Feasibility of Multiparametric Imaging with PET/MR in Head and Neck Squamous Cell Carcinoma
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Feasibility of Multiparametric Imaging with PET/MR in Head and Neck Squamous Cell Carcinoma. / Rasmussen, Jacob H; Nørgaard, Martin; Hansen, Adam E; Vogelius, Ivan R; Aznar, Marianne C; Johannesen, Helle H; Costa, Junia; Engberg, Astrid Margareta Elisabet; Kjær, Andreas; Specht, Lena; Fischer, Barbara M.
In: The Journal of Nuclear Medicine, Vol. 58, No. 1, 01.2017, p. 69-74.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Feasibility of Multiparametric Imaging with PET/MR in Head and Neck Squamous Cell Carcinoma
AU - Rasmussen, Jacob H
AU - Nørgaard, Martin
AU - Hansen, Adam E
AU - Vogelius, Ivan R
AU - Aznar, Marianne C
AU - Johannesen, Helle H
AU - Costa, Junia
AU - Engberg, Astrid Margareta Elisabet
AU - Kjær, Andreas
AU - Specht, Lena
AU - Fischer, Barbara M
N1 - © 2017 by the Society of Nuclear Medicine and Molecular Imaging.
PY - 2017/1
Y1 - 2017/1
N2 - The purpose of this study was to investigate and assess the correlation and reproducibility of multiparametric imaging in head and neck cancer patients.METHODS: Twenty-one patients were included in this prospective scan-rescan study. All patients were scanned twice on an integrated PET and MRI scanner. Gross tumor volumes were defined on T2-weighted MR images, and volumes of interest were defined on diffusion-weighted MRI and (18)F-FDG PET (VOIDWI, VOIPET). Overlap between volumes was assessed as a percentwise overlap. (18)F-FDG uptake and diffusion were measured using SUV and apparent diffusion coefficient, and correlation was tested across and within patients and as a voxel-by-voxel analysis.RESULTS: Seventeen patients were available for correlation analysis, and 12 patients were available for assessment of tumor overlap. The median tumor overlap between VOIDWI and VOIPET was 82% (VOIDWI in VOIPET) and 62% (VOIPET in VOIDWI) on scan 1 and scan 2, respectively. Across patients, the correlation between SUV and apparent diffusion coefficient was weak and nonsignificant. However, in individual patients a weak but significant correlation was identified on a voxel-by-voxel basis.CONCLUSION: In multiparametric imaging with the integrated PET/MR scanner, the VOIs from DWI and (18)F-FDG PET were both within the target volume for radiotherapy and overlapped substantially although not completely. No correlation between (18)F-FDG uptake and DWI could be found across patients, but within individual patients a statistically significant, but weak, voxel-by-voxel correlation was found. The findings suggest that information on glucose uptake and diffusion coefficient carries complementary information of interest that may be relevant for radiotherapy treatment planning.
AB - The purpose of this study was to investigate and assess the correlation and reproducibility of multiparametric imaging in head and neck cancer patients.METHODS: Twenty-one patients were included in this prospective scan-rescan study. All patients were scanned twice on an integrated PET and MRI scanner. Gross tumor volumes were defined on T2-weighted MR images, and volumes of interest were defined on diffusion-weighted MRI and (18)F-FDG PET (VOIDWI, VOIPET). Overlap between volumes was assessed as a percentwise overlap. (18)F-FDG uptake and diffusion were measured using SUV and apparent diffusion coefficient, and correlation was tested across and within patients and as a voxel-by-voxel analysis.RESULTS: Seventeen patients were available for correlation analysis, and 12 patients were available for assessment of tumor overlap. The median tumor overlap between VOIDWI and VOIPET was 82% (VOIDWI in VOIPET) and 62% (VOIPET in VOIDWI) on scan 1 and scan 2, respectively. Across patients, the correlation between SUV and apparent diffusion coefficient was weak and nonsignificant. However, in individual patients a weak but significant correlation was identified on a voxel-by-voxel basis.CONCLUSION: In multiparametric imaging with the integrated PET/MR scanner, the VOIs from DWI and (18)F-FDG PET were both within the target volume for radiotherapy and overlapped substantially although not completely. No correlation between (18)F-FDG uptake and DWI could be found across patients, but within individual patients a statistically significant, but weak, voxel-by-voxel correlation was found. The findings suggest that information on glucose uptake and diffusion coefficient carries complementary information of interest that may be relevant for radiotherapy treatment planning.
KW - Journal Article
U2 - 10.2967/jnumed.116.180091
DO - 10.2967/jnumed.116.180091
M3 - Journal article
C2 - 27609790
VL - 58
SP - 69
EP - 74
JO - The Journal of Nuclear Medicine
JF - The Journal of Nuclear Medicine
SN - 0161-5505
IS - 1
ER -
ID: 173478374