Ultra-processed foods, adiposity and risk of head and neck cancer and oesophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study: a mediation analysis

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Ultra-processed foods, adiposity and risk of head and neck cancer and oesophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study : a mediation analysis. / Morales-Berstein, Fernanda; Biessy, Carine; Viallon, Vivian; Goncalves-Soares, Ana; Casagrande, Corinne; Hémon, Bertrand; Kliemann, Nathalie; Cairat, Manon; Blanco Lopez, Jessica; Al Nahas, Aline; Chang, Kiara; Vamos, Eszter; Rauber, Fernanda; Bertazzi Levy, Renata; Barbosa Cunha, Diana; Jakszyn, Paula; Ferrari, Pietro; Vineis, Paolo; Masala, Giovanna; Catalano, Alberto; Sonestedt, Emily; Borné, Yan; Katzke, Verena; Bajracharya, Rashmita; Agnoli, Claudia; Guevara, Marcela; Heath, Alicia; Radoï, Loredana; Mancini, Francesca; Weiderpass, Elisabete; Huerta, José María; Sánchez, María-José; Tjønneland, Anne; Kyrø, Cecilie; Schulze, Matthias B; Skeie, Guri; Lukic, Marko; Braaten, Tonje; Gunter, Marc; Millett, Christopher; Agudo, Antonio; Brennan, Paul; Borges, M Carolina; Richmond, Rebecca C; Richardson, Tom G; Davey Smith, George; Relton, Caroline L; Huybrechts, Inge; EPIC Network.

I: European Journal of Nutrition, Bind 63, 2024, s. 377–396.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Morales-Berstein, F, Biessy, C, Viallon, V, Goncalves-Soares, A, Casagrande, C, Hémon, B, Kliemann, N, Cairat, M, Blanco Lopez, J, Al Nahas, A, Chang, K, Vamos, E, Rauber, F, Bertazzi Levy, R, Barbosa Cunha, D, Jakszyn, P, Ferrari, P, Vineis, P, Masala, G, Catalano, A, Sonestedt, E, Borné, Y, Katzke, V, Bajracharya, R, Agnoli, C, Guevara, M, Heath, A, Radoï, L, Mancini, F, Weiderpass, E, Huerta, JM, Sánchez, M-J, Tjønneland, A, Kyrø, C, Schulze, MB, Skeie, G, Lukic, M, Braaten, T, Gunter, M, Millett, C, Agudo, A, Brennan, P, Borges, MC, Richmond, RC, Richardson, TG, Davey Smith, G, Relton, CL, Huybrechts, I & EPIC Network 2024, 'Ultra-processed foods, adiposity and risk of head and neck cancer and oesophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study: a mediation analysis', European Journal of Nutrition, bind 63, s. 377–396. https://doi.org/10.1007/s00394-023-03270-1

APA

Morales-Berstein, F., Biessy, C., Viallon, V., Goncalves-Soares, A., Casagrande, C., Hémon, B., Kliemann, N., Cairat, M., Blanco Lopez, J., Al Nahas, A., Chang, K., Vamos, E., Rauber, F., Bertazzi Levy, R., Barbosa Cunha, D., Jakszyn, P., Ferrari, P., Vineis, P., Masala, G., ... EPIC Network (2024). Ultra-processed foods, adiposity and risk of head and neck cancer and oesophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study: a mediation analysis. European Journal of Nutrition, 63, 377–396. https://doi.org/10.1007/s00394-023-03270-1

Vancouver

Morales-Berstein F, Biessy C, Viallon V, Goncalves-Soares A, Casagrande C, Hémon B o.a. Ultra-processed foods, adiposity and risk of head and neck cancer and oesophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study: a mediation analysis. European Journal of Nutrition. 2024;63: 377–396. https://doi.org/10.1007/s00394-023-03270-1

Author

Morales-Berstein, Fernanda ; Biessy, Carine ; Viallon, Vivian ; Goncalves-Soares, Ana ; Casagrande, Corinne ; Hémon, Bertrand ; Kliemann, Nathalie ; Cairat, Manon ; Blanco Lopez, Jessica ; Al Nahas, Aline ; Chang, Kiara ; Vamos, Eszter ; Rauber, Fernanda ; Bertazzi Levy, Renata ; Barbosa Cunha, Diana ; Jakszyn, Paula ; Ferrari, Pietro ; Vineis, Paolo ; Masala, Giovanna ; Catalano, Alberto ; Sonestedt, Emily ; Borné, Yan ; Katzke, Verena ; Bajracharya, Rashmita ; Agnoli, Claudia ; Guevara, Marcela ; Heath, Alicia ; Radoï, Loredana ; Mancini, Francesca ; Weiderpass, Elisabete ; Huerta, José María ; Sánchez, María-José ; Tjønneland, Anne ; Kyrø, Cecilie ; Schulze, Matthias B ; Skeie, Guri ; Lukic, Marko ; Braaten, Tonje ; Gunter, Marc ; Millett, Christopher ; Agudo, Antonio ; Brennan, Paul ; Borges, M Carolina ; Richmond, Rebecca C ; Richardson, Tom G ; Davey Smith, George ; Relton, Caroline L ; Huybrechts, Inge ; EPIC Network. / Ultra-processed foods, adiposity and risk of head and neck cancer and oesophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study : a mediation analysis. I: European Journal of Nutrition. 2024 ; Bind 63. s. 377–396.

