Translational implications of bradyarrhythmia in hibernating brown bears
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Translational implications of bradyarrhythmia in hibernating brown bears. / Gottlieb, Lisa A.; Evans, Alina L.; Fuchs, Boris; Fröbert, Ole; Björkenheim, Anna.
I: Physiological Reports, Bind 11, Nr. 1, e15550, 2023.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Translational implications of bradyarrhythmia in hibernating brown bears
AU - Gottlieb, Lisa A.
AU - Evans, Alina L.
AU - Fuchs, Boris
AU - Fröbert, Ole
AU - Björkenheim, Anna
N1 - Publisher Copyright: © 2023 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.
PY - 2023
Y1 - 2023
N2 - The brown bear Ursus arctos undergoes exceptional physiological adaptions during annual hibernation that minimize energy consumption, including profound decrease in heart rate, cardiac output, and respiratory rate. These changes are completely reversible after the bears reenter into the active state in spring. In this case report, we show episodes of sinus arrest in a hibernating Scandinavian brown bear and in humans, recorded by implantable loop recorders and discuss the possible underlying mechanisms. Lessons learned from cardiac adaptations in hibernating bears might prove useful in the treatment of patients with sinus node dysfunction.
AB - The brown bear Ursus arctos undergoes exceptional physiological adaptions during annual hibernation that minimize energy consumption, including profound decrease in heart rate, cardiac output, and respiratory rate. These changes are completely reversible after the bears reenter into the active state in spring. In this case report, we show episodes of sinus arrest in a hibernating Scandinavian brown bear and in humans, recorded by implantable loop recorders and discuss the possible underlying mechanisms. Lessons learned from cardiac adaptations in hibernating bears might prove useful in the treatment of patients with sinus node dysfunction.
KW - Ursus arctos
KW - bradyarrhythmia
KW - brown bear
KW - hibernation
KW - sinus arrest
KW - sinus node disease
KW - sinus pause
KW - syncope
KW - translational model
UR - http://www.scopus.com/inward/record.url?scp=85145430728&partnerID=8YFLogxK
U2 - 10.14814/phy2.15550
DO - 10.14814/phy2.15550
M3 - Journal article
C2 - 36597216
AN - SCOPUS:85145430728
VL - 11
JO - Physiological Reports
JF - Physiological Reports
SN - 2051-817X
IS - 1
M1 - e15550
ER -
ID: 332193738