Uncoupling of cerebral blood flow and metabolism after single episode of cortical spreading depression in the rat brain
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Uncoupling of cerebral blood flow and metabolism after single episode of cortical spreading depression in the rat brain. / Lauritzen, Martin; Henrik Diemer, Niels.
I: Brain Research, Bind 370, Nr. 2, 09.04.1986, s. 405-408.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Uncoupling of cerebral blood flow and metabolism after single episode of cortical spreading depression in the rat brain
AU - Lauritzen, Martin
AU - Henrik Diemer, Niels
PY - 1986/4/9
Y1 - 1986/4/9
N2 - The present study was undertaken to evaluate whether the persistent hypoperfusion following cortical spreading depression (CSD) in rat brain was accompanied by alterations of regional cortical glucose consumption (rCGU). rCGU was measured using 2-deoxy-[14C]glucose and autoradiography at 15-60 min after single CSD episodes. rCGU did not differ in cortical regions invaded by CSD as compared to the contralateral side and to sham-treated rats. The results suggested impairment of the metabolism-flow couple after CSD.
AB - The present study was undertaken to evaluate whether the persistent hypoperfusion following cortical spreading depression (CSD) in rat brain was accompanied by alterations of regional cortical glucose consumption (rCGU). rCGU was measured using 2-deoxy-[14C]glucose and autoradiography at 15-60 min after single CSD episodes. rCGU did not differ in cortical regions invaded by CSD as compared to the contralateral side and to sham-treated rats. The results suggested impairment of the metabolism-flow couple after CSD.
KW - cerebral glucose consumption
KW - spreading depression
UR - http://www.scopus.com/inward/record.url?scp=0022506730&partnerID=8YFLogxK
U2 - 10.1016/0006-8993(86)90504-4
DO - 10.1016/0006-8993(86)90504-4
M3 - Journal article
C2 - 3708336
AN - SCOPUS:0022506730
VL - 370
SP - 405
EP - 408
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 2
ER -
ID: 201457482