Julien Ochala

Julien Ochala

Associate Professor - Promotion Programme

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    ORCID: 0000-0002-6358-2920

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    1. E-pub ahead of print

      Myonuclear alterations associated with exercise are independent of age in humans

      Battey, E., Ross, J. A., Hoang, A., Wilson, D. G. S., Han, Y., Levy, Y., Pollock, R. D., Kalakoutis, M., Pugh, J. N., Close, G. L., Ellison-Hughes, G. M., Lazarus, N. R., Iskratsch, T., Harridge, S. D. R., Ochala, Julien & Stroud, M. J., 2024, (E-pub ahead of print) In: Journal of Physiology.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Myopathy in acute and long-term COVID-19

      Tankisi, H. & Ochala, Julien, 2022, In: Clinical Neurophysiology. 134, p. 141-142

      Research output: Contribution to journal › Letter › Research › peer-review

    3. Published

      Myopathy-inducing mutation H40Y in ACTA1 hampers actin filament structure and function

      Chan, C., Fan, J., Messer, A. E., Marston, S. B., Iwamoto, H. & Ochala, Julien, 1 Aug 2016, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1862, 8, p. 1453-1458 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Myosin Heavy Chain as a Novel Key Modulator of Striated Muscle Resting State

      Lewis, Christopher T.A. & Ochala, Julien, 2023, In: Physiology. 38, 1, p. 3-9

      Research output: Contribution to journal › Review › Research › peer-review

    5. Published

      Myosin post-translational modifications and function in the presence of myopathy-linked truncating MYH2 mutations

      Sonne, A., Peverelli, L., Hernandez-Lain, A., Domínguez-González, C., Andersen, J. L., Milone, M., Beggs, A. H. & Ochala, Julien, 2023, In: American journal of physiology. Cell physiology. 324, 3, p. C769–C776 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Myostatin inhibition using mrk35 produces skeletal muscle growth and tubular aggregate formation in wild type and TgACTA1D286G nemaline myopathy mice

      Tinklenberg, J. A., Siebers, E. M., Beatka, M. J., Meng, H., Yang, L., Zhang, Z., Ross, J. A., Ochala, Julien, Morris, C., Owens, J. M., Laing, N. G., Nowak, K. J. & Lawlor, M. W., 15 Feb 2018, In: Human Molecular Genetics. 27, 4, p. 638-648 11 p., ddx431.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Nebulin nemaline myopathy recapitulated in a compound heterozygous mouse model with both a missense and a nonsense mutation in Neb

      Laitila, J. M., McNamara, E. L., Wingate, C. D., Goullee, H., Ross, J. A., Taylor, R. L., Van Der Pijl, R., Griffiths, L. M., Harries, R., Ravenscroft, G., Clayton, J. S., Sewry, C., Lawlor, M. W., Ottenheijm, C. A. C., Bakker, A. J., Ochala, Julien, Laing, N. G., Wallgren-Pettersson, C., Pelin, K. & Nowak, K. J., 17 Feb 2020, In: Acta Neuropathologica Communications. 8, 1, 18.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Nemaline Myopathy-Related Skeletal Muscle α-Actin (ACTA1) Mutation, Asp286Gly, Prevents Proper Strong Myosin Binding and Triggers Muscle Weakness

      Ochala, Julien, Ravenscroft, G., Laing, N. G. & Nowak, K. J., 20 Sep 2012, In: PLoS ONE. 7, 9, e45923.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Novel myosin-based therapies for congenital cardiac and skeletal myopathies

      Ochala, Julien & Sun, Y. B., 1 Oct 2016, In: Journal of Medical Genetics. 53, 10, p. 651-654 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Nuclear numbers in syncytial muscle fibers promote size but limit the development of larger myonuclear domains

      Cramer, A. A. W., Prasad, V., Eftestøl, E., Song, T., Hansson, K. A., Dugdale, H. F., Sadayappan, S., Ochala, Julien, Gundersen, K. & Millay, D. P., 2020, In: Nature Communications. 11, 1, 14 p., 6287.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      PGC-1α regulates myonuclear accretion after moderate endurance training

