Carolyn F. Deacon
Carolyn F. Deacon

Associate Professor


  1. 2010
  2. Published

    Linagliptin, a xanthine-based dipeptidyl peptidase-4 inhibitor with an unusual profile for the treatment of type 2 diabetes

    Deacon, Carolyn F. & Holst, Jens Juul, Jan 2010, In : Expert Opinion on Investigational Drugs. 19, 1, p. 133-40 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Little enhancement of meal-induced GLP-1 secretion in Japanese: Comparison of type 2 diabetes and healthy controls

    Yabe, D., Kuroe, A., Lee, S., Watanabe, K., Hyo, T., Hishizawa, M., Kurose, T., Deacon, Carolyn F., Holst, Jens Juul, Hirano, T., Inagaki, N. & Seino, Y., Jan 2010, In : Journal of Diabetes Investigation. 1, 1/2, p. 56-59

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Incretin hormone secretion over the day

    Ahren, B., Carr, R. & Deacon, Carolyn F., 2010, In : Vitamins and Hormones. 84, p. 203-220 18 p.

    Research output: Contribution to journalReviewResearchpeer-review

  5. Published

    Linagliptin, a xanthine-based dipeptidyl peptidase-4 inhibitor with an unusual profile for the treatment of type 2 diabetes

    Deacon, Carolyn F. & Holst, Jens Juul, 2010, In : Expert Opinion on Investigational Drugs. 19, 1, p. 133-140 8 p.

    Research output: Contribution to journalReviewResearchpeer-review

  6. Published

    Pancreatic beta-cell responses to GLP-1 after near-normalization of blood glucose in patients with type 2 diabetes

    Asmar, M., Højberg, P. V., Deacon, Carolyn F., Hare, K., Holst, Jens Juul & Madsbad, Sten, 2010, In : Regulatory Peptides. 160, 1-3, p. 175-80 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Pancreatic ß-cell responses to GLP-1 after near-normalization of blood glucose in patients with type 2 diabetes

    Asmar, M., Højberg, P., Deacon, Carolyn F., Hare, K., Holst, Jens Juul & Madsbad, Sten, 2010, In : Regulatory Peptides. 160, 1-3, p. 175-180 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Secretion and dipeptidyl peptidase-4-mediated metabolism of incretin hormones after a mixed meal or glucose ingestion in obese compared to lean, nondiabetic men

    Carr, R. D., Larsen, M. O., Jelic, K., Lindgren, O., Vikman, J., Holst, Jens Juul, Deacon, Carolyn F. & Ahrén, B., 2010, In : Journal of Clinical Endocrinology and Metabolism. 95, 2, p. 872-8 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    The effect of DPP-4 inhibition with sitagliptin on incretin secretion and on fasting and postprandial glucose turnover in subjects with impaired fasting glucose

    Bock, G., Man, C. D., Micheletto, F., Basu, R., Rn, P. D. G., Laugen, J., Deacon, Carolyn F., Holst, Jens Juul, Toffolo, G., Cobelli, C., Rizza, R. A. & Vella, A., 2010, In : Clinical Endocrinology. 73, p. 189-196

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Twelve weeks treatment with the DPP-4 inhibitor, sitagliptin, prevents degradation of peptide YY and improves glucose- and non-glucose-induced insulin secretion in patients with type 2 diabetes mellitus

    Aaboe, K., Knop, Filip Krag, Vilsbøll, Tina, Deacon, Carolyn F., Holst, Jens Juul, Madsbad, Sten & Krarup, T., 2010, In : Diabetes, Obesity and Metabolism. 12, 4, p. 323-333 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. 2009
  12. Published

    DPP-4 inhibition – advances in our understanding of diabetes management

    Deacon, Carolyn F. & Holst, Jens Juul, 2009, In : European Endocrinology. 4, p. 47-49

    Research output: Contribution to journalReviewResearch

  13. Published

    Differential islet and incretin hormone responses in morning versus afternoon after standardized meal in healthy men

    Lindgren, O., Mari, A., Deacon, Carolyn F., Carr, R. D., Winzell, M. S., Vikman, J. & Ahrén, B., 2009, In : Journal of Clinical Endocrinology and Metabolism. 94, 8, p. 2887-92 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Hyperglycemia acutely lowers the postprandial excursions of glucagon-like Peptide-1 and gastric inhibitory polypeptide in humans

    Vollmer, K., Gardiwal, H., Menge, B. A., Goetze, O., Deacon, Carolyn F., Schmidt, W. E., Holst, Jens Juul & Meier, J. J., 2009, In : Journal of Clinical Endocrinology and Metabolism. 94, 4, p. 1379-85 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Immunoassays for the incretin hormones GIP and GLP-1

