Mette Rosenkilde

Mette Rosenkilde

Professor

Member of:


    1. Published

      Allosteric and orthosteric sites in CC chemokine receptor (CCR5), a chimeric receptor approach

      Thiele, S., Steen, A., Jensen, P. C., Mokrosinski, J., Frimurer, Thomas Michael & Rosenkilde, Mette, 2011, In: Journal of Biological Chemistry. 286, 43, p. 37543-54 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    2. Published

      Determination of the binding mode for the cyclopentapeptide CXCR4 antagonist FC131 using a dual approach of ligand modifications and receptor mutagenesis

      Thiele, S., Mungalpara, J., Steen, A., Rosenkilde, Mette & Våbenø, J., Dec 2014, In: British Journal of Pharmacology. 171, 23, p. 5313-29 17 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    3. Published

      Modulation in selectivity and allosteric properties of small-molecule ligands for CC-chemokine receptors

      Thiele, S., Malmgaard-Clausen, M., Engel-Andreasen, J., Steen, A., Rummel, P. C., Nielsen, M. C., Gloriam, David E., Frimurer, Thomas Michael, Ulven, Trond & Rosenkilde, Mette, 27 Sep 2012, In: Journal of Medicinal Chemistry. 55, 18, p. 8164-77 14 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    4. Published

      A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor

      Sun, W., Chen, L-N., Zhou, Q., Zhao, L-H., Yang, D., Zhang, H., Cong, Z., Shen, D-D., Zhao, F., Zhou, F., Cai, X., Chen, Y., Zhou, Y., Gadgaard, S., van der Velden, W. J. C., Zhao, S., Jiang, Y., Rosenkilde, M. M., Xu, H. E., Zhang, Y. & 1 others, Wang, M., 2020, In: Cell Research. 30, 12, p. 1098-1108

      Research output: Contribution to journalJournal articleResearchpeer-review

    5. Published

      Effects of endogenous GIP in patients with type 2 diabetes

      Stensen, S., Gasbjerg, Lærke Smidt, Krogh, L. L., Skov-Jeppesen, Kirsa, wbf943, wbf943, Jensen, M. H., Dela, Flemming, Hartmann, Bolette, Vilsbøll, Tina, Holst, Jens Juul, Rosenkilde, Mette, Christensen, Mikkel Bring & Knop, Filip Krag, Apr 2021, In: European Journal of Endocrinology. 185, 1, p. 33-45

      Research output: Contribution to journalJournal articleResearchpeer-review

    6. Published
    7. Published
    8. Published

      Glucose-dependent insulinotropic polypeptide (GIP) contributes to sitagliptin-mediated improvement of beta cell function in patients with type 2 diabetes

      Stensen, S., Gasbjerg, Lærke Smidt, Rosenkilde, Mette, Hartmann, Bolette, Vilsbøll, Tina, Holst, Jens Juul, Christensen, M. B. & Knop, Filip Krag, 2021, In: Diabetologia. 64, SUPPL 1, p. 95-95 179.

      Research output: Contribution to journalConference abstract in journalResearch

    9. Published

      Endogenous glucose-dependent insulinotropic polypeptide exerts diverging and tissue specific in obese patients with type 2 diabetes

      Stensen, S., Gasbjerg, Lærke Smidt, Krogh, L. L., wbf943, wbf943, Skov-Jeppesen, Kirsa, Jensen, M. H., Hartmann, Bolette, Vilsbøll, Tina, Holst, Jens Juul, Rosenkilde, Mette, Christensen, M. B. & Knop, Filip Krag, 2019, In: Diabetologia. 62, Supl. 1/SI, p. S270-S271 2 p., 560.

      Research output: Contribution to journalConference abstract in journalResearch

    10. Published

      Molecular Pharmacology of CXCR4 inhibition

      Steen, A. & Rosenkilde, Mette, 2012, Novel Developments in Stem Cell Mobilization : Focus on CXCR4. Fruehauf, S., Zeller, J. W. & Calandra, G. (eds.). Springer Science+Business Media, p. 23-35

      Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

    11. Published

      Biased and g protein-independent signaling of chemokine receptors

      Steen, A., Larsen, O., Thiele, S. & Rosenkilde, Mette, 2014, In: Frontiers in Immunology. 5, p. 1-13 13 p., 277.

      Research output: Contribution to journalJournal articleResearchpeer-review

    12. Published

      Targeting CXCR4 in HIV Cell-Entry Inhibition

      Steen, A., Schwartz, Thue W. & Rosenkilde, Mette, 2010, In: Mini reviews in medicinal chemistry. 9, 14, p. 1605-21 16 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    13. Published

      Biased and Constitutive Signaling in the CC-Chemokine Receptor CCR5 by manipulating the Interface between Transmembrane Helix 6 and 7

      Steen, A., Thiele, S., Guo, D., Gasbjerg, Lærke Smidt, Frimurer, Thomas Michael & Rosenkilde, Mette, 3 May 2013, In: Journal of Biological Chemistry. 288, 18, p. 12511-12521 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    14. Published

      Gating function of isoleucine-116 in TM-3 (position III:16/3.40) for the activity state of the CC-chemokine receptor 5 (CCR5)

      Steen, A., wbf943, wbf943, Thiele, S., Guo, D., Frimurer, Thomas Michael & Rosenkilde, Mette, Mar 2014, In: British Journal of Pharmacology. 171, 6, p. 1566-79 14 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    15. Published

      Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo

      Spiess, Katja, Jeppesen, M. G., Malmgaard-Clausen, M., Krzywkowski, K., Dulal, K., Cheng, T., Hjortø, Gertrud Malene, Larsen, Olav, Burg, J. S., Jarvis, M. A., Garcia, K. C., Zhu, H., Kledal, T. N. & Rosenkilde, Mette, Jul 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 27, p. 8427-8432 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    16. Published

      Identification and functional comparison of seven-transmembrane G-protein-coupled BILF1 receptors in recently discovered nonhuman primate lymphocryptoviruses

      Spiess, Katja, Fares, S., wbf943, wbf943, Hilgenberg, E., Jarvis, M. A., Ehlers, B. & Rosenkilde, Mette, Feb 2015, In: Journal of Virology. 89, 4, p. 2253-67 15 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    17. Published

      Novel Chemokine-Based Immunotoxins for Potent and Selective Targeting of Cytomegalovirus Infected Cells

      Spiess, Katja, Jeppesen, Mads Gravers, Malmgaard-Clausen, M., Krzywkowski, K., Kledal, T. N. & Rosenkilde, Mette, 2017, In: Journal of Immunology Research. 2017, 12 p., 4069260.

      Research output: Contribution to journalJournal articleResearchpeer-review

    18. Published

      Arrestin-independent constitutive endocytosis of GPR125/ADGRA3

      Spiess, Katja, Bagger, Sofie Morsing, Pedersen, Lola Julie Torz, Jensen, Kristian HR, Walser, Anna Louise Silvia, Kvam, J. M., Mogelmose, A. K., Daugvilaite, V., Junnila, R. K., Hjortø, Gertrud Malene & Rosenkilde, Mette, 2019, In: Annals of the New York Academy of Sciences. 1456, p. 186–199

      Research output: Contribution to journalJournal articleResearchpeer-review

    19. Published

      Functional properties of Virus-Encoded and Virus-Regulated 7TM Receptors

      Spiess, Katja & Rosenkilde, Mette, 2014, G Protein-Coupled Receptor Genetics: Research and Methods in the Post-Genomic Era. Stevens, C. W. (ed.). Humana Press, p. 45-64 20 p. (Methods in Pharmacology and Toxicology).

      Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

    20. Published

      The future of antiviral immunotoxins

      Spiess, Katja, Jakobsen, M. H., Kledal, T. N. & Rosenkilde, Mette, Jun 2016, In: Journal of Leukocyte Biology. 99, 6, p. 911-925 15 p.

      Research output: Contribution to journalReviewResearchpeer-review

    21. Published

      GIP(3-30)NH2 is a potent competitive antagonist of the GIP receptor and effectively inhibits GIP-mediated insulin, glucagon, and somatostatin release

      wbf943, wbf943, Gabe, M. N., Gasbjerg, Lærke Smidt, Christiansen, Charlotte Bayer, Svendsen, B., Hartmann, Bolette, Holst, Jens Juul & Rosenkilde, Mette, 2017, In: Biochemical Pharmacology. 131, p. 78-88

      Research output: Contribution to journalJournal articleResearchpeer-review

    22. Published

      Species-specific action of (Pro3)GIP - an efficacious agonist on human GIP receptor, but partial agonist and competitive antagonist on rat and mouse GIP receptors

      wbf943, wbf943, Gasbjerg, Lærke Smidt, Svendsen, B., Christensen, M., Knop, Filip Krag, Hartmann, Bolette, Holst, Jens Juul & Rosenkilde, Mette, Jan 2016, In: British Journal of Pharmacology. 173, 1, p. 27-38 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    23. Published

      The European Research Network on Signal Transduction (ERNEST): Toward a Multidimensional Holistic Understanding of G Protein-Coupled Receptor Signaling

      Sommer, M. E., Selent, J., Carlsson, J., De Graaf, C., Gloriam, David E., Keseru, G. M., Kosloff, M., Mordalski, S., Rizk, A., Rosenkilde, Mette, Sotelo, E., Tiemann, Johanna Katarina Sofie, Tobin, A., Vardjan, N., Waldhoer, M. & Kolb, P., 2020, In: ACS Pharmacology & Translational Science. 3, 2, p. 361-370 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    24. Published

      Investigating GIPR (ant)agonism: A structural analysis of GIP and its receptor

      Smit, F. X., van der Velden, W. J. C., Kizilkaya, Hüsün Sheyma, Nørskov, A., Lückmann, Michael, Hansen, T. N., wbf943, wbf943, Qvotrup, K., Frimurer, Thomas Michael & Rosenkilde, Mette, 2021, In: Structure. 29, 7, p. 679-693.e6 21 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    25. Accepted/In press

      Effects of exogenous GIP and GLP-2 on bone turnover in individuals with type 2 diabetes

      Skov-Jeppesen, Kirsa, Christiansen, Charlotte Bayer, Hansen, L. S., Windeløv, Johanne Agerlin, Hedbäck, N., Gasbjerg, Lærke Smidt, Hindsø, M., Svane, M. S., Madsbad, Sten, Holst, Jens Juul, Rosenkilde, Mette & Hartmann, Bolette, 2024, (Accepted/In press) In: The Journal of clinical endocrinology and metabolism.

      Research output: Contribution to journalJournal articleResearchpeer-review

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