Jens Juul Holst

Jens Juul Holst

Professor

ORCID: 0000-0001-6853-3805

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  1. Published

    Influence of acarbose on postprandial insulin requirements in patients with type 1 diabetes

    Juntti-Berggren, L., Pigon, J., Hellström, P. M., Holst, Jens Juul & Efendic, S., 2000, In: Diab Nutr Metab. 13, p. 7-12

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Postprandial glucose, insulin and incretin responses to grain products in healthy subjects

    Juntunen, K. S., Lioukkonen, H. K., Poutanen, S. K., Niskanen, K. L., Holst, Jens Juul & Mykkänen, M. H., 2002, In: Am. J. Clin. Nutr.. 75, p. 254-262

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Structural differences between rye and wheat bread but not total fiber content may explain the lower postprandial insulin response to rye bread

    Juntunen, K. S., Laaksonen, D. E., Aitio, K., Niskanen, L. K., Holst, Jens Juul, Savolainen, K. E., Liukkonen, K. H., Poutanen, K. S. & Mykkänen, H. M., 2003, In: Am. J. Clin. Nutr.. 78, p. 957-964

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Structural differences between rye and wheat breads but not total fiber content may explain the lower postprandial insulin response to rye bread

    Juntunen, K. S., Laaksonen, D. E., Autio, K., Niskanen, L. K., Holst, Jens Juul, Savolainen, K. E., Liukkonen, K., Poutanen, K. S. & Mykkänen, H. M., Nov 2003, In: Uden navn. 78, 5, p. 957-64 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Pros and cons of Roux en-Y gastric bypass surgery in obese patients with type 2 diabetes

    Justinussen, T., Madsbad, Sten, Holst, Jens Juul & Bojsen-Moller, K. N., 2019, In: Expert Review of Endocrinology & Metabolism. 14, 4, p. 243-257

    Research output: Contribution to journal › Review › Research › peer-review

  6. Published

    Circulating levels of incretin hormones an amylin in the fasting state and after oral glucose in growth hormone (GH-)deficient patients before and after GH replacement. A placebo controlled study

    Jørgensen, J. O. L., Rosenfalck, A. M., Fisker, S., Nyholm, B., Fineman, M. S., Schmitz, O., Madsbad, S., Holst, Jens Juul & Christiansen, J. S., 2000, In: European Journal of Endocrinology. 143, p. 593-599

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Clearance of glucoregulatory peptide hormones during haemodialysis and haemodiafiltration in non-diabetic end-stage renal disease patients

    Jørgensen, M. B., Idorn, T., Knop, Filip Krag, Holst, Jens Juul, Hornum, Mads & Feldt-Rasmussen, Bo, Mar 2015, In: Nephrology, Dialysis, Transplantation. 30, 3, p. 513-20 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Effect of the Incretin Hormones on the Endocrine Pancreas in End-Stage Renal Disease

    Jørgensen, M. B., Idorn, T., Rydahl, C., Hansen, H. P., Bressendorff, I., Brandi, Lisbet, Wewer Albrechtsen, N. J., van Hall, Gerrit, Hartmann, Bolette, Holst, Jens Juul, Knop, Filip Krag, Hornum, Mads & Feldt-Rasmussen, Bo, Jan 2020, In: Journal of Clinical Endocrinology and Metabolism. 105, 3, p. e564-e574

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Acute and long-term effects of Roux-en-Y gastric bypass on glucose metabolism in subjects with Type 2 diabetes and normal glucose tolerance

    Jørgensen, N. B., Jacobsen, S. H., Dirksen, C., Bojsen-Møller, K. N., Naver, L., Hvolris, L., Clausen, T. R., Wulff, B. S., Worm, Dorte, Lindqvist Hansen, D., Madsbad, Sten & Holst, Jens Juul, 2012, In: American Journal of Physiology: Endocrinology and Metabolism. 303, 1, p. E122-31

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Glucose metabolism, gut-brain hormones, and acromegaly treatment: an explorative single centre descriptive analysis

    Jørgensen, N. T., Erichsen, T. M., Jørgensen, M. B., Idorn, T., Feldt-Rasmussen, Bo, Holst, Jens Juul, Feldt-Rasmussen, Ulla & Klose, M., 2023, In: Pituitary. 26, p. 152–163

