Jens Juul Holst
Professor
Endocrinology and Metabolism
Blegdamsvej 3
2200 København N.
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Assessment of Islet Alphaand beta-cell function
Madsbad, Sten & Holst, Jens Juul, 2019, Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease: A Focus on Early Phase Clinical Drug Development. Springer, p. 37-74 38 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Association of type 2 diabetes candidate polymorphisms in KCNQ1 with incretin and insulin secretion
Müssig, K., Staiger, H., Machicao, F., Kirchhoff, K., Guthoff, M., Schäfer, S. A., Kantartzis, K., Silbernagel, G., Stefan, N., Holst, Jens Juul, Gallwitz, B., Häring, H. & Fritsche, A., 2009, In: Diabetes. 58, 7, p. 1715-20 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Associations between ghrelin and leptin and neural food cue reactivity in a fasted and sated state
Wever, M. C. M., van Meer, F., Charbonnier, L., Crabtree, D. R., Buosi, W., Giannopoulou, A., Androutsos, O., Johnstone, A. M., Manios, Y., Meek, C. L., Holst, Jens Juul, Smeets, P. A. M. & Full4Health consortium, F. C., 2021, In: NeuroImage. 240, 11 p., 118374.Research output: Contribution to journal › Journal article › Research › peer-review
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Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis
Sato, S., Dyar, K. A., Treebak, J. T., Jepsen, S. L., Ehrlich, A. M., Ashcroft, S. P., Trost, K., Kunzke, T., Prade, V. M., Small, L., Basse, A. L., Schönke, M., Chen, S., Samad, M., Baldi, P., Barrès, R., Walch, A., Moritz, T., Holst, J. J., Lutter, D. & 2 others, , 2022, In: Cell Metabolism. 34, 2, p. 329-345.e8 26 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Atrial Natriuretic Peptide in the high normal range is associated with lower prevalence of insulin resistance
Jujić, A., Nilsson, P. M., Persson, M., Holst, Jens Juul, Torekov, Signe Sørensen, Lyssenko, V., Groop, L., Melander, O. & Magnusson, M., 27 Jan 2016, In: The Journal of clinical endocrinology and metabolism. 101, 4, p. 1372-1380 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Atrial natriuretic peptide-like immunoreactive material (ANP-L1) is released from the adrenal gland by splanchnic nerve stimulation
Duntas, L., Bornstein, S. R., Scherbaum, W. & Holst, Jens Juul, 1994, In: Exp.Clin.Endocrinol.. 101, p. 371-373Research output: Contribution to journal › Journal article › Research › peer-review
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Attenuated processing of proglucagon and glucagon-like peptide- 1 in carboxypeptidase E-deficient mice
Friis-Hansen, L., Lacourse, K. A., Samuelson, L. C. & Holst, Jens Juul, 2001, In: J. Endocrinol.. 169, p. 595-602Research output: Contribution to journal › Journal article › Research › peer-review
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Augmented GLP-1 Secretion as Seen After Gastric Bypass May Be Obtained by Delaying Carbohydrate Digestion
Martinussen, C., Bojsen-Møller, K. N., Dirksen, C., Svane, M. S., Kristiansen, V. B., Hartmann, Bolette, Holst, Jens Juul & Madsbad, Sten, Aug 2019, In: Journal of Clinical Endocrinology and Metabolism. 104, 8, p. 3233–3244Research output: Contribution to journal › Journal article › Research › peer-review
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Automated detection of hypoglycemia-induced EEG changes recorded by subcutaneous electrodes in subjects with type 1 diabetes--the brain as a biosensor
Juhl, C. B., Højlund, K., Elsborg, R., Poulsen, M. K., Selmar, P. E., Holst, Jens Juul, Christiansen, C. & Beck-Nielsen, H., 1 Apr 2010, In: Diabetes Research and Clinical Practice. 88, 1, p. 22-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Bariatric surgery-which procedure is the optimal choice?
