Tubuloreticular inclusions in skin biopsies from patients with HIV infection.

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Tubuloreticular inclusions in skin biopsies from patients with HIV infection. / Pedersen, C; Horn, T; Junge, Jette; Haahr, S; Nielsen, Jens Ole.

I: Acta Pathologica Microbiologica et Immunologica Scandinavica, Bind 97, Nr. 3, 1989, s. 249-252.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning

Harvard

Pedersen, C, Horn, T, Junge, J, Haahr, S & Nielsen, JO 1989, 'Tubuloreticular inclusions in skin biopsies from patients with HIV infection.', Acta Pathologica Microbiologica et Immunologica Scandinavica, bind 97, nr. 3, s. 249-252. <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2469447&query_hl=8>

APA

Pedersen, C., Horn, T., Junge, J., Haahr, S., & Nielsen, J. O. (1989). Tubuloreticular inclusions in skin biopsies from patients with HIV infection. Acta Pathologica Microbiologica et Immunologica Scandinavica, 97(3), 249-252. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2469447&query_hl=8

Vancouver

Pedersen C, Horn T, Junge J, Haahr S, Nielsen JO. Tubuloreticular inclusions in skin biopsies from patients with HIV infection. Acta Pathologica Microbiologica et Immunologica Scandinavica. 1989;97(3):249-252.

Author

Pedersen, C ; Horn, T ; Junge, Jette ; Haahr, S ; Nielsen, Jens Ole. / Tubuloreticular inclusions in skin biopsies from patients with HIV infection. I: Acta Pathologica Microbiologica et Immunologica Scandinavica. 1989 ; Bind 97, Nr. 3. s. 249-252.

Bibtex

@article{6ea13e0387964b52989fcf8ec782c571,
title = "Tubuloreticular inclusions in skin biopsies from patients with HIV infection.",
abstract = "Skin biopsies obtained from apparently normal skin from 15 HIV infected patients and 6 anti-HIV negative patients were examined by electron microscopy. Tubuloreticular inclusions (TRI) were detected within the cytoplasm of capillary endothelial cells in 5/5 AIDS patients and in 2/5 patients with AIDS related conditions. Biopsies from 5 asymptomatic HIV positive patients and the 6 control subjects were without ultrastructural alterations. The occurrence of TRI was related to low numbers of CD 4+ lymphocytes. 5/7 patients with TRI had elevated serum interferon activity, and in all of the patients without TRI, interferon activity was below detection level. The occurrence of TRI was not dependent on the presence of free p24 antigen in serum. It is concluded that the occurrence of TRI in entothelial cells of skin capillaries is associated with late stages of HIV infection and this may indicate a generalization of this change.",
author = "C Pedersen and T Horn and Jette Junge and S Haahr and Nielsen, {Jens Ole}",
year = "1989",
language = "English",
volume = "97",
pages = "249--252",
journal = "A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica",
issn = "0903-4641",
publisher = "Wiley Online",
number = "3",

}

RIS

TY - JOUR

T1 - Tubuloreticular inclusions in skin biopsies from patients with HIV infection.

AU - Pedersen, C

AU - Horn, T

AU - Junge, Jette

AU - Haahr, S

AU - Nielsen, Jens Ole

PY - 1989

Y1 - 1989

N2 - Skin biopsies obtained from apparently normal skin from 15 HIV infected patients and 6 anti-HIV negative patients were examined by electron microscopy. Tubuloreticular inclusions (TRI) were detected within the cytoplasm of capillary endothelial cells in 5/5 AIDS patients and in 2/5 patients with AIDS related conditions. Biopsies from 5 asymptomatic HIV positive patients and the 6 control subjects were without ultrastructural alterations. The occurrence of TRI was related to low numbers of CD 4+ lymphocytes. 5/7 patients with TRI had elevated serum interferon activity, and in all of the patients without TRI, interferon activity was below detection level. The occurrence of TRI was not dependent on the presence of free p24 antigen in serum. It is concluded that the occurrence of TRI in entothelial cells of skin capillaries is associated with late stages of HIV infection and this may indicate a generalization of this change.

AB - Skin biopsies obtained from apparently normal skin from 15 HIV infected patients and 6 anti-HIV negative patients were examined by electron microscopy. Tubuloreticular inclusions (TRI) were detected within the cytoplasm of capillary endothelial cells in 5/5 AIDS patients and in 2/5 patients with AIDS related conditions. Biopsies from 5 asymptomatic HIV positive patients and the 6 control subjects were without ultrastructural alterations. The occurrence of TRI was related to low numbers of CD 4+ lymphocytes. 5/7 patients with TRI had elevated serum interferon activity, and in all of the patients without TRI, interferon activity was below detection level. The occurrence of TRI was not dependent on the presence of free p24 antigen in serum. It is concluded that the occurrence of TRI in entothelial cells of skin capillaries is associated with late stages of HIV infection and this may indicate a generalization of this change.

M3 - Journal article

VL - 97

SP - 249

EP - 252

JO - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica

JF - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica

SN - 0903-4641

IS - 3

ER -

ID: 34125315