Julien Ochala

Julien Ochala

Associate Professor - Promotion Programme

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    ORCID: 0000-0002-6358-2920

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    1. Candidate gene expression and coding sequence variants in Warmblood horses with myofibrillar myopathy

      Williams, Z. J., Velez-Irizarry, D., Petersen, J. L., Ochala, Julien, Finno, C. J. & Valberg, S. J., 2020, (Accepted/In press) In: Equine Veterinary Journal.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Ryanodine receptor type 1 content decrease-induced endoplasmic reticulum stress is a hallmark of myopathies

      Vidal, J., Fernandez, E. A., Wohlwend, M., Laurila, P. P., Lopez-Mejia, A., Ochala, Julien, Lobrinus, A. J., Kayser, B., Lopez-Mejia, I. C., Place, N. & Zanou, N., 2023, In: Journal of Cachexia, Sarcopenia and Muscle. 14, 6, p. 2882-2897

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      The influence of ageing on the force-velocity-power characteristics of human elbow flexor muscles

      Valour, D., Ochala, Julien, Ballay, Y. & Pousson, M., 1 Apr 2003, In: Experimental Gerontology. 38, 4, p. 387-395 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Myostatin inhibition using mrk35 produces skeletal muscle growth and tubular aggregate formation in wild type and TgACTA1D286G nemaline myopathy mice

      Tinklenberg, J. A., Siebers, E. M., Beatka, M. J., Meng, H., Yang, L., Zhang, Z., Ross, J. A., Ochala, Julien, Morris, C., Owens, J. M., Laing, N. G., Nowak, K. J. & Lawlor, M. W., 15 Feb 2018, In: Human Molecular Genetics. 27, 4, p. 638-648 11 p., ddx431.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Fine-regulation of myosin relaxed states in vertebrate muscle

      Thomsen, Elise Julie Melhedegaard, Sonne, A., Bertelsen, Mads Frost, Vermeulen, E., Ganswindt, A., Wang, T. & Ochala, Julien, 2022, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Myopathy in acute and long-term COVID-19

      Tankisi, H. & Ochala, Julien, 2022, In: Clinical Neurophysiology. 134, p. 141-142

      Research output: Contribution to journal › Letter › Research › peer-review

    7. Defining the contribution of skeletal muscle pyruvate dehydrogenase α1 to exercise performance and insulin action

      Svensson, K., Dent, J. R., Tahvilian, S., Martins, V. F., Sathe, A., Ochala, Julien, Patel, M. S. & Schenk, S., Nov 2018, In: American Journal of Physiology - Endocrinology and Metabolism. 315, 5, p. E1034-E1045

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Abnormal myosin post-translational modifications and ATP turnover time associated with human congenital myopathy-related RYR1 mutations

      Sonne, A., Antonovic, A. K., Thomsen, Elise Julie Melhedegaard, Akter, F., Andersen, J. L., Jungbluth, H., Witting, N., Vissing, John, Zanoteli, E., Fornili, A. & Ochala, Julien, 2023, In: Acta Physiologica. 239, 2, 14 p., e14035.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Myosin post-translational modifications and function in the presence of myopathy-linked truncating MYH2 mutations

      Sonne, A., Peverelli, L., Hernandez-Lain, A., Domínguez-González, C., Andersen, J. L., Milone, M., Beggs, A. H. & Ochala, Julien, 2023, In: American journal of physiology. Cell physiology. 324, 3, p. C769–C776 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      The dawn of the functional genomics era in muscle physiology

      Seaborne, Robert Arthur Elliston & Ochala, Julien, 15 Apr 2023, In: Journal of Physiology. 601, 8, p. 1343-1352

      Research output: Contribution to journal › Review › Research › peer-review

    11. Published

      Dystrophin restoration therapy improves both the reduced excitability and the force drop induced by lengthening contractions in dystrophic mdx skeletal muscle

      Roy, P., Rau, F., Ochala, Julien, Messéant, J., Fraysse, B., Lainé, J., Agbulut, O., Butler-Browne, G., Furling, D. & Ferry, A., 20 Jul 2016, In: Skeletal Muscle. 6, 1, 23.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Exploring the Role of PGC-1α in Defining Nuclear Organisation in Skeletal Muscle Fibres

      Ross, J. A., Pearson, A., Levy, Y., Cardel, B., Handschin, C. & Ochala, Julien, 1 Jun 2017, In: Journal of Cellular Physiology. 232, 6, p. 1270-1274 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Impairments in contractility and cytoskeletal organisation cause nuclear defects in nemaline myopathy

