Visualizing Bacterial Infections With Novel Targeted Molecular Imaging Approaches
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Visualizing Bacterial Infections With Novel Targeted Molecular Imaging Approaches. / Chen, Xueyi; Gallagher, Ferdia; Sellmyer, Mark A.; Ordonez, Alvaro A.; Kjaer, Andreas; Ohliger, Michael; Wilson, David M.; Jain, Sanjay K.
In: The Journal of Infectious Diseases, Vol. 228, No. 4, 2023, p. S249-S258.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Visualizing Bacterial Infections With Novel Targeted Molecular Imaging Approaches
AU - Chen, Xueyi
AU - Gallagher, Ferdia
AU - Sellmyer, Mark A.
AU - Ordonez, Alvaro A.
AU - Kjaer, Andreas
AU - Ohliger, Michael
AU - Wilson, David M.
AU - Jain, Sanjay K.
N1 - Publisher Copyright: © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
PY - 2023
Y1 - 2023
N2 - Although nearly a century has elapsed since the discovery of penicillin, bacterial infections remain a major global threat. Global antibiotic use resulted in an astounding 42 billion doses of antibiotics administered in 2015 with 128 billion annual doses expected by 2030. This overuse of antibiotics has led to the selection of multidrug-resistant "super-bugs," resulting in increasing numbers of patients being susceptible to life-threatening infections with few available therapeutic options. New clinical tools are therefore urgently needed to identify bacterial infections and monitor response to antibiotics, thereby limiting overuse of antibiotics and improving overall health. Next-generation molecular imaging affords unique opportunities to target and identify bacterial infections, enabling spatial characterization as well as noninvasive, temporal monitoring of the natural course of the disease and response to therapy. These emerging noninvasive imaging approaches could overcome several limitations of current tools in infectious disease, such as the need for biological samples for testing with their associated sampling bias. Imaging of living bacteria can also reveal basic biological insights about their behavior in vivo.
AB - Although nearly a century has elapsed since the discovery of penicillin, bacterial infections remain a major global threat. Global antibiotic use resulted in an astounding 42 billion doses of antibiotics administered in 2015 with 128 billion annual doses expected by 2030. This overuse of antibiotics has led to the selection of multidrug-resistant "super-bugs," resulting in increasing numbers of patients being susceptible to life-threatening infections with few available therapeutic options. New clinical tools are therefore urgently needed to identify bacterial infections and monitor response to antibiotics, thereby limiting overuse of antibiotics and improving overall health. Next-generation molecular imaging affords unique opportunities to target and identify bacterial infections, enabling spatial characterization as well as noninvasive, temporal monitoring of the natural course of the disease and response to therapy. These emerging noninvasive imaging approaches could overcome several limitations of current tools in infectious disease, such as the need for biological samples for testing with their associated sampling bias. Imaging of living bacteria can also reveal basic biological insights about their behavior in vivo.
KW - Staphylococcus aureus
KW - AMR
KW - Enterobacterales
KW - pathogen-specific
KW - PET
UR - http://www.scopus.com/inward/record.url?scp=85173016679&partnerID=8YFLogxK
U2 - 10.1093/infdis/jiad078
DO - 10.1093/infdis/jiad078
M3 - Journal article
C2 - 37788506
AN - SCOPUS:85173016679
VL - 228
SP - S249-S258
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 4
ER -
ID: 369866230