Bibtex

@article{7d206ed8dc384a338d74268626153588,
title = "Ultra-processed foods, adiposity and risk of head and neck cancer and oesophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study: a mediation analysis",
abstract = "PURPOSE: To investigate the role of adiposity in the associations between ultra-processed food (UPF) consumption and head and neck cancer (HNC) and oesophageal adenocarcinoma (OAC) in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.METHODS: Our study included 450,111 EPIC participants. We used Cox regressions to investigate the associations between the consumption of UPFs and HNC and OAC risk. A mediation analysis was performed to assess the role of body mass index (BMI) and waist-to-hip ratio (WHR) in these associations. In sensitivity analyses, we investigated accidental death as a negative control outcome.RESULTS: During a mean follow-up of 14.13 ± 3.98 years, 910 and 215 participants developed HNC and OAC, respectively. A 10% g/d higher consumption of UPFs was associated with an increased risk of HNC (hazard ratio [HR] = 1.23, 95% confidence interval [CI] 1.14-1.34) and OAC (HR = 1.24, 95% CI 1.05-1.47). WHR mediated 5% (95% CI 3-10%) of the association between the consumption of UPFs and HNC risk, while BMI and WHR, respectively, mediated 13% (95% CI 6-53%) and 15% (95% CI 8-72%) of the association between the consumption of UPFs and OAC risk. UPF consumption was positively associated with accidental death in the negative control analysis.CONCLUSIONS: We reaffirmed that higher UPF consumption is associated with greater risk of HNC and OAC in EPIC. The proportion mediated via adiposity was small. Further research is required to investigate other mechanisms that may be at play (if there is indeed any causal effect of UPF consumption on these cancers).",
author = "Fernanda Morales-Berstein and Carine Biessy and Vivian Viallon and Ana Goncalves-Soares and Corinne Casagrande and Bertrand H{\'e}mon and Nathalie Kliemann and Manon Cairat and {Blanco Lopez}, Jessica and {Al Nahas}, Aline and Kiara Chang and Eszter Vamos and Fernanda Rauber and {Bertazzi Levy}, Renata and {Barbosa Cunha}, Diana and Paula Jakszyn and Pietro Ferrari and Paolo Vineis and Giovanna Masala and Alberto Catalano and Emily Sonestedt and Yan Born{\'e} and Verena Katzke and Rashmita Bajracharya and Claudia Agnoli and Marcela Guevara and Alicia Heath and Loredana Rado{\"i} and Francesca Mancini and Elisabete Weiderpass and Huerta, {Jos{\'e} Mar{\'i}a} and Mar{\'i}a-Jos{\'e} S{\'a}nchez and Anne Tj{\o}nneland and Cecilie Kyr{\o} and Schulze, {Matthias B} and Guri Skeie and Marko Lukic and Tonje Braaten and Marc Gunter and Christopher Millett and Antonio Agudo and Paul Brennan and Borges, {M Carolina} and Richmond, {Rebecca C} and Richardson, {Tom G} and {Davey Smith}, George and Relton, {Caroline L} and Inge Huybrechts and {EPIC Network}",
note = "{\textcopyright} 2023. The Author(s).",
year = "2024",
doi = "10.1007/s00394-023-03270-1",
language = "English",
volume = "63",
pages = " 377–396",
journal = "European Journal of Nutrition",
issn = "1436-6207",
publisher = "Springer Medizin",

}

RIS

TY - JOUR

T1 - Ultra-processed foods, adiposity and risk of head and neck cancer and oesophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study

