The role of sex on the prevalence of cardiovascular risk factors in children and adolescents with Type 1 diabetes: The SWEET international database
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The role of sex on the prevalence of cardiovascular risk factors in children and adolescents with Type 1 diabetes : The SWEET international database. / Marigliano, Marco; Lanzinger, Stefanie; Zineb, Imane; Barcala, Consuelo; Shah, Amy S.; Svensson, Jannet; Tsochev, Kaloyan; Mazur, Artur; Galli-Tsinopoulou, Assimina; Ioacara, Sorin; Jothydev, Kesavadev; Maffeis, Claudio.
I: Diabetes Research and Clinical Practice, Bind 210, 111616, 2024.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - The role of sex on the prevalence of cardiovascular risk factors in children and adolescents with Type 1 diabetes
T2 - The SWEET international database
AU - Marigliano, Marco
AU - Lanzinger, Stefanie
AU - Zineb, Imane
AU - Barcala, Consuelo
AU - Shah, Amy S.
AU - Svensson, Jannet
AU - Tsochev, Kaloyan
AU - Mazur, Artur
AU - Galli-Tsinopoulou, Assimina
AU - Ioacara, Sorin
AU - Jothydev, Kesavadev
AU - Maffeis, Claudio
N1 - Publisher Copyright: © 2024 The Author(s)
PY - 2024
Y1 - 2024
N2 - Objective: To assess the prevalence of cardiovascular risk factors (CVRFs) in children and adolescents with type 1 diabetes (T1D) in the International SWEET registry and the possible role of clinical variables in modifying the risk of having single or multiple CVRFs. Study design: The study is a cross-sectional study. Cut-off points for CVRFs were fixed according to International Society for Pediatric and Adolescent Diabetes (ISPAD) guidelines and WHO parameters: LDL cholesterol (LDL-C) > 100 mg/dL; Systolic Blood Pressure (BP-SDS) > 90th percentile for sex, age, and height; BMI-SDS > 2SD for sex and age. Logistic regression models were applied to evaluate variables associated with at least 1 or 2 CVRFs among registry children and adolescents. Results: 29,649 individuals with T1D (6–18 years, T1D ≥ 2 years) participating in the SWEET prospective multicenter diabetes registry were included. In the cohort, 41 % had one or more CVRFs, and 10 % had two or more CVRFs. Thirty-five percent of enrolled individuals had LDL-C > 100 mg/dL, 26 % had BMI-SDS > 2SD, and 17 % had Systolic BP-SDS > 90th percentile. Females had higher frequency than males of having 1 or 2 CVRFs (45.1 % vs 37.4 %, 11.8 % vs 7.8 %; p < 0.001). Multivariable logistic regression models showed that sex (female), HbA1c category (>7.0 %), and age (>10 years) were associated with a higher chance of having at least 1 or 2 CVRFs (p < 0.001). Conclusions: In children and adolescents with T1D, female sex, in addition to HbA1c above 7 %, and older age (>10 years) was associated with a higher risk of having at least a CVRF (LDL-C, BMI-SDS, BP) according to internationally defined cut-offs.
AB - Objective: To assess the prevalence of cardiovascular risk factors (CVRFs) in children and adolescents with type 1 diabetes (T1D) in the International SWEET registry and the possible role of clinical variables in modifying the risk of having single or multiple CVRFs. Study design: The study is a cross-sectional study. Cut-off points for CVRFs were fixed according to International Society for Pediatric and Adolescent Diabetes (ISPAD) guidelines and WHO parameters: LDL cholesterol (LDL-C) > 100 mg/dL; Systolic Blood Pressure (BP-SDS) > 90th percentile for sex, age, and height; BMI-SDS > 2SD for sex and age. Logistic regression models were applied to evaluate variables associated with at least 1 or 2 CVRFs among registry children and adolescents. Results: 29,649 individuals with T1D (6–18 years, T1D ≥ 2 years) participating in the SWEET prospective multicenter diabetes registry were included. In the cohort, 41 % had one or more CVRFs, and 10 % had two or more CVRFs. Thirty-five percent of enrolled individuals had LDL-C > 100 mg/dL, 26 % had BMI-SDS > 2SD, and 17 % had Systolic BP-SDS > 90th percentile. Females had higher frequency than males of having 1 or 2 CVRFs (45.1 % vs 37.4 %, 11.8 % vs 7.8 %; p < 0.001). Multivariable logistic regression models showed that sex (female), HbA1c category (>7.0 %), and age (>10 years) were associated with a higher chance of having at least 1 or 2 CVRFs (p < 0.001). Conclusions: In children and adolescents with T1D, female sex, in addition to HbA1c above 7 %, and older age (>10 years) was associated with a higher risk of having at least a CVRF (LDL-C, BMI-SDS, BP) according to internationally defined cut-offs.
KW - Female
KW - HbA1c
KW - Insulin pump
KW - Lipids
KW - Pediatric
U2 - 10.1016/j.diabres.2024.111616
DO - 10.1016/j.diabres.2024.111616
M3 - Journal article
C2 - 38490494
AN - SCOPUS:85188677083
VL - 210
JO - Diabetes Research and Clinical Practice. Supplement
JF - Diabetes Research and Clinical Practice. Supplement
SN - 1572-1671
M1 - 111616
ER -
ID: 387257345