    Deacon, Carolyn F. & Holst, Jens Juul, 2009, In : Best Practice & Research: Clinical Endocrinology & Metabolism. 23, 4, p. 425-32 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Incretin hormones and diabetes mellitus

    Vilsbøll, Tina, Knop, Filip Krag, Deacon, Carolyn F. & Holst, Jens Juul, 2009, Therapeutic Strategies in Diabetes. Stehouwer, C. D. A. & Schaper, N. (eds.). Oxford: Clinical Publishing, p. 99-114

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  17. Published

    Inhibition of neutral endopeptidase 24.11 does not potentiate the improvement in glycemic control obtained with dipeptidyl peptidase-4 inhibition in diabetic Goto-Kakizaki rats

    Simonsen, L., Pilgaard, S., Carr, R. D., Kanstrup, A. B., Holst, Jens Juul & Deacon, Carolyn F., 2009, In : Hormone and Metabolic Research. 41, 11, p. 851-3 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    KATP channel closure ameliorates the impaired insulinotropic effect of glucose-dependent insulinotropic polypeptide (GIP) in patients with type 2 diabetes

    Aaboe, K., Knop, Filip Krag, Vilsbøll, Tina, Vølund, A., Simonsen, U., Deacon, Carolyn F., Madsbad, Sten, Holst, Jens Juul & Krarup, T., 2009, In : Journal of Clinical Endocrinology and Metabolism. 94, 2, p. 603-608

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Long-term exendin-4 treatment delays natural deterioration of glycaemic control in diabetic Goto-Kakizaki rats

    Simonsen, L., Pilgaard, S., Orskov, C., Hartmann, Bolette, Holst, Jens Juul & Deacon, Carolyn F., 2009, In : Diabetes, Obesity and Metabolism. 11, 9, p. 884-90 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Potential of liraglutide in the treatment of patients with type 2 diabetes

    Deacon, Carolyn F., 2009, In : Vascular Health and Risk Management (Online). 5, 1, p. 199-211 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Preserved inhibitory potency of GLP-1 on glucagon secretion in type 2 diabetes mellitus

    Hare, K. J., Knop, Filip Krag, Asmar, M., Madsbad, Sten, Deacon, Carolyn F., Holst, Jens Juul & Vilsbøll, Tina, 2009, In : Journal of Clinical Endocrinology and Metabolism. 94, 12, p. 4679-87 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Saxagliptin: a new dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes

    Deacon, Carolyn F. & Holst, Jens Juul, 2009, In : Advances in Therapy. 26, 5, p. 488-99 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Twelve weeks treatment with the DPP-4 inhibitor sitagliptin improves glycaemic control, but does not improve GLP-1 secretion, in patients with type 2 diabetes - a randomised trial

    Aaboe, K., Knop, F. K., Vilsbøll, Tina, Deacon, Carolyn F., Holst, Jens Juul, Madsbad, Sten & Krarup, T., 2009, In : Diabetologia. p. 748

    Research output: Contribution to journalConference abstract in journalResearch

  24. 2008
  25. Published

    Effect of vildagliptin on glucagon concentration during meals in patients with type 1 diabetes

    Foley, J. E., Ligueros-Saylan, M., He, Y., Holst, Jens Juul, Deacon, Carolyn F., Dunning, B. E., Leone-Jones, A., Yu, T. & Kelley, D. E., Oct 2008, In : Hormone and Metabolic Research. Supplement. 40, 10, p. 727-30 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Glucagon-like peptide receptor agonists and dipeptidyl peptidase-4 inhibitors in the treatment of diabetes: a review of clinical trials

    Madsbad, Sten, Krarup, T., Deacon, Carolyn F. & Holst, Jens Juul, Jul 2008, In : Current Opinion in Clinical Nutrition and Metabolic Care. 11, 4, p. 491-9 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Alogliptin, a potent and selective dipeptidyl peptidase-IV inhibitor for the treatment of type 2 diabetes.

    Deacon, Carolyn F., 2008, In : Current Opinion in Investigational Drugs. 9, 4, p. 402-13 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    DPP-4 inhibitor therapy: new directions in the treatment of type 2 diabetes

    Deacon, Carolyn F., Carr, R. D. & Holst, Jens Juul, 2008, In : Frontiers in Bioscience. 13, p. 1780-94 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Effect of Vildagliptin on Glucagon Concentration During Meals in Patients with Type 1 Diabetes

    Foley, J. E., Ligueros-Saylan, M., He, Y. L., Holst, Jens Juul, Deacon, Carolyn F., Dunning, B. E., Leone-Jones, A., Yu, T. & Kelley, D. E., 2008, In : Hormone and Metabolic Research. 40, 10, p. 727-730 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Effects of the dipeptidyl peptidase-IV inhibitor vildagliptin on incretin hormones, islet function, and postprandial glycemia in subjects with impaired glucose tolerance.

