TY - JOUR

T1 - The Signature Biobank

T2 - A longitudinal biopsychosocial repository of psychiatric emergency patients

AU - Kerr, Philippe

AU - Le Page, Cécile

AU - Giguère, Charles Édouard

AU - Marin, Marie France

AU - Trudel-Fitzgerald, Claudia

AU - Romain, Ahmed Jérôme

AU - Taschereau-Dumouchel, Vincent

AU - Ouellet-Morin, Isabelle

AU - Lecomte, Tania

AU - Potvin, Stéphane

AU - Geoffrion, Steve

AU - Sasseville, Marc

AU - Caihol, Lionel

AU - Lipp, Olivier

AU - Pelletier, Jean François

AU - Dumais, Alexandre

AU - Lesage, Alain

AU - Labelle, Réal

AU - Lavoie, Marc

AU - Godbout, Roger

AU - Vincent, Philippe

AU - Boissonneault, Janick

AU - Findlay, Helen

AU - Lupien, Sonia J.

AU - Guay, Stéphane

AU - Juster, Robert Paul

AU - Consortium, Signature

N1 - Publisher Copyright: © 2024 Elsevier B.V.

PY - 2024/2

Y1 - 2024/2

N2 - The Signature Biobank is a longitudinal repository of biospecimen, psychological, sociodemographic, and diagnostic data that was created in 2012. The Signature Consortium represents a group of approximately one hundred Quebec-based transdisciplinary clinicians and research scientists with various expertise in the field of psychiatry. The objective of the Signature Biobank is to investigate the multi-faceted underpinnings of psychiatric disorders among patients in crisis. The Signature Consortium is expanding and includes new active members that seek to highlight the contributions made by Signature Biobank since its inception. This article details our research protocol, directions, and summarizes contributions. To date, we have collected biological samples (n = 1,986), and questionnaire data (n = 2,085) from psychiatric emergency patients of the Institut universitaire en santé mentale de Montréal (Quebec, Canada), with a large proportion from whom both data types were collected (n = 1,926). In addition to this, a subsample of patients was followed-up at hospital discharge, and two additional outpatient clinic appointments (n = 958 with at least one follow-up). In addition, a socio-demographically matched comparison group of individuals who were not hospitalized for psychiatric disorders (n = 149) was recruited from the surrounding catchment area. To summarize, a systematic review of the literature shows that the Signature Biobank has contributed to better characterizing psychiatric comorbidities, biological profiles, and psychosocial functioning across some of the most common psychiatric disorders, including psychosis, mood, anxiety, and substance use disorders. The Signature Biobank is now one of the world's largest repositories of data collected from patients receiving care at a psychiatric emergency unit.

AB - The Signature Biobank is a longitudinal repository of biospecimen, psychological, sociodemographic, and diagnostic data that was created in 2012. The Signature Consortium represents a group of approximately one hundred Quebec-based transdisciplinary clinicians and research scientists with various expertise in the field of psychiatry. The objective of the Signature Biobank is to investigate the multi-faceted underpinnings of psychiatric disorders among patients in crisis. The Signature Consortium is expanding and includes new active members that seek to highlight the contributions made by Signature Biobank since its inception. This article details our research protocol, directions, and summarizes contributions. To date, we have collected biological samples (n = 1,986), and questionnaire data (n = 2,085) from psychiatric emergency patients of the Institut universitaire en santé mentale de Montréal (Quebec, Canada), with a large proportion from whom both data types were collected (n = 1,926). In addition to this, a subsample of patients was followed-up at hospital discharge, and two additional outpatient clinic appointments (n = 958 with at least one follow-up). In addition, a socio-demographically matched comparison group of individuals who were not hospitalized for psychiatric disorders (n = 149) was recruited from the surrounding catchment area. To summarize, a systematic review of the literature shows that the Signature Biobank has contributed to better characterizing psychiatric comorbidities, biological profiles, and psychosocial functioning across some of the most common psychiatric disorders, including psychosis, mood, anxiety, and substance use disorders. The Signature Biobank is now one of the world's largest repositories of data collected from patients receiving care at a psychiatric emergency unit.

KW - Biobanking

KW - Biological psychiatry

KW - Precision medicine

KW - Psychiatric diagnosis

KW - Psychometrics

KW - Recovery

UR - http://www.scopus.com/inward/record.url?scp=85182374444&partnerID=8YFLogxK

U2 - 10.1016/j.psychres.2024.115718

DO - 10.1016/j.psychres.2024.115718

M3 - Journal article

C2 - 38198857

AN - SCOPUS:85182374444

VL - 332

JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

M1 - 115718

ER -