Julien Ochala

Julien Ochala

Associate Professor - Promotion Programme

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    ORCID: 0000-0002-6358-2920

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    1. Published

      Mechanisms underlying the sparing of masticatory versus limb muscle function in an experimental critical illness model

      Aare, S., Ochala, Julien, Norman, H. S., Radell, P., Eriksson, L. I., Göransson, H., Chen, Y. W., Hoffman, E. P. & Larsson, L., Dec 2011, In: Physiological Genomics. 43, 24, p. 1334-1350 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Binding pocket dynamics along the recovery stroke of human β-cardiac myosin

      Akter, F., Ochala, Julien & Fornili, A., 2023, In: PLOS Computational Biology. 19, 5, 14 p., e1011099.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Comparative study of binding pocket structure and dynamics in cardiac and skeletal myosin

      Antonovic, A. K., Ochala, Julien & Fornili, A., 2023, In: Biophysical Journal. 122, 1, p. 54-62

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Muscle paralysis and myosin loss in a patient with cancer cachexia

      Banduseela, V., Ochala, Julien, Lamberg, K., Kalimo, H. & Larsson, L., Dec 2007, In: Acta Myologica. 26, 3, p. 136-144 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Gene expression and muscle fiber function in a porcine ICU model

      Banduseela, V. C., Ochala, Julien, Chen, Y. W., Göransson, H., Norman, H., Radell, P., Eriksson, L. I., Hoffman, E. P. & Larsson, L., Nov 2009, In: Physiological Genomics. 39, 3, p. 141-159 19 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. E-pub ahead of print

      Myonuclear alterations associated with exercise are independent of age in humans

      Battey, E., Ross, J. A., Hoang, A., Wilson, D. G. S., Han, Y., Levy, Y., Pollock, R. D., Kalakoutis, M., Pugh, J. N., Close, G. L., Ellison-Hughes, G. M., Lazarus, N. R., Iskratsch, T., Harridge, S. D. R., Ochala, Julien & Stroud, M. J., 2024, (E-pub ahead of print) In: Journal of Physiology.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Using nuclear envelope mutations to explore age-related skeletal muscle weakness

      Battey, E., Stroud, M. J. & Ochala, Julien, 28 Aug 2020, In: Clinical Science. 134, 16, p. 2177-2187 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. E-pub ahead of print

      Muscle fibre size and myonuclear positioning in trained and aged humans

      Battey, E., Levy, Y., Pollock, R. D., Pugh, J. N., Close, G. L., Kalakoutis, M., Lazarus, N. R., Harridge, S. D. R., Ochala, Julien & Stroud, M. J., 2024, (E-pub ahead of print) In: Experimental Physiology.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      PGC-1α regulates myonuclear accretion after moderate endurance training

      Battey, E., Furrer, R., Ross, J., Handschin, C., Ochala, Julien & Stroud, M. J., 2022, In: Journal of Cellular Physiology. 237, 1, p. 696-705

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Effect of PGC1-beta ablation on myonuclear organisation

      Beedour, R., Ross, J. A., Levy, Y. & Ochala, Julien, 1 Dec 2019, In: Journal of Muscle Research and Cell Motility. 40, 3-4, p. 335-341 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Reducing dynamin 2 (DNM2) rescues DNM2-related dominant centronuclear myopathy

      Buono, S., Ross, J. A., Tasfaout, H., Levy, Y., Kretz, C., Tayefeh, L., Matson, J., Guo, S., Kessler, P., Monia, B. P., Bitoun, M., Ochala, Julien, Laporte, J. & Cowling, B. S., 23 Oct 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 43, p. 11066-11071 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      A Laing distal myopathy-associated proline substitution in the β-myosin rod perturbs myosin cross-bridging activity

      Buvoli, M., Wilson, G. C., Buvoli, A., Gugel, J. F., Hau, A., Bönnemann, C. G., Paradas, C., Ryba, D. M., Woulfe, K. C., Walker, L. A., Buvoli, T., Ochala, Julien & Leinwand, L. A., 2024, In: The Journal of Clinical Investigation. 134, 9, 16 p., :e172599.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Human skeletal myopathy myosin mutations disrupt myosin head sequestration

      Carrington, G., Hau, A., Kosta, S., Dugdale, H. F., Muntoni, F., D’Amico, A., Van den Bergh, P., Romero, N. B., Malfatti, E., Vilchez, J. J., Oldfors, A., Pajusalu, S., Õunap, K., Giralt-Pujol, M., Zanoteli, E., Campbell, K. S., Iwamoto, H., Peckham, M. & Ochala, Julien, 2023, In: JCI insight. 8, 21, p. 1-19 e172322.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Myopathy-inducing mutation H40Y in ACTA1 hampers actin filament structure and function