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    The exaggerated glucagon-like peptide-1 response is important for the improved β-cell function and glucose tolerance after Roux-en-Y gastric bypass in patients with type 2 diabetes

    Jørgensen, N. B., Dirksen, C., Bojsen-Møller, K. N., Jacobsen, S. H., Worm, Dorte, Hansen, D. L., Kristiansen, V. B., Naver, L., Madsbad, Sten & Holst, Jens Juul, 6 May 2013, In: Diabetes. 62, 9, p. 3044-3052 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Sustained Improvements in Glucose Metabolism Late After Roux-En-Y Gastric Bypass Surgery in Patients with and Without Preoperative Diabetes

    Jørgensen, N. B., Bojsen-Møller, K. N., Dirksen, C., Martinussen, C., Svane, M. S., Kristiansen, V. B., Holst, Jens Juul & Madsbad, Sten, 2019, In: Scientific Reports. 9, 1, 10 p., 15154.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Improvements in glucose metabolism early after gastric bypass surgery are not explained by increases in total bile acids and fibroblast growth factor 19 concentrations

    Jørgensen, N. B., Dirksen, C., Bojsen-Møller, K. N., Kristiansen, V. B., Wulff, B. S., Rainteau, D., Humbert, L., Rehfeld, Jens Frederik, Holst, Jens Juul, Madsbad, Sten & Clausen, T. R., Mar 2015, In: The Journal of clinical endocrinology and metabolism. 100, 3, p. E396-406 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    The effects of variations in dose and method of administration on glucagon like peptide-2 activity in the rat

    Kaji, T., Tanaka, H., Holst, Jens Juul, Redstone, H., Wallace, L., Heuval, E. D. & Sigalet, D. L., 2008, In: European Journal of Pharmacology. 596, 1-3, p. 138-145 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    The effects of variations in dose and method of administration on glucagon like peptide-2 activity in the rat

    Kaji, T., Tanaka, H., Holst, Jens Juul, Redstone, H., Wallace, L., de Heuval, E. & Sigalet, D. L., 31 Oct 2008, In: European Journal of Pharmacology. 596, 1-3, p. 138-45 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Nutritional effects of the serial transverse enteroplasty procedure in experimental short bowel syndrome

    Kaji, T., Tanaka, H., Wallace, L. E., Kravarusic, D., Holst, Jens Juul & Sigalet, D. L., 2009, In: European Journal of Pediatric Surgery. Supplement. 44, 8, p. 1552-9 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Temporal changes in the intestinal growth promoting effects of glucagon-like peptide 2 following intestinal resection

    Kaji, T., Tanaka, H., Redstone, H., Wallace, L. E., Holst, Jens Juul & Sigalet, D. L., 2008, In: Journal of Surgical Research. 152, 2, p. 271-80 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Gut transit is associated with gastrointestinal symptoms and gut hormone profile in patients with cirrhosis

    Kalaitzakis, E., Sadik, R., Holst, Jens Juul, Ohman, L. & Björnsson, E., 2008, In: Clinical Gastroenterology and Hepatology. 7, 3, p. 346-52 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Mechanisms of action of a carbohydrate-reduced, high-protein diet in reducing the risk of postprandial hypoglycemia after Roux-en-Y gastric bypass surgery

    Kandel, D., Bojsen-Møller, K. N., Svane, M. S., Samkani, A., Astrup, A., Holst, Jens Juul, Madsbad, Sten & Krarup, T., 2019, In: American Journal of Clinical Nutrition. 110, 2, p. 296-304 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Molecular mechanisms of lipoapoptosis and metformin protection in GLP-1 secreting cells

    Kappe, C., Holst, Jens Juul, Zhang, Q. & Sjöholm, A., 12 Oct 2012, In: Biochemical and Biophysical Research Communications. 427, 1, p. 91-5 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Metformin protects against lipoapoptosis and enhances GLP-1 secretion from GLP-1-producing cells

    Kappe, C., Patrone, C., Holst, Jens Juul, Zhang, Q. & Sjöholm, A., Mar 2013, In: Journal of Gastroenterology. 48, 3, p. 322-32 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Evidence for paracrine/autocrine regulation of GLP-1-producing cells

