Mette Rosenkilde

Mette Rosenkilde

Professor

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    ORCID: 0000-0001-9600-3254

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    1. Published

      Reversed binding of a small molecule ligand in homologous chemokine receptors - differential role of extracellular loop 2

      Jensen, P. C., Thiele, S., Steen, A., Elder, A., Kolbeck, R., Ghosh, S., Frimurer, Thomas Michael & Rosenkilde, Mette, May 2012, In: British Journal of Pharmacology. 166, 1, p. 258-75 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Reply to: How Many SARS-CoV-2 "Viroporins" Are Really Ion Channels? [Inkl. Correction]

      Toft-Bertelsen, Trine Lisberg, Jeppesen, Mads Gravers, Landbrug, A., Mujezinovic, A., Bentzen, Bo Hjorth, Kledal, T. N. & Rosenkilde, Mette, 2022, In: Communications Biology . 5, 1, 1 p., 860.

      Research output: Contribution to journal › Letter › Research › peer-review

    3. Published

      Recent advances of GIP and future horizons

      Holst, Jens Juul & Rosenkilde, Mette, 2020, In: Peptides. 125, 6 p., 170230.

      Research output: Contribution to journal › Review › Research › peer-review

    4. Published

      Re-routing GPR56 signalling using Gα12/13 G protein chimeras

      Faas, Felix, Nørskov, Amalie, Holst, Peter Johannes, Andersson, A. M., Qvortrup, K., Mathiasen, Signe & Rosenkilde, Mette, 2023, In: Basic and Clinical Pharmacology and Toxicology. 133, 4, p. 378-389

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo

      Spiess, Katja, Jeppesen, M. G., Malmgaard-Clausen, M., Krzywkowski, K., Dulal, K., Cheng, T., Hjortø, Gertrud Malene, Larsen, Olav, Burg, J. S., Jarvis, M. A., Garcia, K. C., Zhu, H., Kledal, T. N. & Rosenkilde, Mette, Jul 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 27, p. 8427-8432 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Rational design of conformationally constrained cyclopentapeptide antagonists for C-x-C chemokine receptor 4 (CXCR4)

      Mungalpara, J., Thiele, S., Eriksen, Ø., Eksteen, J., Rosenkilde, Mette & Våbenø, J., 9 Oct 2012, In: Journal of Medicinal Chemistry. 55, 22, p. 10287-10291 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Rat cytomegalovirus-encoded γ-chemokine vXCL1 is a highly adapted, species-specific agonist for rat XCR1-positive dendritic cells

      Bauer, A., Madela, J., Berg, Christian, Daugvilaite, V., Gurka, S., Mages, H. W., Kroczek, R. A., Rosenkilde, Mette & Voigt, S., 2020, In: Journal of Cell Science. 133, 5, 11 p., jcs236190.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Rare Heterozygous Loss-of-Function Variants in the Human GLP-1 Receptor Are Not Associated With Cardiometabolic Phenotypes

      Melchiorsen, Josefine Ulrikke, Sørensen, Kimmie Vestergaard, Bork-Jensen, J., Kizilkaya, Hüsün Sheyma, Gasbjerg, Lærke Smidt, Hauser, Alexander Sebastian, Rungby, Jørgen, Sørensen, H. T., Vaag, Allan, Nielsen, J. S., Pedersen, Oluf Borbye, Linneberg, Allan René, Hartmann, Bolette, Gjesing, A. P., Holst, Jens Juul, Hansen, Torben, Rosenkilde, Mette & Grarup, Niels, 2023, In: Journal of Clinical Endocrinology and Metabolism. 108, 11, p. 2821–2833 38 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor

      Ugleholdt, Randi Kjærsgaard, Poulsen, M. H., Holst, Peter Johannes, Irminger, J., Orskov, C., Pedersen, Jens, Rosenkilde, Mette, Zhu, X., Steiner, D. F. & Holst, Jens Juul, 2006, In: Journal of Biological Chemistry. 281, 16, p. 11050-7 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Progress toward rationally designed small-molecule peptide and peptidomimetic CXCR4 antagonists

      Vabeno, J., Haug, B. E. & Rosenkilde, Mette, Jul 2015, In: Future Medicinal Chemistry. 7, 10, p. 1261-1283 23 p.

