Carolyn F. Deacon
Associate Professor
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Glucagon-like peptide-1-(7-36)amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine
Hansen, L., Deacon, Carolyn F., Ørskov, Cathrine & Holst, Jens Juul, Nov 1999, In: Molecular Endocrinology. 140, 11, p. 5356-63 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucose-induced incretin hormone release and inactivation are differently modulated by oral fat and protein in mice.
Gunnarsson, P. T., Winzell, M. S., Deacon, Carolyn F., Larsen, M. O., Jelic, K., Carr, R. D. & Ahrén, B., 2006, In: Endocrinology. 147, 7, p. 3173-80 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Sensory nerve desensitization by resiniferatoxin improves glucose tolerance and increases insulin secretion in Zucker Diabetic Fatty rats and is associated with reduced plasma activity of dipeptidyl peptidase IV.
Gram, D. X., Hansen, A. J., Deacon, Carolyn F., Brand, C. L., Ribel, U., Wilken, M., Carr, R. D., Svendsen, O. & Ahrén, B., 2005, In: European Journal of Pharmacology. 509, 2-3, p. 211-7 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test
Gjesing, A. P., Kjems, L. L., Vestmar, M. A., Grarup, Niels, Linneberg, Allan René, Deacon, Carolyn F., Holst, Jens Juul, Pedersen, Oluf Borbye & Hansen, Torben, 1 Jan 2011, In: Diabetologia. 54, 1, p. 103-10 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Effect of Vildagliptin on Glucagon Concentration During Meals in Patients with Type 1 Diabetes
Foley, J. E., Ligueros-Saylan, M., He, Y. L., Holst, Jens Juul, Deacon, Carolyn F., Dunning, B. E., Leone-Jones, A., Yu, T. & Kelley, D. E., 2008, In: Hormone and Metabolic Research. 40, 10, p. 727-730 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Effect of vildagliptin on glucagon concentration during meals in patients with type 1 diabetes
Foley, J. E., Ligueros-Saylan, M., He, Y., Holst, Jens Juul, Deacon, Carolyn F., Dunning, B. E., Leone-Jones, A., Yu, T. & Kelley, D. E., Oct 2008, In: Hormone and Metabolic Research. Supplement. 40, 10, p. 727-30 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Difference in postprandial GLP-1 response despite similar glucose kinetics after consumption of wheat breads with different particle size in healthy men
Eelderink, C., Noort, M. W. J., Sozer, N., Koehorst, M., Holst, Jens Juul, Deacon, Carolyn F., Rehfeld, Jens Frederik, Poutanen, K., Vonk, R. J., Oudhuis, L. & Priebe, M. G., 2017, In: European Journal of Nutrition. 56, 3, p. 1063-1076 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The structure of wheat bread influences the postprandial metabolic response in healthy men
Eelderink, C., Noort, M. W. J., Sozer, N., Koehorst, M., Holst, Jens Juul, Deacon, Carolyn F., Rehfeld, Jens Frederik, Poutanen, K., Vonk, R. J., Oudhuis, L. & Priebe, M. G., Oct 2015, In: Food & Function. 6, 10, p. 3236-48 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Dipeptidyl peptidase-4 inhibitors in the treatment of type 2 diabetes: A comparative review
Deacon, Carolyn F., Jan 2011, In: Diabetes, Obesity and Metabolism. 13, 1, p. 7-18 12 p.Research output: Contribution to journal › Review › Research › peer-review
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Commentary: Is endogenous GLP-1 the only important enhancer of glucose-induced insulin secretion in type 2 diabetes?
Deacon, Carolyn F., 2012, In: Diabetes. 61, 9, p. 2219-2220Research output: Contribution to journal › Journal article › Research › peer-review
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Physiology of incretins in health and disease
Deacon, Carolyn F. & Ahren, B., 2011, In: Review of Diabetic Studies. 8, 3, p. 293-306 14 p.Research output: Contribution to journal › Review › Research › peer-review
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Metabolism of GIP and the contribution of GIP to the glucose-lowering properties of DPP-4 inhibitors
Deacon, Carolyn F., 2020, In: Peptides. 125, 7 p., 170196.Research output: Contribution to journal › Review › Research › peer-review
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DPP-4 inhibition – advances in our understanding of diabetes management
Deacon, Carolyn F. & Holst, Jens Juul, 2009, In: European Endocrinology. 4, p. 47-49Research output: Contribution to journal › Review › Research
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Physiology and Pharmacology of DPP-4 in Glucose Homeostasis and the Treatment of Type 2 Diabetes
Deacon, Carolyn F., 2019, In: Frontiers in Endocrinology. 10, 14 p., 80.Research output: Contribution to journal › Review › Research › peer-review
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Potential cardiovascular effects of incretin-based therapies
Deacon, Carolyn F. & Marx, N., 2012, In: Expert Review of Cardiovascular Therapy. 10, p. 337-351Research output: Contribution to journal › Review › Research › peer-review
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Comparative review of dipeptidyl peptidase-4 inhibitors and sulphonylureas.