      Ross, J. A., Levy, Y., Ripolone, M., Kolb, J. S., Turmaine, M., Holt, M., Lindqvist, J., Claeys, K. G., Weis, J., Monforte, M., Tasca, G., Moggio, M., Figeac, N., Zammit, P. S., Jungbluth, H., Fiorillo, C., Vissing, J., Witting, N., Granzier, H., Zanoteli, E. & 3 others, Hardeman, E. C., Wallgren-Pettersson, C. & Ochala, Julien, 2019, In: Acta Neuropathologica. 138, 3, p. 477-495 19 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      rAAV-related therapy fully rescues myonuclear and myofilament function in X-linked myotubular myopathy

      Ross, J. A., Tasfaout, H., Levy, Y., Morgan, J., Cowling, B. S., Laporte, J., Zanoteli, E., Romero, N. B., Lowe, D. A., Jungbluth, H., Lawlor, M. W., Mack, D. L. & Ochala, Julien, 19 Oct 2020, In: Acta Neuropathologica Communications. 8, 1, 167.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. SIRT1 regulates nuclear number and domain size in skeletal muscle fibers

      Ross, J. A., Levy, Y., Svensson, K., Philp, A., Schenk, S. & Ochala, Julien, Sep 2018, In: Journal of Cellular Physiology. 233, 9, p. 7157-7163 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Sparing of muscle mass and function by passive loading in an experimental intensive care unit model

      Renaud, G., Llano-Diez, M., Ravara, B., Gorza, L., Feng, H. Z., Jin, J. P., Cacciani, N., Gustafson, A. M., Ochala, Julien, Corpeno, R., Li, M., Hedström, Y., Ford, G. C., Nair, K. S. & Larsson, L., Mar 2013, In: Journal of Physiology. 591, 5, p. 1385-1402 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      NEB mutations disrupt the super-relaxed state of myosin and remodel the muscle metabolic proteome in nemaline myopathy

      Ranu, N., Laitila, J., Dugdale, H. F., Mariano, J., Kolb, J. S., Wallgren-Pettersson, C., Witting, N., Vissing, J., Vilchez, J. J., Fiorillo, C., Zanoteli, E., Auranen, M., Jokela, M., Tasca, G., Claeys, K. G., Voermans, N. C., Palmio, J., Huovinen, S., Moggio, M., Beck, T. N. & 3 others, Kontrogianni-Konstantopoulos, A., Granzier, H. & Ochala, Julien, 2022, In: Acta Neuropathologica Communications. 10, 185.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Ryanodine receptor fragmentation and sarcoplasmic reticulum Ca2+ leak after one session of High-intensity interval exercise

      Place, N., Ivarsson, N., Venckunas, T., Neyroud, D., Brazaitis, M., Cheng, A. J., Ochala, Julien, Kamandulis, S., Girard, S., Volungevičius, G., Paužas, H., Mekideche, A., Kayser, B., Martinez-Redondo, V., Ruas, J. L., Bruton, J., Truffert, A., Lanner, J. T., Skurvydas, A. & Westerblad, H., 15 Dec 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 50, p. 15492-15497 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Gender differences in human muscle and joint mechanical properties during plantar flexion in old age

      Ochala, Julien, Valour, D., Pousson, M., Lambertz, D. & Van Hoecke, J., May 2004, In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 59, 5, p. 441-448 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Factors underlying the early limb muscle weakness in acute quadriplegic myopathy using an experimental ICU porcine model

      Ochala, Julien, Ahlbeck, K., Radell, P. J., Eriksson, L. I. & Larsson, L., 2011, In: PLoS ONE. 6, 6, e20876.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Thin filament proteins mutations associated with skeletal myopathies: Defective regulation of muscle contraction

      Ochala, Julien, 2008, In: Journal of Molecular Medicine. 86, 11, p. 1197-1204 8 p.