    Kappe, C., Zhang, Q., Holst, Jens Juul, Nyström, T. & Sjöholm, A., 15 Nov 2013, In: A J P: Cell Physiology (Online). 305, 10, p. C1041-9

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Mechanisms behind the superior effects of interval vs continuous training on glycaemic control in individuals with type 2 diabetes: a randomised controlled trial

    Karstoft, K., Winding, K., Knudsen, S. H., James, N. G., Scheel, M. M., Olesen, J., Holst, Jens Juul, Pedersen, Bente Klarlund & Solomon, T., 2014, In: Diabetologia. 57, 10, p. 2081-2093 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Enteral feeding without pancreatic stimulation.

    Kaushik, N., Pietraszewski, M., Holst, Jens Juul & O'Keefe, S. J. D., 2005, In: Pancreas. 31, 4, p. 353-9 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Addition of rye bran and pea fiber to pork meatballs enhances subjective satiety in healthy men, but does not change glycemic or hormonal responses: A randomized crossover meal test study

    Kehlet, U., Kofod, J., Holst, Jens Juul, Ritz, C., Aaslyng, M. D. & Raben, Anne, 2017, In: Journal of Nutrition. 147, 9, p. 1700-1708 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Mechanisms of gastric emptying disturbances in chronic and acute inflammation of the distal gastrointestinal tract

    Keller, J., Beglinger, C., Holst, Jens Juul, Andresen, V. & Layer, P., Nov 2009, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 297, 5, p. G861-8

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Gastric emptying and disease activity in inflammatory bowel disease

    Keller, J., Binnewies, U., Rösch, M., Holst, Jens Juul, Beglinger, C., Andresen, V. & Layer, P., 2015, In: European Journal of Clinical Investigation. 45, 12, p. 1234-42 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Inhibition of human pancreatic and biliary output but not intestinal motility by physiological intraileal lipid loads.

    Keller, J., Holst, Jens Juul & Layer, P., 2005, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 290, 4, p. G704-9

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Mechanisms of Gastric Emptying Disturbances in Chronic and Acute Inflammation of the Distal Gastrointestinal Tract

    Keller, J., Beglinger, C., Holst, Jens Juul, Andresen, V. & Layer, P., 2009, In: American Journal of Physiology: Gastrointestinal and Liver Physiology.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Incretin and glucagon levels in adult offspring exposed to maternal diabetes in pregnancy

    Kelstrup, L., Clausen, Tine Dalsgaard, Mathiesen, Elisabeth, Hansen, Torben, Holst, Jens Juul & Damm, Peter, 2015, In: Journal of Clinical Endocrinology and Metabolism. 100, 5, p. 1967-75 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Genetic variation within the TRPM5 locus associates with prediabetic phenotypes in subjects at increased risk for type 2 diabetes

    Ketterer, C., Müssig, K., Heni, M., Dudziak, K., Randrianarisoa, E., Wagner, R., Machicao, F., Stefan, N., Holst, Jens Juul, Fritsche, A., Häring, H. & Staiger, H., 2011, In: Metabolism. 60, 9, p. 1325-1333 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Treatment of type 1 diabetic patients with glucagon-like peptide-1 (GLP-1) and GLP-1R agonists

    Kielgast, U., Holst, Jens Juul & Madsbad, Sten, Nov 2009, In: Current Diabetes Reviews. 5, 4, p. 266-75 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Antidiabetic actions of endogenous and exogenous GLP-1 in type 1 diabetic patients with and without residual ß-cell function

    Kielgast, U., Holst, Jens Juul & Madsbad, Sten, May 2011, In: Diabetes. 60, 5, p. 1599-1607 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Four weeks of treatment with liraglutide reduces insulin dose without loss of glycemic control in type 1 diabetic patients with and without residual beta-cell function

    Kielgast, U., Krarup, T., Holst, Jens Juul, Madsbad, Sten & Krarup, T., Jul 2011, In: Diabetes Care. 34, 7, p. 1463-1468 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Effect of glucagon-like peptide-1 on alpha- and beta-cell function in C-peptide-negative type 1 diabetic patients