    Rosenstock, J., Foley, J. E., Rendell, M., Landin-Olsson, M., Holst, Jens Juul, Deacon, Carolyn F., Rochotte, E. & Baron, M. A., 2008, In : Diabetes Care. 31, 1, p. 30-5 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Glucagon-like peptide receptor agonists and dipeptidyl peptidase-4 inhibitors in the treatment of diabetes: a review of clinical trials

    Madsbad, Sten, Krarup, T., Deacon, Carolyn F., Holst, Jens Juul, Madsbad, Sten, Krarup, T., Deacon, C. F. & Holst, J. J., 2008, In : Current Opinion in Clinical Nutrition and Metabolic Care. 11, 4, p. 491-9 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Glucagon-like peptide-1, glucose homeostasis and diabetes.

    Holst, Jens Juul, Deacon, Carolyn F., Vilsbøll, Tina, Krarup, T. & Madsbad, Sten, 2008, In : Trends in Molecular Medicine. 14, 4, p. 161-8 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Incretin and islet hormonal responses to fat and protein ingestion in healthy men.

    Carr, R. D., Larsen, M. O., Winzell, M. S., Jelic, K., Lindgren, O., Deacon, Carolyn F. & Ahrén, B., 2008, In : American Journal of Physiology: Endocrinology and Metabolism. 295, 4, p. E779-84

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    KATP channel closure ameliorates the impaired insulinotropic effect of glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes

    Aaboe, K., Knop, Filip Krag, Vilsboll, T., Vølund, A., Simonsen, U., Deacon, Carolyn F., Madsbad, Sten, Holst, Jens Juul & Krarup, T., 2008, In : Journal of Clinical Endocrinology and Metabolism. 94, 2, p. 603-8 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Measurements Inhibition of DPP-4 evokes pancreatic and extra-pancreatic mechanisms that improve glucose homeostasis in type 2 diabetes mellitus.

    Azuma, K., Radikova, Z., Mancino, J., Toledo, F., Thomas, E., Kangani, C., Dalla Man, C., Cobelli, C., Holst, Jens Juul, Deacon, Carolyn F., He, Y., Ligueros-Saylan, M., Serra, D. & Kelley, D., 2008, In : Journal of Clinical Endocrinology and Metabolism. 93, p. 459-463

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Overnight hypoxic exposure and glucagon-like peptide-1 and leptin levels in humans.

    Snyder, E. M., Carr, R. D., Deacon, Carolyn F. & Johnson, B. D., 2008, In : Applied Physiology, Nutrition and Metabolism. 33, 5, p. 929-35 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    The effect of dipeptidyl peptidase 4 inhibition on gastric volume, satiation and enteroendocrine secretion in Type 2 diabetes: a double blind, placebo-controlled crossover study.

    Vella, A., Bock, G., Giesler, P. D., Burton, D. B., Serra, D. B., Saylan, M. L., Deacon, Carolyn F., Foley, J. E., Rizza, R. A. & Camilleri, M., 2008, In : Clinical Endocrinology.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    The incretin system and its role in type 2 diabetes mellitus

    Holst, Jens Juul, Vilsbøll, Tina & Deacon, Carolyn F., 2008, In : Molecular and Cellular Endocrinology. 297, 1-2, p. 127-136 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. 2007
  40. Published

    Dipeptidyl peptidase 4 inhibition with sitagliptin: a new therapy for type 2 diabetes.

    Deacon, Carolyn F., 2007, In : Expert Opinion on Investigational Drugs. 16, 4, p. 533-45 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Exendin-4, but not dipeptidyl peptidase IV inhibition, increases small intestinal mass in GK rats.

    Simonsen, L., Pilgaard, S., Orskov, C., Rosenkilde, Mette, Hartmann, B., Holst, Jens Juul & Deacon, Carolyn F., 2007, In : American Journal of Physiology: Gastrointestinal and Liver Physiology. 293, 1, p. G288-95

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Incretin-based treatment of type 2 diabetes: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors.

    Deacon, Carolyn F., 2007, In : Diabetes, Obesity and Metabolism. 9 Suppl 1, p. 23-31 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Measurements of islet function and glucose metabolism with the dipeptidyl peptidase 4 inhibitor vildagliptin in patients with type 2 diabetes

    Azuma, K., Rádiková, Z., Mancino, J., Toledo, F. G. S., Thomas, E., Kangani, C., Dalla Man, C., Cobelli, C., Holst, Jens Juul, Deacon, Carolyn F., He, Y., Ligueros-Saylan, M., Serra, D., Foley, J. E. & Kelley, D. E., 2007, In : Journal of Clinical Endocrinology and Metabolism. 93, 2, p. 459-464 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    New horizons in diabetes therapy

    Holst, Jens Juul & Deacon, Carolyn F., 2007, In : Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry. 7, 1, p. 49-55 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Pharmacodynamics of vildagliptin in patients with type 2 diabetes during OGTT.

