Carolyn F. Deacon
Associate Professor
- 1995
- Published
Both subcutaneously and intravenously administered glucagon-like peptide-1 are rapidly degraded from the amino terminus in type II diabetic patients and in healthy subjects.
Deacon, Carolyn F., Nauck, M. A., Nielsen, M. T., Pridal, L. & Holst, Jens Juul, 1995, In: Diabetes. 44, p. 1126-1131Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Degradation of glucagon-like peptide-1 in vitro yields an N-terminally truncated peptide which is a major endogenous metabolite in vivo.
Deacon, Carolyn F., Johnsen, A. H. & Holst, Jens Juul, 1995, In: Journal of Clinical Endocrinology and Metabolism. 80, p. 952-957Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Human colon produces fully processed glucagon-like peptide-1 (7-36 amide).
Deacon, Carolyn F., Johnsen, A. H. & Holst, Jens Juul, 1995, In: FEBS Letters. 372, p. 269-272.Research output: Contribution to journal › Journal article › Research › peer-review
- 1996
- Published
Plasma TNF-x is associated with insulin mediated suppression of free fatty acids and net lipid oxidation in HIV-infected patients with lipodystrophy
Haugaard, S. B., Andersen, O., Pedersen, S. B., Dela, Flemming & Deacon, Carolyn F., 1996, In: Metabolism - Clinical and Experimental. 55(2), p. 175-182Research output: Contribution to journal › Journal article › Research › peer-review
- 1997
- Published
Posttranslational processing of proglucagon and postsecretory fate of proglucagon products.
Holst, Jens Juul, Ørskov, C., Hartmann, B. & Deacon, Carolyn F., 1997, The Insulinotropic Gut Hormone Glucagon-like Peptide-1.. Basel: Karger, p. 24-48Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- 1998
- Published
Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide 1 in the anesthetized pig.
Deacon, Carolyn F., Hughes, T. E. & Holst, Jens Juul, 1998, In: Diabetes. 47, p. 764-769Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1 which have extended metabolic stability and improved biological activity
Deacon, Carolyn F., Knudsen, L. B., Madsen, K., Wiberg, F. C., Jacobsen, O. & Holst, Jens Juul, 1998, In: Diabetologia. 41, p. 271-278Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhibition of the activity of dipeptidyl-peptidase IV as a treatment for type 2 diabetes
Holst, Jens Juul & Deacon, Carolyn F., 1998, In: Diabetes. 47, p. 1663-1670Research output: Contribution to journal › Journal article › Research › peer-review
- Published
On the treatment of diabetes mellitus with glucagon-like peptide-1.
Holst, Jens Juul, Deacon, Carolyn F., Toft-Nielsen, M. & Bjerre-Knudsen, L., 1998, In: Annals of the New York Academy of Sciences. 865, p. 336-343Research output: Contribution to journal › Journal article › Research › peer-review
- 1999
- Published
Glucagon-like peptide-1(7-36)amide is transformed to glucagon-like peptide-1 (9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the intestinal L-cells
Hansen, L., Deacon, Carolyn F., Ørskov, C. & Holst, Jens Juul, 1999, In: Endokrinologiya. 140, p. 5356-5363Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon-like peptide-1: A basis for new approaches to the management of Diabetes
Deacon, Carolyn F., Holst, Jens Juul & Carr, R. D., 1999, In: Drugs of Today. 35, p. 159-170Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon-like peptide-1: a basis for new approaches to the management of diabetes
Deacon, Carolyn F., Holst, Jens Juul & Carr, R. D., Mar 1999, In: Drugs of Today. 35, 3, p. 159-70 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon-like peptide-1-(7-36)amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine
Hansen, L., Deacon, Carolyn F., Ørskov, Cathrine & Holst, Jens Juul, Nov 1999, In: Molecular Endocrinology. 140, 11, p. 5356-63 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2000
- Published
Degradation of endogenous and exogenous gastric inhibitory polypeptide in healthy and in type 2 diabetic subjects as revealed using a new assay for the intact peptide
Deacon, Carolyn F., Nauck, M. A., Meier, J., Hücking, K. & Holst, Jens Juul, 2000, In: Journal of Clinical Endocrinology and Metabolism. 85, p. 3575-3581Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In vivo and in vitro degradation of glucagon-like peptide-2 in humans
Hartmann, B., Harr, M. B., Jeppesen, P. B., Wojdemann, M., Deacon, Carolyn F., Mortensen, P. B. & Holst, Jens Juul, 2000, In: Journal of Clinical Endocrinology and Metabolism. 85, p. 2884-2888Research output: Contribution to journal › Journal article › Research › peer-review
- 2001
- Published
Dipeptidyl peptidase IV inhibition reduces the degradation and clearance of GIP and potentiates its insulinotropic and antihyperglycemic effects in anesthetized pigs
Deacon, Carolyn F., Danielsen, P., Klarskov, L., Holst, Jens Juul & Olesen, M., 2001, In: Diabetes. 50, p. 1588-1597Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reduced insulinotropic effect of gastric inhibitory polypeptide in first-degree relatives of patients with type 2 diabetes
Meier, J. J., Huking, K., Holst, Jens Juul, Deacon, Carolyn F., Schmiegel, W. H. & Nauck, M. A., 2001, In: Diabetes. 50, p. 2497-2504Research output: Contribution to journal › Journal article › Research › peer-review
- 2002
- Published
Dipeptidyl peptidase IV inhibition as an approach to the treatment and prevention of type 2 diabetes: a historical perspective.
