Julien Ochala

Julien Ochala

Associate Professor - Promotion Programme

Member of:

    ORCID: 0000-0002-6358-2920

    Publication year:
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    1 - 50 out of 89Page size: 50
    1. 2003
    2. Published

      The influence of ageing on the force-velocity-power characteristics of human elbow flexor muscles

      Valour, D., Ochala, Julien, Ballay, Y. & Pousson, M., 1 Apr 2003, In: Experimental Gerontology. 38, 4, p. 387-395 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. 2004
    4. Published

      Changes in mechanical properties of human plantar flexor muscles in ageing

      Ochala, Julien, Lambertz, D., Pousson, M., Goubel, F. & Van Hoecke, J., Mar 2004, In: Experimental Gerontology. 39, 3, p. 349-358 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Gender differences in human muscle and joint mechanical properties during plantar flexion in old age

      Ochala, Julien, Valour, D., Pousson, M., Lambertz, D. & Van Hoecke, J., May 2004, In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 59, 5, p. 441-448 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. 2005
    7. Published

      Effect of strength training on musculotendinous stiffness in elderly individuals

      Ochala, Julien, Lambertz, D., Van Hoecke, J. & Pousson, M., May 2005, In: European Journal of Applied Physiology. 94, 1-2, p. 126-133 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. 2006
    9. Published

      Single skeletal muscle fiber behavior after a quick stretch in young and older men: A possible explanation of the relative preservation of eccentric force in old age

      Ochala, Julien, Dorer, D. J., Frontera, W. R. & Krivickas, L. S., Jul 2006, In: Pflugers Archiv European Journal of Physiology. 452, 4, p. 464-470 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. 2007
    11. Published

      Single skeletal muscle fiber elastic and contractile characteristics in young and older men

      Ochala, Julien, Frontera, W. R., Dorer, D. J., Van Hoecke, J. & Krivickas, L. S., Apr 2007, In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 62, 4, p. 375-381 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Effects of a R133W β-tropomyosin mutation on regulation of muscle contraction in single human muscle fibres

      Ochala, Julien, Li, M., Tajsharghi, H., Kimber, E., Tulinius, M., Oldfors, A. & Larsson, L., 1 Jun 2007, In: Journal of Physiology. 581, 3, p. 1283-1292 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Changes in muscle and joint elasticity following long-term strength training in old age

      Ochala, Julien, Lambertz, D., Hoecke, J. & Pousson, M., Jul 2007, In: European Journal of Applied Physiology. 100, 5, p. 491-498 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Muscle paralysis and myosin loss in a patient with cancer cachexia

      Banduseela, V., Ochala, Julien, Lamberg, K., Kalimo, H. & Larsson, L., Dec 2007, In: Acta Myologica. 26, 3, p. 136-144 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. 2008

    16. Thin filament proteins mutations associated with skeletal myopathies: Defective regulation of muscle contraction

      Ochala, Julien, 2008, In: Journal of Molecular Medicine. 86, 11, p. 1197-1204 8 p.

      Research output: Contribution to journal › Review › Research › peer-review

    17. Published

      Effects of a preferential myosin loss on Ca2+ activation of force generation in single human skeletal muscle fibres

      Ochala, Julien & Larsson, L., Apr 2008, In: Experimental Physiology. 93, 4, p. 486-495 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Defective regulation of contractile function in muscle fibres carrying an E41K β-tropomyosin mutation

      Ochala, Julien, Li, M., Ohlsson, M., Oldfors, A. & Larsson, L., 15 Jun 2008, In: Journal of Physiology. 586, 12, p. 2993-3004 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. 2009
    20. Published

      Maintenance of muscle mass, fiber size, and contractile function in mice lacking the Z-disc protein myotilin

      Ochala, Julien, Carpn, O. & Larsson, L., 2009, In: Upsala Journal of Medical Sciences. 114, 4, p. 235-241 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Gene expression and muscle fiber function in a porcine ICU model

      Banduseela, V. C., Ochala, Julien, Chen, Y. W., Göransson, H., Norman, H., Radell, P., Eriksson, L. I., Hoffman, E. P. & Larsson, L., Nov 2009, In: Physiological Genomics. 39, 3, p. 141-159 19 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. 2010
    23. Published

      Ca2+ sensitizers: An emerging class of agents for counterbalancing weakness in skeletal muscle diseases?

