Mette Rosenkilde

Mette Rosenkilde

Professor

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    ORCID: 0000-0001-9600-3254

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    1. Published

      Microbiological exploitation of the chemokine system

      Holst, Peter Johannes & Rosenkilde, Mette, 2003, In: Microbes and Infection. 5, 2, p. 179-87 8 p.

      Research output: Contribution to journal › Review › Research

    2. Published

      Microbiological exploitation of the chemokine system

      Holst, Peter Johannes & Rosenkilde, Mette, 2003, In: Microbes and Infection. Vol. 2, p. 179-87

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      The Glucagon Receptor Antagonist LY2409021 has No Effect on Postprandial Glucose in Type 2 Diabetes

      Hædersdal, S., Lund, A., Maagensen, H., Nielsen-Hannerup, E., Gasbjerg, Lærke Smidt, Rosenkilde, Mette, Forman, Julie Lyng, van Hall, Gerrit, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, 2022, In: European Journal of Endocrinology. 186, 2, p. 207-221 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Peroxynitrite Exposure of CXCL12 Impairs Monocyte, Lymphocyte and Endothelial Cell Chemotaxis, Lymphocyte Extravasation in vivo and Anti-HIV-1 Activity

      Janssens, R., Boff, D., Ruytinx, P., Mortier, A., Vanheule, V., Larsen, Olav, Daugvilaite, V., Rosenkilde, Mette, Noppen, S., Liekens, S., Schols, D., De Meester, I., Opdenakker, G., Struyf, S., Teixeira, M. M., Amaral, F. A. & Proost, P., 2018, In: Frontiers in Immunology. 9, p. 1933

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Natural nitration of CXCL12 reduces its signaling capacity and chemotactic activity in vitro and abrogates intra-articular lymphocyte recruitment in vivo

      Janssens, R., Mortier, A., Boff, D., Vanheule, V., Gouwy, M., Franck, C., Larsen, Olav, Rosenkilde, Mette, Damme, J. V., Amaral, F. A., Teixeira, M. M., Struyf, S. & Proost, P., 2016, In: OncoTarget. 7, 38, p. 62439-62459 21 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Truncation of CXCL12 by CD26 reduces its CXC chemokine receptor 4- and atypical chemokine receptor 3-dependent activity on endothelial cells and lymphocytes

      Janssens, R., Mortier, A., Boff, D., Ruytinx, P., Gouwy, M., Vantilt, B., Larsen, Olav, Daugvilaite, V., Rosenkilde, Mette, Parmentier, M., Noppen, S., Liekens, S., Van Damme, J., Struyf, S., Teixeira, M. M., Amaral, F. A. & Proost, P., 2017, In: Biochemical Pharmacology. 132, p. 92-101 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Reversed binding of a small molecule ligand in homologous chemokine receptors - differential role of extracellular loop 2

      Jensen, P. C., Thiele, S., Steen, A., Elder, A., Kolbeck, R., Ghosh, S., Frimurer, Thomas Michael & Rosenkilde, Mette, May 2012, In: British Journal of Pharmacology. 166, 1, p. 258-75 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding

      Jensen, P. C., Thiele, S., Ulven, Trond, Schwartz, Thue W. & Rosenkilde, Mette, 17 Jun 2008, In: Journal of Biological Chemistry. 283, 34, p. 23121-23128 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Molecular interaction of a potent nonpeptide agonist with the chemokine receptor CCR8

      Jensen, P. C., Nygaard, R., Thiele, S., Elder, A., Zhu, G., Kolbeck, R., Ghosh, S., Schwartz, Thue W. & Rosenkilde, Mette, 2007, In: Molecular Pharmacology. 72, 2, p. 327-40 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding

      Jensen, P. C., Thiele, S., Ulven, T., Schwartz, Thue W. & Rosenkilde, Mette, 2008, In: Journal of Biological Chemistry. 283, 34, p. 23121-8 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Chapter 8. Activation mechanisms of chemokine receptors

      Jensen, P. C. & Rosenkilde, Mette, 2009, In: Methods in Enzymology. 461, p. 171-90 19 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7

      Jørgensen, Astrid Sissel, Larsen, Olav, Uetz-von Allmen, E., Lückmann, Michael, Legler, D. F., Frimurer, Thomas Michael, Veldkamp, C. T., Hjortø, Gertrud Malene & Rosenkilde, Mette, 2019, In: Frontiers in Immunology. 10, 14 p., 2156.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Biased action of the CXCR4-targeting drug plerixafor is essential for its superior hematopoietic stem cell mobilization

      Jørgensen, Astrid Sissel, Daugvilaite, V., De Filippo, K., Berg, Christian, Mavri, M., Benned-Jensen, T., Juzenaite, G., Hjortø, Gertrud Malene, Rankin, S., Vabeno, J. & Rosenkilde, Mette, 2021, In: Communications Biology . 4, 1, 12 p., 569.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      The C-terminal peptide of CCL21 drastically augments CCL21 activity through the dendritic cell lymph node homing receptor CCR7 by interaction with the receptor N-terminus

