Extreme vetting of dopamine receptor oligomerization
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Extreme vetting of dopamine receptor oligomerization. / Asher, Wesley B.; Mathiasen, Signe; Holsey, Michael D.; Grinnell, Steven G.; Lambert, Nevin A.; Javitch, Jonathan A.
Receptors. Humana Press, 2017. p. 99-127 (Receptors, Vol. 33).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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TY - CHAP
T1 - Extreme vetting of dopamine receptor oligomerization
AU - Asher, Wesley B.
AU - Mathiasen, Signe
AU - Holsey, Michael D.
AU - Grinnell, Steven G.
AU - Lambert, Nevin A.
AU - Javitch, Jonathan A.
N1 - Publisher Copyright: © Springer International Publishing AG 2017.
PY - 2017
Y1 - 2017
N2 - Numerous reports have emerged over the past two decades suggesting that dopamine receptors form dimeric and/or higher-order oligomeric complexes. The existence of these complexes and their functional properties are of significant interest, as they may provide strategies for developing novel therapeutics that selectively target dopamine receptor complexes with the potential for more refined cellular therapeutics and reduced side-effects. However, there is still great debate and controversy surrounding the structural and functional aspects of dopamine receptor oligomers as well as their physiological relevance. Much of the uncertainty stems from the methodologies employed to understand these complexes, which have clear limitations and/or are not yet fully understood. Herein, we provide an overview of the literature focusing mainly on dopamine receptor homomeric complexes and selected dopamine receptor heteromeric complexes with the goal of providing a critical discussion of the methodology and the logic of the scientific inferences in this body of work.
AB - Numerous reports have emerged over the past two decades suggesting that dopamine receptors form dimeric and/or higher-order oligomeric complexes. The existence of these complexes and their functional properties are of significant interest, as they may provide strategies for developing novel therapeutics that selectively target dopamine receptor complexes with the potential for more refined cellular therapeutics and reduced side-effects. However, there is still great debate and controversy surrounding the structural and functional aspects of dopamine receptor oligomers as well as their physiological relevance. Much of the uncertainty stems from the methodologies employed to understand these complexes, which have clear limitations and/or are not yet fully understood. Herein, we provide an overview of the literature focusing mainly on dopamine receptor homomeric complexes and selected dopamine receptor heteromeric complexes with the goal of providing a critical discussion of the methodology and the logic of the scientific inferences in this body of work.
KW - BRET
KW - Co-immunoprecipitation
KW - Dimerization
KW - Dopamine receptors
KW - FRET
KW - Methodology
KW - Oligomerization
KW - Signaling crosstalk
KW - Structure
UR - http://www.scopus.com/inward/record.url?scp=85051712989&partnerID=8YFLogxK
U2 - 10.1007/978-3-319-60174-8_5
DO - 10.1007/978-3-319-60174-8_5
M3 - Book chapter
AN - SCOPUS:85051712989
T3 - Receptors
SP - 99
EP - 127
BT - Receptors
PB - Humana Press
ER -
ID: 311722496