomyopathy

KW - Congenital heart disease

KW - Muscle disease

UR - http://www.scopus.com/inward/record.url?scp=84978871066&partnerID=8YFLogxK

U2 - 10.1136/jmedgenet-2016-103881

DO - 10.1136/jmedgenet-2016-103881

M3 - Journal article

C2 - 27412953

AN - SCOPUS:84978871066

VL - 53

SP - 651

EP - 654

JO - Journal of Medical Genetics

JF - Journal of Medical Genetics

SN - 0022-2593

IS - 10

ER -

ID: 245662454