      Research output: Contribution to journal › Review › Research › peer-review

    22. Published

      Thick and thin filament proteins: Acquired and hereditary sarcomeric protein diseases

      Ochala, Julien & Larsson, L., 2012, Muscle. Elsevier Science Inc., Vol. 2. p. 1023-1030 8 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    23. Published

      Defective regulation of contractile function in muscle fibres carrying an E41K β-tropomyosin mutation

      Ochala, Julien, Li, M., Ohlsson, M., Oldfors, A. & Larsson, L., 15 Jun 2008, In: Journal of Physiology. 586, 12, p. 2993-3004 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Disrupted myosin cross-bridge cycling kinetics triggers muscle weakness in nebulin-related myopathy

      Ochala, Julien, Lehtokari, V. L., Iwamoto, H., Li, M., Feng, H. Z., Jin, J. P., Yagi, N., Wallgren-Pettersson, C., Pénisson-Besnier, I. & Larsson, L., Jun 2011, In: FASEB Journal. 25, 6, p. 1903-1913 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      X-ray recordings reveal how a human disease-linked skeletal muscle α-actin mutation leads to contractile dysfunction

      Ochala, Julien, Ravenscroft, G., McNamara, E., Nowak, K. J. & Iwamoto, H., Dec 2015, In: Journal of Structural Biology. 192, 3, p. 331-335 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Thick and Thin Filament Proteins: Acquired and Hereditary Sarcomeric Protein Diseases

      Ochala, Julien & Larsson, L., 18 Jul 2012, Muscle: Fundamental Biology and Mechanisms of Disease. Elsevier, Vol. 1-2. p. 1023-1030 8 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    27. Published

      Preferential skeletal muscle myosin loss in response to mechanical silencing in a novel rat intensive care unit model: Underlying mechanisms

      Ochala, Julien, Gustafson, A. M., Diez, M. L., Renaud, G., Li, M., Aare, S., Qaisar, R., Banduseela, V. C., Hedström, Y., Tang, X., Dworkin, B., Ford, G. C., Nair, K. S., Perera, S., Gautel, M. & Larsson, L., Apr 2011, In: Journal of Physiology. 589, 8, p. 2007-2026 20 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      A myopathy-linked tropomyosin mutation severely alters thin filament conformational changes during activation

      Ochala, Julien, Iwamoto, H., Larsson, L. & Yagi, N., 25 May 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 21, p. 9807-12 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Pointed-end capping by tropomodulin modulates actomyosin crossbridge formation in skeletal muscle fibers

      Ochala, Julien, Gokhin, D. S., Iwamoto, H. & Fowler, V. M., Jan 2014, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 28, 1, p. 408-15 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Myofilament lattice structure in presence of a skeletal myopathy-related tropomyosin mutation

      Ochala, Julien & Iwamoto, H., Aug 2013, In: Journal of Muscle Research and Cell Motility. 34, 3-4, p. 171-175 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Congenital myopathy-causing tropomyosin mutations induce thin filament dysfunction via distinct physiological mechanisms

      Ochala, Julien, Gokhin, D. S., Pénisson-Besnier, I., Quijano-Roy, S., Monnier, N., Lunardi, J., Romero, N. B. & Fowler, V. M., Oct 2012, In: Human Molecular Genetics. 21, 20, p. 4473-4485 13 p., dds289.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Nemaline Myopathy-Related Skeletal Muscle α-Actin (ACTA1) Mutation, Asp286Gly, Prevents Proper Strong Myosin Binding and Triggers Muscle Weakness

      Ochala, Julien, Ravenscroft, G., Laing, N. G. & Nowak, K. J., 20 Sep 2012, In: PLoS ONE. 7, 9, e45923.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Skeletal and cardiac αactin isoforms differently modulate myosin cross-bridge formation and myofibre force production

      Ochala, Julien, Iwamoto, H., Ravenscroft, G., Laing, N. G. & Nowak, K. J., Nov 2013, In: Human Molecular Genetics. 22, 21, p. 4398-4404 7 p., ddt289.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Changes in muscle and joint elasticity following long-term strength training in old age

      Ochala, Julien, Lambertz, D., Hoecke, J. & Pousson, M., Jul 2007, In: European Journal of Applied Physiology. 100, 5, p. 491-498 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Myofibre hyper-contractility in horses expressing the myosin heavy chain myopathy mutation, myh1e321g

      Ochala, Julien, Finno, C. J. & Valberg, S. J., 2021, In: Cells. 10, 12, 3428.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Effect of strength training on musculotendinous stiffness in elderly individuals

      Ochala, Julien, Lambertz, D., Van Hoecke, J. & Pousson, M., May 2005, In: European Journal of Applied Physiology. 94, 1-2, p. 126-133 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Maintenance of muscle mass, fiber size, and contractile function in mice lacking the Z-disc protein myotilin

