Overnight hypoxic exposure and glucagon-like peptide-1 and leptin levels in humans.

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Overnight hypoxic exposure and glucagon-like peptide-1 and leptin levels in humans. / Snyder, Eric M; Carr, Richard D; Deacon, Carolyn F; Johnson, Bruce D.

In: Applied Physiology, Nutrition and Metabolism, Vol. 33, No. 5, 2008, p. 929-35.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Snyder, EM, Carr, RD, Deacon, CF & Johnson, BD 2008, 'Overnight hypoxic exposure and glucagon-like peptide-1 and leptin levels in humans.', Applied Physiology, Nutrition and Metabolism, vol. 33, no. 5, pp. 929-35. https://doi.org/10.1139/h08-079

APA

Snyder, E. M., Carr, R. D., Deacon, C. F., & Johnson, B. D. (2008). Overnight hypoxic exposure and glucagon-like peptide-1 and leptin levels in humans. Applied Physiology, Nutrition and Metabolism, 33(5), 929-35. https://doi.org/10.1139/h08-079

Vancouver

Snyder EM, Carr RD, Deacon CF, Johnson BD. Overnight hypoxic exposure and glucagon-like peptide-1 and leptin levels in humans. Applied Physiology, Nutrition and Metabolism. 2008;33(5):929-35. https://doi.org/10.1139/h08-079

Author

Snyder, Eric M ; Carr, Richard D ; Deacon, Carolyn F ; Johnson, Bruce D. / Overnight hypoxic exposure and glucagon-like peptide-1 and leptin levels in humans. In: Applied Physiology, Nutrition and Metabolism. 2008 ; Vol. 33, No. 5. pp. 929-35.

Bibtex

@article{82703690ab4811ddb5e9000ea68e967b,
title = "Overnight hypoxic exposure and glucagon-like peptide-1 and leptin levels in humans.",
abstract = "Altitude exposure has been associated with loss of appetite and weight loss in healthy humans; however, the endocrine factors that contribute to these changes remain unclear. Leptin and glucagon-like peptide-1 (GLP-1) are peptide hormones that contribute to the regulation of appetite. Leptin increases with hypoxia; however, the influence of hypoxia on GLP-1 has not been studied in animals or humans to date. We sought to determine the influence of normobaric hypoxia on plasma leptin and GLP-1 levels in 25 healthy humans. Subjects ingested a control meal during normoxia and after 17 h of exposure to normobaric hypoxia (fraction of inspired oxygen of 12.5{\%}, simulating approximately 4100 m). Plasma leptin was assessed before the meal, and GLP-1 was assessed premeal, at 20 min postmeal, and at 40 min postmeal. We found that hypoxia caused a significant elevation in plasma leptin levels (normoxia, 4.9 +/- 0.8 pg.mL-1; hypoxia, 7.7 +/- 1.5 pg.mL-1; p < 0.05; range, -16{\%} to 190{\%}), no change in the average GLP-1 response to hypoxia, and only a small trend toward an increase in GLP-1 levels 40 min postmeal (fasting, 15.7 +/- 0.9 vs 15.9 +/- 0.7 pmol.L-1; 20 min postmeal, 21.7 +/- 0.9 vs 21.8 +/- 1.2 pmol.L-1; 40 min postmeal, 19.5 +/- 1.2 vs. 21.0 +/- 1.2 pmol.L-1 for normoxia and hypoxia, respectively; p > 0.05 normoxia vs hypoxia). There was a correlation between SaO2 and leptin after the 17 h exposure (r = 0.45; p < 0.05), but no relation between SaO2 and GLP-1. These data confirm that leptin increases with hypoxic exposure in humans. Further study is needed to determine the influence of hypoxia and altitude on GLP-1 levels.",
author = "Snyder, {Eric M} and Carr, {Richard D} and Deacon, {Carolyn F} and Johnson, {Bruce D}",
year = "2008",
doi = "10.1139/h08-079",
language = "English",
volume = "33",
pages = "929--35",
journal = "Applied Physiology, Nutrition and Metabolism",
issn = "1715-5312",
publisher = "Canadian Science Publishing",
number = "5",

}

RIS

TY - JOUR

T1 - Overnight hypoxic exposure and glucagon-like peptide-1 and leptin levels in humans.