Deacon, Carolyn F. & Lebovitz, H., 2016, In: Diabetes, Obesity and Metabolism. 18, 4, p. 333-347 15 p.Research output: Contribution to journal › Review › Research › peer-review
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A comparative review of DPP-4 inhibitors and sulphonylureas
Deacon, Carolyn F. & Lebovitz, H., 2016, In: Diabetes, Obesity and Metabolism. 18, p. 333-347Research output: Contribution to journal › Journal article › Research › peer-review
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Circulation and degradation of GIP and GLP-1
Deacon, Carolyn F., 2004, In: Hormone and Metabolic Research. 36, p. 761-765Research output: Contribution to journal › Journal article › Research › peer-review
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Glycaemic efficacy of glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors as add-on therapy to metformin in subjects with type 2 diabetes—a review and meta analysis
Deacon, Carolyn F., Mannucci, E. & Ahren, B., 2012, In: Diabetes, Obesity and Metabolism Online. 14, 8, p. 762-767Research output: Contribution to journal › Review › Research › peer-review
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Linagliptin, a xanthine-based dipeptidyl peptidase-4 inhibitor with an unusual profile for the treatment of type 2 diabetes
Deacon, Carolyn F. & Holst, Jens Juul, 2010, In: Expert Opinion on Investigational Drugs. 19, 1, p. 133-140 8 p.Research output: Contribution to journal › Review › Research › peer-review
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DPP-4 inhibitors
Deacon, Carolyn F., 2016, Handbook of incretin therapies in type 2 diabetes. Gough, S. (ed.). Switzerland: Springer, p. 45-60Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication
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A review of dipeptidyl peptidase-4 inhibitors. Hot topics from randomised controlled trials
Deacon, Carolyn F., 2018, In: Diabetes, Obesity and Metabolism. 20, Suppl. 1, p. 34-46Research output: Contribution to journal › Review › Research › peer-review
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Dipeptidyl peptidase 4 inhibitors in the treatment of type 2 diabetes mellitus
Deacon, Carolyn F., 2020, In: Nature Reviews Endocrinology. 16, 11, p. 642-653Research output: Contribution to journal › Review › Research › peer-review
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What do we know about the secretion and degradation of incretin hormones?
Deacon, Carolyn F., 2005, In: Regulatory Peptides. 128, 2, p. 117-24 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes: comparison, efficacy and safety
Deacon, Carolyn F. & Holst, Jens Juul, Oct 2013, In: Expert Opinion on Pharmacotherapy. 14, 15, p. 2047-58 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Inhibitors of dipeptidyl peptidase IV: a novel approach for the prevention and treatment of Type 2 diabetes?
Deacon, Carolyn F., Ahrén, B. & Holst, Jens Juul, 2004, In: Expert Opinion on Investigational Drugs. 13, 9, p. 1091-102 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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DPP-4 inhibitor therapy: new directions in the treatment of type 2 diabetes
Deacon, Carolyn F., Carr, R. D. & Holst, Jens Juul, 2008, In: Frontiers in Bioscience. 13, p. 1780-94 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Differential regional metabolism of glucagon in anesthetized pigs.
Deacon, Carolyn F., Kelstrup, M., Trebbien, R., Klarskov, L., Olesen, M. & Holst, Jens Juul, 2003, In: American Journal of Physiology: Endocrinology and Metabolism. 285, 3, p. E552-60Research output: Contribution to journal › Journal article › Research › peer-review
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Incretin-based treatment of type 2 diabetes: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors.
Deacon, Carolyn F., 2007, In: Diabetes, Obesity and Metabolism. 9 Suppl 1, p. 23-31 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Dipeptidyl peptidase IV inhibitors: a promising new therapeutic approach for the management of type 2 diabetes.
Deacon, Carolyn F. & Holst, Jens Juul, 2005, In: International Journal of Biochemistry & Cell Biology. 38, 5-6, p. 831-44 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A review of dipeptidyl peptidase-4 inhibitors: Hot topics from randomized controlled trials
Deacon, Carolyn F., Feb 2018, In: Diabetes, Obesity and Metabolism. 20, p. 34-46 13 p.Research output: Contribution to journal › Review › Research › peer-review
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Peptide degradation and the role of DPP-4 inhibitors in the treatment of type 2 diabetes
Deacon, Carolyn F., Feb 2018, In: Peptides. 100, p. 150-157 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Saxagliptin: a new dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes
Deacon, Carolyn F. & Holst, Jens Juul, 2009, In: Advances in Therapy. 26, 5, p. 488-99 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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GLP-1-(9-36) amide reduces blood glucose in anesthetized pigs by a mechanism that does not involve insulin secretion.
