Pontus Emanuel Gourdon
Associate Professor
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Dynein regulates Kv7.4 channel trafficking from the cell membrane
van der Horst, Jennifer, Rognant, Salomé, Abbott, G. W., Ozhathil, Lijo Cherian, Hägglund, Per Mårten, Barrese, V., Chuang, Christine, Jespersen, Thomas, Davies, Michael J., Greenwood, I. A., Gourdon, Pontus Emanuel, Aalkjær, Christian & Jepps, Thomas Andrew Qvistgaard, 2021, In: Journal of General Physiology. 153, 3, 19 p., e202012760.Research output: Contribution to journal › Journal article › Research › peer-review
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Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function
Zhang, L., Simonsen, C., Zimova, L., Wang, Kaituo, Moparthi, L., Gaudet, R., Ekoff, M., Nilsson, G., Hellmich, U. A., Vlachova, V., Gourdon, Pontus Emanuel & Zygmunt, P. M., 2022, In: Nature Communications. 13, 1, 18 p., 7483.Research output: Contribution to journal › Journal article › Research › peer-review
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Isolation and Crystallization of the D156C Form of Optogenetic ChR2
Zhang, L., Wang, Kaituo, Ning, S., Pedersen, Per Amstrup, Duelli, A. S. & Gourdon, Pontus Emanuel, 2022, In: Cells. 11, 5, 11 p., 895.Research output: Contribution to journal › Journal article › Research › peer-review
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Purification of Functional Human TRP Channels Recombinantly Produced in Yeast
Zhang, L., Wang, Kaituo, Klærke, Dan Arne, Callø, Kirstine, Lowrey, L., Pedersen, Per Amstrup, Gourdon, Pontus Emanuel & Gotfryd, K., 2019, In: Cells. 8, 2, p. 1-20 148.Research output: Contribution to journal › Journal article › Research › peer-review
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The two-domain elevator-type mechanism of zinc-transporting ZIP proteins
Wiuf, A., Steffen, Jonas Hyld, Becares, E. R., Gronberg, C., Mahato, D. R., Rasmussen, Søren Gøgsig Faarup, Andersson, M., Croll, T., Gotfryd, K. & Gourdon, Pontus Emanuel, 2022, In: Science Advances. 8, 28, 13 p., 4331.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure and mechanism of Zn2+-transporting P-type ATPases
Wang, Kaituo, Sitsel, O., Meloni, G., Autzen, Henriette Elisabeth, Andersson, M., Klymchuk, T., Nielsen, A. M., Rees, D. C., Nissen, P. & Gourdon, Pontus Emanuel, 23 Oct 2014, In: Nature. 514, 7523, p. 518-22 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding
Wang, Kaituo, Dagil, Robert, Lavstsen, Thomas, Misra, S. K., Spliid, C. B., Wang, Y., Gustavsson, Tobias, Sandoval, D. R., Vidal-Calvo, E. E., Choudhary, Swati, Agerbæk, Mette Ørskov, Lindorff-Larsen, Kresten, Nielsen, Morten Agertoug, Theander, Thor Grundtvig, Sharp, J. S., Clausen, Thomas Mandel, Gourdon, Pontus Emanuel & Salanti, Ali, 2021, In: Nature Communications. 12, 1, 10 p., 2956.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure of the human ClC-1 chloride channel
Wang, Kaituo, Preisler, Sarah Spruce, Zhang, L., Cui, Y., Missel, Julie Winkel, Grønberg, C., Gotfryd, K., Lindahl, E., Andersson, M., Callø, Kirstine, Egea, P. F., Klærke, Dan Arne, Pusch, M., Pedersen, Per Amstrup, Zhou, Z. H. & Gourdon, Pontus Emanuel, 2019, In: PLOS Biology. 17, 4, p. 1-20 e3000218.Research output: Contribution to journal › Journal article › Research › peer-review
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The role of water coordination in the pH-dependent gating of hAQP10
Truelsen, S. F., Missel, Julie Winkel, Gotfryd, K., Pedersen, Per Amstrup, Gourdon, Pontus Emanuel, Lindorff-Larsen, Kresten & Hélix-Nielsen, C., 2022, In: B B A - Biomembranes. 1864, 1, 13 p., 183809.Research output: Contribution to journal › Journal article › Research › peer-review
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Identification of bile acid-CoA:amino acid N-acyltransferase as the hepatic N-acyl taurine synthase for polyunsaturated fatty acids