      Chan, C., Fan, J., Messer, A. E., Marston, S. B., Iwamoto, H. & Ochala, Julien, 1 Aug 2016, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1862, 8, p. 1453-1458 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Nuclear numbers in syncytial muscle fibers promote size but limit the development of larger myonuclear domains

      Cramer, A. A. W., Prasad, V., Eftestøl, E., Song, T., Hansson, K. A., Dugdale, H. F., Sadayappan, S., Ochala, Julien, Gundersen, K. & Millay, D. P., 2020, In: Nature Communications. 11, 1, 14 p., 6287.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Activation of eIF4E-binding-protein-1 rescues mTORC1-induced sarcopenia by expanding lysosomal degradation capacity

      Crombie, E. M., Kim, S., Adamson, S., Dong, H., Lu, T. C., Wu, Y., Wu, Y., Levy, Y., Stimple, N., Lam, W. M. R., Hey, H. W. D., Withers, D. J., Hsu, A. L., Bay, B. H., Ochala, Julien & Tsai, S. Y., 2023, In: Journal of Cachexia, Sarcopenia and Muscle. 14, p. 198–213

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      The effects of resistance exercise training on mitochondrial myopathy patients

      Di Leo, V., Newman, J., Lawless, C., Robertson, F., Levy, Y., Ochala, Julien, Pickett, S., Hudson, G., Gorman, G., Tuppen, H., Vincent, A. & Russell, O., 2022, In: Neuromuscular Disorders. 32, p. S72-S72 FP.16.

      Research output: Contribution to journal › Conference abstract in journal › Research

    18. Published

      Can we talk about myoblast fusion?

      Dugdale, H. F. & Ochala, Julien, 2021, In: American Journal of Physiology - Cell Physiology. 321, 3, p. C504-C506

      Research output: Contribution to journal › Review › Research › peer-review

    19. Molecular consequences of the myopathy-related D286G mutation on actin function

      Fan, J., Chan, C., McNamara, E. L., Nowak, K. J., Iwamoto, H. & Ochala, Julien, 1 Dec 2018, In: Frontiers in Physiology. 9, 1756.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Early clinical and pre-clinical therapy development in Nemaline myopathy

      Fisher, G., Mackels, L., Markati, T., Sarkozy, A., Ochala, Julien, Jungbluth, H., Ramdas, S. & Servais, L., 28 Dec 2022, In: Expert Opinion On Therapeutic Targets. 26, 10, p. 853–867

      Research output: Contribution to journal › Review › Research › peer-review

    21. Published

      Skeletal Muscle: A Brief Review of Structure and Function

      Frontera, W. R. & Ochala, Julien, 4 Mar 2015, In: Behavior Genetics. 45, 2, p. 183-195 13 p.

      Research output: Contribution to journal › Review › Research › peer-review

    22. Tropomodulin 1 directly controls thin filament length in both wild-type and tropomodulin 4-deficient skeletal muscle

      Gokhin, D. S., Ochala, Julien, Domenighetti, A. A. & Fowler, V. M., 15 Dec 2015, In: Development (Cambridge, England). 142, 24, p. 4351-62 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Slow myosin heavy chain 1 is required for slow myofibril and muscle fibre growth but not for myofibril initiation

      Hau, H. T. A., Kelu, J. J., Ochala, Julien & Hughes, S. M., Jul 2023, In: Developmental Biology. 499, p. 47-58 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Correction: Impaired adaptive response to mechanical overloading in dystrophic skeletal muscle (PLoS ONE)

      Joanne, P., Hourdé, C., Ochala, Julien, Caudéran, Y., Medja, F., Vignaud, A., Mouisel, E., Hadj-Said, W., Arandel, L., Garcia, L., Goyenvalle, A., Mounier, R., Zibroba, D., Sakamato, K., Butler-Browne, G., Agbulut, O. & Ferry, A., 27 Jun 2013, In: PLoS ONE. 8, 6

      Research output: Contribution to journal › Comment/debate › Research › peer-review

    25. Congenital myopathies: disorders of excitation-contraction coupling and muscle contraction

      Jungbluth, H., Treves, S., Zorzato, F., Sarkozy, A., Ochala, Julien, Sewry, C., Phadke, R., Gautel, M. & Muntoni, F., Mar 2018, In: Nature Reviews. Neurology. 14, 3, p. 151-167 17 p.