    Kielgast, U., Asmar, M., Madsbad, Sten & Holst, Jens Juul, 2010, In: Journal of Clinical Endocrinology and Metabolism. 95, 5, p. 2492-6 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Cecal infusion of butyrate increases intestinal cell proliferation in piglets

    Kien, C. L., Blauwiekel, R., Bunn, J. Y., Jetton, T. L., Frankel, W. L. & Holst, Jens Juul, 2007, In: Journal of Nutrition. 137, 4, p. 916-922 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Glucagon-like peptide-1 as a treatment for chemotherapy-induced mucositis

    Kissow, Hannelouise, Hartmann, Bolette, Holst, Jens Juul & Poulsen, Steen Seier, 20 Oct 2012, In: Gut.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Exogenous glucagon-like peptide-2 (GLP-2) prevents chemotherapy-induced mucositis in rat small intestine

    Kissow, Hannelouise, Viby, N., Hartmann, Bolette, Holst, Jens Juul, Timm, M., Thim, L. & Poulsen, Steen Seier, 2012, In: Cancer Chemotherapy and Pharmacology. Supplement. 70, 1, p. 39-48 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Glucagon-like peptide-1 (GLP-1) receptor agonism or DPP-4 inhibition does not accelerate neoplasia in carcinogen treated mice

    Kissow, Hannelouise, Hartmann, Bolette, Holst, Jens Juul, Viby, N., Gasbjerg, Lærke Smidt, Rosenkilde, Mette, Hare, K. J. & Poulsen, Steen Seier, 10 Nov 2012, In: Regulatory Peptides. 179, 1-3, p. 91-100 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Accepted/In press

    Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes

    Kizilkaya, H. S., Sørensen, K. V., Madsen, J. S., Lindquist, P., Douros, J. D., Bork-Jensen, J., Berghella, A., Gerlach, P. A., Gasbjerg, L. S., Mokrosiński, J., Mowery, S. A., Knerr, P. J., Finan, B., Campbell, J. E., D’Alessio, D. A., Perez-Tilve, D., Faas, F., Mathiasen, S., Rungby, J., Sørensen, H. T. & 15 others, Vaag, A., Nielsen, J. S., Holm, Jens-Christian, Lauenborg, J., Damm, Peter, Pedersen, Oluf Borbye, Linneberg, Allan René, Hartmann, Bolette, Holst, Jens Juul, Hansen, Torben, Wright, S. C., Lauschke, V. M., Grarup, N., Hauser, Alexander Sebastian & Rosenkilde, Mette, 2024, (Accepted/In press) In: Nature Metabolism.

    Research output: Contribution to journal › Letter › Research › peer-review

  41. Published

    Neprilysin inhibition increases plasma glucagon concentrations in humans with possible implications for hepatic amino acid metabolism

    Liver-Alpha-Cell Axis Grp, L. A. G., 2020, In: Diabetologia. 63, SUPPL 1, p. S72-S72 1 p., 144.

    Research output: Contribution to journal › Conference abstract in journal › Research

  42. Published

    Development and evaluation of a glucagon sensitivity test

    Kjeldsen, Sasha Alexandra Sampson, Jensen, N. J., Nilsson, M. S. D., Nybing, J. D., Linden, F. H., Hogh-Schmidt, E., Boesen, Mikael Ploug, Madsbad, Sten, Vilstrup, H. V. A., Rashu, E. B., Gluud, Lise Lotte, Haugaard, Steen Bendix, Holst, Jens Juul, Rungby, Jørgen & Albrechtsen, Nicolai Jacob Wewer, 2021, In: Diabetologia. 64, SUPPL 1, p. 189-189 365.