Deacon, Carolyn F. & Holst, Jens Juul, 2002, In: Biochemical and Biophysical Research Communications. 294, 1, p. 1-4 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GLP-1-(9-36) amide reduces blood glucose in anesthetized pigs by a mechanism that does not involve insulin secretion.
Deacon, Carolyn F., Plamboeck, A., Møller, Søren & Holst, Jens Juul, 2002, In: American Journal of Physiology: Endocrinology and Metabolism. 282, 4, p. E873-9Research output: Contribution to journal › Journal article › Research › peer-review
- Published
NN2211: a long-acting glucagon-like peptide-1 derivative with anti-diabetic effects in glucose-intolerant pigs.
Ribel, U., Larsen, M. O., Rolin, B., Carr, R. D., Wilken, M., Sturis, J., Westergaard, L., Deacon, Carolyn F. & Knudsen, L. B., 2002, In: European Journal of Pharmacology. 451, 2, p. 217-25 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The long-acting GLP-1 derivative NN2211 ameliorates glycemia and increases beta-cell mass in diabetic mice.
Rolin, B., Larsen, M. O., Gotfredsen, C. F., Deacon, Carolyn F., Carr, R. D., Wilken, M. & Knudsen, L. B., 2002, In: American Journal of Physiology: Endocrinology and Metabolism. 283, 4, p. E745-52Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Preservation of active incretin hormones by inhibition of dipeptidyl peptidase IV suppresses meal-induced incretin secretion in dogs
Deacon, Carolyn F., Wamberg, S., Bie, P., Hughes, T. E. & Holst, Jens Juul, Feb 2002, In: Journal of Endocrinology. 172, 2, p. 355-62 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2003
- Published
Differential regional metabolism of glucagon in anesthetized pigs.
Deacon, Carolyn F., Kelstrup, M., Trebbien, R., Klarskov, L., Olesen, M. & Holst, Jens Juul, 2003, In: American Journal of Physiology: Endocrinology and Metabolism. 285, 3, p. E552-60Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GLP-1 derivative liraglutide in rats with beta-cell deficiencies: influence of metabolic state on beta-cell mass dynamics.
Sturis, J., Gotfredsen, C. F., Rømer, J., Rolin, B., Ribel, U., Brand, C. L., Wilken, M., Wassermann, K., Deacon, Carolyn F., Carr, R. D. & Knudsen, L. B., 2003, In: British Journal of Pharmacology. 140, 1, p. 123-32 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Gastric inhibitory polypeptide (GIP) dose-dependently stimulates glucagon secretion in healthy human subjects at euglycaemia
Meier, J. J., Gallwitz, N., Siepmann, N., Holst, Jens Juul, Deacon, Carolyn F., Schmidt, W. E. & Nauck, M. A., 2003, In: Diabetologia. 46, p. 798-801Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impaired intestinal proglucagon processing in mice lacking prohormone convertase 1.
