Jens Juul Holst
Professor
Endocrinology and Metabolism
Blegdamsvej 3
2200 København N.
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Differential action of TGR5 agonists on GLP-2 secretion and promotion of intestinal adaptation in a piglet short bowel model
Lin, S., Stoll, B., Robinson, J., Pastor, J. J., Marini, J. C., Ipharraguerre, I. R., Hartmann, Bolette, Holst, Jens Juul, Cruz, S., Lau, P., Olutoye, O., Fang, Z. & Burrin, D. G., May 2019, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 316, 5, p. G641-G652Research output: Contribution to journal › Journal article › Research › peer-review
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Copeptin, a surrogate marker for arginine vasopressin secretion, is positively associated with glucagon
Lundegaard Asferg, C., Bjørn Andersen, U., Linneberg, Allan René, Goetze, Jens P. , Holst, Jens Juul & Jeppesen, J. L., 2019, In: Diabetic Medicine. 36, 11, p. 1408-1411 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Greater glucagon-like peptide-1 responses to oral glucose are associated with lower central and peripheral blood pressures
Lundgren, J. R., Faerch, K., Witte, D. R., Jonsson, Anna Elisabet, Pedersen, Oluf Borbye, Hansen, Torben, Lauritzen, T., Holst, Jens Juul, Vistisen, D., Jorgensen, M. E., Torekov, Signe Sørensen & Johansen, N. B., 2019, In: Cardiovascular Diabetology. 18, 1, 9 p., 130.Research output: Contribution to journal › Journal article › Research › peer-review
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Mechanisms preserving insulin action during high dietary fat intake
Lundsgaard, Anne-Marie, Holm, J. B., Sjøberg, K. A., Bojsen-Møller, K. N., Myrmel, L. S., Fjære, E., Jensen, Benjamin Anderschou Holbech, Nicolaisen, T. S., Hingst, J. R., Hansen, S. L., Doll, S., Geyer, P. E., Deshmukh, Atul Shahaji, Holst, Jens Juul, Madsen, L., Kristiansen, Karsten, Wojtaszewski, Jørgen F P, Richter, Erik A. & Kiens, Bente, 2019, In: Cell Metabolism. 29, 1, p. 50-63, e1-e4 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Assessment of Islet Alphaand beta-cell function
Madsbad, Sten & Holst, Jens Juul, 2019, Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease: A Focus on Early Phase Clinical Drug Development. Springer, p. 37-74 38 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Bariatric surgery-which procedure is the optimal choice?
Madsbad, Sten & Holst, Jens Juul, 2019, In: Lancet. 393, 10178, p. 1263-1264Research output: Contribution to journal › Comment/debate › Research
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Gastrointestinal motility, gut hormone secretion, and energy intake after oral loads of free fatty acid or triglyceride in older and middle-aged men
Madsen, J. L., Damgaard, Morten, Fuglsang, S., Dirksen, C., Holst, Jens Juul & Graff, J., 2019, In: Appetite. 132, p. 18-24 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Augmented GLP-1 Secretion as Seen After Gastric Bypass May Be Obtained by Delaying Carbohydrate Digestion
Martinussen, C., Bojsen-Møller, K. N., Dirksen, C., Svane, M. S., Kristiansen, V. B., Hartmann, Bolette, Holst, Jens Juul & Madsbad, Sten, Aug 2019, In: Journal of Clinical Endocrinology and Metabolism. 104, 8, p. 3233–3244Research output: Contribution to journal › Journal article › Research › peer-review
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Bile Modulates Secretion of Incretins and Insulin: A Study of Human Extrahepatic Cholestasis
Mezza, T., Moffa, S., Ferraro, P. M., Quero, G., Capece, U., Carfi, A., Cefalo, C. M. A., Cinti, F., Sorice, G. P., Impronta, F., Mari, A., Pontecorvi, A., Alfieri, S., Holst, Jens Juul & Giaccari, A., 2019, In: Journal of Clinical Endocrinology & Metabolism. 104, 7, p. 2685-2694Research output: Contribution to journal › Journal article › Research › peer-review