Trammell, Sam, Gamon, Luke Francis, Gotfryd, K., Michler, Katja Thorøe, Alrehaili, B. D., Rix, I., Knop, Filip Krag, Gourdon, Pontus Emanuel, Lee, Y. K., Davies, Michael J., Gillum, M. P. & Grevengoed, Trisha Jean, 2023, In: Journal of Lipid Research. 64, 9, 9 p., 100361.Research output: Contribution to journal › Journal article › Research › peer-review
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Crystal structure of AcrB in complex with a single transmembrane subunit reveals another twist
Toernroth-Horsefield, S., Gourdon, Pontus Emanuel, Horsefield, R., Brive, L., Yamamoto, N., Mori, H., Snijder, A. & Neutze, R., Dec 2007, In: Structure. 15, 12, p. 1663-1673Research output: Contribution to journal › Journal article › Research › peer-review
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Assessing water permeability of aquaporins in a proteoliposome-based stopped-flow setup
Steffen, Jonas Hyld, Missel, Julie Winkel, Al-Jubair, T., Kitchen, P., Salman, M. M., Bill, R. M., Törnroth-Horsefield, S. & Gourdon, Pontus Emanuel, 2022, In: STAR Protocols. 3, 2, 11 p., 101312.Research output: Contribution to journal › Journal article › Research › peer-review
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Identifying Heterozipper β-Sheet in Twisted Amyloid Aggregation
Song, Y., Dai, B., Wang, Y., Wang, Y., Liu, C., Gourdon, Pontus Emanuel, Liu, L., Wang, Kaituo & Dong, M., 2022, In: Nano Letters. 22, 9, p. 3707–3712Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of ATP7A missense mutants suggests a correlation between intracellular trafficking and severity of Menkes disease
Skjørringe, T., Pedersen, Per Amstrup, Thorborg, S. S., Nissen, P., Gourdon, Pontus Emanuel & Møller, L. B., 7 Apr 2017, In: Scientific Reports. 7, 18 p., 757.Research output: Contribution to journal › Journal article › Research › peer-review
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Crystallization of P-type ATPases by the High Lipid-Detergent (HiLiDe) Method
Sitsel, O., Wang, Kaituo, Liu, X. & Gourdon, Pontus Emanuel, 2016, P-Type ATPases: Methods and Protocols. Bublitz, M. (ed.). Springer, Vol. 1377. p. 413-420 8 p. (Methods in Molecular Biology, Vol. 1377).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Structure and Function of Cu(I)- and Zn(II)-ATPases
Sitsel, O., Grønberg, C., Autzen, Henriette Elisabeth, Wang, Kaituo, Meloni, G., Nissen, P. & Gourdon, Pontus Emanuel, 22 Sep 2015, In: Biochemistry. 54, 37, p. 5673-5683 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural basis of ion uptake in copper-transporting P1B-type ATPases
Salustros, N., Gronberg, C., Abeyrathna, N. S., Lyu, Pin, Oradd, F., Wang, Kaituo, Andersson, M., Meloni, G. & Gourdon, Pontus Emanuel, 2022, In: Nature Communications. 13, 1, 11 p., 5121.Research output: Contribution to journal › Journal article › Research › peer-review
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Mechanisms of a Mycobacterium tuberculosis Active Peptide
Rao, K. U., Li, P., Welinder, C., Tenland, E., Gourdon, Pontus Emanuel, Sturegård, E., Ho, J. C. S. & Godaly, G., 2023, In: Pharmaceutics. 15, 2, 16 p., 540.Research output: Contribution to journal › Journal article › Research › peer-review
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Endothelial protein C receptor binding induces conformational changes to severe malaria-associated group A PfEMP1
Raghavan, Sai Sundar Rajan, Turner, Louise, Jensen, R. W., Johansen, Nicolai Tidemand, Jensen, D. S., Gourdon, Pontus Emanuel, Zhang, J., Wang, Y., Theander, Thor Grundtvig, Wang, Kaituo & Lavstsen, Thomas, 2023, In: Structure. 31, 10, p. 1174-1183.e4Research output: Contribution to journal › Journal article › Research › peer-review
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Cryo-EM reveals the conformational epitope of human monoclonal antibody PAM1.4 broadly reacting with polymorphic malarial protein VAR2CSA
