The role of hypothiocyanous acid (HOSCN) in biological systems
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The role of hypothiocyanous acid (HOSCN) in biological systems. / Hawkins, Clare L.
In: Free Radical Research, Vol. 43, No. 12, 12.2009, p. 1147-58.Research output: Contribution to journal › Journal article › Commissioned › peer-review
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TY - JOUR
T1 - The role of hypothiocyanous acid (HOSCN) in biological systems
AU - Hawkins, Clare L
PY - 2009/12
Y1 - 2009/12
N2 - Hypohalous acids (HOX), produced by peroxidase-catalysed reactions of halide and pseudohalide ions with H(2)O(2), play an important role in the human immune system. However, there is compelling evidence that these oxidants also mediate host tissue damage and contribute to the progression of a number of inflammatory diseases. Although it is well established that significant amounts of hypothiocyanous acid (HOSCN) are formed under physiological conditions, the reactions of this oxidant with host biological systems are relatively poorly characterized. It is generally accepted that HOSCN is a mild oxidant that reacts selectively with thiols. However, it is becoming increasingly recognized that this selectivity can result in the induction of significant cellular damage, which may contribute to disease. This review will outline the formation and reactivity of HOSCN and the role of this oxidant in biological systems.
AB - Hypohalous acids (HOX), produced by peroxidase-catalysed reactions of halide and pseudohalide ions with H(2)O(2), play an important role in the human immune system. However, there is compelling evidence that these oxidants also mediate host tissue damage and contribute to the progression of a number of inflammatory diseases. Although it is well established that significant amounts of hypothiocyanous acid (HOSCN) are formed under physiological conditions, the reactions of this oxidant with host biological systems are relatively poorly characterized. It is generally accepted that HOSCN is a mild oxidant that reacts selectively with thiols. However, it is becoming increasingly recognized that this selectivity can result in the induction of significant cellular damage, which may contribute to disease. This review will outline the formation and reactivity of HOSCN and the role of this oxidant in biological systems.
KW - Animals
KW - Apoptosis
KW - Humans
KW - Oxidants
KW - Oxidative Stress
KW - Thiocyanates
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
KW - Review
M3 - Journal article
C2 - 19905977
VL - 43
SP - 1147
EP - 1158
JO - Free Radical Research
JF - Free Radical Research
SN - 1071-5762
IS - 12
ER -
ID: 174497579