      Research output: Contribution to journal › Review › Research › peer-review

    11. Published

      Probing the Molecular Interactions between CXC Chemokine Receptor 4 (CXCR4) and an Arginine-Based Tripeptidomimetic Antagonist (KRH-1636)

      Zachariassen, Z. G., Karlshøj, S., Haug, B. E., Rosenkilde, Mette & Vabeno, J., 22 Oct 2015, In: Journal of Medicinal Chemistry. 58, 20, p. 8141-8153 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Probing Biased Signaling in Chemokine Receptors

      Amarandi, R. M., Hjortø, Gertrud Malene, Rosenkilde, Mette & Karlshøj, S., 2016, Methods in Enzymology. Academic Press, Vol. 570. p. 155-186 32 p. (Methods in Enzymology, Vol. 570).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    13. Published

      Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist

      Simmons, G., Clapham, P. R., Picard, L., Offord, R. E., Rosenkilde, Mette, Schwartz, Thue W., Buser, R., Weels, T. N. C. & Proudfoot, A., 1997, In: Kexue (Shanghai). 276, p. 276-279

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Potency of ligands correlates with affinity measured against agonist and inverse agonists but not against neutral ligand in constitutively active chemokine receptor

      Rosenkilde, Mette & Schwartz, Thue W., 2000, In: Molecular Pharmacology. 57, no. 3, p. 602-9

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Post-infection treatment with the E protein inhibitor BIT225 reduces disease severity and increases survival of K18-hACE2 transgenic mice infected with a lethal dose of SARS-CoV-2

      Ewart, G., Bobardt, M., Bentzen, Bo Hjorth, Yan, Y., Thomson, A., Klumpp, K., Becker, S., Rosenkilde, Mette, Miller, M. & Gallay, P., 2023, In: PLoS Pathogens. 19, 8 August, 20 p., e1011328.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding

      Jensen, P. C., Thiele, S., Ulven, Trond, Schwartz, Thue W. & Rosenkilde, Mette, 17 Jun 2008, In: Journal of Biological Chemistry. 283, 34, p. 23121-23128 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding

      Jensen, P. C., Thiele, S., Ulven, T., Schwartz, Thue W. & Rosenkilde, Mette, 2008, In: Journal of Biological Chemistry. 283, 34, p. 23121-8 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Porcine glucagon-like peptide-2: structure, signaling, metabolism and effects

      Pedersen, N. B., Hjøllund, K. R., Johnsen, A. H., Ørskov, Cathrine, Rosenkilde, Mette, Hartmann, B. & Holst, Jens Juul, 2007, In: Regulatory Peptides. 146, 1-3, p. 310-320 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Physiology of the Incretin Hormones, GIP and GLP-1-Regulation of Release and Posttranslational Modifications

      Holst, Jens Juul, Albrechtsen, Nicolai Jacob Wewer, Rosenkilde, Mette & Deacon, Carolyn F., 2019, In: Comprehensive Physiology. 9, 4, p. 1339-1381

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Phorbol esters and SDF-1 induce rapid endocytosis and down-modulation of the chemokine receptor CXCR4

      Signoret, N., Oldridge, J., Pelchen-Matthews, A., Klasse, P. J., Tran, T., Brass, L. F., Rosenkilde, Mette, Schwartz, Thue W., Luther, M. A., Wells, T. N. C., Hoxie, J. A. & March, M., 1997, In: Journal of Cell Biology. 139, no. 3, p. 651-664

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Pharmacological and structure-activity relationship studies of oleoyl-lysophosphatidylinositol synthetic mimetics

      Paternoster, S., Simpson, P. V., Kokh, E., Kizilkaya, Hüsün Sheyma, Rosenkilde, Mette, Mancera, R. L., Keating, D. J., Massi, M. & Falasca, M., 2021, In: Pharmacological Research. 172, 105822.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Pharmacokinetics of oral and intravenous melatonin in healthy volunteers

      Andersen, Lars Peter Kloster, Werner, M. U., Rosenkilde, Mette, Harpsøe, N. G., Fuglsang, H., Rosenberg, Jacob & Gögenur, Ismail, 2016, In: BMC Pharmacology and Toxicology. 17, p. 1-5 5 p., 8.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Pharmacokinetics of high-dose intravenous melatonin in humans

      Andersen, Lars Peter Kloster, Werner, M. U., Rosenkilde, Mette, Fenger, A. Q., Petersen, M. C., Rosenberg, Jacob & Gögenur, Ismail, Mar 2016, In: Journal of Clinical Pharmacology. 56, 3, p. 324-9 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Perspective: Implications of Ligand-Receptor Binding Kinetics for Therapeutic Targeting of G Protein-Coupled Receptors

      van der Velden, W. J. C., Heitman, L. H. & Rosenkilde, Mette, 2020, In: ACS Pharmacology & Translational Science. 3, 2, p. 179-189 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Peroxynitrite Exposure of CXCL12 Impairs Monocyte, Lymphocyte and Endothelial Cell Chemotaxis, Lymphocyte Extravasation in vivo and Anti-HIV-1 Activity

      Janssens, R., Boff, D., Ruytinx, P., Mortier, A., Vanheule, V., Larsen, Olav, Daugvilaite, V., Rosenkilde, Mette, Noppen, S., Liekens, S., Schols, D., De Meester, I., Opdenakker, G., Struyf, S., Teixeira, M. M., Amaral, F. A. & Proost, P., 2018, In: Frontiers in Immunology. 9, p. 1933

      Research output: Contribution to journal › Journal article › Research › peer-review

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