    Research output: Contribution to journal › Conference abstract in journal › Research

  43. Published

    Markers of Glucagon Resistance Improve With Reductions in Hepatic Steatosis and Body Weight in Type 2 Diabetes

    Kjeldsen, Sasha Alexandra Sampson, Thomsen, M. N., Skytte, M. J., Samkani, A., Richter, Michael Martin, Frystyk, J., Magkos, Faidon, Hansen, E., Thomsen, Henrik S., Holst, Jens Juul, Madsbad, Sten, Haugaard, Steen Bendix, Krarup, T. & Albrechtsen, Nicolai Jacob Wewer, 2023, In: Journal of the Endocrine Society. 7, 11, 11 p., bvad122.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Development of a glucagon sensitivity test in humans: Pilot data and the GLUSENTIC study protocol

    Kjeldsen, S. A. S., Richter, M. M., Jensen, N. J., Nilsson, M. S. D., Heinz, N., Nybing, J. D., Linden, F. H., Høgh-Schmidt, E., Boesen, M. P., Madsbad, S., Vilstrup, H., Schiødt, F. V., Møller, A., Nørgaard, K., Schmidt, S., Rashu, E. B., Gluud, L. L., Haugaard, S. B., Holst, J. J., Rungby, J. & 1 others, Albrechtsen, Nicolai Jacob Wewer, 2023, In: Peptides. 161, 10 p., 170938.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Neprilysin Inhibition Increases Glucagon Levels in Humans and Mice With Potential Effects on Amino Acid Metabolism

    Kjeldsen, Sasha Alexandra Sampson, Hansen, L. H., Esser, N., Mongovin, S., Winther-Sørensen, Marie, Galsgaard, Katrine Douglas, Dal, Jenna Elizabeth Hunt, Kissow, Hannelouise, Ceutz, F. R., Terzic, D., Mark, P. D., Plomgaard, Peter Stendahl, Goetze, Jens P. , Goossens, G. H., Blaak, E. E., Deacon, Carolyn F., Rosenkilde, Mette, Zraika, S., Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2021, In: Endocrine Research. 5, 9, 15 p., bvab084.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Neprilysin activity is increased in metabolic dysfunction-associated steatotic liver disease and normalizes after bariatric surgery or GLP-1 therapy

    Kjeldsen, S. A. S., Gluud, L. L., Werge, M. P., Pedersen, J. S., Bendtsen, F., Alexiadou, K., Tan, T., Torekov, S. S., Iepsen, E. W., Jensen, N. J., Richter, M. M., Goetze, J. P., Rungby, J., Hartmann, B., Holst, J. J., Holst, B., Holt, J., Gustafsson, F., Madsbad, S., Svane, M. S. & 2 others, Bojsen-Møller, K. N. & Albrechtsen, Nicolai Jacob Wewer, 2023, In: iScience. 26, 11, 13 p., 108190.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    The influence of GLP-1 on glucose-induced insulin secretion: effect on ß-cells sensitivity in type 2 and non-diabetic subjects

    Kjems, L. L., Holst, Jens Juul, Vølund, A. A. & Madsbad, S., 2003, In: Diabetes. 52, p. 380-386

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    The influence of GLP-1 on glucose-stimulated insulin secretion: effects on beta-cell sensitivity in type 2 and nondiabetic subjects

    Kjems, L. L., Holst, Jens Juul, Vølund, A. & Madsbad, Sten, Feb 2003, In: Diabetes. 52, 2, p. 380-6 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Increased intensity of physical activity stimulates subsequent fat intake

    Klausen, B., Toubro, S., Ranneries, C., Rehfeld, J. F., Holst, Jens Juul, Christensen, N. J. & Astrup, A., 1999, In: International Journal of Obesity. 23, p. 1282-1287

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Exenatide once weekly for alcohol use disorder investigated in a randomized, placebo-controlled clinical trial

    Klausen, M. K., Jensen, M. E., Møller, M., le Dous, N., Jensen, A-M. Ø., Zeeman, V. A., Johannsen, C-F., Lee, A. M., Thomsen, G. K., Macoveanu, J., Fisher, P. M., Gillum, M. P., Jørgensen, N. R., Bergmann, M. L., Enghusen Poulsen, H., Becker, U., Holst, J. J., Benveniste, H., Volkow, N. D., Vollstädt-Klein, S. & 5 others, Miskowiak, Kamilla, Ekstrøm, Claus Thorn, Knudsen, Gitte Moos, Visboll, T. & Fink-Jensen, Anders, 2022, In: JCI insight. 19, 20 p., e159863.

    Research output: Contribution to journal › Journal article › Research › peer-review

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