Carolyn F. Deacon

Carolyn F. Deacon

Associate Professor


  1. 1995
  2. Published

    Both subcutaneously and intravenously administered glucagon-like peptide-1 are rapidly degraded from the amino terminus in type II diabetic patients and in healthy subjects. / Deacon, C.F.; Nauck, M.A.; Nielsen, M.T.; Pridal, L.; Holst, Jens Juul.

    In: Diabetes, No. 44, 1995, p. 1126-1131.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Degradation of glucagon-like peptide-1 in vitro yields an N-terminally truncated peptide which is a major endogenous metabolite in vivo. / Deacon, C.F.; Johnsen, A.H.; Holst, Jens Juul.

    In: Journal of Clinical Endocrinology and Metabolism, No. 80, 1995, p. 952-957.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Human colon produces fully processed glucagon-like peptide-1 (7-36 amide). / Deacon, C.F.; Johnsen, A.H.; Holst, Jens Juul.

    In: FEBS Letters, No. 372, 1995, p. 269-272.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. 1996
  6. Published

    Plasma TNF-x is associated with insulin mediated suppression of free fatty acids and net lipid oxidation in HIV-infected patients with lipodystrophy. / Haugaard, S.B.; Andersen, O.; Pedersen, S.B.; Dela, Flemming; Deacon, C.F.

    In: Metabolism - Clinical and Experimental, No. 55(2), 1996, p. 175-182.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. 1997
  8. Published

    Posttranslational processing of proglucagon and postsecretory fate of proglucagon products. / Holst, Jens Juul; Ørskov, C.; Hartmann, Bolette; Deacon, C.F.

    The Insulinotropic Gut Hormone Glucagon-like Peptide-1.. Basel : Karger, 1997. p. 24-48.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  9. 1998
  10. Published

    Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide 1 in the anesthetized pig. / Deacon, C.F.; Hughes, T.E.; Holst, J.J.

    In: Diabetes, No. 47, 1998, p. 764-769.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1 which have extended metabolic stability and improved biological activity. / Deacon, C.F.; Knudsen, L.B.; Madsen, K.; Wiberg, F.C.; Jacobsen, O.; Holst, J.J.

    In: Diabetologia, No. 41, 1998, p. 271-278.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Inhibition of the activity of dipeptidyl-peptidase IV as a treatment for type 2 diabetes. / Holst, J.J.; Deacon, C.F.

    In: Diabetes, No. 47, 1998, p. 1663-1670.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    On the treatment of diabetes mellitus with glucagon-like peptide-1. / Holst, J.J.; Deacon, C.F.; Toft-Nielsen, M.; Bjerre-Knudsen, L.

    In: Annals of the New York Academy of Sciences, No. 865, 1998, p. 336-343.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. 1999
  15. Published

    Glucagon-like peptide-1(7-36)amide is transformed to glucagon-like peptide-1 (9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the intestinal L-cells. / Hansen, L.; Deacon, C.F.; Ørskov, C.; Holst, J.J.

    In: Endokrinologiya, No. 140, 1999, p. 5356-5363.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Glucagon-like peptide-1: A basis for new approaches to the management of Diabetes. / Deacon, C.F.; Holst, J.J.; Carr, R.D.

    In: Drugs of Today, No. 35, 1999, p. 159-170.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Glucagon-like peptide-1 : a basis for new approaches to the management of diabetes. / Deacon, C F; Holst, Jens Juul; Carr, R D.

    In: Drugs of Today, Vol. 35, No. 3, 03.1999, p. 159-70.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Glucagon-like peptide-1-(7-36)amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine. / Hansen, L; Deacon, C F; Orskov, C; Holst, J J.

    In: Molecular Endocrinology, Vol. 140, No. 11, 11.1999, p. 5356-63.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. 2000
  20. Published

    Degradation of endogenous and exogenous gastric inhibitory polypeptide in healthy and in type 2 diabetic subjects as revealed using a new assay for the intact peptide. / Deacon, C.F.; Nauck, M.A.; Meier, J.; Hücking, K.; Holst, J.J.

    In: Journal of Clinical Endocrinology and Metabolism, No. 85, 2000, p. 3575-3581.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    In vivo and in vitro degradation of glucagon-like peptide-2 in humans. / Hartmann, Bolette; Harr, M.B.; Jeppesen, P.B.; Wojdemann, M.; Deacon, C.F.; Mortensen, P.B.; Holst, J.J.