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Peptone-mediated glucagon-like peptide-1 secretion depends on intestinal absorption and activation of basolaterally located Calcium-Sensing Receptors
Modvig, Ida Marie, Kuhre, Rune Ehrenreich & Holst, Jens Juul, Apr 2019, In: Physiological Reports. 7, 8, 13 p., e14056.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucose homeostasis in statin users-The LIFESTAT study
Morville, T., Dohlmann, T., Kuhlman, A. B., Monberg, T., Torp, M., Hartmann, Bolette, Holst, Jens Juul, Larsen, Steen, Helge, Jørn Wulff & Dela, Flemming, 2019, In: Diabetes - Metabolism: Research and Reviews (Print Edition). 35, 3, 9 p., e3110.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon-like peptide 1 (GLP-1)
Mueller, T. D., Finan, B., Bloom, S. R., D'Alessio, D., Drucker, D. J., Flatt, P. R., Fritsche, A., Gribble, F., Grill, H. J., Habener, J. F., Holst, J. J., Langhans, W., Meier, J. J., Nauck, M. A., Perez-Tilve, D., Pocai, A., Reimann, F., Sandoval, D. A., Schwartz, T. W., Seeley, R. J. & 5 others, , 2019, In: Molecular Metabolism. 30, p. 72-130Research output: Contribution to journal › Review › Research › peer-review
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Plasma FGF-19 Levels are Increased in Patients with Post-Bariatric Hypoglycemia
Mulla, C. M., Goldfine, A. B., Dreyfuss, J. M., Houten, S., Pan, H., Pober, D. M., Albrechtsen, Nicolai Jacob Wewer, Svane, M. S., Schmidt, J. B., Holst, Jens Juul, Craig, C. M., McLaughlin, T. L. & Patti, M., 2019, In: Obesity Surgery. 29, 7, p. 2092-2099Research output: Contribution to journal › Journal article › Research › peer-review
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Circulating but not faecal short-chain fatty acids are related to insulin sensitivity, lipolysis and GLP-1 concentrations in humans
Muller, M., Hernandez, M. A. G., Goossens, G. H., Reijnders, D., Holst, Jens Juul, Jocken, J. W. E., van Eijk, H., Canfora, E. E. & Blaak, E. E., 2019, In: Scientific Reports. 9, 9 p., 12515.Research output: Contribution to journal › Journal article › Research › peer-review
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Glepaglutide, a novel long-acting glucagon-like peptide-2 analogue, for patients with short bowel syndrome: a randomised phase 2 trial
Naimi, R. M., Hvistendahl, M., Enevoldsen, L. H., Madsen, J. L., Fuglsang, S., Poulsen, Steen Seier, Kissow, Hannelouise, Pedersen, Jens, Nerup, N., Ambrus, R., Achiam, Michael Patrick, Svendsen, L. B., Holst, Jens Juul, Hartmann, Bolette, Hansen, S. H., Dragsted, Lars Ove, Steensberg, A., Mouritzen, U., Hansen, M. B. & Jeppesen, Palle Bekker, 2019, In: The Lancet Gastroenterology and Hepatology. 4, 5, p. 354-363 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The effect of DPP-4-protected GLP-1 (7-36) on coronary microvascular function in obese adults
Nilsson, M., Bové, K. B., Suhrs, E., Hermann, T., Madsbad, Sten, Holst, Jens Juul, Prescott, Eva & Zander, M., Mar 2019, In: IJC Heart and Vasculature. 22, p. 139-144Research output: Contribution to journal › Journal article › Research › peer-review
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A Pilot Study Showing Acute Inhibitory Effect of GLP-1 on the Bone Resorption Marker CTX in Humans
Nissen, A., Marstrand, S., Skov-Jeppesen, Kirsa, Bremholm, L., Hornum, Mads, Andersen, U. B., Holst, Jens Juul, Rosenkilde, M. M. & Hartmann, Bolette, 2019, In: JBMR Plus. 3, 10, 6 p., e10209.Research output: Contribution to journal › Journal article › Research › peer-review
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Plasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease
Niu, Lili, Geyer, P. E., Albrechtsen, Nicolai Jacob Wewer, Gluud, Lise Lotte, Santos, A., Doll, S., Treit, P. V., Holst, Jens Juul, Knop, Filip Krag, Vilsbøll, Tina, Junker, A., Sachs, S., Stemmer, K., Müller, T. D., Tschöp, M. H., Hofmann, S. M. & Mann, Matthias, 2019, In: Molecular Systems Biology. 15, 16 p., e8793.Research output: Contribution to journal › Journal article › Research › peer-review