    He, Y., Wang, Y., Bullock, J. M., Deacon, Carolyn F., Holst, Jens Juul, Dunning, B. E., Ligueros-Saylan, M. & Foley, J. E., 2007, In : Journal of Clinical Pharmacology. 47, 5, p. 633-41 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Pharmacokinetics and pharmacodynamics of vildagliptin in patients with type 2 diabetes mellitus.

    He, Y., Serra, D., Wang, Y., Campestrini, J., Riviere, G., Deacon, Carolyn F., Holst, Jens Juul, Schwartz, S., Nielsen, J. C. & Ligueros-Saylan, M., 2007, In : Clinical Pharmacokinetics. 46, 7, p. 577-88 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Suppression of glucagon secretion is lower after oral glucose administration than during intravenous glucose administration in human subjects

    Meier, J. J., Deacon, Carolyn F., Schmidt, W. E., Holst, Jens Juul & Nauck, M. A., 2007, In : Diabetologia. 50, 4, p. 806-813 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    The dipeptidyl peptidase IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single-dose administration in type 2 diabetic patients.

    Balas, B., Baig, M. R., Watson, C., Dunning, B. E., Ligueros-Saylan, M., Wang, Y., He, Y., Darland, C., Holst, Jens Juul, Deacon, Carolyn F., Cusi, K., Mari, A., Foley, J. E. & DeFronzo, R. A., 2007, In : Journal of Clinical Endocrinology and Metabolism. 92, 4, p. 1249-55 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    The dipeptidyl peptidase-4 inhibitor vildagliptin improves beta-cell function and insulin sensitivity in subjects with impaired fasting glucose

    Utzschneider, K. M., Tong, J., Montgomery, B., Udayasankar, J., Gerchman, F., Marcovina, S. M., Watson, C. E., Ligueros-Saylan, M. A., Foley, J. E., Holst, Jens Juul, Deacon, Carolyn F. & Kahn, S. E., 2007, In : Diabetes Care. 31, 1, p. 108-113 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. 2006
  51. Published

    Plasma dipeptidyl peptidase-IV activity in patients with type-2 diabetes mellitus correlates positively with HbAlc levels, but is not acutely affected by food intake

    Ryskjaer, J., Deacon, Carolyn F., Carr, R. D., Krarup, T., Madsbad, Sten, Holst, Jens Juul, Vilsbøll, Tina, Ryskjaer, J., Deacon, C. F., Carr, R. D., Krarup, T., Madsbad, Sten, Holst, J. J. & Vilsbøll, T., 1 Sep 2006, In : European Journal of Endocrinology. 155, 3, p. 485-93 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Exendin-4, but not glucagon-like peptide-1, is cleared exclusively by glomerular filtration in anaesthetised pigs

    Simonsen, L., Holst, Jens Juul & Deacon, Carolyn F., Apr 2006, In : Diabetologia. 49, 4, p. 706-12 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    The metabolite generated by dipeptidyl-peptidase 4 metabolism of glucagon-like peptide-1 has no influence on plasma glucose levels in patients with type 2 diabetes

    Zander, M., Madsbad, Sten, Deacon, Carolyn F. & Holst, Jens Juul, Feb 2006, In : Diabetologia. 49, 2, p. 369-74 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels after an oral glucose tolerance test in patients with type 2 diabetes.

    Herman, G. A., Bergman, A., Stevens, C., Kotey, P., Yi, B., Zhao, P., Dietrich, B., Golor, G., Schrodter, A., Keymeulen, B., Lasseter, K. C., Kipnes, M. S., Snyder, K., Hilliard, D., Tanen, M., Cilissen, C., De Smet, M., de Lepeleire, I., Van Dyck, K., Wang, A. Q., Zeng, W., Davies, M. J., Tanaka, W., Holst, Jens Juul, Deacon, Carolyn F., Gottesdiener, K. M. & Wagner, J. A., 2006, In : Journal of Clinical Endocrinology and Metabolism. 91, 11, p. 4612-9 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Exendin-4, but not glucagon-like peptide-1, is cleared exclusively by glomerular filtration in anaesthetised pigs

    Simonsen, L., Holst, Jens Juul & Deacon, Carolyn F., 2006, In : Diabetologia. 49, 4, p. 706-712 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    GIP-(3-42) does not antagonize insulinotropic effects of GIP at physiological concentrations.

