Virilizing adrenocortical adenoma responsive to gonadotrophin.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Virilizing adrenocortical adenoma responsive to gonadotrophin. / Blichert-Toft, M; Vejlsted, H; Hehlet, H; Albrechtsen, R.

I: Acta Endocrinologica, Bind 78, Nr. 1, 1975, s. 77-85.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Blichert-Toft, M, Vejlsted, H, Hehlet, H & Albrechtsen, R 1975, 'Virilizing adrenocortical adenoma responsive to gonadotrophin.', Acta Endocrinologica, bind 78, nr. 1, s. 77-85.

APA

Blichert-Toft, M., Vejlsted, H., Hehlet, H., & Albrechtsen, R. (1975). Virilizing adrenocortical adenoma responsive to gonadotrophin. Acta Endocrinologica, 78(1), 77-85.

Vancouver

Blichert-Toft M, Vejlsted H, Hehlet H, Albrechtsen R. Virilizing adrenocortical adenoma responsive to gonadotrophin. Acta Endocrinologica. 1975;78(1):77-85.

Author

Blichert-Toft, M ; Vejlsted, H ; Hehlet, H ; Albrechtsen, R. / Virilizing adrenocortical adenoma responsive to gonadotrophin. I: Acta Endocrinologica. 1975 ; Bind 78, Nr. 1. s. 77-85.

Bibtex

@article{528938705c9511dd8d9f000ea68e967b,
title = "Virilizing adrenocortical adenoma responsive to gonadotrophin.",
abstract = "A virilizing adrenocortical adenoma was demonstrated in a yound female. Urinary 17-ketosteroid excretion and subfractions, plasma testosterone level and urinary 17-ketogenic steroid excretion were markedly increased. Dehydroepiandrosterone was the main constituent of the androgen excess. Otherwise the adrenocortical function was found to be normal as evaluated from measurements of cortisol, corticosterone and their metabolites under basal conditions and during dynamic tests. The androgen excess showed an unexpected response to trophic hormones. Human chorionic gonadotrophin stimulation resulted in a pronounced increase in androgen production, whereas no gonadotrophin-dependency could be demonstrated by means of the oestrogen suppression test. Similarly, no corticotrophin-dependency could be demonstrated by corticotrophin stimulation and suppression tests. Removal of the tumour resulted in normalization of the androgen production and no abnormal response upon human chorionic gonadotrophin administration could now be found. The inappropriate response of tumours to trophic hormones is discussed. It is concluded that the reliability of stimulation and suppression tests in determining the site of excessive androgen production should be accepted with reservation.",
author = "M Blichert-Toft and H Vejlsted and H Hehlet and R Albrechtsen",
note = "Keywords: 11-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma; Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Adult; Androgens; Androsterone; Chorionic Gonadotropin; Corticosterone; Dehydroepiandrosterone; Dexamethasone; Etiocholanolone; Female; Humans; Hydrocortisone; Hydroxycorticosteroids; Ovary; Pregnancy; Stimulation, Chemical; Testosterone",
year = "1975",
language = "English",
volume = "78",
pages = "77--85",
journal = "European Journal of Endocrinology",
issn = "0804-4643",
publisher = "BioScientifica Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - Virilizing adrenocortical adenoma responsive to gonadotrophin.

AU - Blichert-Toft, M

AU - Vejlsted, H

AU - Hehlet, H

AU - Albrechtsen, R

N1 - Keywords: 11-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma; Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Adult; Androgens; Androsterone; Chorionic Gonadotropin; Corticosterone; Dehydroepiandrosterone; Dexamethasone; Etiocholanolone; Female; Humans; Hydrocortisone; Hydroxycorticosteroids; Ovary; Pregnancy; Stimulation, Chemical; Testosterone

PY - 1975

Y1 - 1975

N2 - A virilizing adrenocortical adenoma was demonstrated in a yound female. Urinary 17-ketosteroid excretion and subfractions, plasma testosterone level and urinary 17-ketogenic steroid excretion were markedly increased. Dehydroepiandrosterone was the main constituent of the androgen excess. Otherwise the adrenocortical function was found to be normal as evaluated from measurements of cortisol, corticosterone and their metabolites under basal conditions and during dynamic tests. The androgen excess showed an unexpected response to trophic hormones. Human chorionic gonadotrophin stimulation resulted in a pronounced increase in androgen production, whereas no gonadotrophin-dependency could be demonstrated by means of the oestrogen suppression test. Similarly, no corticotrophin-dependency could be demonstrated by corticotrophin stimulation and suppression tests. Removal of the tumour resulted in normalization of the androgen production and no abnormal response upon human chorionic gonadotrophin administration could now be found. The inappropriate response of tumours to trophic hormones is discussed. It is concluded that the reliability of stimulation and suppression tests in determining the site of excessive androgen production should be accepted with reservation.

AB - A virilizing adrenocortical adenoma was demonstrated in a yound female. Urinary 17-ketosteroid excretion and subfractions, plasma testosterone level and urinary 17-ketogenic steroid excretion were markedly increased. Dehydroepiandrosterone was the main constituent of the androgen excess. Otherwise the adrenocortical function was found to be normal as evaluated from measurements of cortisol, corticosterone and their metabolites under basal conditions and during dynamic tests. The androgen excess showed an unexpected response to trophic hormones. Human chorionic gonadotrophin stimulation resulted in a pronounced increase in androgen production, whereas no gonadotrophin-dependency could be demonstrated by means of the oestrogen suppression test. Similarly, no corticotrophin-dependency could be demonstrated by corticotrophin stimulation and suppression tests. Removal of the tumour resulted in normalization of the androgen production and no abnormal response upon human chorionic gonadotrophin administration could now be found. The inappropriate response of tumours to trophic hormones is discussed. It is concluded that the reliability of stimulation and suppression tests in determining the site of excessive androgen production should be accepted with reservation.

M3 - Journal article

C2 - 163565

VL - 78

SP - 77

EP - 85

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

SN - 0804-4643

IS - 1

ER -

ID: 5237661