Madsbad, Sten & Holst, Jens Juul, 2019, In: Lancet. 393, 10178, p. 1263-1264Research output: Contribution to journal › Comment/debate › Research
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Biased GLP-2 agonist with strong G protein-coupling but impaired arrestin recruitment and receptor desensitization enhances intestinal growth in mice
Gabe, M. B. N., Christensen, Liv von Voss, Dal, Jenna Elizabeth Hunt, Gadgaard, S., Gasbjerg, Lærke Smidt, Holst, Jens Juul, Kissow, Hannelouise, Hartmann, Bolette & Rosenkilde, Mette, Jan 2023, In: British Journal of Pharmacology. 180, 13, p. 1674-1689Research output: Contribution to journal › Journal article › Research › peer-review
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Bile Acids Trigger GLP-1 Release Predominantly by Accessing Basolaterally Located G Protein-Coupled Bile Acid Receptors
Brighton, C. A., Rievaj, J., Kuhre, Rune Ehrenreich, Glass, L. L., Schoonjans, K., Holst, Jens Juul, Gribble, F. M. & Reimann, F., 2015, In: Endocrinology. 156, 11, p. 3961-1370 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Bile Modulates Secretion of Incretins and Insulin: A Study of Human Extrahepatic Cholestasis
Mezza, T., Moffa, S., Ferraro, P. M., Quero, G., Capece, U., Carfi, A., Cefalo, C. M. A., Cinti, F., Sorice, G. P., Impronta, F., Mari, A., Pontecorvi, A., Alfieri, S., Holst, Jens Juul & Giaccari, A., 2019, In: Journal of Clinical Endocrinology & Metabolism. 104, 7, p. 2685-2694Research output: Contribution to journal › Journal article › Research › peer-review
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Bile acid mediated effects on gut integrity and performance of early-weaned piglets
de Diego-Cabero, N., Mereu, A., Menoyo, D., Holst, Jens Juul & Ipharraguerre, I. R., 2015, In: B M C Veterinary Research. 11, 1, p. 1-8 8 p., 111.Research output: Contribution to journal › Journal article › Research › peer-review
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Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas.
Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Larsen, Olav, Jepsen, Sara Lind, Balk-Møller, E., Andersen, Daniel Bjørklund, Deacon, Carolyn F., Schoonjans, K., Reimann, F., Gribble, F. M., Albrechtsen, Reidar, Hartmann, Bolette, Rosenkilde, Mette & Holst, Jens Juul, 2018, In: Molecular Metabolism. 11, p. 84-95 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents
Christiansen, Charlotte Bayer, Trammell, Sam, Albrechtsen, Nicolai Jacob Wewer, Schoonjans, K., Albrechtsen, Reidar, Gillum, M. P., Kuhre, Rune Ehrenreich & Holst, Jens Juul, 2019, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 316, 5, p. G574-G584 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Bile acids induce glucagon-like peptide 2 secretion with limited effects on intestinal adaptation in early weaned pigs
Ipharraguerre, I. R., Tedó, G., Menoyo, D., de Diego Cabero, N., Holst, Jens Juul, Nofrarías, M., Mereu, A. & Burrin, D. G., Dec 2013, In: Journal of Nutrition. 143, 12, p. 1899-905 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Bilio-enteric flow and plasma concentrations of bile acids after gastric bypass and sleeve gastrectomy
Eiken, A., Fuglsang, S., Eiken, M., Svane, M. S., Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Hansen, S. H., Trammell, Sam, Svenningsen, J. S., Rehfeld, Jens Frederik, Bojsen-Møller, K. N., Jørgensen, N. B., Holst, Jens Juul, Madsbad, Sten, Madsen, J. L. & Dirkse, C., 2020, In: International Journal of Obesity. 44, p. 1872-1883Research output: Contribution to journal › Journal article › Research › peer-review
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Biliopancreatic diversion with duodenal switch (BPD-DS) and single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) result in distinct post-prandial hormone profiles