    Deacon, Carolyn F., Plamboeck, A., Rosenkilde, Mette, de Heer, J. & Holst, Jens Juul, 2006, In : American Journal of Physiology: Endocrinology and Metabolism. 291, 3, p. E468-75

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    Glucose-induced incretin hormone release and inactivation are differently modulated by oral fat and protein in mice.

    Gunnarsson, P. T., Winzell, M. S., Deacon, Carolyn F., Larsen, M. O., Jelic, K., Carr, R. D. & Ahrén, B., 2006, In : Endocrinology. 147, 7, p. 3173-80 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    Glucose-stimulated prehepatic insulin secretion is associated with circulating alanine, triglyceride, glucagon, lactate and TNF-alpha in patients with HIV-lipodystrophy

    Haugaard, S. B., Andersen, O., Pedersen, S. B., Dela, Flemming, Deacon, Carolyn F., Holst, Jens Juul, Iversen, J. & Madsbad, Sten, 2006, In : HIV Medicine. 7, 3, p. 163-72 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. Published

    Influence of gastric inhibitory polypeptide on pentagastrin-stimulated gastric acid secretion in patients with type 2 diabetes and healthy controls.

    Meier, J. J., Nauck, M. A., Kask, B., Holst, Jens Juul, Deacon, Carolyn F., Schmidt, W. E. & Gallwitz, B., 2006, In : World Journal of Gastroenterology. 12, 12, p. 1874-80 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. Published

    Metabolism of glucagon-like peptide-2 in pigs: role of dipeptidyl peptidase IV.

    Hansen, Lene, Hare, K. J., Hartmann, B., Deacon, Carolyn F., Ugleholdt, R. K., Plamboeck, A. & Holst, Jens Juul, 2006, In : Regulatory Peptides. 138, 2-3, p. 126-32 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  61. Published

    Role of GLP-1 analogues and DDP-IV inhibitors in the treatment of type 2 diabetes

    Holst, Jens Juul & Deacon, Carolyn F., 2006, In : Avances en Diabetologia. 22, 2, p. 115-125 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  62. Published

    The elimination rates of intact GIP as well as its primary metabolite, GIP 3-42, are similar in type 2 diabetic patients and healthy subjects.

    Vilsbøll, Tina, Agersø, H., Lauritsen, T., Deacon, Carolyn F., Aaboe, K., Madsbad, Sten, Krarup, T. & Holst, Jens Juul, 2006, In : Regulatory Peptides. 137, 3, p. 168-72 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  63. Published

    The glucagon-like peptide-1 metabolite GLP-1-(9-36) amide reduces postprandial glycemia independently of gastric emptying and insulin secretion in humans.

    Meier, J. J., Gethmann, A., Nauck, M. A., Götze, O., Schmitz, F., Deacon, Carolyn F., Gallwitz, B., Schmidt, W. E. & Holst, Jens Juul, 2006, In : American Journal of Physiology: Endocrinology and Metabolism. 290, 6, p. E1118-23

    Research output: Contribution to journalJournal articleResearchpeer-review

  64. Published

    The metabolite generated by dipeptidyl-peptidase 4 metabolism of glucagon-like peptide-1 has no influence on plasma glucose levels in patients with type 2 diabetes

    Zander, M., Madsbad, S., Deacon, Carolyn F. & Holst, Jens Juul, 2006, In : Diabetologia. 49, 2, p. 369-374 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  65. 2005
  66. Published

    Neutral endopeptidase 24.11 and dipeptidyl peptidase IV are both mediators of the degradation of glucagon-like peptide 1 in the anaesthetised pig

    Plamboeck, A., Holst, Jens Juul, Carr, R. D. & Deacon, Carolyn F., Sep 2005, In : Diabetologia. 48, 9, p. 1882-90 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  67. Published

    Secretion of incretin hormones and the insulinotropic effect of gastric inhibitory polypeptide in women with a history of gestational diabetes

    Meier, J. J., Gallwitz, B., Askenas, M., Vollmer, K., Deacon, Carolyn F., Holst, Jens Juul, Schmidt, W. E. & Nauck, M. A., Sep 2005, In : Diabetologia. 48, 9, p. 1872-81 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  68. Published

    Vildagliptin, a dipeptidyl peptidase-IV inhibitor, improves model-assessed beta-cell function in patients with type 2 diabetes

    Mari, A., Sallas, W. M., He, Y. L., Watson, C., Ligueros-Saylan, M., Dunning, B. E., Deacon, Carolyn F., Holst, Jens Juul & Foley, J. E., Aug 2005, In : The Journal of clinical endocrinology and metabolism. 90, 8, p. 4888-94 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  69. Published

    Glucagon-like peptide-1 mediates the therapeutic actions of DPP-IV inhibitors

    Holst, Jens Juul & Deacon, Carolyn F., Apr 2005, In : Diabetologia. 48, 4, p. 612-5 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  70. Published

    Enhanced glucagon-like peptide-1 (GLP-1) response to oral glucose in glucose-intolerant HIV-infected patients on antiretroviral therapy

    Andersen, Ove, Haugaard, Steen Bendix, Holst, Jens Juul, Deacon, Carolyn F., Iversen, J., Andersen, U. B., Nielsen, J. O. & Madsbad, Sten, Mar 2005, In : HIV Medicine. 6, 2, p. 91-8 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  71. Published

    Dipeptidyl peptidase IV inhibitors: a promising new therapeutic approach for the management of type 2 diabetes.