Deacon, Carolyn F., Plamboeck, A., Møller, Søren & Holst, Jens Juul, 2002, In: American Journal of Physiology: Endocrinology and Metabolism. 282, 4, p. E873-9Research output: Contribution to journal › Journal article › Research › peer-review
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GIP-(3-42) does not antagonize insulinotropic effects of GIP at physiological concentrations.
Deacon, Carolyn F., Plamboeck, A., Rosenkilde, Mette, de Heer, J. & Holst, Jens Juul, 2006, In: American Journal of Physiology: Endocrinology and Metabolism. 291, 3, p. E468-75Research output: Contribution to journal › Journal article › Research › peer-review
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Alogliptin, a potent and selective dipeptidyl peptidase-IV inhibitor for the treatment of type 2 diabetes.
Deacon, Carolyn F., 2008, In: Current Opinion in Investigational Drugs. 9, 4, p. 402-13 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Therapeutic strategies based on glucagon-like peptide 1.
Deacon, Carolyn F., 2004, In: Diabetes. 53, 9, p. 2181-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Dipeptidyl peptidase IV inhibition as an approach to the treatment and prevention of type 2 diabetes: a historical perspective.
Deacon, Carolyn F. & Holst, Jens Juul, 2002, In: Biochemical and Biophysical Research Communications. 294, 1, p. 1-4 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Potential of liraglutide in the treatment of patients with type 2 diabetes
Deacon, Carolyn F., 2009, In: Vascular Health and Risk Management (Online). 5, 1, p. 199-211 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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MK-431 (Merck).
Deacon, Carolyn F., 2005, In: Current Opinion in Investigational Drugs. 6, 4, p. 419-26 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Immunoassays for the incretin hormones GIP and GLP-1
Deacon, Carolyn F. & Holst, Jens Juul, 2009, In: Best Practice & Research: Clinical Endocrinology & Metabolism. 23, 4, p. 425-32 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Dipeptidyl peptidase 4 inhibition with sitagliptin: a new therapy for type 2 diabetes.
Deacon, Carolyn F., 2007, In: Expert Opinion on Investigational Drugs. 16, 4, p. 533-45 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Linagliptin, a xanthine-based dipeptidyl peptidase-4 inhibitor with an unusual profile for the treatment of type 2 diabetes
Deacon, Carolyn F. & Holst, Jens Juul, Jan 2010, In: Expert Opinion on Investigational Drugs. 19, 1, p. 133-40 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Degradation of endogenous and exogenous gastric inhibitory polypeptide in healthy and in type 2 diabetic subjects as revealed using a new assay for the intact peptide
Deacon, Carolyn F., Nauck, M. A., Meier, J., Hücking, K. & Holst, Jens Juul, 2000, In: Journal of Clinical Endocrinology and Metabolism. 85, p. 3575-3581Research output: Contribution to journal › Journal article › Research › peer-review
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Degradation of glucagon-like peptide-1 in vitro yields an N-terminally truncated peptide which is a major endogenous metabolite in vivo.
Deacon, Carolyn F., Johnsen, A. H. & Holst, Jens Juul, 1995, In: Journal of Clinical Endocrinology and Metabolism. 80, p. 952-957Research output: Contribution to journal › Journal article › Research › peer-review
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Dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1 which have extended metabolic stability and improved biological activity
Deacon, Carolyn F., Knudsen, L. B., Madsen, K., Wiberg, F. C., Jacobsen, O. & Holst, Jens Juul, 1998, In: Diabetologia. 41, p. 271-278Research output: Contribution to journal › Journal article › Research › peer-review
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Both subcutaneously and intravenously administered glucagon-like peptide-1 are rapidly degraded from the amino terminus in type II diabetic patients and in healthy subjects.
Deacon, Carolyn F., Nauck, M. A., Nielsen, M. T., Pridal, L. & Holst, Jens Juul, 1995, In: Diabetes. 44, p. 1126-1131Research output: Contribution to journal › Journal article › Research › peer-review
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Dipeptidyl peptidase IV inhibition reduces the degradation and clearance of GIP and potentiates its insulinotropic and antihyperglycemic effects in anesthetized pigs
Deacon, Carolyn F., Danielsen, P., Klarskov, L., Holst, Jens Juul & Olesen, M., 2001, In: Diabetes. 50, p. 1588-1597Research output: Contribution to journal › Journal article › Research › peer-review
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Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide 1 in the anesthetized pig.
Deacon, Carolyn F., Hughes, T. E. & Holst, Jens Juul, 1998, In: Diabetes. 47, p. 764-769Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon-like peptide-1: A basis for new approaches to the management of Diabetes
Deacon, Carolyn F., Holst, Jens Juul & Carr, R. D., 1999, In: Drugs of Today. 35, p. 159-170Research output: Contribution to journal › Journal article › Research › peer-review
ID: 9220
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Glucagon-like peptide-1 receptor signaling in acinar cells causes growth dependent release of pancreatic enzymes
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Acute effects of dietary carbohydrate restriction on glycemia, lipemia and appetite regulating hormones in normal-weight to obese subjects
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302
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Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production
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