Pereira, S. S., Guimarães, M., Almeida, R., Pereira, A. M., Lobato, C. B., Hartmann, Bolette, Hilsted, Linda, Holst, Jens Juul, Nora, M. & Monteiro, M. P., 2019, In: International Journal of Obesity. 43, p. 2518-2527Research output: Contribution to journal › Journal article › Research › peer-review
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Biological effects and metabolic rates of GLP-1 7-36 amide and GLP-1 7-37 in healthy volunteers are indistinguishable
Ørskov, Cathrine, Wettergren, A. & Holst, Jens Juul, 1993, In: Diabetes. 42, p. 658-661Research output: Contribution to journal › Journal article › Research › peer-review
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Biological effects and metabolic rates of glucagonlike peptide-1 7-36 amide and glucagonlike peptide-1 7-37 in healthy subjects are indistinguishable
Ørskov, Cathrine, Wettergren, A. & Holst, Jens Juul, May 1993, In: Diabetes. 42, 5, p. 658-61 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Blood glucose control in healthy subject and patients receiving intravenous glucose infusion or total parenteral nutrition using glucagon-like peptide 1
Nauck, M. A., Walberg, J., Vethacke, A., El-Ouaghlidi, A., Senkal, M., Holst, Jens Juul, Gallwitz, B., Gallwitz, J. B., Schmidt, W. E. & Schmiegel, W., 15 Apr 2004, In: Regulatory Peptides. 118, 1-2, p. 89-97 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Blood glucose control in healthy subject and patients receiving intravenous glucose infusion or total parenteral nutrition using glucagon-like peptide-1
Nauck, M. A., Walberg, J., Vethacke, A., El-Quaghlidi, A., Senkal, M., Holst, Jens Juul, Gallwitz, J. B., Schmidt, W. E. & Schmiegel, W., 2004, In: Regul. Pept.. 118, p. 89-97Research output: Contribution to journal › Journal article › Research › peer-review
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Body weight and metabolic risk factors in patients with type 2 diabetes on a self-selected high-protein low-carbohydrate diet
Alzahrani, A. H. A., Skytte, M. J., Samkani, A., Thomsen, M. N., Astrup, A., Ritz, C., Chabanova, E., Frystyk, J., Holst, Jens Juul, Thomsen, Henrik S., Madsbad, Sten, Haugaard, Steen Bendix, Krarup, T., Larsen, T. M. & Magkos, Faidon, 2021, In: European Journal of Nutrition. 60, 8, p. 4473-4482 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Bombesin inhibits histamine release from the rat oxyntic mucosa by a somatostatin-dependent mechanism.
Sandvik, A. K., Brenna, E., Sundan, A., Holst, Jens Juul & Waldum, H. L., 1997, In: Scandinavian Journal of Gastroenterology. 30, p. 427-432Research output: Contribution to journal › Journal article › Research › peer-review
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Bone resorption is decreased postprandially by intestinal factors and glucagon-like peptide-2 is a possible candidate
Holst, Jens Juul, Hartmann, B., Gottschalck, I. B., Jeppesen, P. B., Miholic, J. & Henriksen, D. B., 2007, In: Scandinavian Journal of Gastroenterology. 42, 7, p. 814-820 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Bone resorption is decreased postprandially by intestinal factors and glucagon-like peptide-2 is a possible candidate
Holst, Jens Juul, Hartmann, Bolette, Gottschalck, I. B., Jeppesen, Palle Bekker, Miholic, J. & Henriksen, D. B., Jul 2007, In: Scandinavian Journal of Gastroenterology. 42, 7, p. 814-20 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Both GLP-1 and GIP are insulinotropic at basal and postprandial glucose levels and contribute nearly equally to the incretin effect of a meal in healthy subjects
Vilsbøll, T., Krarup, T., Madsbad, Sten & Holst, Jens Juul, 15 Jul 2003, In: Regulatory Peptides. 114, 2-3, p. 115-21 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Both subcutaneously and intravenously administered glucagon-like peptide-1 are rapidly degraded from the amino terminus in type II diabetic patients and in healthy subjects.