T2 - a mediation analysis

AU - Morales-Berstein, Fernanda

AU - Biessy, Carine

AU - Viallon, Vivian

AU - Goncalves-Soares, Ana

AU - Casagrande, Corinne

AU - Hémon, Bertrand

AU - Kliemann, Nathalie

AU - Cairat, Manon

AU - Blanco Lopez, Jessica

AU - Al Nahas, Aline

AU - Chang, Kiara

AU - Vamos, Eszter

AU - Rauber, Fernanda

AU - Bertazzi Levy, Renata

AU - Barbosa Cunha, Diana

AU - Jakszyn, Paula

AU - Ferrari, Pietro

AU - Vineis, Paolo

AU - Masala, Giovanna

AU - Catalano, Alberto

AU - Sonestedt, Emily

AU - Borné, Yan

AU - Katzke, Verena

AU - Bajracharya, Rashmita

AU - Agnoli, Claudia

AU - Guevara, Marcela

AU - Heath, Alicia

AU - Radoï, Loredana

AU - Mancini, Francesca

AU - Weiderpass, Elisabete

AU - Huerta, José María

AU - Sánchez, María-José

AU - Tjønneland, Anne

AU - Kyrø, Cecilie

AU - Schulze, Matthias B

AU - Skeie, Guri

AU - Lukic, Marko

AU - Braaten, Tonje

AU - Gunter, Marc

AU - Millett, Christopher

AU - Agudo, Antonio

AU - Brennan, Paul

AU - Borges, M Carolina

AU - Richmond, Rebecca C

AU - Richardson, Tom G

AU - Davey Smith, George

AU - Relton, Caroline L

AU - Huybrechts, Inge

AU - EPIC Network

N1 - © 2023. The Author(s).

PY - 2024

Y1 - 2024

N2 - PURPOSE: To investigate the role of adiposity in the associations between ultra-processed food (UPF) consumption and head and neck cancer (HNC) and oesophageal adenocarcinoma (OAC) in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.METHODS: Our study included 450,111 EPIC participants. We used Cox regressions to investigate the associations between the consumption of UPFs and HNC and OAC risk. A mediation analysis was performed to assess the role of body mass index (BMI) and waist-to-hip ratio (WHR) in these associations. In sensitivity analyses, we investigated accidental death as a negative control outcome.RESULTS: During a mean follow-up of 14.13 ± 3.98 years, 910 and 215 participants developed HNC and OAC, respectively. A 10% g/d higher consumption of UPFs was associated with an increased risk of HNC (hazard ratio [HR] = 1.23, 95% confidence interval [CI] 1.14-1.34) and OAC (HR = 1.24, 95% CI 1.05-1.47). WHR mediated 5% (95% CI 3-10%) of the association between the consumption of UPFs and HNC risk, while BMI and WHR, respectively, mediated 13% (95% CI 6-53%) and 15% (95% CI 8-72%) of the association between the consumption of UPFs and OAC risk. UPF consumption was positively associated with accidental death in the negative control analysis.CONCLUSIONS: We reaffirmed that higher UPF consumption is associated with greater risk of HNC and OAC in EPIC. The proportion mediated via adiposity was small. Further research is required to investigate other mechanisms that may be at play (if there is indeed any causal effect of UPF consumption on these cancers).

AB - PURPOSE: To investigate the role of adiposity in the associations between ultra-processed food (UPF) consumption and head and neck cancer (HNC) and oesophageal adenocarcinoma (OAC) in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.METHODS: Our study included 450,111 EPIC participants. We used Cox regressions to investigate the associations between the consumption of UPFs and HNC and OAC risk. A mediation analysis was performed to assess the role of body mass index (BMI) and waist-to-hip ratio (WHR) in these associations. In sensitivity analyses, we investigated accidental death as a negative control outcome.RESULTS: During a mean follow-up of 14.13 ± 3.98 years, 910 and 215 participants developed HNC and OAC, respectively. A 10% g/d higher consumption of UPFs was associated with an increased risk of HNC (hazard ratio [HR] = 1.23, 95% confidence interval [CI] 1.14-1.34) and OAC (HR = 1.24, 95% CI 1.05-1.47). WHR mediated 5% (95% CI 3-10%) of the association between the consumption of UPFs and HNC risk, while BMI and WHR, respectively, mediated 13% (95% CI 6-53%) and 15% (95% CI 8-72%) of the association between the consumption of UPFs and OAC risk. UPF consumption was positively associated with accidental death in the negative control analysis.CONCLUSIONS: We reaffirmed that higher UPF consumption is associated with greater risk of HNC and OAC in EPIC. The proportion mediated via adiposity was small. Further research is required to investigate other mechanisms that may be at play (if there is indeed any causal effect of UPF consumption on these cancers).

U2 - 10.1007/s00394-023-03270-1

DO - 10.1007/s00394-023-03270-1

M3 - Journal article

C2 - 37989797

VL - 63

SP - 377

EP - 396

JO - European Journal of Nutrition

JF - European Journal of Nutrition

SN - 1436-6207

ER -

ID: 377784646