      Research output: Contribution to journal › Review › Research › peer-review

    26. Current and future therapeutic approaches to the congenital myopathies

      Jungbluth, H., Ochala, Julien, Treves, S. & Gautel, M., Apr 2017, In: Seminars in Cell and Developmental Biology. 64, p. 191-200 10 p.

      Research output: Contribution to journal › Review › Research › peer-review

    27. Published

      Methodological considerations in measuring specific force in human single skinned muscle fibres

      Kalakoutis, M., Di Giulio, I., Douiri, A., Ochala, Julien, Harridge, S. D. R. & Woledge, R. C., 2021, In: Acta Physiologica. 233, 3, p. 1-18 e13719.

      Research output: Contribution to journal › Review › Research › peer-review

    28. Published

      Revisiting specific force loss in human permeabilized single skeletal muscle fibers obtained from older individuals

      Kalakoutis, M., Pollock, R. D., Lazarus, N. R., Atkinson, R. A., George, M., Berber, O., Woledge, R. C., Ochala, Julien & Harridge, S. D. R., 2023, In: American journal of physiology. Cell physiology. 325, 1, p. C172-C185

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      A rational approach to selective targeting of skeletal myosin

      Katarina Antonovic, A., Ochala, Julien & Fornili, A., 2023, In: Biophysical Journal. 122, 3S1, p. 117a

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Relationship between force and size in human single muscle fibres

      Krivickas, L. S., Dorer, D. J., Ochala, Julien & Frontera, W. R., May 2011, In: Experimental Physiology. 96, 5, p. 539-547 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Myofibrillar myopathy caused by a mutation in the motor domain of mouse MyHC IIb

      Kurapati, R., McKenna, C., Lindqvist, J., Williams, D., Simon, M., LeProust, E., Baker, J., Cheeseman, M., Carroll, N., Denny, P., Laval, S., Lochmüller, H., Ochala, Julien & Blanco, G., Apr 2012, In: Human Molecular Genetics. 21, 8, p. 1706-1724 19 p., ddr605.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Nebulin nemaline myopathy recapitulated in a compound heterozygous mouse model with both a missense and a nonsense mutation in Neb

      Laitila, J. M., McNamara, E. L., Wingate, C. D., Goullee, H., Ross, J. A., Taylor, R. L., Van Der Pijl, R., Griffiths, L. M., Harries, R., Ravenscroft, G., Clayton, J. S., Sewry, C., Lawlor, M. W., Ottenheijm, C. A. C., Bakker, A. J., Ochala, Julien, Laing, N. G., Wallgren-Pettersson, C., Pelin, K. & Nowak, K. J., 17 Feb 2020, In: Acta Neuropathologica Communications. 8, 1, 18.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Prelamin A causes aberrant myonuclear arrangement and results in muscle fiber weakness

      Levy, Y., Ross, J. A., Niglas, M., Snetkov, V. A., Lynham, S., Liao, C., Puckelwartz, M. J., Hsu, Y., McNally, E. M., Alsheimer, M., Harridge, S. D., Young, S. G., Fong, L. G., Español, Y., Lopez-Otin, C., Kennedy, B. K., Lowe, D. A. & Ochala, Julien, 4 Oct 2018, In: JCI insight. 3, 19

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Myosin Heavy Chain as a Novel Key Modulator of Striated Muscle Resting State

      Lewis, Christopher T.A. & Ochala, Julien, 2023, In: Physiology. 38, 1, p. 3-9

      Research output: Contribution to journal › Review › Research › peer-review

    35. Published

      Physical activity impacts resting skeletal muscle myosin conformation and lowers its ATP consumption

      Lewis, C. T. A., Tabrizian, L., Nielsen, J., Laitila, J., Beck, T. N., Olsen, M. S., Ognjanovic, M. M., Aagaard, P., Hokken, R., Laugesen, S., Ingersen, A., Andersen, J. L., Soendenbroe, C., Helge, J. W., Dela, F., Larsen, S., Sahl, R. E., Rømer, T., Hansen, M. T., Frandsen, J. & 2 others, Suetta, Charlotte & Ochala, Julien, 2023, In: The Journal of general physiology. 155, 7, 8 p., e202213268.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Aberrant post-translational modifications compromise human myosin motor function in old age