Deacon, Carolyn F., Nauck, M. A., Nielsen, M. T., Pridal, L. & Holst, Jens Juul, 1995, In: Diabetes. 44, p. 1126-1131Research output: Contribution to journal › Journal article › Research › peer-review
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Butyrate and hexanoate-enriched triglycerides increase postprandrial systemic butyrate and hexanoate in men with overweight/obesity: A double-blind placebo-controlled randomized crossover trial
van Deuren, T., Smolders, L., Hartog, A., Bouwman, F. G., Holst, Jens Juul, Venema, K., Blaak, E. E. & Canfora, E. E., 2023, In: Frontiers in Nutrition. 9, 19 p., 1066950.Research output: Contribution to journal › Journal article › Research › peer-review
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C-cell hyperplasia accompanying thyroid diseases other than medullary carcinoma: an immunocytochemical study by means of antibodies to calcitonin and somatostatin
Scopsi, L., di Palma, S., Ferrari, C., Holst, Jens Juul & Rehfeld, J. F., 1991, In: Modern Pathology. Vol 4, no.3, p. 297-304Research output: Contribution to journal › Journal article › Research › peer-review
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CCK-1 and CCK-2 receptor agonism do not stimulate GLP-1 and neurotensin secretion in the isolated perfused rat small intestine or GLP-1 and PYY secretion in the rat colon
Modvig, Ida Marie, Christiansen, Charlotte Bayer, Rehfeld, Jens Frederik, Holst, Jens Juul & Veedfald, Simon, 2020, In: Physiological Reports. 8, 2, 8 p., 14352.Research output: Contribution to journal › Journal article › Research › peer-review
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Calcitonin gene-related peptide (CGRP) in the nipple of the rat mammary gland
Thulesen, J., Rasmussen, T. N., Schmidt, P., Holst, Jens Juul & Poulsen, Steen Seier, Dec 1994, In: Histochemistry. 102, 6, p. 437-444 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Calcitonin gene-related peptide: effect on contractile activity and luminal-cross-sectional area in isolated, perfused porcine ileum
Rasmussen, T. N., Gregersen, H., Harling, H. & Holst, Jens Juul, 1993, In: Scandinavian Journal of Gastroenterology. 27, p. 787-792Research output: Contribution to journal › Journal article › Research › peer-review
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Can Metabolite and Hormone Profiles Provide a Rationale for Choosing Between Bariatric Procedures?
Guimarães, M., Pereira, S. S., Holst, Jens Juul, Nora, M. & Monteiro, M. P., 2021, In: Obesity Surgery. 31, p. 2174-2179Research output: Contribution to journal › Journal article › Research › peer-review
- E-pub ahead of print
Canagliflozin or acarbose versus placebo to ameliorate post-bariatric hypoglycaemia - The HypoBar I randomized clinical trial protocol
Lobato, C. B., wql596, wql596, Bojsen-Møller, Kirstine Nyvold, Martinussen, C., Veedfald, Simon, Holst, Jens Juul, Madsbad, Sten, Jørgensen, N. B. & Dirksen, Carsten Moro, 2024, (E-pub ahead of print) In: Diabetic Medicine. e15320.Research output: Contribution to journal › Journal article › Research › peer-review
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Carboxypeptidase-B-like processing of the C-terminus of glucagon-like peptide-2 in pig and human small intestine
Ørskov, Cathrine, Buhl, T., Rabenhøj, L., Kofod, H. & Holst, Jens Juul, 24 Apr 1989, In: F E B S Letters. 247, 2, p. 193-6 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cardiovascular and metabolic effects of 48-h glucagon-like peptide-1 infusion in compensated chronic patients with heart failure
Halbirk, M., Nørrelund, H., Møller, N., Holst, Jens Juul, Schmitz, O., Nielsen, B. R. R., Nielsen-Kudsk, J. E., Nielsen, S. S., Nielsen, T. T., Eiskjaer, H., Bøtker, H. E. & Wiggers, H., 1 Mar 2010, In: American Journal of Physiology: Heart and Circulatory Physiology. 298, 3, p. H1096-H1102Research output: Contribution to journal › Journal article › Research › peer-review
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Cardiovascular effects of high-dose glucagon: a randomised clinical trial
Petersen, K. M., Bogevig, S., Riis, T., Andersson, N. A. W., Dalhoff, Kim, Holst, Jens Juul, Knop, Filip Krag, Faber, Jens, Petersen, Tonny Studsgaard & Christensen, Mikkel Bring, 2020, In: Diabetologia. 63, SUPPL 1, p. S231-S231Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Cardiovascular effects of incretins - focus on glucagon-like peptide-1 receptor agonists
Madsbad, Sten & Holst, Jens Juul, 2023, In: Cardiovascular Research. p. 886–904 19 p.Research output: Contribution to journal › Review › Research › peer-review
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Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test
Gjesing, A. P., Kjems, L. L., Vestmar, M. A., Grarup, Niels, Linneberg, Allan René, Deacon, Carolyn F., Holst, Jens Juul, Pedersen, Oluf Borbye & Hansen, Torben, 1 Jan 2011, In: Diabetologia. 54, 1, p. 103-10 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Case report: Somatostatin producing teratoma, causing rapidly alternating extreme hyperglycemia and hypoglycemia, and ovarian somatostatinoma
Gregersen, G., Holst, Jens Juul, Trankjaer, A., Stadil, F. & Mogensen, A. M., 2002, In: Metabolism. 51, 9, p. 1180-1183 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cecal infusion of butyrate increases intestinal cell proliferation in piglets
Kien, C. L., Blauwiekel, R., Bunn, J. Y., Jetton, T. L., Frankel, W. L. & Holst, Jens Juul, 2007, In: Journal of Nutrition. 137, 4, p. 916-922 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1.
