The thymus reconstituted nude rat: lymphocyte subpopulations and immunological characteristics

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Standard

The thymus reconstituted nude rat : lymphocyte subpopulations and immunological characteristics. / Hougen, H P; Klausen, B.

I: Thymus, Bind 10, Nr. 3-4, 1987, s. 207-17.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Hougen, HP & Klausen, B 1987, 'The thymus reconstituted nude rat: lymphocyte subpopulations and immunological characteristics', Thymus, bind 10, nr. 3-4, s. 207-17.

APA

Hougen, H. P., & Klausen, B. (1987). The thymus reconstituted nude rat: lymphocyte subpopulations and immunological characteristics. Thymus, 10(3-4), 207-17.

Vancouver

Hougen HP, Klausen B. The thymus reconstituted nude rat: lymphocyte subpopulations and immunological characteristics. Thymus. 1987;10(3-4):207-17.

Author

Hougen, H P ; Klausen, B. / The thymus reconstituted nude rat : lymphocyte subpopulations and immunological characteristics. I: Thymus. 1987 ; Bind 10, Nr. 3-4. s. 207-17.

Bibtex

@article{47c06c02288c48008c5c8d4930fb5986,
title = "The thymus reconstituted nude rat: lymphocyte subpopulations and immunological characteristics",
abstract = "The monoclonal antibodies OX6, OX19, W3/13, OX7, OX8, and W3/25 were used to gain information about the distribution of different lymphocyte subpopulations in peripheral lymphoid organs of neonatally isogeneic and allogeneic thymus reconstituted nude rats. Splenic mitogen responsiveness, xenogeneic skin rejection, and antibody titers were also measured in the same groups of animals. The experiments showed that both allogeneic and isogeneic thymus grafting cause a significant amplification of cells in the different T lymphocyte subpopulations. The functional tests, however, indicate that the T cell response is far better following isografting. We, therefore, conclude that isogeneic thymus grafting is an easy method of reconstituting the nude rat immunologically.",
keywords = "Animals, Antibodies, Monoclonal, Antigens, Surface, Crosses, Genetic, Lymphocyte Activation, Male, Rats, Rats, Inbred Lew, Rats, Mutant Strains, Rats, Nude, Spleen, T-Lymphocytes, Thymus Gland",
author = "Hougen, {H P} and B Klausen",
year = "1987",
language = "English",
volume = "10",
pages = "207--17",
journal = "Thymus",
publisher = "Kluwer Academic Publishers",
number = "3-4",

}

RIS

TY - JOUR

T1 - The thymus reconstituted nude rat

T2 - lymphocyte subpopulations and immunological characteristics

AU - Hougen, H P

AU - Klausen, B

PY - 1987

Y1 - 1987

N2 - The monoclonal antibodies OX6, OX19, W3/13, OX7, OX8, and W3/25 were used to gain information about the distribution of different lymphocyte subpopulations in peripheral lymphoid organs of neonatally isogeneic and allogeneic thymus reconstituted nude rats. Splenic mitogen responsiveness, xenogeneic skin rejection, and antibody titers were also measured in the same groups of animals. The experiments showed that both allogeneic and isogeneic thymus grafting cause a significant amplification of cells in the different T lymphocyte subpopulations. The functional tests, however, indicate that the T cell response is far better following isografting. We, therefore, conclude that isogeneic thymus grafting is an easy method of reconstituting the nude rat immunologically.

AB - The monoclonal antibodies OX6, OX19, W3/13, OX7, OX8, and W3/25 were used to gain information about the distribution of different lymphocyte subpopulations in peripheral lymphoid organs of neonatally isogeneic and allogeneic thymus reconstituted nude rats. Splenic mitogen responsiveness, xenogeneic skin rejection, and antibody titers were also measured in the same groups of animals. The experiments showed that both allogeneic and isogeneic thymus grafting cause a significant amplification of cells in the different T lymphocyte subpopulations. The functional tests, however, indicate that the T cell response is far better following isografting. We, therefore, conclude that isogeneic thymus grafting is an easy method of reconstituting the nude rat immunologically.

KW - Animals

KW - Antibodies, Monoclonal

KW - Antigens, Surface

KW - Crosses, Genetic

KW - Lymphocyte Activation

KW - Male

KW - Rats

KW - Rats, Inbred Lew

KW - Rats, Mutant Strains

KW - Rats, Nude

KW - Spleen

KW - T-Lymphocytes

KW - Thymus Gland

M3 - Journal article

C2 - 3501184

VL - 10

SP - 207

EP - 217

JO - Thymus

JF - Thymus

IS - 3-4

ER -

ID: 44516307