Ugleholdt, Randi Kjærsgaard, Zhu, X., Deacon, Carolyn F., Ørskov, Cathrine, Steiner, D. F. & Holst, Jens Juul, 2003, In: Endocrinology. 145, 3, p. 1349-55 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neutral endopeptidase 24.11 and dipeptidyl peptidase IV are both involved in regulating the metabolic stability of glucagon-like peptide-1 in vivo.
Plamboeck, A., Holst, Jens Juul, Carr, R. D. & Deacon, Carolyn F., 2003, In: Advances in Experimental Medicine and Biology. 524, p. 303-12 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Similar insulin secretory response to a gastric inhibitory polypeptide bolus injection at euglycemia in first-degree relatives of patients with type 2 diabetes and control subjects.
Meier, J. J., Nauck, M. A., Siepmann, N., Greulich, M., Holst, Jens Juul, Deacon, Carolyn F., Schmidt, W. E. & Gallwitz, B., 2003, In: Metabolism - Clinical and Experimental. 52, 12, p. 1579-85 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The reduction in hepatic insulin clearance after oral glucose is not mediated by gastric inhibitory polypeptide (GIP).
Meier, J. J., Gallwitz, B., Siepmann, N., Holst, Jens Juul, Deacon, Carolyn F., Schmidt, W. E. & Nauck, M. A., 2003, In: Regulatory Peptides. 113, 1-3, p. 95-100 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Valine pyrrolidide preserves intact glucose-dependent insulinotropic peptide and improves abnormal glucose tolerance in minipigs with reduced beta-cell mass.
Larsen, M. O., Rolin, B., Ribel, U., Wilken, M., Deacon, Carolyn F., Svendsen, O., Gotfredsen, C. F. & Carr, R. D., 2003, In: Experimental Diabesity Research. 4, 2, p. 93-105 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Gastric inhibitory polypeptide (GIP) dose-dependently stimulates glucagon secretion in healthy human subjects at euglycaemia
Meier, J. J., Gallwitz, B., Siepmann, N., Holst, Jens Juul, Deacon, Carolyn F., Schmidt, W. E. & Nauck, M. A., Jun 2003, In: Diabetologia. 46, 6, p. 798-801 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2004
- Published
Circulation and degradation of GIP and GLP-1
Deacon, Carolyn F., 2004, In: Hormone and Metabolic Research. 36, p. 761-765Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon-like peptide 1 and inhibitors of dipeptidyl peptidase IV in the treatment of type 2 diabetes mellitus.
Holst, Jens Juul & Deacon, Carolyn F., 2004, In: Current Opinion in Pharmacology. 4, 6, p. 589-96 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhibitors of dipeptidyl peptidase IV: a novel approach for the prevention and treatment of Type 2 diabetes?
Deacon, Carolyn F., Ahrén, B. & Holst, Jens Juul, 2004, In: Expert Opinion on Investigational Drugs. 13, 9, p. 1091-102 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neutral endopeptidase 24.11 is important for the degradation of both endogenous and exogenous glucagon in anesthetized pigs.
Trebbien, R., Klarskov, L., Olesen, M., Holst, Jens Juul, Carr, R. D. & Deacon, Carolyn F., 2004, In: American Journal of Physiology: Endocrinology and Metabolism. 287, 3, p. E431-8Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Secretion of incretin hormones (GIP and GLP-1) and incretin effect after oral glucose in first-degree relatives of patients with type 2 diabetes.
Nauck, M. A., El-Ouaghlidi, A., Gabrys, B., Hücking, K., Holst, Jens Juul, Deacon, Carolyn F., Gallwitz, B., Schmidt, W. E. & Meier, J. J., 2004, In: Regulatory Peptides. 122, 3, p. 209-17 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Secretion, degradation, and elimination of glucagon-like peptide 1 and gastric inhibitory polypeptide in patients with chronic renal insufficiency and healthy control subjects.
Meier, J. J., Nauck, M. A., Kranz, D., Holst, Jens Juul, Deacon, Carolyn F., Gaeckler, D., Schmidt, W. E. & Gallwitz, B., 2004, In: Diabetes. 53, 3, p. 654-62 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Stimulation of insulin secretion by intravenous bolus injection and continuous infusion of gastric inhibitory polypeptide in patients with type 2 diabetes and healthy control subjects.