Holst, Jens Juul, Gromada, K. & Rorsman, P., 1998, In: Pflugers Arch.. 435, p. 583-594Research output: Contribution to journal › Journal article › Research › peer-review
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Central 5-HT Neurotransmission Modulates Weight Loss following Gastric Bypass Surgery in Obese Individuals
Haahr, M. E., Hansen, D. L., Fisher, P. M., Svarer, C., Stenbæk, D. S., Madsen, K., Madsen, J., Holst, Jens Juul, Baaré, W. F. C., Højgaard, Liselotte, Almdal, T. & Knudsen, G. M., 8 Apr 2015, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 35, 14, p. 5884-5889 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cephalic phase secretion of insulin and other enteropancreatic hormones in humans
Veedfald, Simon, Plamboeck, A., Deacon, Carolyn F., Hartmann, Bolette, Knop, Filip Krag, Vilsbøll, Tina & Holst, Jens Juul, 1 Jan 2016, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 310, 1, p. G43-51Research output: Contribution to journal › Journal article › Research › peer-review
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Cerebral effects of glucagon-like peptide-1 receptor blockade before and after Roux-en-Y gastric bypass surgery in obese women: A proof-of-concept resting-state functional MRI study
van Duinkerken, E., Bernardes, G., van Bloemendaal, L., Veltman, D. J., Barkhof, F., Mograbi, D. C., Gerdes, V. E. A., Deacon, Carolyn F., Holst, Jens Juul, Drent, M. L., Diamant, M., ten Kulve, J. & Ijzerman, R. G., 2021, In: Diabetes, Obesity and Metabolism. 23, 2, p. 415-424 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cerebrovascular changes following administration of gammaglobulins against substance P or calcitonin gene related peptide in monkey with subarachnoid haemorrhage
Shiokawa, Y., Holst, Jens Juul, Rasmussen, J. T. N., Schmidt, P. & Svendgaard, N., 1993, In: British J. of Neurosurgery. 7, p. 507-518Research output: Contribution to journal › Journal article › Research › peer-review
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Changes in Gastrointestinal Hormone Responses, Insulin Sensitivity, and Beta-Cell Function Within 2 Weeks After Gastric Bypass in Non-diabetic Subjects
Jacobsen, S. H., Olesen, S. C., Dirksen, C., Jørgensen, N. B., Bojsen-Møller, K. N., Kielgast, U., Worm, Dorte, Almdal, Thomas Peter, Naver, L. S., Hvolris, L. E., Rehfeld, Jens Frederik, Wulff, B. S., Clausen, T. R., Hansen, D. L., Holst, Jens Juul & Madsbad, Sten, 2012, In: Obesity Surgery. 22, 7, p. 1084-96 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Changes in Glucose Homeostasis after Roux-en-Y Gastric Bypass Surgery for Obesity at Day Three, Two Months, and One Year after Surgery: Role of Gut Peptides
Falkén, Y., Hellström, P. M., Holst, Jens Juul & Näslund, E., 2011, In: Journal of Clinical Endocrinology and Metabolism. 96, 7, p. 2227-35 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 4207
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Meal induced gut hormone secretion is altered in aerobically trained compared to sedentary young healthy males
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Copenhagen study of overweight patients with coronary artery disease undergoing low energy diet or interval training: the randomized CUT-IT trial protocol
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Whole grain-rich diet reduces body weight and systemic low-grade inflammation without inducing major changes of the gut microbiome: a randomised cross-over trial
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