Raghavan, Sai Sundar Rajan, Dagil, Robert, Lopez-Perez, Mary, Conrad, J., Bassi, Maria Rosaria, Quintana Varon, Maria del Pilar, Choudhary, Swati, Gustavsson, Tobias, Wang, Y., Gourdon, Pontus Emanuel, Ofori, M. F., Christensen, S. B., Minja, D. T. R., Schmiegelow, Christentze, Nielsen, Morten Agertoug, Barfod, Lea Klingenberg, Hviid, Lars, Salanti, Ali, Lavstsen, Thomas & Wang, Kaituo, 2022, In: PLoS Pathogens. 18, 11, e1010924.Research output: Contribution to journal › Journal article › Research › peer-review
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Saccharomyces cerevisiae as a superior host for overproduction of prokaryotic integral membrane proteins
Preisler, Sarah Spruce, Wiuf, A. D., Friis, M., Kjaergaard, L., Hurd, M., Becares, E. R., Nurup, C. N., Bjoerkskov, F. B., Szathmáry, Z., Gourdon, Pontus Emanuel, Callø, Kirstine, Klærke, Dan Arne, Gotfryd, K. & Pedersen, Per Amstrup, 2021, In: Current research in structural biology. 3, p. 51-71 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Initiating Heavy-atom Based Phasing by Multi-Dimensional Molecular Replacement
Pedersen, B. P., Gourdon, Pontus Emanuel, Liu, X., Karlsen, J. L. & Nissen, P., 28 Mar 2014, In: arXiv. p. 1-19 19 p.Research output: Contribution to journal › Journal article › Research
Initiating heavy-atom-based phasing by multi-dimensional molecular replacement
Pedersen, B. P., Gourdon, Pontus Emanuel, Liu, X., Karlsen, J. L. & Nissen, P., 1 Mar 2016, In: Acta crystallographica Section D: Structural biology . 72, 3, p. 440-445 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Copper binding leads to increased dynamics in the regulatory N-terminal domain of full-length human copper transporter ATP7B
Orädd, F., Steffen, Jonas Hyld, Gourdon, Pontus Emanuel & Andersson, M., 2022, In: PLOS Computational Biology. 18, 9 September, 21 p., e1010074.Research output: Contribution to journal › Journal article › Research › peer-review
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Crystal Structure of Na+, K+-ATPase in the Na+-Bound State
Nyblom, M., Poulsen, H., Gourdon, Pontus Emanuel, Reinhard, L., Andersson, M., Lindahl, E., Fedosova, N. & Nissen, P., 4 Oct 2013, In: Science. 342, 6154, p. 123-127Research output: Contribution to journal › Journal article › Research › peer-review
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Principles to recover copper-conducting CTR proteins for the purpose of structural and functional studies
Nayeri, N., Li, P., Górecki, K., Lindkvist-Petersson, K. & Gourdon, Pontus Emanuel, 2023, In: Protein Expression and Purification. 203, 8 p., 106213.Research output: Contribution to journal › Journal article › Research › peer-review
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Cyclohexyl-alpha maltoside as a highly efficient tool for membrane protein studies
Missel, Julie Winkel, Salustros, N., Becares, E. R., Steffen, Jonas Hyld, Laursen, A. G., Garcia, A. S., Garcia-Alai, M. M., Kolar, C., Gourdon, Pontus Emanuel & Gotfryd, K., 2021, In: Current Research in Structural Biology. 3, p. 85-94 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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On Allosteric Modulation of P-Type Cu+-ATPases
Mattle, D., Sitsel, O., Autzen, Henriette Elisabeth, Meloni, G., Gourdon, Pontus Emanuel & Nissen, P., 10 Jul 2013, In: Journal of Molecular Biology. 425, 13, p. 2299-2308Research output: Contribution to journal › Journal article › Research › peer-review
A sulfur-based transport pathway in Cu+-ATPases
Mattle, D., Zhang, L., Sitsel, O., Pedersen, L. T., Moncelli, M. R., Tadini-Buoninsegni, F., Gourdon, Pontus Emanuel, Rees, D. C., Nissen, P. & Meloni, G., 1 Jun 2015, In: E M B O Reports. 16, 6, p. 728-470 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Isolation and Characterization of Nanobodies against a Zinc-Transporting P-Type ATPase
Longhin, E., Gronberg, C., Hu, Q., Duelli, A. S., Andersen, K. R., Laursen, N. S. & Gourdon, Pontus Emanuel, 2018, In: Antibodies. 7, 4, 15 p., 39.Research output: Contribution to journal › Journal article › Research › peer-review
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Overproduction of PIB-Type ATPases
