Overnight hypoxic exposure and glucagon-like peptide-1 and leptin levels in humans.
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Altitude exposure has been associated with loss of appetite and weight loss in healthy humans; however, the endocrine factors that contribute to these changes remain unclear. Leptin and glucagon-like peptide-1 (GLP-1) are peptide hormones that contribute to the regulation of appetite. Leptin increases with hypoxia; however, the influence of hypoxia on GLP-1 has not been studied in animals or humans to date. We sought to determine the influence of normobaric hypoxia on plasma leptin and GLP-1 levels in 25 healthy humans. Subjects ingested a control meal during normoxia and after 17 h of exposure to normobaric hypoxia (fraction of inspired oxygen of 12.5%, simulating approximately 4100 m). Plasma leptin was assessed before the meal, and GLP-1 was assessed premeal, at 20 min postmeal, and at 40 min postmeal. We found that hypoxia caused a significant elevation in plasma leptin levels (normoxia, 4.9 +/- 0.8 pg.mL-1; hypoxia, 7.7 +/- 1.5 pg.mL-1; p <0.05; (fasting, + - -16% 0.7 0.9 1.2 15.7 15.9 19.5 190%), 20 21.0 21.7 21.8 40 a an and average change for glp-1 hypoxia, in increase levels min no normoxia only p pmol.l-1 pmol.l-1; postmeal postmeal, range, respectively; response small the to toward trend vs vs.>0.05;> 0.05 normoxia vs hypoxia). There was a correlation between SaO2 and leptin after the 17 h exposure (r = 0.45; p < 0.05), but no relation between SaO2 and GLP-1. These data confirm that leptin increases with hypoxic exposure in humans. Further study is needed to determine the influence of hypoxia and altitude on GLP-1 levels.
|Journal||Applied Physiology, Nutrition and Metabolism|
|Number of pages||6|
|Publication status||Published - 2008|