Infrared thermographic assessment of changes in skin temperature during hypoglycaemia in patients with type 1 diabetes
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Infrared thermographic assessment of changes in skin temperature during hypoglycaemia in patients with type 1 diabetes. / Sejling, Anne-Sophie; Lange, Kai H W; Frandsen, Christian S; Diemar, Sarah S; Tarnow, Lise; Faber, Jens; Holst, Jens J; Hartmann, Bolette; Hilsted, Linda; Kjaer, Troels W; Juhl, Claus B; Thorsteinsson, Birger; Pedersen-Bjergaard, Ulrik.
In: Diabetologia, Vol. 58, 2015, p. 1898–1906.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Infrared thermographic assessment of changes in skin temperature during hypoglycaemia in patients with type 1 diabetes
AU - Sejling, Anne-Sophie
AU - Lange, Kai H W
AU - Frandsen, Christian S
AU - Diemar, Sarah S
AU - Tarnow, Lise
AU - Faber, Jens
AU - Holst, Jens J
AU - Hartmann, Bolette
AU - Hilsted, Linda
AU - Kjaer, Troels W
AU - Juhl, Claus B
AU - Thorsteinsson, Birger
AU - Pedersen-Bjergaard, Ulrik
PY - 2015
Y1 - 2015
N2 - AIMS/HYPOTHESIS: Hypoglycaemia is associated with reduced skin temperature (Ts). We studied whether infrared thermography can detect Ts changes during hypoglycaemia in patients with type 1 diabetes and how the Ts response differs between patients with normal hypoglycaemia awareness and hypoglycaemia unawareness.METHODS: Twenty-four patients with type 1 diabetes (ten aware, 14 unaware) were studied during normoglycaemia (5.0-6.0 mmol/l), hypoglycaemia (2.0-2.5 mmol/l) and during recovery from hypoglycaemia (5.0-6.0 mmol/l) using hyperinsulinaemic glucose clamping. During each 1 h phase, Ts was measured twice by infrared thermography imaging in pre-defined areas (nose, glabella and the five left fingertips), symptoms of hypoglycaemia were scored and blood was sampled.RESULTS: Ts decreased during hypoglycaemia on the nose and glabella. The highest decrements were recorded on the nose (aware: -2.6°C, unaware: -1.1°C). In aware patients, the differences in temperature were statistically significant on both nose and glabella, whereas there was only a trend in the unaware group. There was a significant difference in hypoglycaemia-induced temperature changes between the groups. Patients in the aware group had higher hypoglycaemia symptom scores and higher adrenaline (epinephrine) levels during hypoglycaemia.CONCLUSIONS/INTERPRETATION: The hypoglycaemia-associated decrement in Ts can be assessed by infrared thermography and is larger in patients with normal hypoglycaemia awareness compared with unaware patients.
AB - AIMS/HYPOTHESIS: Hypoglycaemia is associated with reduced skin temperature (Ts). We studied whether infrared thermography can detect Ts changes during hypoglycaemia in patients with type 1 diabetes and how the Ts response differs between patients with normal hypoglycaemia awareness and hypoglycaemia unawareness.METHODS: Twenty-four patients with type 1 diabetes (ten aware, 14 unaware) were studied during normoglycaemia (5.0-6.0 mmol/l), hypoglycaemia (2.0-2.5 mmol/l) and during recovery from hypoglycaemia (5.0-6.0 mmol/l) using hyperinsulinaemic glucose clamping. During each 1 h phase, Ts was measured twice by infrared thermography imaging in pre-defined areas (nose, glabella and the five left fingertips), symptoms of hypoglycaemia were scored and blood was sampled.RESULTS: Ts decreased during hypoglycaemia on the nose and glabella. The highest decrements were recorded on the nose (aware: -2.6°C, unaware: -1.1°C). In aware patients, the differences in temperature were statistically significant on both nose and glabella, whereas there was only a trend in the unaware group. There was a significant difference in hypoglycaemia-induced temperature changes between the groups. Patients in the aware group had higher hypoglycaemia symptom scores and higher adrenaline (epinephrine) levels during hypoglycaemia.CONCLUSIONS/INTERPRETATION: The hypoglycaemia-associated decrement in Ts can be assessed by infrared thermography and is larger in patients with normal hypoglycaemia awareness compared with unaware patients.
U2 - 10.1007/s00125-015-3616-6
DO - 10.1007/s00125-015-3616-6
M3 - Journal article
C2 - 25985748
VL - 58
SP - 1898
EP - 1906
JO - Diabetologia
JF - Diabetologia
SN - 0012-186X
ER -
ID: 149078651