Liu, X., Sitsel, O., Wang, Kaituo & Gourdon, Pontus Emanuel, 2016, P-Type ATPases: Methods and Protocols. Bublitz, M. (ed.). Springer, Vol. 1377. p. 29-36 8 p. (Methods in Molecular Biology, Vol. 1377).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Permeability and ammonia selectivity in aquaporin TIP2;1: linking structure to function
Lindahl, V., Gourdon, Pontus Emanuel, Andersson, M. & Hess, B., 2018, In: Scientific Reports. 8, 13 p., 2995 .Research output: Contribution to journal › Journal article › Research › peer-review
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Structures of Atm1 provide insight into [2Fe-2S] cluster export from mitochondria
Li, P., Hendricks, A. L., Wang, Y., Villones, R. L. E., Lindkvist-Petersson, K., Meloni, G., Cowan, J. A., Wang, Kaituo & Gourdon, Pontus Emanuel, 2022, In: Nature Communications. 13, 1, 12 p., 4339.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure and transport mechanism of P5B-ATPases
Li, P., Wang, Kaituo, Salustros, N., Grønberg, C. & Gourdon, Pontus Emanuel, 2021, In: Nature Communications. 12, 1, 8 p., 3973.Research output: Contribution to journal › Journal article › Research › peer-review
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PcoB is a defense outer membrane protein that facilitates cellular uptake of copper
Li, P., Nayeri, N., Górecki, K., Becares, E. R., Wang, Kaituo, Mahato, D. R., Andersson, M., Abeyrathna, S. S., Lindkvist-Petersson, K., Meloni, G., Missel, Julie Winkel & Gourdon, Pontus Emanuel, 2022, In: Protein Science. 31, 7, p. 1-16 e4364.Research output: Contribution to journal › Journal article › Research › peer-review
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The role of phosphorylation in calmodulin-mediated gating of human AQP0
Kreida, S., Roche, J. V., Missel, Julie Winkel, Al-Jubair, T., Hagströmer, C. J., Wittenbecher, V., Linse, S., Gourdon, Pontus Emanuel & Törnroth-Horsefield, S., 2024, In: The Biochemical journal. 481, 1, p. 17-32 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Heterologous expression and purification of an active human TRPV3 ion channel
Kol, S., Braun, C. S., Thiel, G., Doyle, D. A., Sundström, M., Gourdon, Pontus Emanuel & Nissen, P., 1 Dec 2013, In: The F E B S Journal (Online). 280, 23, p. 6010-6021 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema
Kitchen, P., Salman, M. M., Halsey, A. M., Clarke-Bland, C., MacDonald, J. A., Ishida, H., Vogel, H. J., Almutiri, S., Logan, A., Kreida, S., Al-Jubair, T., Missel, Julie Winkel, Gourdon, Pontus Emanuel, Törnroth-Horsefield, S., Conner, M. T., Ahmed, Z., Conner, A. C. & Bill, R. M., 2020, In: Cell. 181, 4, p. 784-799Research output: Contribution to journal › Journal article › Research › peer-review
Crystal Structure of an Ammonia-Permeable Aquaporin
Kirscht, A., Kaptan, S. S., Bienert, G. P., Chaumont, F., Nissen, P., de Groot, B. L., Kjellbom, P., Gourdon, Pontus Emanuel & Johanson, U., Mar 2016, In: PLoS Biology. 14, 3, 19 p., e1002411.Research output: Contribution to journal › Journal article › Research › peer-review
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Conformational regulation of charge recombination reactions in a photosynthetic bacterial reaction center
Katona, G., Snijder, A., Gourdon, Pontus Emanuel, Andréasson, U., Hansson, O., Andréasson, L. & Neutze, R., Jul 2005, In: Nature Structural and Molecular Biology. 12, 7, p. 630-1 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Phospholipid flipping involves a central cavity in P4 ATPases
Jensen, M. S., Costa, S., Duelli, A. S., Andersen, P. A., Poulsen, L. R., Stanchev, L. D., Gourdon, Pontus Emanuel, Palmgren, Michael, Pomorski, Thomas Guenther & Lopez Marques, Rosa Laura, 2017, In: Scientific Reports. 7, 13 p., 17621.Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular basis for human aquaporin inhibition
