Thymic epithelial cells. I. Expression of strong suppressive (veto) activity in mouse thymic epithelial cell cultures
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Thymic epithelial cells. I. Expression of strong suppressive (veto) activity in mouse thymic epithelial cell cultures. / Claesson, Mogens Helweg; Ropke, C.
I: Scandinavian Journal of Immunology, Bind 32, Nr. 6, 01.12.1990, s. 595-600.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Thymic epithelial cells. I. Expression of strong suppressive (veto) activity in mouse thymic epithelial cell cultures
AU - Claesson, Mogens Helweg
AU - Ropke, C
PY - 1990/12/1
Y1 - 1990/12/1
N2 - We show that thymic epithelial cells grown under serum-free conditions in a chemically defined culture medium can act as veto cells in vitro. The veto activity of thymic epithelial cells results in inactivation of specific alloreactive cytotoxic T-cell precursors at the clonal level. It is concluded that the epithelial stromal cells of the thymus, by acting as veto cells, may be responsible for the negative intrathymic selection of self-reactive thymocytes leading to elimination of the vast majority of immature thymic lymphocytes.
AB - We show that thymic epithelial cells grown under serum-free conditions in a chemically defined culture medium can act as veto cells in vitro. The veto activity of thymic epithelial cells results in inactivation of specific alloreactive cytotoxic T-cell precursors at the clonal level. It is concluded that the epithelial stromal cells of the thymus, by acting as veto cells, may be responsible for the negative intrathymic selection of self-reactive thymocytes leading to elimination of the vast majority of immature thymic lymphocytes.
KW - Animals
KW - Culture Media
KW - Down-Regulation
KW - Epithelium
KW - Female
KW - Histocompatibility Antigens Class I
KW - Immune Tolerance
KW - Isoantigens
KW - Mice
KW - Mice, Inbred BALB C
KW - Mice, Inbred C3H
KW - Mice, Inbred C57BL
KW - T-Lymphocytes, Cytotoxic
KW - Thymus Gland
M3 - Journal article
C2 - 2270438
VL - 32
SP - 595
EP - 600
JO - Scandinavian Journal of Immunology, Supplement
JF - Scandinavian Journal of Immunology, Supplement
SN - 0301-6323
IS - 6
ER -
ID: 33022701