Gertrud Malene Hjortø

Gertrud Malene Hjortø

Associate Professor


Publication year:
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1 - 25 out of 40Page size: 25
  1. 2023
  2. Published

    Chemokine binding to PSGL-1 is controlled by O-glycosylation and tyrosine sulfation

    Goth, C. K., Mehta, A. Y., McQuillan, A. M., Baker, K. J., Hanes, M. S., Park, S. S., Stavenhagen, K., Hjortø, Gertrud Malene, Heimburg-Molinaro, J., Chaikof, E. L., Rosenkilde, Mette & Cummings, R. D., 2023, In: Cell Chemical Biology. 30, 8, p. 893-905.e7

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization

    Kjær, Viktoria Madeline Skovgaard, Daugvilaite, V., Stepniewski, T. M., Madsen, C. M., Jørgensen, Astrid Sissel, Bhuskute, K. R., Inoue, A., Ulven, Trond, Benned-Jensen, T., Hjorth, Siv Annegrethe, Hjortø, Gertrud Malene, Moo, Ee Von, Selent, J. & Rosenkilde, Mette, 2023, In: Science Signaling. 16, 779, 13 p., eabl4283.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    “Glyco-sulfo barcodes” regulate chemokine receptor function

    Verhallen, L., Lackman, Jarkko Juhani, Wendt, R., Gustavsson, Martin, Yang, Zhang, Narimatsu, Yoshiki, Sørensen, Daniel Madriz, Lafferty, K. M., Gouwy, M., Marques, P. E., Hjortø, Gertrud Malene, Rosenkilde, Mette, Proost, P. & Goth, C. K., 2023, In: Cellular and Molecular Life Sciences. 80, 2, 18 p., 55.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. 2022
  6. Published

    Rewiring host–microbe interactions and barrier function during gastrointestinal inflammation

    Jensen, Sune K. , Pærregaard, S. I., Brandum, E. P., Jørgensen, Astrid Sissel, Hjortø, Gertrud Malene & Jensen, Benjamin Anderschou Holbech, 25 Jan 2022, In: Gastroenterology Report. 10, p. 1-15 goac008.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    GPR183 is Dispensable for B1 cell Accumulation and Function, but Affects B2 cell Abundance, in the Omentum and Peritoneal Cavity

    Barington, L., Christensen, Liv von Voss, Pedersen, K. K., Arfelt, K. N., Roumain, M., Jensen, Kristian HR, Kjær, Viktoria Madeline Skovgaard, Daugvilaite, V., Kearney, J. F., Christensen, Jan Pravsgaard, Hjortø, Gertrud Malene, Muccioli, G. G., Holst, Peter Johannes & Rosenkilde, Mette, 2022, In: Cells. 11, 3, 19 p., 494.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Selective Boosting of CCR7-Acting Chemokines; Short Peptides Boost Chemokines with Short Basic Tails, Longer Peptides Boost Chemokines with Long Basic Tails

    Brandum, E. P., Jørgensen, Astrid Sissel, Calvo, M. B., Spiess, Katja, Peterson, F. C., Yang, Zhang, Volkman, B. F., Veldkamp, C. T., Rosenkilde, Mette, Goth, C. K. & Hjortø, Gertrud Malene, 2022, In: International Journal of Molecular Sciences. 23, 3, 20 p., 1397.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. 2021
  10. Published

    Biased action of the CXCR4-targeting drug plerixafor is essential for its superior hematopoietic stem cell mobilization

    Jørgensen, Astrid Sissel, Daugvilaite, V., De Filippo, K., Berg, Christian, Mavri, M., Benned-Jensen, T., Juzenaite, G., Hjortø, Gertrud Malene, Rankin, S., Vabeno, J. & Rosenkilde, Mette, 2021, In: Communications Biology . 4, 1, 12 p., 569.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    GLP-1 Val8: A Biased GLP-1R Agonist with Altered Binding Kinetics and Impaired Release of Pancreatic Hormones in Rats

    van der Velden, W. J. C., Smit, F. X., Christiansen, Charlotte Bayer, Møller, T. C., Hjortø, Gertrud Malene, Larsen, Olav, Schiellerup, S. P., Bräuner, Hans, Holst, Jens Juul, Hartmann, Bolette, Frimurer, Thomas Michael & Rosenkilde, Mette, 2021, In: ACS Pharmacology & Translational Science. 4, 1, p. 296-313 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    The C-terminal peptide of CCL21 drastically augments CCL21 activity through the dendritic cell lymph node homing receptor CCR7 by interaction with the receptor N-terminus

    Jørgensen, Astrid Sissel, Brandum, E. P., Mikkelsen, J. M., Orfin, K. A., Boilesen, D. R., Egerod, Kristoffer Lihme, Moussouras, N. A., Vilhardt, Frederik, Kalinski, P., Basse, P., Chen, Yen-Hsi, Yang, Zhang, Dwinell, M. B., Volkman, B. F., Veldkamp, C. T., Holst, Peter Johannes, Lahl, K., Goth, C. K., Rosenkilde, Mette & Hjortø, Gertrud Malene, 2021, In: Cellular and Molecular Life Sciences. 78, p. 6963-6978 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. 2020
  14. Published

    Structural Features of an Extended C-Terminal Tail Modulate the Function of the Chemokine CCL21

    Moussouras, N. A., Hjortø, Gertrud Malene, Peterson, F. C., Szpakowska, M., Chevigné, A., Rosenkilde, Mette, Volkman, B. F. & Dwinell, M. B., 7 Apr 2020, In: Biochemistry. 59, 13, p. 1338-1350 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Three-Dimensional Explant Platform for Studies on Choroid Plexus Epithelium

