Thomas Mandrup-Poulsen

Thomas Mandrup-Poulsen

Professor

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    1. Published

      Age-dependent transition from islet insulin hypersecretion to hyposecretion in mice with the long QT-syndrome loss-of-function mutation Kcnq1-A340V

      Lubberding, Anniek Frederike, Zhang, J., Lundh, M., Nielsen, Thomas Svava, Søndergaard, M. S., Villadsen, M., Skovhøj, E. Z., Boer, G. A., Hansen, J. B., Thomsen, Morten Bækgaard, Treebak, Jonas Thue, Holst, Jens Juul, Kanters, Jørgen K., Mandrup-Poulsen, Thomas, Jespersen, Thomas, Emanuelli, Brice & Torekov, Signe Sørensen, 2021, In: Scientific Reports. 11, 1, 14 p., 12253.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Celebrities in the heart, strangers in the pancreatic beta cell: Voltage-gated potassium channels Kv7.1 and Kv11.1 bridge long QT syndrome with hyperinsulinaemia as well as type 2 diabetes

      Lubberding, Anniek Frederike, Juhl, C. R., Skovhøj, Emil Zeng, Kanters, Jørgen K., Mandrup-Poulsen, Thomas & Torekov, Signe Sørensen, 2022, In: Acta Physiologica. 234, 3, 18 p., 13781.

      Research output: Contribution to journal › Review › Research › peer-review

    3. Published

      Lysine deacetylases are produced in pancreatic beta cells and are differentially regulated by proinflammatory cytokines

      Lundh, M., Christensen, D. P., Rasmussen, D. N., Mascagni, P., Dinarello, C. A., Billestrup, Nils, Grunnet, L. G. & Mandrup-Poulsen, Thomas, 1 Dec 2010, In: Diabetologia. 53, 12, p. 2569-78 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children

      Lundh, M., Christensen, D. P., Damgaard Nielsen, M., Richardson, S. J., Dahllöf, M. S., Skovgaard, T., Berthelsen, J., Dinarello, C. A., Stevenazzi, A., Mascagni, P., Grunnet, Louise Groth, Morgan, N. G. & Mandrup-Poulsen, Thomas, 2012, In: Diabetologia. 55, 9, p. 2421-31

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      HDAC3 inhibition rescues pancreatic beta cells from glucolipotoxicity and improves insulin secretion in obese diabetic rats

      Lundh, M., Galbo, T., Wagner, F. F., Christensen, D. P., Walpita, D., Gale, J. P., Zhang, Y., Hooker, J., Shulman, G. I., Mandrup-Poulsen, Thomas, Holson, E. B. & Wagner, B. K., Sep 2013, In: Diabetologia. 56, 1 suppl, p. S219-S219

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Small-molecule inhibition of inflammatory β-cell death

      Lundh, M., Scully, S. S., Mandrup-Poulsen, Thomas & Wagner, B. K., Sep 2013, In: Diabetes, Obesity and Metabolism Online. 15 , 3, p. 176-84 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Histone deacetylase 3 inhibition improves glycaemia and insulin secretion in obese diabetic rats

      Lundh, M., Galbo, T., Poulsen, Steen Seier & Mandrup-Poulsen, Thomas, Jul 2015, In: Diabetes, Obesity and Metabolism. 17, 7, p. 703-7 5 p.

      Research output: Contribution to journal › Letter › Research › peer-review

    8. Published

      The immunoproteasome is induced by cytokines and regulates apoptosis in human islets

      Lundh, M., Bugliani, M., Dahlby, T., Chou, D. H., Wagner , B., Ghiasi, S. M., De Tata, V., Chen, Z., Lund, Marianne N., Davies, Michael J., Marchetti, P. & Mandrup-Poulsen, Thomas, 2017, In: Journal of Endocrinology. 233, 3, p. 369-379 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets.

      Maedler, K., Størling, J., Sturis, J., Zuellig, R. A., Spinas, G. A., Arkhammar, P. O. G., Mandrup-Poulsen, Thomas & Donath, M. Y., 2004, In: Diabetes. 53, 7, p. 1706-13 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      (19)F-heptuloses as tools for the non-invasive imaging of GLUT2-expressing cells

      Malaisse, W. J., Zhang, Y., Louchami, K., Sharma, S., Dresselaers, T., Himmelreich, U., Novotny, G. W., Mandrup-Poulsen, Thomas, Waschke, D., Leshch, Y., Thimm, J., Thiem, J. & Sener, A., 2012, In: Archives of Biochemistry and Biophysics. 517, 2, p. 138-43 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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