Parenteral nutrition impairs plasma bile acid and gut hormone responses to mixed meal testing in lean healthy men
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Parenteral nutrition impairs plasma bile acid and gut hormone responses to mixed meal testing in lean healthy men. / Meessen, Emma C.E.; Bakker, Guido J.; Nieuwdorp, Max; Dallinga-Thie, Geesje M.; Kemper, E. Marleen; Olde Damink, Steven W.; Romijn, Johannes A.; Hartmann, Bolette; Holst, Jens J.; Knop, Filip K.; Groen, Albert K.; Schaap, Frank G.; Soeters, Maarten R.
In: Clinical Nutrition, Vol. 40, No. 3, 2021, p. 1013-1021.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Parenteral nutrition impairs plasma bile acid and gut hormone responses to mixed meal testing in lean healthy men
AU - Meessen, Emma C.E.
AU - Bakker, Guido J.
AU - Nieuwdorp, Max
AU - Dallinga-Thie, Geesje M.
AU - Kemper, E. Marleen
AU - Olde Damink, Steven W.
AU - Romijn, Johannes A.
AU - Hartmann, Bolette
AU - Holst, Jens J.
AU - Knop, Filip K.
AU - Groen, Albert K.
AU - Schaap, Frank G.
AU - Soeters, Maarten R.
PY - 2021
Y1 - 2021
N2 - Background & aims: To investigate the acute effects of intravenous vs enteral meal administration on circulating bile acid and gut hormone responses. Methods: In a randomized crossover design, we compared the effects of duodenal (via a nasoduodenal tube) vs parenteral (intravenous) administration over 180 min of identical mixed meals on circulating bile acid and gut hormone concentrations in eight healthy lean men. We analysed the bile acid and gut hormone responses in two periods: the intraprandial period from time point (T) 0 until T180 during meal administration and the postprandial period from T180 until T360, after discontinuation of meal administration. Results: Intravenous meal administration decreased the intraprandial (AUC (μmol/L∗min) duodenal 1469 ± 284 vs intravenous 240 ± 39, p < 0.01) and postprandial bile acid response (985 ± 240 vs 223 ± 5, p < 0.05) and was accompanied by decreased gut hormone responses including glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, glucagon-like peptide 2 and fibroblast growth factor 19. Furthermore, intravenous meal administration elicited greater glucose concentrations, but similar insulin concentrations compared to enteral administration. Conclusions: Compared to enteral administration, parenteral nutrition results in lower postprandial bile acid and gut hormone responses in healthy lean men. This was accompanied by higher glucose concentrations in the face of similar insulin concentrations exposing a clear incretin effect of enteral mixed meal administration. The alterations in bile acid homeostasis were apparent after only one intravenous meal.
AB - Background & aims: To investigate the acute effects of intravenous vs enteral meal administration on circulating bile acid and gut hormone responses. Methods: In a randomized crossover design, we compared the effects of duodenal (via a nasoduodenal tube) vs parenteral (intravenous) administration over 180 min of identical mixed meals on circulating bile acid and gut hormone concentrations in eight healthy lean men. We analysed the bile acid and gut hormone responses in two periods: the intraprandial period from time point (T) 0 until T180 during meal administration and the postprandial period from T180 until T360, after discontinuation of meal administration. Results: Intravenous meal administration decreased the intraprandial (AUC (μmol/L∗min) duodenal 1469 ± 284 vs intravenous 240 ± 39, p < 0.01) and postprandial bile acid response (985 ± 240 vs 223 ± 5, p < 0.05) and was accompanied by decreased gut hormone responses including glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, glucagon-like peptide 2 and fibroblast growth factor 19. Furthermore, intravenous meal administration elicited greater glucose concentrations, but similar insulin concentrations compared to enteral administration. Conclusions: Compared to enteral administration, parenteral nutrition results in lower postprandial bile acid and gut hormone responses in healthy lean men. This was accompanied by higher glucose concentrations in the face of similar insulin concentrations exposing a clear incretin effect of enteral mixed meal administration. The alterations in bile acid homeostasis were apparent after only one intravenous meal.
KW - Bile acids
KW - Fibroblast growth factor 19
KW - Glucagon-like peptide 1
KW - Mixed meal test
KW - Parenteral nutrition
KW - Postprandial
U2 - 10.1016/j.clnu.2020.06.032
DO - 10.1016/j.clnu.2020.06.032
M3 - Journal article
C2 - 32747206
AN - SCOPUS:85088866584
VL - 40
SP - 1013
EP - 1021
JO - Clinical Nutrition
JF - Clinical Nutrition
SN - 0261-5614
IS - 3
ER -
ID: 251689513