Nils Billestrup

Nils Billestrup

Professor

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    ORCID: 0000-0002-4968-8067

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    1. Published

      Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling

      Adams, T. E., Hansen, J. A., Starr, R., Nicola, N. A., Hilton, D. J. & Billestrup, Nils, 16 Jan 1998, In: The Journal of Biological Chemistry. 273, 3, p. 1285-7 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Identification of phenylalanine 346 in the rat growth hormone receptor as being critical for ligand-mediated internalization and down-regulation

      Allevato, G., Billestrup, Nils, Goujon, L., Galsgaard, E. D., Norstedt, G., Postel-Vinay, M. C., Kelly, P. A. & Nielsen, Jens Høiriis, 21 Jul 1995, In: The Journal of Biological Chemistry. 270, 29, p. 17210-4 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1

      Argetsinger, L. S., Hsu, G. W., Myers, M. G., Billestrup, Nils, White, M. F. & Carter-Su, C., 16 Jun 1995, In: The Journal of Biological Chemistry. 270, 24, p. 14685-92 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Growth hormone, interferon-gamma, and leukemia inhibitory factor utilize insulin receptor substrate-2 in intracellular signaling

      Argetsinger, L. S., Norstedt, G., Billestrup, Nils, White, M. F. & Carter-Su, C., 15 Nov 1996, In: The Journal of Biological Chemistry. 271, 46, p. 29415-21 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Pituitary mammosomatotroph adenomas develop in old mice transgenic for growth hormone-releasing hormone

      Asa, S. L., Kovacs, K., Stefaneanu, L., Horvath, E., Billestrup, Nils, Gonzalez-Manchon, C. & Vale, W., Mar 1990, In: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 193, 3, p. 232-5 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Pituitary adenomas in mice transgenic for growth hormone-releasing hormone

      Asa, S. L., Kovacs, K., Stefaneanu, L., Horvath, E., Billestrup, Nils, Gonzalez-Manchon, C. & Vale, W., Nov 1992, In: Endocrinology. 131, 5, p. 2083-9 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Growth hormone (GH)-independent dimerization of GH receptor by a leucine zipper results in constitutive activation

      Behncken, S. N., Billestrup, Nils, Brown, R., Amstrup, J., Conway-Campbell, B. & Waters, M. J., 2 Jun 2000, In: The Journal of Biological Chemistry. 275, 22, p. 17000-7 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Pannexin-2-deficiency sensitizes pancreatic beta-cells to cytokine-induced apoptosis in vitro and impairs glucose tolerance in vivo

      Berchtold, L. A., Miani, M., Diep, T. A., Madsen, A. N., Cigliola, V., Colli, M., Miskovic Krivokapic, Jelena, Pociot, Flemming, Eizirik, D. L., Meda, P., Holst, Birgitte, Billestrup, Nils & Storling, J., 2017, In: Molecular and Cellular Endocrinology. 448, p. 108-121 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      The stimulatory effect of growth hormone, prolactin, and placental lactogen on beta-cell proliferation is not mediated by insulin-like growth factor-I

      Billestrup, Nils & Nielsen, Jens Høiriis, Aug 1991, In: Endocrinology. 129, 2, p. 883-8 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Growth hormone receptor C-terminal domains required for growth hormone-induced intracellular free Ca2+ oscillations and gene transcription

      Billestrup, Nils, Bouchelouche, P., Allevato, G., Ilondo, M. & Nielsen, Jens Høiriis, 28 Mar 1995, In: Proceedings of the National Academy of Sciences of the United States of America. 92, 7, p. 2725-9 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Growth of the endocrine pancreas: the role of somatolactogenic hormones and receptors

      Billestrup, Nils, Møldrup, A., Allevato, G., Petersen, Erik Brinch, Pedersen, Johan, Hansen, J. A. & Nielsen, Jens Høiriis, Feb 1993, In: Biochemical Society Transactions. 21, 1, p. 146-9 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Molecular dissection of the growth hormone receptor. Identification of distinct cytoplasmic domains corresponding to different signaling pathways

      Billestrup, Nils, Allevato, G., Møldrup, A., Galsgaard, E. D., Amstrup, J., Hansen, J. A., Svensson, C. & Nielsen, Jens Høiriis, 7 Sep 1995, In: Annals of the New York Academy of Sciences. 766, p. 481-3 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Introduction of exogenous growth hormone receptors augments growth hormone-responsive insulin biosynthesis in rat insulinoma cells