    In: Journal of Clinical Endocrinology and Metabolism, No. 85, 2000, p. 2884-2888.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. 2001
  23. Published

    Dipeptidyl peptidase IV inhibition reduces the degradation and clearance of GIP and potentiates its insulinotropic and antihyperglycemic effects in anesthetized pigs. / Deacon, C.F.; Danielsen, P.; Klarskov, L.; Holst, J.J.; Olesen, M.

    In: Diabetes, No. 50, 2001, p. 1588-1597.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Reduced insulinotropic effect of gastric inhibitory polypeptide in first-degree relatives of patients with type 2 diabetes. / Meier, J.J.; Huking, K.; Holst, J.J.; Deacon, C.F.; Schmiegel, W.H.; Nauck, M.A.

    In: Diabetes, No. 50, 2001, p. 2497-2504.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. 2002
  26. Published

    Dipeptidyl peptidase IV inhibition as an approach to the treatment and prevention of type 2 diabetes: a historical perspective. / Deacon, Carolyn F; Holst, Jens J.

    In: Biochemical and Biophysical Research Communications, Vol. 294, No. 1, 2002, p. 1-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    GLP-1-(9-36) amide reduces blood glucose in anesthetized pigs by a mechanism that does not involve insulin secretion. / Deacon, Carolyn F; Plamboeck, Astrid; Møller, Søren; Holst, Jens J.

    In: American Journal of Physiology: Endocrinology and Metabolism, Vol. 282, No. 4, 2002, p. E873-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    NN2211: a long-acting glucagon-like peptide-1 derivative with anti-diabetic effects in glucose-intolerant pigs. / Ribel, Ulla; Larsen, Marianne O; Rolin, Bidda; Carr, Richard D; Wilken, Michael; Sturis, Jeppe; Westergaard, Lisbet; Deacon, Carolyn F; Knudsen, Lotte Bjerre.

    In: European Journal of Pharmacology, Vol. 451, No. 2, 2002, p. 217-25.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    The long-acting GLP-1 derivative NN2211 ameliorates glycemia and increases beta-cell mass in diabetic mice. / Rolin, Bidda; Larsen, Marianne O; Gotfredsen, Carsten F; Deacon, Carolyn F; Carr, Richard D; Wilken, Michael; Knudsen, Lotte Bjerre.

    In: American Journal of Physiology: Endocrinology and Metabolism, Vol. 283, No. 4, 2002, p. E745-52.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Preservation of active incretin hormones by inhibition of dipeptidyl peptidase IV suppresses meal-induced incretin secretion in dogs. / Deacon, C F; Wamberg, S; Bie, P; Hughes, T E; Holst, Jens Juul.

    In: Journal of Endocrinology, Vol. 172, No. 2, 02.2002, p. 355-62.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. 2003
  32. Published

    Differential regional metabolism of glucagon in anesthetized pigs. / Deacon, Carolyn F; Kelstrup, Mette; Trebbien, Ramona; Klarskov, Letty; Olesen, Mette; Holst, Jens J.

    In: American Journal of Physiology: Endocrinology and Metabolism, Vol. 285, No. 3, 2003, p. E552-60.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    GLP-1 derivative liraglutide in rats with beta-cell deficiencies: influence of metabolic state on beta-cell mass dynamics. / Sturis, Jeppe; Gotfredsen, Carsten F; Rømer, John; Rolin, Bidda; Ribel, Ulla; Brand, Christian L; Wilken, Michael; Wassermann, Karsten; Deacon, Carolyn F; Carr, Richard D; Knudsen, Lotte Bjerre.

    In: British Journal of Pharmacology, Vol. 140, No. 1, 2003, p. 123-32.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Gastric inhibitory polypeptide (GIP) dose-dependently stimulates glucagon secretion in healthy human subjects at euglycaemia. / Meier, J.J.; Gallwitz, N.; Siepmann, N.; Holst, Jens Juul; Deacon, C.F.; Schmidt, W.E.; Nauck, M.A.

    In: Diabetologia, No. 46, 2003, p. 798-801.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Impaired intestinal proglucagon processing in mice lacking prohormone convertase 1. / Ugleholdt, Randi; Zhu, Xiaorong; Deacon, Carolyn F; Ørskov, Cathrine; Steiner, Donald F; Holst, Jens J.