      Jørgensen, Astrid Sissel, Brandum, E. P., Mikkelsen, J. M., Orfin, K. A., Boilesen, D. R., Egerod, Kristoffer Lihme, Moussouras, N. A., Vilhardt, Frederik, Kalinski, P., Basse, P., Chen, Yen-Hsi, Yang, Zhang, Dwinell, M. B., Volkman, B. F., Veldkamp, C. T., Holst, Peter Johannes, Lahl, K., Goth, C. K., Rosenkilde, Mette & Hjortø, Gertrud Malene, 2021, In: Cellular and Molecular Life Sciences. 78, p. 6963-6978 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Biased signaling of G protein-coupled receptors: rom a chemokine receptor CCR7 perspective

      Jørgensen, Astrid Sissel, Rosenkilde, Mette & Hjortø, Gertrud Malene, Mar 2018, In: General and Comparative Endocrinology. 258, SI, p. 4-14

      Research output: Contribution to journal › Review › Research › peer-review

    16. Published

      Molecular Mechanism of Action for Allosteric Modulators and Agonists in CC-chemokine Receptor 5 (CCR5)

      Karlshøj, S., Amarandi, R. M., Larsen, Olav, Daugvilaite, V., Steen, A., Brvar, M., Pui, A., Frimurer, Thomas Michael, Ulven, Trond & Rosenkilde, Mette, 23 Dec 2016, In: Journal of Biological Chemistry. 291, 52, p. 26860-26874

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Glucagon-like peptide-1 (GLP-1) receptor agonism or DPP-4 inhibition does not accelerate neoplasia in carcinogen treated mice

      Kissow, Hannelouise, Hartmann, Bolette, Holst, Jens Juul, Viby, N., Gasbjerg, Lærke Smidt, Rosenkilde, Mette, Hare, K. J. & Poulsen, Steen Seier, 10 Nov 2012, In: Regulatory Peptides. 179, 1-3, p. 91-100 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Loss of Function Glucose-Dependent Insulinotropic Polypeptide Receptor Variants Are Associated With Alterations in BMI, Bone Strength and Cardiovascular Outcomes

      Kizilkaya, Hüsün Sheyma, Sørensen, Kimmie Vestergaard, Kibsgaard, C. J., Gasbjerg, Lærke Smidt, Hauser, Alexander Sebastian, wbf943, wbf943, Grarup, Niels & Rosenkilde, Mette, 2021, In: Frontiers in Cell and Developmental Biology. 9, 12 p., 749607.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. E-pub ahead of print

      Using LanM Enzymes to Modify Glycagon-Like Peptides 1 and 2 in E.coli

      Kjeldgaard Larsen, C., Lindquist, Peter, Rosenkilde, Mette, Ravn Madsen, A., Haselmann, K., Glendorf, T., Olesen, K., Bank Kodal, A. L. & Tørring, T., 3 May 2024, (E-pub ahead of print) In: ChemBioChem. p. e202400201

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Neprilysin inhibition increases plasma glucagon concentrations in humans with possible implications for hepatic amino acid metabolism

      Liver-Alpha-Cell Axis Grp, L. A. G., 2020, In: Diabetologia. 63, SUPPL 1, p. S72-S72 1 p., 144.

      Research output: Contribution to journal › Conference abstract in journal › Research

    21. Published

      Neprilysin Inhibition Increases Glucagon Levels in Humans and Mice With Potential Effects on Amino Acid Metabolism

      Kjeldsen, Sasha Alexandra Sampson, Hansen, L. H., Esser, N., Mongovin, S., Winther-Sørensen, Marie, Galsgaard, Katrine Douglas, Dal, Jenna Elizabeth Hunt, Kissow, Hannelouise, Ceutz, F. R., Terzic, D., Mark, P. D., Plomgaard, Peter Stendahl, Goetze, Jens P. , Goossens, G. H., Blaak, E. E., Deacon, Carolyn F., Rosenkilde, Mette, Zraika, S., Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2021, In: Endocrine Research. 5, 9, 15 p., bvab084.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Discovery of GPR183 Agonists Based on an Antagonist Scaffold

      Kjær, Viktoria Madeline Skovgaard, Ieremias, L., Daugvilaite, V., Lückmann, Michael, Frimurer, Thomas Michael, Ulven, Trond, Rosenkilde, Mette & Våbenø, J., 2021, In: ChemMedChem. 16, 17, p. 2623-2627

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization

      Kjær, Viktoria Madeline Skovgaard, Daugvilaite, V., Stepniewski, T. M., Madsen, C. M., Jørgensen, Astrid Sissel, Bhuskute, K. R., Inoue, A., Ulven, Trond, Benned-Jensen, T., Hjorth, Siv Annegrethe, Hjortø, Gertrud Malene, Moo, Ee Von, Selent, J. & Rosenkilde, Mette, 2023, In: Science Signaling. 16, 779, 13 p., eabl4283.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Ligand entry pathways control the chemical space recognized by GPR183

      Kjær, Viktoria Madeline Skovgaard, Stępniewski, T. M., Medel-Lacruz, B., Reinmuth, L., Ciba, Marija, Ulven, Elisabeth Rexen, Bonomi, M., Selent, J. & Rosenkilde, Mette, 2023, In: Chemical Science. 14, 39, p. 10671-10683

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      CD4-chemokine receptor hybrids in human immunodeficiency virus type 1 infection

      Klasse, P. J., Rosenkilde, Mette, Signoret, N., Pelchen-Matthews, A., Schwartz, Thue W. & Marsh, M., 1999, In: Journal of Virology. 73, no. 9, p. 7453-7466

      Research output: Contribution to journal › Journal article › Research › peer-review

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