    Deacon, Carolyn F. & Holst, Jens Juul, 2005, In : International Journal of Biochemistry & Cell Biology. 38, 5-6, p. 831-44 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  72. Published

    Enhanced glucagon-like peptide- 1 (GLP-1) response to oral glucose in glucose intolerant HIV-infected patients on antiretroviral therapy

    Andersen, O., Haugaard, S. B., Holst, Jens Juul, Deacon, Carolyn F., Iversen, J., Andersen, U. B., Nielsen, J. O. & Madsbad, S., 2005, In : HIV Medicine. 6, p. 91-98

    Research output: Contribution to journalJournal articleResearchpeer-review

  73. Published

    For debate: Are antidiabetic actions of DPP-IV inhibitors mediated by glucagon-like peptide- 1?

    Holst, Jens Juul & Deacon, Carolyn F., 2005, In : Diabetologia. 48, p. 612-615

    Research output: Contribution to journalJournal articleResearchpeer-review

  74. Published

    Glucagon-like peptide-1 mediates the therapeutic actions of Dpp-IV inhibitors

    Holst, Jens Juul & Deacon, Carolyn F., 2005, In : Diabetologia. 48, p. 612-615

    Research output: Contribution to journalJournal articleResearchpeer-review

  75. Published

    Insulinotropic effect of gastric inhibitory polypeptide (GIP) in women with a history of gestational diabetes

    Meier, J. J., Gallwitz, B., Askenas, M., Vollmer, K., Deacon, Carolyn F., Holst, Jens Juul, Schmidt, W. E. & Nauck, M. A., 2005, In : Diabetologia. 48, p. 1872-1881

    Research output: Contribution to journalJournal articleResearch

  76. Published

    MK-431 (Merck).

    Deacon, Carolyn F., 2005, In : Current Opinion in Investigational Drugs. 6, 4, p. 419-26 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  77. Published

    Neutral Endopeptidase 24.11 and dipeptidyl peptidase IV are both physiological mediators of the degradation of glucagon-like peptide-1 in the anaesthetized pig

    Plamboeck, A., Holst, Jens Juul, Carr, R. D. & Deacon, Carolyn F., 2005, In : Diabetologia. 48, p. 1882-1890

    Research output: Contribution to journalJournal articleResearchpeer-review

  78. Published

    Normal secretion and action of the gut incretin hormones glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in young men with low birth weight

    Schou, J. H., Pilgaard, K., Vilsbøll, Tina, Jensen, C. B., Deacon, Carolyn F., Holst, Jens Juul, Vølund, A., Madsbad, Sten & Vaag, A. A., 2005, In : Journal of Clinical Endocrinology and Metabolism. 90, 8, p. 4912-19 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  79. Published

    Sensory nerve desensitization by resiniferatoxin improves glucose tolerance and increases insulin secretion in Zucker Diabetic Fatty rats and is associated with reduced plasma activity of dipeptidyl peptidase IV.

    Gram, D. X., Hansen, A. J., Deacon, Carolyn F., Brand, C. L., Ribel, U., Wilken, M., Carr, R. D., Svendsen, O. & Ahrén, B., 2005, In : European Journal of Pharmacology. 509, 2-3, p. 211-7 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  80. Published

    The incretin enhancer vildagliptin, a dipeptidyl peptidase-IV inhibitor, improves model-assessed -cell function in patients with type 2 diabetes

    Mari, A., Sallas, W. M., He, Y. L., Watson, C., Ligueros-Saylan, M., Dunning, B. E., Deacon, Carolyn F., Holst, Jens Juul & Foley, J. E., 2005, In : Journal of Clinical Endocrinology and Metabolism. 90, p. 4888-4894

    Research output: Contribution to journalJournal articleResearch

  81. Published

    Vildagliptin, a dipeptidyl peptidase-IV inhibitor improves model-assessed beta-cell function in patients with type 2 diabetes

    Mari, A., Sallas, W. M., He, Y. L., Watson, C., Ligueros-Saylan, M., Duning, B. E., Deacon, Carolyn F., Holst, Jens Juul & Foley, J. E., 2005, In : J. Clin. Endocrinol. Metab.. 90, p. 4888-4894

    Research output: Contribution to journalJournal articleResearch

  82. Published

    What do we know about the secretion and degradation of incretin hormones?