Meier, J. J., Gallwitz, B., Kask, B., Deacon, Carolyn F., Holst, Jens Juul, Schmidt, W. E. & Nauck, M. A., 2004, In: Diabetes. 53 Suppl 3, p. S220-4Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The major glucagon-like peptide-1 metabolite, GLP-1-(9-36)-amide, does not affect glucose or insulin levels in mice.
Rolin, B., Deacon, Carolyn F., Carr, R. D. & Ahrén, B., 2004, In: European Journal of Pharmacology. 494, 2-3, p. 283-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Therapeutic strategies based on glucagon-like peptide 1.
Deacon, Carolyn F., 2004, In: Diabetes. 53, 9, p. 2181-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2005
- Published
Dipeptidyl peptidase IV inhibitors: a promising new therapeutic approach for the management of type 2 diabetes.
Deacon, Carolyn F. & Holst, Jens Juul, 2005, In: International Journal of Biochemistry & Cell Biology. 38, 5-6, p. 831-44 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Enhanced glucagon-like peptide- 1 (GLP-1) response to oral glucose in glucose intolerant HIV-infected patients on antiretroviral therapy
Andersen, O., Haugaard, S. B., Holst, Jens Juul, Deacon, Carolyn F., Iversen, J., Andersen, U. B., Nielsen, J. O. & Madsbad, S., 2005, In: HIV Medicine. 6, p. 91-98Research output: Contribution to journal › Journal article › Research › peer-review
- Published
For debate: Are antidiabetic actions of DPP-IV inhibitors mediated by glucagon-like peptide- 1?
Holst, Jens Juul & Deacon, Carolyn F., 2005, In: Diabetologia. 48, p. 612-615Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon-like peptide-1 mediates the therapeutic actions of Dpp-IV inhibitors
Holst, Jens Juul & Deacon, Carolyn F., 2005, In: Diabetologia. 48, p. 612-615Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Insulinotropic effect of gastric inhibitory polypeptide (GIP) in women with a history of gestational diabetes
Meier, J. J., Gallwitz, B., Askenas, M., Vollmer, K., Deacon, Carolyn F., Holst, Jens Juul, Schmidt, W. E. & Nauck, M. A., 2005, In: Diabetologia. 48, p. 1872-1881Research output: Contribution to journal › Journal article › Research
- Published
MK-431 (Merck).
Deacon, Carolyn F., 2005, In: Current Opinion in Investigational Drugs. 6, 4, p. 419-26 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neutral Endopeptidase 24.11 and dipeptidyl peptidase IV are both physiological mediators of the degradation of glucagon-like peptide-1 in the anaesthetized pig
Plamboeck, A., Holst, Jens Juul, Carr, R. D. & Deacon, Carolyn F., 2005, In: Diabetologia. 48, p. 1882-1890Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Normal secretion and action of the gut incretin hormones glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in young men with low birth weight
Schou, J. H., Pilgaard, K., Vilsbøll, Tina, Jensen, C. B., Deacon, Carolyn F., Holst, Jens Juul, Vølund, A., Madsbad, Sten & Vaag, Allan, 2005, In: Journal of Clinical Endocrinology and Metabolism. 90, 8, p. 4912-19 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sensory nerve desensitization by resiniferatoxin improves glucose tolerance and increases insulin secretion in Zucker Diabetic Fatty rats and is associated with reduced plasma activity of dipeptidyl peptidase IV.
Gram, D. X., Hansen, A. J., Deacon, Carolyn F., Brand, C. L., Ribel, U., Wilken, M., Carr, R. D., Svendsen, O. & Ahrén, B., 2005, In: European Journal of Pharmacology. 509, 2-3, p. 211-7 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The incretin enhancer vildagliptin, a dipeptidyl peptidase-IV inhibitor, improves model-assessed -cell function in patients with type 2 diabetes
Mari, A., Sallas, W. M., He, Y. L., Watson, C., Ligueros-Saylan, M., Dunning, B. E., Deacon, Carolyn F., Holst, Jens Juul & Foley, J. E., 2005, In: Journal of Clinical Endocrinology and Metabolism. 90, p. 4888-4894Research output: Contribution to journal › Journal article › Research
ID: 9220
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Glucagon-like peptide-1 receptor signaling in acinar cells causes growth dependent release of pancreatic enzymes
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Acute effects of dietary carbohydrate restriction on glycemia, lipemia and appetite regulating hormones in normal-weight to obese subjects
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Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production
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