    In: Endocrinology, Vol. 145, No. 3, 2003, p. 1349-55.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Neutral endopeptidase 24.11 and dipeptidyl peptidase IV are both involved in regulating the metabolic stability of glucagon-like peptide-1 in vivo. / Plamboeck, Astrid; Holst, Jens J; Carr, Richard D; Deacon, Carolyn F.

    In: Advances in Experimental Medicine and Biology, Vol. 524, 2003, p. 303-12.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Similar insulin secretory response to a gastric inhibitory polypeptide bolus injection at euglycemia in first-degree relatives of patients with type 2 diabetes and control subjects. / Meier, Juris J; Nauck, Michael A; Siepmann, Nina; Greulich, Michael; Holst, Jens J; Deacon, Carolyn F; Schmidt, Wolfgang E; Gallwitz, Baptist.

    In: Metabolism - Clinical and Experimental, Vol. 52, No. 12, 2003, p. 1579-85.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    The reduction in hepatic insulin clearance after oral glucose is not mediated by gastric inhibitory polypeptide (GIP). / Meier, Juris J; Gallwitz, Baptist; Siepmann, Nina; Holst, Jens J; Deacon, Carolyn F; Schmidt, Wolfgang E; Nauck, Michael A.

    In: Regulatory Peptides, Vol. 113, No. 1-3, 2003, p. 95-100.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Valine pyrrolidide preserves intact glucose-dependent insulinotropic peptide and improves abnormal glucose tolerance in minipigs with reduced beta-cell mass. / Larsen, Marianne Olholm; Rolin, Bidda; Ribel, Ulla; Wilken, Michael; Deacon, Carolyn F; Svendsen, Ove; Gotfredsen, Carsten F; Carr, Richard David.

    In: Experimental Diabesity Research, Vol. 4, No. 2, 2003, p. 93-105.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Gastric inhibitory polypeptide (GIP) dose-dependently stimulates glucagon secretion in healthy human subjects at euglycaemia. / Meier, J J; Gallwitz, B; Siepmann, N; Holst, Jens Juul; Deacon, C F; Schmidt, W E; Nauck, M A.

    In: Diabetologia, Vol. 46, No. 6, 06.2003, p. 798-801.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. 2004
  42. Published

    Circulation and degradation of GIP and GLP-1. / Deacon, Carolyn F.

    In: Hormone and Metabolic Research, No. 36, 2004, p. 761-765.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Glucagon-like peptide 1 and inhibitors of dipeptidyl peptidase IV in the treatment of type 2 diabetes mellitus. / Holst, Jens Juul; Deacon, Carolyn F.

    In: Current Opinion in Pharmacology, Vol. 4, No. 6, 2004, p. 589-96.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Inhibitors of dipeptidyl peptidase IV: a novel approach for the prevention and treatment of Type 2 diabetes? / Deacon, Carolyn F; Ahrén, Bo; Holst, Jens J.

    In: Expert Opinion on Investigational Drugs, Vol. 13, No. 9, 2004, p. 1091-102.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Neutral endopeptidase 24.11 is important for the degradation of both endogenous and exogenous glucagon in anesthetized pigs. / Trebbien, Ramona; Klarskov, Letty; Olesen, Mette; Holst, Jens J; Carr, Richard D; Deacon, Carolyn F.

    In: American Journal of Physiology: Endocrinology and Metabolism, Vol. 287, No. 3, 2004, p. E431-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Secretion of incretin hormones (GIP and GLP-1) and incretin effect after oral glucose in first-degree relatives of patients with type 2 diabetes. / Nauck, Michael A; El-Ouaghlidi, Andrea; Gabrys, Bartholomäus; Hücking, Katrin; Holst, Jens J; Deacon, Carolyn F; Gallwitz, Baptist; Schmidt, Wolfgang E; Meier, Juris J.

    In: Regulatory Peptides, Vol. 122, No. 3, 2004, p. 209-17.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Secretion, degradation, and elimination of glucagon-like peptide 1 and gastric inhibitory polypeptide in patients with chronic renal insufficiency and healthy control subjects. / Meier, Juris J; Nauck, Michael A; Kranz, Daniel; Holst, Jens J; Deacon, Carolyn F; Gaeckler, Dirk; Schmidt, Wolfgang E; Gallwitz, Baptist.

    In: Diabetes, Vol. 53, No. 3, 2004, p. 654-62.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Stimulation of insulin secretion by intravenous bolus injection and continuous infusion of gastric inhibitory polypeptide in patients with type 2 diabetes and healthy control subjects. / Meier, Juris J; Gallwitz, Baptist; Kask, Bartholomaeus; Deacon, Carolyn F; Holst, Jens J; Schmidt, Wolfgang E; Nauck, Michael A.