      Li, M., Ogilvie, H., Ochala, Julien, Artemenko, K., Iwamoto, H., Yagi, N., Bergquist, J. & Larsson, L., Apr 2015, In: Aging Cell. 14, 2, p. 228-35 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      A myopathy-related actin mutation increases contractile function

      Lindqvist, J., Pénisson-Besnier, I., Iwamoto, H., Li, M., Yagi, N. & Ochala, Julien, May 2012, In: Acta Neuropathologica. 123, 5, p. 739-746 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Modulating myosin restores muscle function in a mouse model of nemaline myopathy

      Lindqvist, J., Levy, Y., Pati-Alam, A., Hardeman, E. C., Gregorevic, P. & Ochala, Julien, 1 May 2016, In: Annals of Neurology. 79, 5, p. 717-725 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Sexually dimorphic myofilament function in a mouse model of nemaline myopathy

      Lindqvist, J., Hardeman, E. C. & Ochala, Julien, 15 Dec 2014, In: Archives of Biochemistry and Biophysics. 564, p. 37-42 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Distinct underlying mechanisms of limb and respiratory muscle fiber weaknesses in nemaline myopathy

      Lindqvist, J., Cheng, A. J., Renaud, G., Hardeman, E. C. & Ochala, Julien, Jun 2013, In: Journal of Neuropathology and Experimental Neurology. 72, 6, p. 472-481 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      The fraction of strongly bound cross-bridges is increased in mice that carry the myopathy-linked myosin heavy chain mutation MYH4L342Q

      Lindqvist, J., Iwamoto, H., Blanco, G. & Ochala, Julien, May 2013, In: DMM Disease Models and Mechanisms. 6, 3, p. 834-840 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Physiological impact and disease reversion for the severe form of centronuclear myopathy linked to Dynamin

      Massana Muñoz, X., Kretz, C., Silva-Rojas, R., Ochala, Julien, Menuet, A., Romero, N. B., Cowling, B. S. & Laporte, J., 18 Aug 2020, In: JCI insight. 5, 18, 16 p., e137899.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      CaMKK2 is not involved in contraction-stimulated AMPK activation and glucose uptake in skeletal muscle

      Negoita, F., Addinsall, A. B., Hellberg, K., Bringas, C. F., Hafen, P. S., Sermersheim, T. J., Agerholm, M., Lewis, C. T. A., Ahwazi, D., Ling, N. X. Y., Larsen, J. K., Deshmukh, A. S., Hossain, M. A., Oakhill, J. S., Ochala, J., Brault, J. J., Sankar, U., Drewry, D. H., Scott, J. W., Witczak, C. A. & 1 others, Sakamoto, Kei, 2023, In: Molecular Metabolism. 75, 14 p., 101761.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Ca2+ sensitizers: An emerging class of agents for counterbalancing weakness in skeletal muscle diseases?

      Ochala, Julien, Feb 2010, In: Neuromuscular Disorders. 20, 2, p. 98-101 4 p.

      Research output: Contribution to journal › Review › Research › peer-review

    45. Published

      Changes in mechanical properties of human plantar flexor muscles in ageing

      Ochala, Julien, Lambertz, D., Pousson, M., Goubel, F. & Van Hoecke, J., Mar 2004, In: Experimental Gerontology. 39, 3, p. 349-358 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Diaphragm muscle weakness in an experimental porcine intensive care unit model

      Ochala, Julien, Renaud, G., Diez, M. L., Banduseela, V. C., Aare, S., Ahlbeck, K., Radell, P. J., Eriksson, L. I. & Larsson, L., 2011, In: PLoS ONE. 6, 6, e20558.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Novel myosin-based therapies for congenital cardiac and skeletal myopathies

      Ochala, Julien & Sun, Y. B., 1 Oct 2016, In: Journal of Medical Genetics. 53, 10, p. 651-654 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Effects of a preferential myosin loss on Ca2+ activation of force generation in single human skeletal muscle fibres

      Ochala, Julien & Larsson, L., Apr 2008, In: Experimental Physiology. 93, 4, p. 486-495 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Gender differences in human muscle and joint mechanical properties during plantar flexion in old age

      Ochala, Julien, Valour, D., Pousson, M., Lambertz, D. & Van Hoecke, J., May 2004, In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 59, 5, p. 441-448 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      EMD 57033 partially reverses ventilator-induced diaphragm muscle fibre calcium desensitisation

      Ochala, Julien, Radell, P. J., Eriksson, L. I. & Larsson, L., Feb 2010, In: Pflugers Archiv European Journal of Physiology. 459, 3, p. 475-483 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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