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Plasma proteome profiling discovers potential biomarkers of non-alcoholic fatty liver disease
Niu, Lili, Gupta, R., Geyer, P. E., Albrechtsen, Nicolai Jacob Wewer, Gluud, Lise Lotte, Santos, A., Doll, S., Holst, Jens Juul, Knop, Filip Krag, Vilsbøll, Tina, Junker, A., Sachs, S., Stemmer, K., Mueller, T. D., Tschoep, M. H., Hofmann, S. M. & Mann, Matthias, Aug 2019, In: Molecular & Cellular Proteomics. 18, 8, p. S71 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
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Are early dumping and postprandial hypoglycaemia after Roux-en-Y gastric bypass related events? [Meeting Abstract}
Ohrstrom, C. C., Hansen, D. L., Holst, Jens Juul, Kielgast, U. L. & Worm, Dorte, 2019, In: Diabetologia. 62, Supl. 1/SI, p. S48-S48 92.Research output: Contribution to journal › Conference abstract in journal › Research
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Postprandial hypoglycaemia after Roux-en-Y gastric bypass and the effects of acarbose, sitagliptin, verapamil, liraglutide and pasireotide
Ohrstrom, C. C., Worm, Dorte, Hojager, A., Andersen, D., Holst, Jens Juul, Kielgast, U. L. & Hansen, D. L., 2019, In: Diabetes, Obesity and Metabolism. 21, 9, p. 2142-2151Research output: Contribution to journal › Journal article › Research › peer-review
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Postprandial levels of GLP-1, GIP and glucagon after 2 years of weight loss with a Paleolithic diet: a randomised controlled trial in healthy obese women
Otten, J., Ryberg, M., Mellberg, C., Andersson, T., Chorell, E., Lindahl, B., Larsson, C., Holst, Jens Juul & Olsson, T., 2019, In: European Journal of Endocrinology. 180, 6, p. 417-427Research output: Contribution to journal › Journal article › Research › peer-review
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Gut hormone release after gastric bypass depends on the length of the biliopancreatic limb
Patrício, B. G., Morais, T., Guimarães, M., Veedfald, Simon, Hartmann, Bolette, Hilsted, Linda, Holst, Jens Juul, Nora, M. & Monteiro, M. P., 1 May 2019, In: International Journal of Obesity. 43, 5, p. 1009-1018Research output: Contribution to journal › Journal article › Research › peer-review
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Biliopancreatic diversion with duodenal switch (BPD-DS) and single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) result in distinct post-prandial hormone profiles
Pereira, S. S., Guimarães, M., Almeida, R., Pereira, A. M., Lobato, C. B., Hartmann, Bolette, Hilsted, Linda, Holst, Jens Juul, Nora, M. & Monteiro, M. P., 2019, In: International Journal of Obesity. 43, p. 2518-2527Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of active commuting and leisure-time exercise on appetite in individuals with overweight and obesity
Quist, Jonas Salling, Blond, Martin Bæk, Gram, A. S., Steenholt, C. B., Janus, C., Holst, Jens Juul, Rehfeld, Jens Frederik, Sjödin, Anders Mikael, Stallknecht, Bente Merete & Rosenkilde, M., 2019, In: Journal of Applied Physiology. 126, 4, p. 941-951Research output: Contribution to journal › Journal article › Research › peer-review
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Whole grain-rich diet reduces body weight and systemic low-grade inflammation without inducing major changes of the gut microbiome: a randomised cross-over trial
Roager, H. M., Vogt, J. K., Kristensen, M. B., Hansen, L. B. S., Ibrügger, S., Mærkedahl, R. B., Bahl, M. I., Lind, M. V., Nielsen, R. L., Frøkiær, H., Gøbel, R. J., Landberg, R., Ross, A. B., Brix, S., Holck, J., Meyer, A. S., Sparholt, M. H., Christensen, A. F., Carvalho, V., Hartmann, B. & 18 others, , Jan 2019, In: Gut. 68, 1, p. 83-93 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones
Rudenko, Olga, Shang, J., Munk, A., Ekberg, J. P., Petersen, N., Engelstoft, M. S., Egerod, Kristoffer Lihme, Hjorth, Siv Annegrethe, Wu, M., Feng, Y., Zhou, Y., Mokrosinski, J., Thams, P., Reimann, F., Gribble, F., Rehfeld, Jens Frederik, Holst, Jens Juul, Treebak, Jonas Thue, Howard, A. D. & Schwartz, Thue W., 2019, In: Molecular Metabolism. 19, p. 49-64 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Gut Hormones and Their Effect on Bone Metabolism. Potential Drug Therapies in Future Osteoporosis Treatment
Schiellerup, S. P., Skov-Jeppesen, Kirsa, Windeløv, Johanne Agerlin, Svane, M. S., Holst, Jens Juul, Hartmann, Bolette & Rosenkilde, Mette, 2019, In: Frontiers in Endocrinology. 10, 13 p., 75.Research output: Contribution to journal › Review › Research › peer-review
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GLP-2 and GIP exert separate effects on bone turnover: A randomized, placebo-controlled, crossover study in healthy young men
Skov-Jeppesen, Kirsa, Svane, M. S., Martinussen, C., Gabe, M. B. N., Gasbjerg, Lærke Smidt, Veedfald, Simon, Bojsen-Møller, K. N., Madsbad, Sten, Holst, Jens Juul, Rosenkilde, Mette & Hartmann, Bolette, 2019, In: Bone. 125, p. 178-185Research output: Contribution to journal › Journal article › Research › peer-review
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A carbohydrate-reduced high-protein diet improves HbA1c and liver fat content in weight stable participants with type 2 diabetes: a randomised controlled trial
fbg982, fbg982, Samkani, A., Petersen, A. D., Thomsen, M. N., Astrup, A., Chabanova, E., Frystyk, J., Holst, Jens Juul, Thomsen, Henrik S., Madsbad, Sten, Larsen, T. M., Haugaard, Steen Bendix & Krarup, T., 2019, In: Diabetologia. 62, 11, p. 2066-2078 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Preserved glucose response to low-dose glucagon after exercise in insulin-pump-treated individuals with type 1 diabetes: a randomised crossover study
Steineck, I. I. K., Ranjan, A., Schmidt, S., Clausen, T. R., Holst, Jens Juul & Nørgaard, Kirsten, 2019, In: Diabetologia. 62, 4, p. 582-592Research output: Contribution to journal › Journal article › Research › peer-review
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Gastric Emptying and Distal Gastrectomy Independently Enhance Postprandial Glucagon-Like Peptide-1 Release After a Mixed Meal and Improve Glycemic Control in Subjects Having Undergone Pancreaticoduodenectomy
Steiner, E., Breuer, R., Kazianka, L., Wewalka, M., Stimpfl, T., Reiter, B., Holst, Jens Juul & Miholic, J., 2019, In: Pancreas. 48, 7, p. 953-957Research output: Contribution to journal › Journal article › Research › peer-review
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Endogenous glucose-dependent insulinotropic polypeptide exerts diverging and tissue specific in obese patients with type 2 diabetes
Stensen, S., Gasbjerg, Lærke Smidt, Krogh, L. L., wbf943, wbf943, Skov-Jeppesen, Kirsa, Jensen, M. H., Hartmann, Bolette, Vilsbøll, Tina, Holst, Jens Juul, Rosenkilde, Mette, Christensen, M. B. & Knop, Filip Krag, 2019, In: Diabetologia. 62, Supl. 1/SI, p. S270-S271 2 p., 560.Research output: Contribution to journal › Conference abstract in journal › Research
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Effect of liraglutide on body weight and microvascular function in non-diabetic overweight women with coronary microvascular dysfunction
Suhrs, H. E., Raft, K. F., Bové, K., Madsbad, Sten, Holst, Jens Juul, Zander, M. & Prescott, Eva, 2 Jan 2019, In: International Journal of Cardiology. 283, p. 28-34Research output: Contribution to journal › Journal article › Research › peer-review
