Transfer of bromocriptine across the blood-brain barrier in man

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Standard

Transfer of bromocriptine across the blood-brain barrier in man. / Friis, M L; Paulson, O B; Hertz, M M.

I: Acta Neurologica Scandinavica, Bind 59, Nr. 2-3, 03.1979, s. 88-95.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Friis, ML, Paulson, OB & Hertz, MM 1979, 'Transfer of bromocriptine across the blood-brain barrier in man', Acta Neurologica Scandinavica, bind 59, nr. 2-3, s. 88-95. https://doi.org/10.1111/j.1600-0404.1979.tb02915.x

APA

Friis, M. L., Paulson, O. B., & Hertz, M. M. (1979). Transfer of bromocriptine across the blood-brain barrier in man. Acta Neurologica Scandinavica, 59(2-3), 88-95. https://doi.org/10.1111/j.1600-0404.1979.tb02915.x

Vancouver

Friis ML, Paulson OB, Hertz MM. Transfer of bromocriptine across the blood-brain barrier in man. Acta Neurologica Scandinavica. 1979 mar.;59(2-3):88-95. https://doi.org/10.1111/j.1600-0404.1979.tb02915.x

Author

Friis, M L ; Paulson, O B ; Hertz, M M. / Transfer of bromocriptine across the blood-brain barrier in man. I: Acta Neurologica Scandinavica. 1979 ; Bind 59, Nr. 2-3. s. 88-95.

Bibtex

@article{e821bb0eec2a4098aebfb1f104f6ae42,
title = "Transfer of bromocriptine across the blood-brain barrier in man",
abstract = "The transfer of 14C-bromocriptine across the blood-brain barrier was studied in 10 patients using the double indicator single injection method. The extraction (E) of bromocriptine was 8 % (quartiles: 6 and 14 %). Based on the results the cerebral uptake velocity of bromocriptine was calculated assuming constant arterial drug concentration. Its T 1/2 was found to be 12--24 minutes, depending on the tissue-blood partition coefficient.",
keywords = "Adult, Aged, Blood-Brain Barrier, Brain/metabolism, Brain Diseases/drug therapy, Bromocriptine/blood, Carbon Radioisotopes, Cerebrovascular Circulation, Female, Humans, Male, Middle Aged, Radioisotope Dilution Technique, Time Factors",
author = "Friis, {M L} and Paulson, {O B} and Hertz, {M M}",
year = "1979",
month = mar,
doi = "10.1111/j.1600-0404.1979.tb02915.x",
language = "English",
volume = "59",
pages = "88--95",
journal = "Acta Neurologica Scandinavica, Supplement",
issn = "0065-1427",
publisher = "Wiley-Blackwell",
number = "2-3",

}

RIS

TY - JOUR

T1 - Transfer of bromocriptine across the blood-brain barrier in man

AU - Friis, M L

AU - Paulson, O B

AU - Hertz, M M

PY - 1979/3

Y1 - 1979/3

N2 - The transfer of 14C-bromocriptine across the blood-brain barrier was studied in 10 patients using the double indicator single injection method. The extraction (E) of bromocriptine was 8 % (quartiles: 6 and 14 %). Based on the results the cerebral uptake velocity of bromocriptine was calculated assuming constant arterial drug concentration. Its T 1/2 was found to be 12--24 minutes, depending on the tissue-blood partition coefficient.

AB - The transfer of 14C-bromocriptine across the blood-brain barrier was studied in 10 patients using the double indicator single injection method. The extraction (E) of bromocriptine was 8 % (quartiles: 6 and 14 %). Based on the results the cerebral uptake velocity of bromocriptine was calculated assuming constant arterial drug concentration. Its T 1/2 was found to be 12--24 minutes, depending on the tissue-blood partition coefficient.

KW - Adult

KW - Aged

KW - Blood-Brain Barrier

KW - Brain/metabolism

KW - Brain Diseases/drug therapy

KW - Bromocriptine/blood

KW - Carbon Radioisotopes

KW - Cerebrovascular Circulation

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Radioisotope Dilution Technique

KW - Time Factors

U2 - 10.1111/j.1600-0404.1979.tb02915.x

DO - 10.1111/j.1600-0404.1979.tb02915.x

M3 - Journal article

C2 - 377891

VL - 59

SP - 88

EP - 95

JO - Acta Neurologica Scandinavica, Supplement

JF - Acta Neurologica Scandinavica, Supplement

SN - 0065-1427

IS - 2-3

ER -

ID: 275605354