      Ochala, Julien, Feb 2010, In: Neuromuscular Disorders. 20, 2, p. 98-101 4 p.

      Research output: Contribution to journal › Review › Research › peer-review

    24. Published

      EMD 57033 partially reverses ventilator-induced diaphragm muscle fibre calcium desensitisation

      Ochala, Julien, Radell, P. J., Eriksson, L. I. & Larsson, L., Feb 2010, In: Pflugers Archiv European Journal of Physiology. 459, 3, p. 475-483 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      A myopathy-linked tropomyosin mutation severely alters thin filament conformational changes during activation

      Ochala, Julien, Iwamoto, H., Larsson, L. & Yagi, N., 25 May 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 21, p. 9807-12 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. 2011
    27. Published

      Diaphragm muscle weakness in an experimental porcine intensive care unit model

      Ochala, Julien, Renaud, G., Diez, M. L., Banduseela, V. C., Aare, S., Ahlbeck, K., Radell, P. J., Eriksson, L. I. & Larsson, L., 2011, In: PLoS ONE. 6, 6, e20558.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Factors underlying the early limb muscle weakness in acute quadriplegic myopathy using an experimental ICU porcine model

      Ochala, Julien, Ahlbeck, K., Radell, P. J., Eriksson, L. I. & Larsson, L., 2011, In: PLoS ONE. 6, 6, e20876.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Preferential skeletal muscle myosin loss in response to mechanical silencing in a novel rat intensive care unit model: Underlying mechanisms

      Ochala, Julien, Gustafson, A. M., Diez, M. L., Renaud, G., Li, M., Aare, S., Qaisar, R., Banduseela, V. C., Hedström, Y., Tang, X., Dworkin, B., Ford, G. C., Nair, K. S., Perera, S., Gautel, M. & Larsson, L., Apr 2011, In: Journal of Physiology. 589, 8, p. 2007-2026 20 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Relationship between force and size in human single muscle fibres

      Krivickas, L. S., Dorer, D. J., Ochala, Julien & Frontera, W. R., May 2011, In: Experimental Physiology. 96, 5, p. 539-547 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Disrupted myosin cross-bridge cycling kinetics triggers muscle weakness in nebulin-related myopathy

      Ochala, Julien, Lehtokari, V. L., Iwamoto, H., Li, M., Feng, H. Z., Jin, J. P., Yagi, N., Wallgren-Pettersson, C., Pénisson-Besnier, I. & Larsson, L., Jun 2011, In: FASEB Journal. 25, 6, p. 1903-1913 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Mechanisms underlying the sparing of masticatory versus limb muscle function in an experimental critical illness model

      Aare, S., Ochala, Julien, Norman, H. S., Radell, P., Eriksson, L. I., Göransson, H., Chen, Y. W., Hoffman, E. P. & Larsson, L., Dec 2011, In: Physiological Genomics. 43, 24, p. 1334-1350 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. 2012
    34. Published

      Thick and thin filament proteins: Acquired and hereditary sarcomeric protein diseases

      Ochala, Julien & Larsson, L., 2012, Muscle. Elsevier Science Inc., Vol. 2. p. 1023-1030 8 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    35. Published

      Myofibrillar myopathy caused by a mutation in the motor domain of mouse MyHC IIb

      Kurapati, R., McKenna, C., Lindqvist, J., Williams, D., Simon, M., LeProust, E., Baker, J., Cheeseman, M., Carroll, N., Denny, P., Laval, S., Lochmüller, H., Ochala, Julien & Blanco, G., Apr 2012, In: Human Molecular Genetics. 21, 8, p. 1706-1724 19 p., ddr605.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      A myopathy-related actin mutation increases contractile function

      Lindqvist, J., Pénisson-Besnier, I., Iwamoto, H., Li, M., Yagi, N. & Ochala, Julien, May 2012, In: Acta Neuropathologica. 123, 5, p. 739-746 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Thick and Thin Filament Proteins: Acquired and Hereditary Sarcomeric Protein Diseases

      Ochala, Julien & Larsson, L., 18 Jul 2012, Muscle: Fundamental Biology and Mechanisms of Disease. Elsevier, Vol. 1-2. p. 1023-1030 8 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    38. Published

