Elevated plasma glucagon-like peptide 1 and 2 concentrations in ileum resected short bowel patients with a preserved colon
Research output: Contribution to journal › Journal article › Research › peer-review
The glucagon-like peptides (GLP) 1 and 2 are secreted postprandially from L cells located mainly in the ileum. Both hormones prolong intestinal transit and GLP-2 is intestinotrophic in rodents. Patients with a jejunostomy have poor adaptation, rapid gastric and intestinal transit, and impaired postprandial GLP-2 secretion. Ileum resected short bowel patients with a preserved colon show evidence of functional adaptation and have normal gastric emptying.
Original language | English |
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Journal | Gut |
Volume | 47 |
Issue number | 3 |
Pages (from-to) | 370-6 |
Number of pages | 7 |
ISSN | 0017-5749 |
Publication status | Published - Sep 2000 |
- Adaptation, Physiological, Adult, Aged, Area Under Curve, Case-Control Studies, Fasting, Female, Glucagon, Glucagon-Like Peptide 1, Glucagon-Like Peptide 2, Humans, Ileum, Male, Middle Aged, Peptide Fragments, Peptides, Postprandial Period, Protein Precursors, Radioimmunoassay, Short Bowel Syndrome
Research areas
ID: 47486403