    Petersen, N., Pedersen, Lola Julie Torz, Jensen, Kristian HR, Hjortø, Gertrud Malene, Spiess, Katja & Rosenkilde, Mette, 2020, In: Frontiers in Cellular Neuroscience. 14, 11 p., 108.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. 2019
  17. Published

    Arrestin-independent constitutive endocytosis of GPR125/ADGRA3

    Spiess, Katja, Bagger, Sofie Morsing, Pedersen, Lola Julie Torz, Jensen, Kristian HR, Walser, Anna Louise Silvia, Kvam, J. M., Mogelmose, A. K., Daugvilaite, V., Junnila, R. K., Hjortø, Gertrud Malene & Rosenkilde, Mette, 2019, In: Annals of the New York Academy of Sciences. 1456, p. 186–199

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7

    Jørgensen, Astrid Sissel, Larsen, Olav, Uetz-von Allmen, E., Lückmann, Michael, Legler, D. F., Frimurer, Thomas Michael, Veldkamp, C. T., Hjortø, Gertrud Malene & Rosenkilde, Mette, 2019, In: Frontiers in Immunology. 10, 14 p., 2156.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. 2018
  20. Published

    Biased signaling of G protein-coupled receptors: rom a chemokine receptor CCR7 perspective

    Jørgensen, Astrid Sissel, Rosenkilde, Mette & Hjortø, Gertrud Malene, Mar 2018, In: General and Comparative Endocrinology. 258, SI, p. 4-14

    Research output: Contribution to journal › Review › Research › peer-review

  21. Published

    CCL19 with CCL21-tail displays enhanced glycosaminoglycan binding with retained chemotactic potency in dendritic cells

    Jørgensen, Astrid Sissel, Adogamhe, P. E., Laufer, J. M., Legler, D. F., Veldkamp, C. T., Rosenkilde, M. M. & Hjortø, Gertrud Malene, 2018, In: Journal of Leukocyte Biology. 104, 2, p. 401-411

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Ligand-selective small molecule modulators of the constitutively active vGPCR US28

    Amarandi, R., Lückmann, Michael, Melynis, M., Jakobsen, M. H., Fallah, Z., Spiess, Katja, Hjortø, Gertrud Malene, Pui, A., Frimurer, Thomas Michael & Rosenkilde, Mette, 2018, In: European Journal of Medicinal Chemistry. 155, p. 244-254

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy

    Miles, T. F., Spiess, Katja, Jude, K. M., Tsutsumi, N., Burg, J. S., Ingram, J. R., Waghray, D., Hjortø, Gertrud Malene, Larsen, Olav, Ploegh, H. L., Rosenkilde, Mette & Garcia, K. C., 2018, In: eLife. 7, 23 p., e35850 .

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. 2017
  25. Published

    Signaling via G proteins mediates tumorigenic effects of GPR87

    Arfelt, K. N., Fares, S., wbf943, wbf943, Hjortø, Gertrud Malene, Gasbjerg, Lærke Smidt, Molleskov-Jensen, A., Benned-Jensen, T. & Rosenkilde, Mette, Jan 2017, In: Cellular Signalling. 30, p. 9-18

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. 2016
  27. Published

    Differential CCR7 Targeting in Dendritic Cells by Three Naturally Occurring CC-Chemokines

    Hjortø, Gertrud Malene, Larsen, Olav, Steen, A., Daugvilaite, V., Berg, Christian, Fares, S., Hansen, M., Ali, S. & Rosenkilde, Mette, 9 Dec 2016, In: Frontiers in Immunology. 7, 568.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Autocrine CCL19 blocks dendritic cell migration toward weak gradients of CCL21

    Hansen, M., Met, Özcan, Larsen, N. B., Rosenkilde, Mette, Andersen, Mads Hald, Svane, Inge Marie & Hjortø, Gertrud Malene, Sep 2016, In: Cytotherapy. 18, 9, p. 1187-1196

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Discovery and Characterization of Biased Allosteric Agonists of the Chemokine Receptor CXCR3

    Milanos, L., Brox, R., Frank, T., Poklukar, G., Palmisano, R., Waibel, R., Einsiedel, J., Dürr, M., Ivanović-Burmazović, I., Larsen, Olav, Hjortø, Gertrud Malene, Rosenkilde, M. M. & Tschammer, N., 2016, In: Journal of Medicinal Chemistry. 59, 5, p. 2222-2243 22 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Probing Biased Signaling in Chemokine Receptors

    Amarandi, R. M., Hjortø, Gertrud Malene, Rosenkilde, Mette & Karlshøj, S., 2016, Methods in Enzymology. Academic Press, Vol. 570. p. 155-186 32 p. (Methods in Enzymology, Vol. 570).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  31. 2015
  32. Published

    Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo

    Spiess, Katja, Jeppesen, M. G., Malmgaard-Clausen, M., Krzywkowski, K., Dulal, K., Cheng, T., Hjortø, Gertrud Malene, Larsen, Olav, Burg, J. S., Jarvis, M. A., Garcia, K. C., Zhu, H., Kledal, T. N. & Rosenkilde, Mette, Jul 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 27, p. 8427-8432 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Confinement dependent chemotaxis in two-photon polymerized linear migration constructs with highly definable concentration gradients

    Hjortø, Gertrud Malene, Olsen, M. H., Svane, Inge Marie & Larsen, N. B., Apr 2015, In: Biomedical Microdevices. 17, 2, p. 1-10 10 p., 30.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. 2013
  35. Published

    In-chip fabrication of free-form 3D constructs for directed cell migration analysis

    Olsen, M. H., Hjortø, Gertrud Malene, Hansen, M., Met, Özcan, Svane, Inge Marie & Larsen, N. B., 21 Dec 2013, In: Lab On a Chip. 13, 24, p. 4800-4809 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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ID: 113657078