      Battey, E., Furrer, R., Ross, J., Handschin, C., Ochala, Julien & Stroud, M. J., 2022, In: Journal of Cellular Physiology. 237, 1, p. 696-705

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Physical activity impacts resting skeletal muscle myosin conformation and lowers its ATP consumption

      Lewis, C. T. A., Tabrizian, L., Nielsen, J., Laitila, J., Beck, T. N., Olsen, M. S., Ognjanovic, M. M., Aagaard, P., Hokken, R., Laugesen, S., Ingersen, A., Andersen, J. L., Soendenbroe, C., Helge, J. W., Dela, F., Larsen, S., Sahl, R. E., Rømer, T., Hansen, M. T., Frandsen, J. & 2 others, Suetta, Charlotte & Ochala, Julien, 2023, In: The Journal of general physiology. 155, 7, 8 p., e202213268.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Physiological impact and disease reversion for the severe form of centronuclear myopathy linked to Dynamin

      Massana Muñoz, X., Kretz, C., Silva-Rojas, R., Ochala, Julien, Menuet, A., Romero, N. B., Cowling, B. S. & Laporte, J., 18 Aug 2020, In: JCI insight. 5, 18, 16 p., e137899.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Pointed-end capping by tropomodulin modulates actomyosin crossbridge formation in skeletal muscle fibers

      Ochala, Julien, Gokhin, D. S., Iwamoto, H. & Fowler, V. M., Jan 2014, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 28, 1, p. 408-15 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Predominant myosin superrelaxed state in canine myocardium with naturally occurring dilated cardiomyopathy

      Ochala, Julien, Lewis, Christopher T.A. , Beck, T., Iwamoto, H., Hessel, A. L., Campbell, K. S. & Pyle, W. G., 2023, In: American journal of physiology. Heart and circulatory physiology. 325, 3, p. H585-H591

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Preferential skeletal muscle myosin loss in response to mechanical silencing in a novel rat intensive care unit model: Underlying mechanisms

      Ochala, Julien, Gustafson, A. M., Diez, M. L., Renaud, G., Li, M., Aare, S., Qaisar, R., Banduseela, V. C., Hedström, Y., Tang, X., Dworkin, B., Ford, G. C., Nair, K. S., Perera, S., Gautel, M. & Larsson, L., Apr 2011, In: Journal of Physiology. 589, 8, p. 2007-2026 20 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Prelamin A causes aberrant myonuclear arrangement and results in muscle fiber weakness

      Levy, Y., Ross, J. A., Niglas, M., Snetkov, V. A., Lynham, S., Liao, C., Puckelwartz, M. J., Hsu, Y., McNally, E. M., Alsheimer, M., Harridge, S. D., Young, S. G., Fong, L. G., Español, Y., Lopez-Otin, C., Kennedy, B. K., Lowe, D. A. & Ochala, Julien, 4 Oct 2018, In: JCI insight. 3, 19

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Reducing dynamin 2 (DNM2) rescues DNM2-related dominant centronuclear myopathy

      Buono, S., Ross, J. A., Tasfaout, H., Levy, Y., Kretz, C., Tayefeh, L., Matson, J., Guo, S., Kessler, P., Monia, B. P., Bitoun, M., Ochala, Julien, Laporte, J. & Cowling, B. S., 23 Oct 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 43, p. 11066-11071 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Relationship between force and size in human single muscle fibres

      Krivickas, L. S., Dorer, D. J., Ochala, Julien & Frontera, W. R., May 2011, In: Experimental Physiology. 96, 5, p. 539-547 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Remodeling of skeletal muscle myosin metabolic states in hibernating mammals