    Deacon, Carolyn F., 2005, In : Regulatory Peptides. 128, 2, p. 117-24 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  83. 2004
  84. Published

    Circulation and degradation of GIP and GLP-1

    Deacon, Carolyn F., 2004, In : Hormone and Metabolic Research. 36, p. 761-765

    Research output: Contribution to journalJournal articleResearchpeer-review

  85. Published

    Glucagon-like peptide 1 and inhibitors of dipeptidyl peptidase IV in the treatment of type 2 diabetes mellitus.

    Holst, Jens Juul & Deacon, Carolyn F., 2004, In : Current Opinion in Pharmacology. 4, 6, p. 589-96 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  86. Published

    Inhibitors of dipeptidyl peptidase IV: a novel approach for the prevention and treatment of Type 2 diabetes?

    Deacon, Carolyn F., Ahrén, B. & Holst, Jens Juul, 2004, In : Expert Opinion on Investigational Drugs. 13, 9, p. 1091-102 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  87. Published

    Neutral endopeptidase 24.11 is important for the degradation of both endogenous and exogenous glucagon in anesthetized pigs.

    Trebbien, R., Klarskov, L., Olesen, M., Holst, Jens Juul, Carr, R. D. & Deacon, Carolyn F., 2004, In : American Journal of Physiology: Endocrinology and Metabolism. 287, 3, p. E431-8

    Research output: Contribution to journalJournal articleResearchpeer-review

  88. Published

    Secretion of incretin hormones (GIP and GLP-1) and incretin effect after oral glucose in first-degree relatives of patients with type 2 diabetes.

    Nauck, M. A., El-Ouaghlidi, A., Gabrys, B., Hücking, K., Holst, Jens Juul, Deacon, Carolyn F., Gallwitz, B., Schmidt, W. E. & Meier, J. J., 2004, In : Regulatory Peptides. 122, 3, p. 209-17 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  89. Published

    Secretion, degradation, and elimination of glucagon-like peptide 1 and gastric inhibitory polypeptide in patients with chronic renal insufficiency and healthy control subjects.

    Meier, J. J., Nauck, M. A., Kranz, D., Holst, Jens Juul, Deacon, Carolyn F., Gaeckler, D., Schmidt, W. E. & Gallwitz, B., 2004, In : Diabetes. 53, 3, p. 654-62 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  90. Published

    Stimulation of insulin secretion by intravenous bolus injection and continuous infusion of gastric inhibitory polypeptide in patients with type 2 diabetes and healthy control subjects.

    Meier, J. J., Gallwitz, B., Kask, B., Deacon, Carolyn F., Holst, Jens Juul, Schmidt, W. E. & Nauck, M. A., 2004, In : Diabetes. 53 Suppl 3, p. S220-4

    Research output: Contribution to journalJournal articleResearchpeer-review

  91. Published

    The major glucagon-like peptide-1 metabolite, GLP-1-(9-36)-amide, does not affect glucose or insulin levels in mice.

    Rolin, B., Deacon, Carolyn F., Carr, R. D. & Ahrén, B., 2004, In : European Journal of Pharmacology. 494, 2-3, p. 283-8 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  92. Published

    Therapeutic strategies based on glucagon-like peptide 1.

    Deacon, Carolyn F., 2004, In : Diabetes. 53, 9, p. 2181-9 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  93. 2003
  94. Published

    Gastric inhibitory polypeptide (GIP) dose-dependently stimulates glucagon secretion in healthy human subjects at euglycaemia

    Meier, J. J., Gallwitz, B., Siepmann, N., Holst, Jens Juul, Deacon, Carolyn F., Schmidt, W. E. & Nauck, M. A., Jun 2003, In : Diabetologia. 46, 6, p. 798-801 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  95. Published

    Differential regional metabolism of glucagon in anesthetized pigs.

    Deacon, Carolyn F., Kelstrup, M., Trebbien, R., Klarskov, L., Olesen, M. & Holst, Jens Juul, 2003, In : American Journal of Physiology: Endocrinology and Metabolism. 285, 3, p. E552-60

    Research output: Contribution to journalJournal articleResearchpeer-review

  96. Published

    GLP-1 derivative liraglutide in rats with beta-cell deficiencies: influence of metabolic state on beta-cell mass dynamics.