      Nemaline Myopathy-Related Skeletal Muscle α-Actin (ACTA1) Mutation, Asp286Gly, Prevents Proper Strong Myosin Binding and Triggers Muscle Weakness

      Ochala, Julien, Ravenscroft, G., Laing, N. G. & Nowak, K. J., 20 Sep 2012, In: PLoS ONE. 7, 9, e45923.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Congenital myopathy-causing tropomyosin mutations induce thin filament dysfunction via distinct physiological mechanisms

      Ochala, Julien, Gokhin, D. S., Pénisson-Besnier, I., Quijano-Roy, S., Monnier, N., Lunardi, J., Romero, N. B. & Fowler, V. M., Oct 2012, In: Human Molecular Genetics. 21, 20, p. 4473-4485 13 p., dds289.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. 2013
    41. Published

      Sparing of muscle mass and function by passive loading in an experimental intensive care unit model

      Renaud, G., Llano-Diez, M., Ravara, B., Gorza, L., Feng, H. Z., Jin, J. P., Cacciani, N., Gustafson, A. M., Ochala, Julien, Corpeno, R., Li, M., Hedström, Y., Ford, G. C., Nair, K. S. & Larsson, L., Mar 2013, In: Journal of Physiology. 591, 5, p. 1385-1402 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      The fraction of strongly bound cross-bridges is increased in mice that carry the myopathy-linked myosin heavy chain mutation MYH4L342Q

      Lindqvist, J., Iwamoto, H., Blanco, G. & Ochala, Julien, May 2013, In: DMM Disease Models and Mechanisms. 6, 3, p. 834-840 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Distinct underlying mechanisms of limb and respiratory muscle fiber weaknesses in nemaline myopathy

      Lindqvist, J., Cheng, A. J., Renaud, G., Hardeman, E. C. & Ochala, Julien, Jun 2013, In: Journal of Neuropathology and Experimental Neurology. 72, 6, p. 472-481 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Correction: Impaired adaptive response to mechanical overloading in dystrophic skeletal muscle (PLoS ONE)

      Joanne, P., Hourdé, C., Ochala, Julien, Caudéran, Y., Medja, F., Vignaud, A., Mouisel, E., Hadj-Said, W., Arandel, L., Garcia, L., Goyenvalle, A., Mounier, R., Zibroba, D., Sakamato, K., Butler-Browne, G., Agbulut, O. & Ferry, A., 27 Jun 2013, In: PLoS ONE. 8, 6

      Research output: Contribution to journal › Comment/debate › Research › peer-review

    45. Published

      Myofilament lattice structure in presence of a skeletal myopathy-related tropomyosin mutation

      Ochala, Julien & Iwamoto, H., Aug 2013, In: Journal of Muscle Research and Cell Motility. 34, 3-4, p. 171-175 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Skeletal and cardiac αactin isoforms differently modulate myosin cross-bridge formation and myofibre force production

      Ochala, Julien, Iwamoto, H., Ravenscroft, G., Laing, N. G. & Nowak, K. J., Nov 2013, In: Human Molecular Genetics. 22, 21, p. 4398-4404 7 p., ddt289.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. 2014

    48. Pointed-end capping by tropomodulin modulates actomyosin crossbridge formation in skeletal muscle fibers

      Ochala, Julien, Gokhin, D. S., Iwamoto, H. & Fowler, V. M., Jan 2014, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 28, 1, p. 408-15 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Sexually dimorphic myofilament function in a mouse model of nemaline myopathy

      Lindqvist, J., Hardeman, E. C. & Ochala, Julien, 15 Dec 2014, In: Archives of Biochemistry and Biophysics. 564, p. 37-42 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. 2015
    51. Published

      Skeletal Muscle: A Brief Review of Structure and Function

      Frontera, W. R. & Ochala, Julien, 4 Mar 2015, In: Behavior Genetics. 45, 2, p. 183-195 13 p.