      Lewis, C. T. A., Melhedegaard, E. G., Ognjanovic, M. M., Olsen, M. S., Laitila, J., Seaborne, R. A. E., Gronset, M., Zhang, C., Iwamoto, H., Hessel, A. L., Kuehn, M. N., Merino, C., Amigo, N., Frobert, O., Giroud, S., Staples, J. F., Goropashnaya, A. V., Fedorov, V. B., Barnes, B., Toien, O. & 3 others, Drew, K., Sprenger, R. J. & Ochala, Julien, 2024, In: eLife. 13, 26 p., RP94616.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Revisiting specific force loss in human permeabilized single skeletal muscle fibers obtained from older individuals

      Kalakoutis, M., Pollock, R. D., Lazarus, N. R., Atkinson, R. A., George, M., Berber, O., Woledge, R. C., Ochala, Julien & Harridge, S. D. R., 2023, In: American journal of physiology. Cell physiology. 325, 1, p. C172-C185

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Ryanodine receptor fragmentation and sarcoplasmic reticulum Ca2+ leak after one session of High-intensity interval exercise

      Place, N., Ivarsson, N., Venckunas, T., Neyroud, D., Brazaitis, M., Cheng, A. J., Ochala, Julien, Kamandulis, S., Girard, S., Volungevičius, G., Paužas, H., Mekideche, A., Kayser, B., Martinez-Redondo, V., Ruas, J. L., Bruton, J., Truffert, A., Lanner, J. T., Skurvydas, A. & Westerblad, H., 15 Dec 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 50, p. 15492-15497 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Ryanodine receptor type 1 content decrease-induced endoplasmic reticulum stress is a hallmark of myopathies

      Vidal, J., Fernandez, E. A., Wohlwend, M., Laurila, P. P., Lopez-Mejia, A., Ochala, Julien, Lobrinus, A. J., Kayser, B., Lopez-Mejia, I. C., Place, N. & Zanou, N., 2023, In: Journal of Cachexia, Sarcopenia and Muscle. 14, 6, p. 2882-2897

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. SIRT1 regulates nuclear number and domain size in skeletal muscle fibers

      Ross, J. A., Levy, Y., Svensson, K., Philp, A., Schenk, S. & Ochala, Julien, Sep 2018, In: Journal of Cellular Physiology. 233, 9, p. 7157-7163 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Sexually dimorphic myofilament function in a mouse model of nemaline myopathy

      Lindqvist, J., Hardeman, E. C. & Ochala, Julien, 15 Dec 2014, In: Archives of Biochemistry and Biophysics. 564, p. 37-42 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Single skeletal muscle fiber behavior after a quick stretch in young and older men: A possible explanation of the relative preservation of eccentric force in old age

      Ochala, Julien, Dorer, D. J., Frontera, W. R. & Krivickas, L. S., Jul 2006, In: Pflugers Archiv European Journal of Physiology. 452, 4, p. 464-470 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Single skeletal muscle fiber elastic and contractile characteristics in young and older men

      Ochala, Julien, Frontera, W. R., Dorer, D. J., Van Hoecke, J. & Krivickas, L. S., Apr 2007, In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 62, 4, p. 375-381 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Skeletal Muscle: A Brief Review of Structure and Function

      Frontera, W. R. & Ochala, Julien, 4 Mar 2015, In: Behavior Genetics. 45, 2, p. 183-195 13 p.

      Research output: Contribution to journal › Review › Research › peer-review

    29. Published

      Skeletal and cardiac αactin isoforms differently modulate myosin cross-bridge formation and myofibre force production

      Ochala, Julien, Iwamoto, H., Ravenscroft, G., Laing, N. G. & Nowak, K. J., Nov 2013, In: Human Molecular Genetics. 22, 21, p. 4398-4404 7 p., ddt289.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Slow myosin heavy chain 1 is required for slow myofibril and muscle fibre growth but not for myofibril initiation

      Hau, H. T. A., Kelu, J. J., Ochala, Julien & Hughes, S. M., Jul 2023, In: Developmental Biology. 499, p. 47-58 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Sparing of muscle mass and function by passive loading in an experimental intensive care unit model