    In: Diabetes, Vol. 53 Suppl 3, 2004, p. S220-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    The major glucagon-like peptide-1 metabolite, GLP-1-(9-36)-amide, does not affect glucose or insulin levels in mice. / Rolin, Bidda; Deacon, Carolyn F; Carr, Richard D; Ahrén, Bo.

    In: European Journal of Pharmacology, Vol. 494, No. 2-3, 2004, p. 283-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Therapeutic strategies based on glucagon-like peptide 1. / Deacon, Carolyn F.

    In: Diabetes, Vol. 53, No. 9, 2004, p. 2181-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. 2005
  52. Published

    Dipeptidyl peptidase IV inhibitors: a promising new therapeutic approach for the management of type 2 diabetes. / Deacon, Carolyn F; Holst, Jens J.

    In: International Journal of Biochemistry & Cell Biology, Vol. 38, No. 5-6, 2005, p. 831-44.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Enhanced glucagon-like peptide- 1 (GLP-1) response to oral glucose in glucose intolerant HIV-infected patients on antiretroviral therapy. / Andersen, O.; Haugaard, S.B.; Holst, Jens Juul; Deacon, Carolyn F.; Iversen, J.; Andersen, U.B.; Nielsen, J.O.; Madsbad, S.

    In: HIV Medicine, Vol. 6, 2005, p. 91-98.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    For debate: Are antidiabetic actions of DPP-IV inhibitors mediated by glucagon-like peptide- 1? / Holst, Jens Juul; Deacon, Carolyn F.

    In: Diabetologia, No. 48, 2005, p. 612-615.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Glucagon-like peptide-1 mediates the therapeutic actions of Dpp-IV inhibitors. / Holst, Jens Juul; Deacon, Carolyn F.

    In: Diabetologia, No. 48, 2005, p. 612-615.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    Insulinotropic effect of gastric inhibitory polypeptide (GIP) in women with a history of gestational diabetes. / Meier, J.J.; Gallwitz, B.; Askenas, M.; Vollmer, K.; Deacon, C.F.; Holst, J.J.; Schmidt, W.E.; Nauck, M.A.

    In: Diabetologia, No. 48, 2005, p. 1872-1881.

    Research output: Contribution to journalJournal articleResearch

  57. Published

    MK-431 (Merck). / Deacon, Carolyn F.

    In: Current Opinion in Investigational Drugs, Vol. 6, No. 4, 2005, p. 419-26.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    Neutral Endopeptidase 24.11 and dipeptidyl peptidase IV are both physiological mediators of the degradation of glucagon-like peptide-1 in the anaesthetized pig. / Plamboeck, A.; Holst, J.J.; Carr, R.D.; Deacon, C.F.

    In: Diabetologia, No. 48, 2005, p. 1882-1890.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. Published

    Normal secretion and action of the gut incretin hormones glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in young men with low birth weight. / Schou, Jakob Hagen; Pilgaard, Kasper; Vilsbøll, Tina; Jensen, Christine B; Deacon, Carolyn F; Holst, Jens Juul; Vølund, Aage; Madsbad, Sten; Vaag, Allan A.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 90, No. 8, 2005, p. 4912-19.

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. Published

    Sensory nerve desensitization by resiniferatoxin improves glucose tolerance and increases insulin secretion in Zucker Diabetic Fatty rats and is associated with reduced plasma activity of dipeptidyl peptidase IV. / Gram, Dorte X; Hansen, Anker J; Deacon, Carolyn F; Brand, Christian L; Ribel, Ulla; Wilken, Michael; Carr, Richard D; Svendsen, Ove; Ahrén, Bo.

    In: European Journal of Pharmacology, Vol. 509, No. 2-3, 2005, p. 211-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  61. Published

    The incretin enhancer vildagliptin, a dipeptidyl peptidase-IV inhibitor, improves model-assessed -cell function in patients with type 2 diabetes. / Mari, A.; Sallas, W.M.; He, Y.L.; Watson, C.; Ligueros-Saylan, M.; Dunning, B.E.; Deacon, Carolyn F.; Holst, Jens Juul; Foley, J.E.

    In: Journal of Clinical Endocrinology and Metabolism, No. 90, 2005, p. 4888-4894.

    Research output: Contribution to journalJournal articleResearch

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