Huang, P., Åbacka, H., Wilson, C. J., Wind, Malene Lykke, Rűtzler, M., Hagström-Andersson, A., Gourdon, Pontus Emanuel, de Groot, B. L., Venskutonytė, R. & Lindkvist-Petersson, K., 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 7, e2319682121.Research output: Contribution to journal › Journal article › Research › peer-review
Aquaglyceroporins and orthodox aquaporins in human adipocytes
Huang, P., Hansen, J. S., Saba, K. H., Bergman, A., Negoita, F., Gourdon, Pontus Emanuel, Hagström-Andersson, A. & Lindkvist-Petersson, K., 1 Feb 2022, In: B B A - Biomembranes. 1864, 1, 183795.Research output: Contribution to journal › Journal article › Research › peer-review
Cryo-EM structure supports a role of AQP7 as a junction protein
Huang, P., Venskutonytė, R., Prasad, R. B., Ardalani, H., de Maré, S. W., Fan, X., Li, P., Spégel, P., Yan, N., Gourdon, Pontus Emanuel, Artner, I. & Lindkvist-Petersson, K., 2023, In: Nature Communications. 14, 1, 12 p., 600.Research output: Contribution to journal › Journal article › Research › peer-review
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FK506-Binding Protein 2 Participates in Proinsulin Folding
Hoefner, C., Bryde, T. H., Pihl, C., Tiedemann, S. N., Bresson, S. E., Hotiana, H. A., Khilji, M. S., Santos, T. D., Puglia, M., Pisano, P., Majewska, M., Durzynska, J., Klindt, K., Klusek, J., Perone, M. J., Bucki, R., Hägglund, P. M., Gourdon, P. E., Gotfryd, K., Urbaniak, E. & 5 others, , 2023, In: Biomolecules. 13, 1, 20 p., 152.Research output: Contribution to journal › Journal article › Research › peer-review
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The rapid “teabag” method for high-end purification of membrane proteins
Hering, J., Missel, Julie Winkel, Zhang, L., Gunnarsson, A., Castaldo, M., Pedersen, Per Amstrup, Ek, M., Gourdon, Pontus Emanuel & Snijder, H. J., 2020, In: Scientific Reports. 10, 11 p., 16167.Research output: Contribution to journal › Journal article › Research › peer-review
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Peroxynitrous acid (ONOOH) modifies the structure of anastellin and influences its capacity to polymerize fibronectin
He, Jianfei, Becares, E. R., Thulstrup, Peter Waaben, Gamon, Luke Francis, Pedersen, J. N., Otzen, D., Gourdon, Pontus Emanuel, Davies, Michael J. & Hägglund, Per Mårten, 2020, In: Redox Biology. 36, 11 p., 101631.Research output: Contribution to journal › Journal article › Research › peer-review
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Anastellin impacts on the processing of extracellular matrix fibronectin and stimulates release of cytokines from coronary artery smooth muscle cells
He, Jianfei, Steffen, Jonas Hyld, Thulstrup, Peter Waaben, Pedersen, J. N., Sauerland, Max Benjamin, Otzen, D. E., Hawkins, Clare Louise, Gourdon, Pontus Emanuel, Davies, Michael J. & Hägglund, Per Mårten, 2022, In: Scientific Reports. 12, 1, 15 p., 22051.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural and functional analysis of aquaporin-2 mutants involved in nephrogenic diabetes insipidus
Hagströmer, C. J., Steffen, Jonas Hyld, Kreida, S., Al-Jubair, T., Frick, A., Gourdon, Pontus Emanuel & Törnroth-Horsefield, S., Dec 2023, In: Scientific Reports. 13, 1, 15 p., 14674.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 108586181
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A high-yield co-expression system for the purification of an intact drs2p-cdc50p lipid flippase complex, critically dependent on and stabilized by phosphatidylinositol-4-phosphate
Research output: Contribution to journal › Journal article › Research › peer-review
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Purification and functional comparison of nine human Aquaporins produced in Saccharomyces cerevisiae for the purpose of biophysical characterization
Research output: Contribution to journal › Journal article › Research › peer-review
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186
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Structure of the human ClC-1 chloride channel
Research output: Contribution to journal › Journal article › Research › peer-review
Published