      Research output: Contribution to journal › Review › Research › peer-review

    52. Aberrant post-translational modifications compromise human myosin motor function in old age

      Li, M., Ogilvie, H., Ochala, Julien, Artemenko, K., Iwamoto, H., Yagi, N., Bergquist, J. & Larsson, L., Apr 2015, In: Aging Cell. 14, 2, p. 228-35 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    53. Published

      X-ray recordings reveal how a human disease-linked skeletal muscle α-actin mutation leads to contractile dysfunction

      Ochala, Julien, Ravenscroft, G., McNamara, E., Nowak, K. J. & Iwamoto, H., Dec 2015, In: Journal of Structural Biology. 192, 3, p. 331-335 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    54. Published

      Ryanodine receptor fragmentation and sarcoplasmic reticulum Ca2+ leak after one session of High-intensity interval exercise

      Place, N., Ivarsson, N., Venckunas, T., Neyroud, D., Brazaitis, M., Cheng, A. J., Ochala, Julien, Kamandulis, S., Girard, S., Volungevičius, G., Paužas, H., Mekideche, A., Kayser, B., Martinez-Redondo, V., Ruas, J. L., Bruton, J., Truffert, A., Lanner, J. T., Skurvydas, A. & Westerblad, H., 15 Dec 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 50, p. 15492-15497 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    55. Tropomodulin 1 directly controls thin filament length in both wild-type and tropomodulin 4-deficient skeletal muscle

      Gokhin, D. S., Ochala, Julien, Domenighetti, A. A. & Fowler, V. M., 15 Dec 2015, In: Development (Cambridge, England). 142, 24, p. 4351-62 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    56. 2016

    57. Modulating myosin restores muscle function in a mouse model of nemaline myopathy

      Lindqvist, J., Levy, Y., Pati-Alam, A., Hardeman, E. C., Gregorevic, P. & Ochala, Julien, 1 May 2016, In: Annals of Neurology. 79, 5, p. 717-725 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    58. Published

      Dystrophin restoration therapy improves both the reduced excitability and the force drop induced by lengthening contractions in dystrophic mdx skeletal muscle

      Roy, P., Rau, F., Ochala, Julien, Messéant, J., Fraysse, B., Lainé, J., Agbulut, O., Butler-Browne, G., Furling, D. & Ferry, A., 20 Jul 2016, In: Skeletal Muscle. 6, 1, 23.

      Research output: Contribution to journal › Journal article › Research › peer-review

    59. Published

      Myopathy-inducing mutation H40Y in ACTA1 hampers actin filament structure and function

      Chan, C., Fan, J., Messer, A. E., Marston, S. B., Iwamoto, H. & Ochala, Julien, 1 Aug 2016, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1862, 8, p. 1453-1458 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    60. Published

      Novel myosin-based therapies for congenital cardiac and skeletal myopathies

      Ochala, Julien & Sun, Y. B., 1 Oct 2016, In: Journal of Medical Genetics. 53, 10, p. 651-654 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    61. 2017

    62. Current and future therapeutic approaches to the congenital myopathies

      Jungbluth, H., Ochala, Julien, Treves, S. & Gautel, M., Apr 2017, In: Seminars in Cell and Developmental Biology. 64, p. 191-200 10 p.

      Research output: Contribution to journal › Review › Research › peer-review

    63. Exploring the Role of PGC-1α in Defining Nuclear Organisation in Skeletal Muscle Fibres

      Ross, J. A., Pearson, A., Levy, Y., Cardel, B., Handschin, C. & Ochala, Julien, 1 Jun 2017, In: Journal of Cellular Physiology. 232, 6, p. 1270-1274 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    64. 2018

    65. Myostatin inhibition using mrk35 produces skeletal muscle growth and tubular aggregate formation in wild type and TgACTA1D286G nemaline myopathy mice

      Tinklenberg, J. A., Siebers, E. M., Beatka, M. J., Meng, H., Yang, L., Zhang, Z., Ross, J. A., Ochala, Julien, Morris, C., Owens, J. M., Laing, N. G., Nowak, K. J. & Lawlor, M. W., 15 Feb 2018, In: Human Molecular Genetics. 27, 4, p. 638-648 11 p., ddx431.

      Research output: Contribution to journal › Journal article › Research › peer-review

    66. Congenital myopathies: disorders of excitation-contraction coupling and muscle contraction

      Jungbluth, H., Treves, S., Zorzato, F., Sarkozy, A., Ochala, Julien, Sewry, C., Phadke, R., Gautel, M. & Muntoni, F., Mar 2018, In: Nature Reviews. Neurology. 14, 3, p. 151-167 17 p.

      Research output: Contribution to journal › Review › Research › peer-review

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