      Ochala, Julien, Carpn, O. & Larsson, L., 2009, In: Upsala Journal of Medical Sciences. 114, 4, p. 235-241 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Single skeletal muscle fiber behavior after a quick stretch in young and older men: A possible explanation of the relative preservation of eccentric force in old age

      Ochala, Julien, Dorer, D. J., Frontera, W. R. & Krivickas, L. S., Jul 2006, In: Pflugers Archiv European Journal of Physiology. 452, 4, p. 464-470 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Effects of a R133W β-tropomyosin mutation on regulation of muscle contraction in single human muscle fibres

      Ochala, Julien, Li, M., Tajsharghi, H., Kimber, E., Tulinius, M., Oldfors, A. & Larsson, L., 1 Jun 2007, In: Journal of Physiology. 581, 3, p. 1283-1292 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Predominant myosin superrelaxed state in canine myocardium with naturally occurring dilated cardiomyopathy

      Ochala, Julien, Lewis, Christopher T.A. , Beck, T., Iwamoto, H., Hessel, A. L., Campbell, K. S. & Pyle, W. G., 2023, In: American journal of physiology. Heart and circulatory physiology. 325, 3, p. H585-H591

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Changes in mechanical properties of human plantar flexor muscles in ageing

      Ochala, Julien, Lambertz, D., Pousson, M., Goubel, F. & Van Hoecke, J., Mar 2004, In: Experimental Gerontology. 39, 3, p. 349-358 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Novel myosin-based therapies for congenital cardiac and skeletal myopathies

      Ochala, Julien & Sun, Y. B., 1 Oct 2016, In: Journal of Medical Genetics. 53, 10, p. 651-654 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Single skeletal muscle fiber elastic and contractile characteristics in young and older men

      Ochala, Julien, Frontera, W. R., Dorer, D. J., Van Hoecke, J. & Krivickas, L. S., Apr 2007, In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 62, 4, p. 375-381 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Diaphragm muscle weakness in an experimental porcine intensive care unit model

      Ochala, Julien, Renaud, G., Diez, M. L., Banduseela, V. C., Aare, S., Ahlbeck, K., Radell, P. J., Eriksson, L. I. & Larsson, L., 2011, In: PLoS ONE. 6, 6, e20558.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Effects of a preferential myosin loss on Ca2+ activation of force generation in single human skeletal muscle fibres

      Ochala, Julien & Larsson, L., Apr 2008, In: Experimental Physiology. 93, 4, p. 486-495 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      EMD 57033 partially reverses ventilator-induced diaphragm muscle fibre calcium desensitisation

      Ochala, Julien, Radell, P. J., Eriksson, L. I. & Larsson, L., Feb 2010, In: Pflugers Archiv European Journal of Physiology. 459, 3, p. 475-483 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Ca2+ sensitizers: An emerging class of agents for counterbalancing weakness in skeletal muscle diseases?

      Ochala, Julien, Feb 2010, In: Neuromuscular Disorders. 20, 2, p. 98-101 4 p.

      Research output: Contribution to journal › Review › Research › peer-review

    48. Published

      CaMKK2 is not involved in contraction-stimulated AMPK activation and glucose uptake in skeletal muscle

      Negoita, F., Addinsall, A. B., Hellberg, K., Bringas, C. F., Hafen, P. S., Sermersheim, T. J., Agerholm, M., Lewis, C. T. A., Ahwazi, D., Ling, N. X. Y., Larsen, J. K., Deshmukh, A. S., Hossain, M. A., Oakhill, J. S., Ochala, J., Brault, J. J., Sankar, U., Drewry, D. H., Scott, J. W., Witczak, C. A. & 1 others, Sakamoto, Kei, 2023, In: Molecular Metabolism. 75, 14 p., 101761.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Physiological impact and disease reversion for the severe form of centronuclear myopathy linked to Dynamin

      Massana Muñoz, X., Kretz, C., Silva-Rojas, R., Ochala, Julien, Menuet, A., Romero, N. B., Cowling, B. S. & Laporte, J., 18 Aug 2020, In: JCI insight. 5, 18, 16 p., e137899.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      A myopathy-related actin mutation increases contractile function

      Lindqvist, J., Pénisson-Besnier, I., Iwamoto, H., Li, M., Yagi, N. & Ochala, Julien, May 2012, In: Acta Neuropathologica. 123, 5, p. 739-746 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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