      Renaud, G., Llano-Diez, M., Ravara, B., Gorza, L., Feng, H. Z., Jin, J. P., Cacciani, N., Gustafson, A. M., Ochala, Julien, Corpeno, R., Li, M., Hedström, Y., Ford, G. C., Nair, K. S. & Larsson, L., Mar 2013, In: Journal of Physiology. 591, 5, p. 1385-1402 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      The dawn of the functional genomics era in muscle physiology

      Seaborne, Robert Arthur Elliston & Ochala, Julien, 15 Apr 2023, In: Journal of Physiology. 601, 8, p. 1343-1352

      Research output: Contribution to journal › Review › Research › peer-review

    33. Published

      The effects of resistance exercise training on mitochondrial myopathy patients

      Di Leo, V., Newman, J., Lawless, C., Robertson, F., Levy, Y., Ochala, Julien, Pickett, S., Hudson, G., Gorman, G., Tuppen, H., Vincent, A. & Russell, O., 2022, In: Neuromuscular Disorders. 32, p. S72-S72 FP.16.

      Research output: Contribution to journal › Conference abstract in journal › Research

    34. Published

      The fraction of strongly bound cross-bridges is increased in mice that carry the myopathy-linked myosin heavy chain mutation MYH4L342Q

      Lindqvist, J., Iwamoto, H., Blanco, G. & Ochala, Julien, May 2013, In: DMM Disease Models and Mechanisms. 6, 3, p. 834-840 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      The influence of ageing on the force-velocity-power characteristics of human elbow flexor muscles

      Valour, D., Ochala, Julien, Ballay, Y. & Pousson, M., 1 Apr 2003, In: Experimental Gerontology. 38, 4, p. 387-395 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Thick and Thin Filament Proteins: Acquired and Hereditary Sarcomeric Protein Diseases

      Ochala, Julien & Larsson, L., 18 Jul 2012, Muscle: Fundamental Biology and Mechanisms of Disease. Elsevier, Vol. 1-2. p. 1023-1030 8 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    37. Published

      Thick and thin filament proteins: Acquired and hereditary sarcomeric protein diseases

      Ochala, Julien & Larsson, L., 2012, Muscle. Elsevier Science Inc., Vol. 2. p. 1023-1030 8 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    38. Thin filament proteins mutations associated with skeletal myopathies: Defective regulation of muscle contraction

      Ochala, Julien, 2008, In: Journal of Molecular Medicine. 86, 11, p. 1197-1204 8 p.

      Research output: Contribution to journal › Review › Research › peer-review

    39. Tropomodulin 1 directly controls thin filament length in both wild-type and tropomodulin 4-deficient skeletal muscle

      Gokhin, D. S., Ochala, Julien, Domenighetti, A. A. & Fowler, V. M., 15 Dec 2015, In: Development (Cambridge, England). 142, 24, p. 4351-62 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Using nuclear envelope mutations to explore age-related skeletal muscle weakness

      Battey, E., Stroud, M. J. & Ochala, Julien, 28 Aug 2020, In: Clinical Science. 134, 16, p. 2177-2187 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      X-ray recordings reveal how a human disease-linked skeletal muscle α-actin mutation leads to contractile dysfunction

      Ochala, Julien, Ravenscroft, G., McNamara, E., Nowak, K. J. & Iwamoto, H., Dec 2015, In: Journal of Structural Biology. 192, 3, p. 331-335 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      rAAV-related therapy fully rescues myonuclear and myofilament function in X-linked myotubular myopathy

      Ross, J. A., Tasfaout, H., Levy, Y., Morgan, J., Cowling, B. S., Laporte, J., Zanoteli, E., Romero, N. B., Lowe, D. A., Jungbluth, H., Lawlor, M. W., Mack, D. L. & Ochala, Julien, 19 Oct 2020, In: Acta Neuropathologica Communications. 8, 1, 167.

      Research output: Contribution to journal › Journal article › Research › peer-review

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