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Postprandial Nutrient Handling and Gastrointestinal Hormone Secretion After Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy
Svane, M. S., Bojsen-Moller, K. N., Martinussen, C., Dirksen, C., Madsen, J. L., Reitelseder, S., Holm, L., Rehfeld, Jens Frederik, Kristiansen, V. B., van Hall, Gerrit, Holst, Jens Juul & Madsbad, Sten, 2019, In: Gastroenterology. 156, 6, p. 1627-1641Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of glucagon-like peptide 1 analogs on alcohol intake in alcohol-preferring vervet monkeys
Thomsen, M., Holst, Jens Juul, Molander, A., Linnet, Kristian, Ptito, M. & Fink-Jensen, Anders, Feb 2019, In: Psychopharmacology. 236, 2, p. 603–611Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of a high-protein/moderate-carbohydrate diet on appetite, gut peptides, and endocannabinoids: A Preview study
Tischmann, L., Drummen, M., Gatta-Cherifi, B., Raben, Anne, Fogelholm, M., Hartmann, Bolette, Holst, Jens Juul, Matias, I., Cota, D., Mensink, R. P., Peters, J., Westerterp-Plantenga, M. S. & Adam, T. C., 2019, In: Nutrients. 11, 16 p., 2269.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucose homeostasis and the gastrointestinal tract
Veedfald, Simon, Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 2019, Molecular Nutrition Carbohydrates. Elsevier, p. 3-19 17 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Acipimox Acutely Increases GLP-1 Concentrations in Overweight Subjects and Hypopituitary Patients
Vestergaard, E. T., Hjelholt, A. J., Kuhre, Rune Ehrenreich, Møller, N., Larraufie, P., Gribble, F. M., Reimann, F., Jessen, N., Holst, Jens Juul & Jørgensen, J. O. L., 2019, In: The Journal of clinical endocrinology and metabolism. 104, 7, p. 2581-2592Research output: Contribution to journal › Journal article › Research › peer-review
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The liver-alpha cell axis and type 2 diabetes
Albrechtsen, Nicolai Jacob Wewer, Pedersen, Jens, Galsgaard, Katrine Douglas, Winther-Sørensen, Marie, Suppli, M. P., Janah, L., Gromada, J., Vilstrup, H., Knop, Filip Krag & Holst, Jens Juul, 2019, In: Endocrine Reviews. 40, 5, p. 1353-1366Research output: Contribution to journal › Review › Research › peer-review
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Sacubitril/Valsartan Augments Postprandial Plasma Concentrations of Active GLP-1 When Combined With Sitagliptin in Men
Albrechtsen, Nicolai Jacob Wewer, Mark, P. D., Terzic, D., Hansen, L. H., Andersen, U. Ø., Hartmann, Bolette, Carr, R. D., Gustafsson, Finn, Deacon, Carolyn F., Holst, Jens Juul, Goetze, Jens P. & Plomgaard, Peter Stendahl, 2019, In: Journal of Clinical Endocrinology and Metabolism. 104, 9, p. 3868-3876Research output: Contribution to journal › Journal article › Research › peer-review
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Short-chain fatty acids and regulation of pancreatic endocrine secretion in mice
Ørgaard, A., Jepsen, Sara Lind & Holst, Jens Juul, 2019, In: Islets. 11, 5, p. 103-111Research output: Contribution to journal › Journal article › Research › peer-review
ID: 4207
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Meal induced gut hormone secretion is altered in aerobically trained compared to sedentary young healthy males
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2909
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Copenhagen study of overweight patients with coronary artery disease undergoing low energy diet or interval training: the randomized CUT-IT trial protocol
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694
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Whole grain-rich diet reduces body weight and systemic low-grade inflammation without inducing major changes of the gut microbiome: a randomised cross-over trial
Research output: Contribution to journal › Journal article › Research › peer-review
Published