Thyroid function and ultrasonically determined thyroid size in patients receiving long-term lithium treatment
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Thyroid function and ultrasonically determined thyroid size in patients receiving long-term lithium treatment. / Perrild, H.; Hegedus, L.; Baastrup, P. C.; Kayser, L.; Kastberg, S.
I: American Journal of Psychiatry, Bind 147, Nr. 11, 1990, s. 1518-1521.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Thyroid function and ultrasonically determined thyroid size in patients receiving long-term lithium treatment
AU - Perrild, H.
AU - Hegedus, L.
AU - Baastrup, P. C.
AU - Kayser, L.
AU - Kastberg, S.
PY - 1990
Y1 - 1990
N2 - Thyroid function was investigated in 100 manic-depressive patients. Goiter was more common in patients treated with lithium for 1-5 years (44%) or more than 10 years (50%) than in patients who never received lithium (16%). Smoking contributed significantly to thyroid size and goiter. In nonsmoking patients, ultrasonically determined thyroid volume was significantly related to treatment duration. The mechanism behind this increased thyroid volume is unclear, as most patients had normal serum thyrotropin levels and no thyroid autoimmunity. Subclinical or overt hypothyroidism was found in 4% and 21% of patients treated for 1-5 and more than 10 years, respectively. Since few hypothyroid patients had autoimmunity or goiter, lithium may affect the thyroid gland directly.
AB - Thyroid function was investigated in 100 manic-depressive patients. Goiter was more common in patients treated with lithium for 1-5 years (44%) or more than 10 years (50%) than in patients who never received lithium (16%). Smoking contributed significantly to thyroid size and goiter. In nonsmoking patients, ultrasonically determined thyroid volume was significantly related to treatment duration. The mechanism behind this increased thyroid volume is unclear, as most patients had normal serum thyrotropin levels and no thyroid autoimmunity. Subclinical or overt hypothyroidism was found in 4% and 21% of patients treated for 1-5 and more than 10 years, respectively. Since few hypothyroid patients had autoimmunity or goiter, lithium may affect the thyroid gland directly.
UR - http://www.scopus.com/inward/record.url?scp=0025130824&partnerID=8YFLogxK
U2 - 10.1176/ajp.147.11.1518
DO - 10.1176/ajp.147.11.1518
M3 - Journal article
C2 - 2221166
AN - SCOPUS:0025130824
VL - 147
SP - 1518
EP - 1521
JO - The American Journal of Psychiatry
JF - The American Journal of Psychiatry
SN - 0002-953X
IS - 11
ER -
ID: 335355125