    Sturis, J., Gotfredsen, C. F., Rømer, J., Rolin, B., Ribel, U., Brand, C. L., Wilken, M., Wassermann, K., Deacon, Carolyn F., Carr, R. D. & Knudsen, L. B., 2003, In : British Journal of Pharmacology. 140, 1, p. 123-32 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  97. Published

    Gastric inhibitory polypeptide (GIP) dose-dependently stimulates glucagon secretion in healthy human subjects at euglycaemia

    Meier, J. J., Gallwitz, N., Siepmann, N., Holst, Jens Juul, Deacon, Carolyn F., Schmidt, W. E. & Nauck, M. A., 2003, In : Diabetologia. 46, p. 798-801

    Research output: Contribution to journalJournal articleResearchpeer-review

  98. Published

    Impaired intestinal proglucagon processing in mice lacking prohormone convertase 1.

    Ugleholdt, R., Zhu, X., Deacon, Carolyn F., Ørskov, Cathrine, Steiner, D. F. & Holst, Jens Juul, 2003, In : Endocrinology. 145, 3, p. 1349-55 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  99. Published

    Neutral endopeptidase 24.11 and dipeptidyl peptidase IV are both involved in regulating the metabolic stability of glucagon-like peptide-1 in vivo.

    Plamboeck, A., Holst, Jens Juul, Carr, R. D. & Deacon, Carolyn F., 2003, In : Advances in Experimental Medicine and Biology. 524, p. 303-12 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  100. Published

    Similar insulin secretory response to a gastric inhibitory polypeptide bolus injection at euglycemia in first-degree relatives of patients with type 2 diabetes and control subjects.

    Meier, J. J., Nauck, M. A., Siepmann, N., Greulich, M., Holst, Jens Juul, Deacon, Carolyn F., Schmidt, W. E. & Gallwitz, B., 2003, In : Metabolism - Clinical and Experimental. 52, 12, p. 1579-85 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  101. Published

    The reduction in hepatic insulin clearance after oral glucose is not mediated by gastric inhibitory polypeptide (GIP).

    Meier, J. J., Gallwitz, B., Siepmann, N., Holst, Jens Juul, Deacon, Carolyn F., Schmidt, W. E. & Nauck, M. A., 2003, In : Regulatory Peptides. 113, 1-3, p. 95-100 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  102. Published

    Valine pyrrolidide preserves intact glucose-dependent insulinotropic peptide and improves abnormal glucose tolerance in minipigs with reduced beta-cell mass.

    Larsen, M. O., Rolin, B., Ribel, U., Wilken, M., Deacon, Carolyn F., Svendsen, O., Gotfredsen, C. F. & Carr, R. D., 2003, In : Experimental Diabesity Research. 4, 2, p. 93-105 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  103. 2002
  104. Published

    Preservation of active incretin hormones by inhibition of dipeptidyl peptidase IV suppresses meal-induced incretin secretion in dogs

    Deacon, Carolyn F., Wamberg, S., Bie, P., Hughes, T. E. & Holst, Jens Juul, Feb 2002, In : Journal of Endocrinology. 172, 2, p. 355-62 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  105. Published

    Dipeptidyl peptidase IV inhibition as an approach to the treatment and prevention of type 2 diabetes: a historical perspective.

    Deacon, Carolyn F. & Holst, Jens Juul, 2002, In : Biochemical and Biophysical Research Communications. 294, 1, p. 1-4 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  106. Published

    GLP-1-(9-36) amide reduces blood glucose in anesthetized pigs by a mechanism that does not involve insulin secretion.

    Deacon, Carolyn F., Plamboeck, A., Møller, Søren & Holst, Jens Juul, 2002, In : American Journal of Physiology: Endocrinology and Metabolism. 282, 4, p. E873-9

    Research output: Contribution to journalJournal articleResearchpeer-review

  107. Published

    NN2211: a long-acting glucagon-like peptide-1 derivative with anti-diabetic effects in glucose-intolerant pigs.

    Ribel, U., Larsen, M. O., Rolin, B., Carr, R. D., Wilken, M., Sturis, J., Westergaard, L., Deacon, Carolyn F. & Knudsen, L. B., 2002, In : European Journal of Pharmacology. 451, 2, p. 217-25 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  108. Published

    The long-acting GLP-1 derivative NN2211 ameliorates glycemia and increases beta-cell mass in diabetic mice.

    Rolin, B., Larsen, M. O., Gotfredsen, C. F., Deacon, Carolyn F., Carr, R. D., Wilken, M. & Knudsen, L. B., 2002, In : American Journal of Physiology: Endocrinology and Metabolism. 283, 4, p. E745-52

    Research output: Contribution to journalJournal articleResearchpeer-review

  109. 2001
  110. Published

    Dipeptidyl peptidase IV inhibition reduces the degradation and clearance of GIP and potentiates its insulinotropic and antihyperglycemic effects in anesthetized pigs

    Deacon, Carolyn F., Danielsen, P., Klarskov, L., Holst, Jens Juul & Olesen, M., 2001, In : Diabetes. 50, p. 1588-1597

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 9220