      Billestrup, Nils, Møldrup, A., Serup, Palle, Mathews, L. S., Norstedt, G. & Nielsen, Jens Høiriis, Sep 1990, In: Proceedings of the National Academy of Sciences of the United States of America. 87, 18, p. 7210-4 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Molecular mechanism of growth hormone signalling

      Billestrup, Nils, Hansen, J. A., Hansen, L. H., Møldrup, A., Galsgaard, E. D. & Nielsen, Jens Høiriis, Apr 1998, In: Endocrine Journal. 45 Suppl, p. S41-5

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Identification of intracellular domains in the growth hormone receptor involved in signal transduction

      Billestrup, Nils, Allevato, G., Norstedt, G., Møldrup, A. & Nielsen, Jens Høiriis, Jul 1994, In: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 206, 3, p. 205-9 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Growth hormone-releasing factor induces c-fos expression in cultured primary pituitary cells

      Billestrup, Nils, Mitchell, R. L., Vale, W. & Verma, I. M., Apr 1987, In: Molecular endocrinology (Baltimore, Md.). 1, 4, p. 300-5 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      ID'ing a novel inhibitor of β-cell function, Id1

      Billestrup, Nils, Oct 2011, In: Diabetes. 60, 10, p. 2455-6 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Growth hormone-releasing factor stimulates proliferation of somatotrophs in vitro

      Billestrup, Nils, Swanson, L. W. & Vale, W., Sep 1986, In: Proceedings of the National Academy of Sciences of the United States of America. 83, 18, p. 6854-7 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Growth hormone binding to specific receptors stimulates growth and function of cloned insulin-producing rat insulinoma RIN-5AH cells

      Billestrup, Nils & Martin, J. M., Mar 1985, In: Endocrinology. 116, 3, p. 1175-81 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Human growth hormone binding and stimulation of insulin biosynthesis in cloned rat insulinoma cells

      Billestrup, Nils, 1985, In: Biomedica Biochimica Acta. 44, 1, p. 85-7 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Inhibition of somatotroph growth and growth hormone biosynthesis by activin in vitro

      Billestrup, Nils, González-Manchón, C., Potter, E. & Vale, W., Feb 1990, In: Molecular endocrinology (Baltimore, Md.). 4, 2, p. 356-62 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Dedifferentiation for replication of human beta-cells: a division between mice and men?

      Billestrup, Nils & Otonkoski, T., 2008, In: Diabetes. 57, 6, p. 1457-8 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      CRFR1 activation protects against cytokine-induced beta cell death

      Blaabjerg, L., Christensen, G. L., Matsumoto, M., van der Meulen, T., Huising, M. O., Billestrup, Nils & Vale, W., 16 Oct 2014, In: Journal of Molecular Endocrinology. 53, p. 417-427 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Suppressor of cytokine signalling-3 inhibits Tumor necrosis factor-alpha induced apoptosis and signalling in beta cells

      Bruun, C., Heding, P. E., Rønn, S. G., Frobøse, H., Rhodes, C. J., Mandrup-Poulsen, Thomas & Billestrup, Nils, 2009, In: Molecular and Cellular Endocrinology. 311, 1-2, p. 32-8 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Inhibition of beta cell growth and function by bone morphogenetic proteins

      Bruun, C., Christensen, G. L., Jacobsen, M. L. B., Kanstrup, M. B., Jensen, P. R., Fjordvang, H., Mandrup-Poulsen, Thomas & Billestrup, Nils, 27 Sep 2014, In: Diabetologia. 57, 12, p. 2546-54 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      ß-cell specific overexpression of suppressor of cytokine signalling-3 does not protect against multiple low dose streptozotocin induced type 1 diabetes in mice

      Börjesson, A., Rønn, S. G., Karlsen, A. E., Billestrup, Nils & Sandler, S., 30 Apr 2011, In: Immunology Letters. 136, 1, p. 74-9 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Growth hormone and prolactin stimulate the expression of rat preadipocyte factor-1/delta-like protein in pancreatic islets: molecular cloning and expression pattern during development and growth of the endocrine pancreas

      Carlsson, C., Tornehave, D., Lindberg, K., Galante, P., Billestrup, Nils, Michelsen, B., Larsson, L. I. & Nielsen, Jens Høiriis, Sep 1997, In: Endocrinology. 138, 9, p. 3940-8 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus

      Christensen, D. P., Dahllöf, M. S., Lundh, M., Rasmussen, D. N., Nielsen, M. D., Billestrup, Nils, Grunnet, L. G. & Mandrup-Poulsen, Thomas, 2011, In: Molecular Medicine. 17, 5-6, p. 378-90 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection

      Christensen, D. P., Gysemans, C., Lundh, M., Dahllöf, M. S., Noesgaard, D., Schmidt, S. F., Mandrup, S., Birkbak, N., Workman, C., Piemonti, L., Blaabjerg, L., Monzani, V., Fossati, G., Mascagni, P., Paraskevas, S., Aikin, R. A., Billestrup, N., Grunnet, L. G., Dinarello, C. A., Mathieu, C. & 1 others, Mandrup-Poulsen, Thomas, 6 Jan 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 3, p. 1055-9 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Bone morphogenetic protein 4 inhibits insulin secretion from rodent beta cells through regulation of calbindin1 expression and reduced voltage-dependent calcium currents

      Christensen, G. L., Jacobsen, M. L. B., Wendt, A., Mollet, I. G., Friberg, J., Frederiksen, K. S., Meyer, M., Bruun, C., Eliasson, L. & Billestrup, Nils, Jun 2015, In: Diabetologia. 58, 6, p. 1282-1290 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Growth hormone receptor expression and function in pituitary adenomas

      Clausen, L. R., Kristiansen, M. T., Rasmussen, L. M., Billestrup, Nils, Blaabjerg, O., Ledet, T. & Jørgensen, J. O. L., May 2004, In: Clinical Endocrinology. 60, 5, p. 576-83 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells

      Collombat, P., Xu, X., Ravassard, P., Sosa-Pineda, B., Dussaud, S., Billestrup, Nils, Madsen, O. D., Serup, P., Heimberg, H. & Mansouri, A., 2009, In: Cell. 138, 3, p. 449-62 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Preparation of 125I-protein A usable for up to 10 months in immunoassays

      Dyrberg, T. & Billestrup, Nils, 6 Jul 1984, In: Journal of Immunological Methods. 71, 2, p. 193-201 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Deficient SOCS3 and SHP-1 Expression in Psoriatic T Cells

      Eriksen, K. W., Woetmann, Anders , Skov, Lone, Krejsgaard, T., Bovin, L. F., Hansen, M. L., Grønbæk, Kirsten, Billestrup, Nils, Nissen, Mogens Holst, Geisler, Carsten, Wasik, M. A. & Ødum, Niels, 2010, In: Journal of Investigative Dermatology. 130, 6, p. 1590-7 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic beta-cells

      Friedrichsen, B. N., Richter, H. E., Hansen, J. A., Rhodes, C. J., Nielsen, Jens Høiriis, Billestrup, Nils & Møldrup, A., May 2003, In: Molecular endocrinology (Baltimore, Md.). 17, 5, p. 945-58 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Dissociation between skeletal muscle inhibitor-{kappa}B kinase/nuclear factor-{kappa}B pathway activity and insulin sensitivity in nondiabetic twins

      Friedrichsen, M., Ribel-Madsen, R., Wojtaszewski, Jørgen F P, Grunnet, Louise Groth, Richter, Erik A., Billestrup, Nils, Ploug, Thorkil, Vaag, A. & Poulsen, P., 2010, In: Journal of Clinical Endocrinology and Metabolism. 95, 1, p. 414-421 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Identification of a growth hormone-responsive STAT5-binding element in the rat insulin 1 gene

      Galsgaard, E. D., Gouilleux, F., Groner, B., Serup, Palle, Billestrup, Nils & Nielsen, Jens Høiriis, Jun 1996, In: Molecular endocrinology (Baltimore, Md.). 10, 6, p. 652-60 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Regulation of glucose transport and c-fos and egr-1 expression in cells with mutated or endogenous growth hormone receptors

      Gong, T. W., Meyer, D. J., Liao, J., Hodge, C. L., Campbell, G. S., Wang, X., Billestrup, Nils, Carter-Su, C. & Schwartz, J., Apr 1998, In: Endocrinology. 139, 4, p. 1863-71 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling

      Greenhalgh, C. J., Metcalf, D., Thaus, A. L., Corbin, J. E., Uren, R., Morgan, P. O., Fabri, L. J., Zhang, J., Martin, H. M., Willson, T. A., Billestrup, Nils, Nicola, N. A., Baca, M., Alexander, W. S. & Hilton, D. J., 25 Oct 2002, In: The Journal of Biological Chemistry. 277, 43, p. 40181-4 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells

      Grunnet, L. G., Aikin, R., Tonnesen, M. F., Paraskevas, S., Blaabjerg, L., Størling, J., Rosenberg, L., Billestrup, Nils, Maysinger, D. & Mandrup-Poulsen, Thomas, 2009, In: Diabetes. 58, 8, p. 1807-15 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity

      Gylvin, T., Nolsøe, R., Hansen, Torben, Nielsen, E. M. D., Bergholdt, R., Karlsen, A. E., Billestrup, Nils, Borch-Johnsen, K., Pedersen, O., Mandrup-Poulsen, Thomas, Nerup, J. & Pociot, Flemming, 1 Jul 2004, In: Diabetologia. 47, 7, p. 1273-7 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Growth arrest specific protein (GAS) 6: a role in the regulation of proliferation and functional capacity of the perinatal rat beta cell

      Haase, T. N., Rasmussen, M., Jaksch, C. A. M., Gaarn, L. W., Petersen, C. K., Billestrup, Nils & Nielsen, Jens Høiriis, Apr 2013, In: Diabetologia. 56, 4, p. 763-773 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      The mitogenic effect of Gas6 on pancreatic beta cells is mediated via the receptor tyrosine kinase Axl

      Haase, T. N., Gustafsson, A., Nalla, A., Ringholm, L., Damm, Peter, Mathiesen, Elisabeth, Dahlback, B., Billestrup, Nils & Nielsen, Jens Høiriis, Sep 2014, In: Diabetologia. 57, 1 Suppl, p. S173-S174 408.

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    44. Published

      The role of GH receptor tyrosine phosphorylation in Stat5 activation

      Hansen, J. A., Hansen, Lars Hestbjerg, Wang, X., Kopchick, J. J., Gouilleux, F., Groner, B., Møldrup, A., Galsgaard, E. D., Nielsen, Jens Høiriis & Billestrup, Nils, Jun 1997, In: Journal of Molecular Endocrinology. 18, 3, p. 213-21 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Mechanism of inhibition of growth hormone receptor signaling by suppressor of cytokine signaling proteins

      Hansen, J. A., Lindberg, K., Hilton, D. J., Nielsen, Jens Høiriis & Billestrup, Nils, Nov 1999, In: Molecular endocrinology (Baltimore, Md.). 13, 11, p. 1832-43 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic ß cell fate in response to cytokines

      Hansen, J. B., Tonnesen, M. F., Madsen, A. N., Hagedorn, P., Friberg, J., Grunnet, L. G., Heller, R. S., Nielsen, A. Ø., Størling, J., Baeyens, L., Anker-Kitai, L., Qvortrup, K., Bouwens, L., Efrat, S., Aalund, M., Andrews, N. C., Billestrup, N., Karlsen, A. E., Holst, B., Pociot, F. & 1 others, Mandrup-Poulsen, Thomas, 2012, In: Cell Metabolism. 16, 4, p. 449-61 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Accepted/In press

      Genetic deficiency of tissue inhibitor of metalloproteinase (TIMP) 1 does not affect apoptosis in cytokine-exposed mouse islets in vitro.

      Hansen, J. B., Tonnesen, M. F., Rømer, M. U. K., Billestrup, Nils, Brunner, N. & Mandrup-Poulsen, Thomas, 2010, (Accepted/In press).

      Research output: Contribution to conference › Conference abstract for conference › Research

    48. Published

      Characterization of the inhibitory effect of growth hormone on primary preadipocyte differentiation

      Hansen, L. H., Madsen, B., Teisner, B., Nielsen, Jens Høiriis & Billestrup, Nils, Aug 1998, In: Molecular endocrinology (Baltimore, Md.). 12, 8, p. 1140-9 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Identification of tyrosine residues in the intracellular domain of the growth hormone receptor required for transcriptional signaling and Stat5 activation

      Hansen, L. H., Wang, X., Kopchick, J. J., Bouchelouche, P., Galsgaard, E. D., Nielsen, Jens Høiriis & Billestrup, Nils, 24 May 1996, In: The Journal of Biological Chemistry. 271, 21, p. 12669-73 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      CRFR1 is expressed on pancreatic beta cells, promotes beta cell proliferation, and potentiates insulin secretion in a glucose-dependent manner

      Huising, M. O., van der Meulen, T., Vaughan, J. M., Matsumoto, M., Donaldson, C. J., Park, H., Billestrup, Nils & Vale, W. W., 2009, In: Proceedings of the National Academy of Science of the United States of America. 107, 2, p. 912-7 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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