AU - Snyder, Eric M

AU - Carr, Richard D

AU - Deacon, Carolyn F

AU - Johnson, Bruce D

PY - 2008

Y1 - 2008

N2 - Altitude exposure has been associated with loss of appetite and weight loss in healthy humans; however, the endocrine factors that contribute to these changes remain unclear. Leptin and glucagon-like peptide-1 (GLP-1) are peptide hormones that contribute to the regulation of appetite. Leptin increases with hypoxia; however, the influence of hypoxia on GLP-1 has not been studied in animals or humans to date. We sought to determine the influence of normobaric hypoxia on plasma leptin and GLP-1 levels in 25 healthy humans. Subjects ingested a control meal during normoxia and after 17 h of exposure to normobaric hypoxia (fraction of inspired oxygen of 12.5%, simulating approximately 4100 m). Plasma leptin was assessed before the meal, and GLP-1 was assessed premeal, at 20 min postmeal, and at 40 min postmeal. We found that hypoxia caused a significant elevation in plasma leptin levels (normoxia, 4.9 +/- 0.8 pg.mL-1; hypoxia, 7.7 +/- 1.5 pg.mL-1; p < 0.05; range, -16% to 190%), no change in the average GLP-1 response to hypoxia, and only a small trend toward an increase in GLP-1 levels 40 min postmeal (fasting, 15.7 +/- 0.9 vs 15.9 +/- 0.7 pmol.L-1; 20 min postmeal, 21.7 +/- 0.9 vs 21.8 +/- 1.2 pmol.L-1; 40 min postmeal, 19.5 +/- 1.2 vs. 21.0 +/- 1.2 pmol.L-1 for normoxia and hypoxia, respectively; p > 0.05 normoxia vs hypoxia). There was a correlation between SaO2 and leptin after the 17 h exposure (r = 0.45; p < 0.05), but no relation between SaO2 and GLP-1. These data confirm that leptin increases with hypoxic exposure in humans. Further study is needed to determine the influence of hypoxia and altitude on GLP-1 levels.

AB - Altitude exposure has been associated with loss of appetite and weight loss in healthy humans; however, the endocrine factors that contribute to these changes remain unclear. Leptin and glucagon-like peptide-1 (GLP-1) are peptide hormones that contribute to the regulation of appetite. Leptin increases with hypoxia; however, the influence of hypoxia on GLP-1 has not been studied in animals or humans to date. We sought to determine the influence of normobaric hypoxia on plasma leptin and GLP-1 levels in 25 healthy humans. Subjects ingested a control meal during normoxia and after 17 h of exposure to normobaric hypoxia (fraction of inspired oxygen of 12.5%, simulating approximately 4100 m). Plasma leptin was assessed before the meal, and GLP-1 was assessed premeal, at 20 min postmeal, and at 40 min postmeal. We found that hypoxia caused a significant elevation in plasma leptin levels (normoxia, 4.9 +/- 0.8 pg.mL-1; hypoxia, 7.7 +/- 1.5 pg.mL-1; p < 0.05; range, -16% to 190%), no change in the average GLP-1 response to hypoxia, and only a small trend toward an increase in GLP-1 levels 40 min postmeal (fasting, 15.7 +/- 0.9 vs 15.9 +/- 0.7 pmol.L-1; 20 min postmeal, 21.7 +/- 0.9 vs 21.8 +/- 1.2 pmol.L-1; 40 min postmeal, 19.5 +/- 1.2 vs. 21.0 +/- 1.2 pmol.L-1 for normoxia and hypoxia, respectively; p > 0.05 normoxia vs hypoxia). There was a correlation between SaO2 and leptin after the 17 h exposure (r = 0.45; p < 0.05), but no relation between SaO2 and GLP-1. These data confirm that leptin increases with hypoxic exposure in humans. Further study is needed to determine the influence of hypoxia and altitude on GLP-1 levels.

U2 - 10.1139/h08-079

DO - 10.1139/h08-079

M3 - Journal article

C2 - 18923568

VL - 33

SP - 929

EP - 935

JO - Applied Physiology, Nutrition and Metabolism

JF - Applied Physiology, Nutrition and Metabolism

SN - 1715-5312

IS - 5

ER -

ID: 8416720