The role of glial pathology in Huntington's disease

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiForskningfagfællebedømt

This review will focus on the contribution of glial pathology to HD, particularly so with regard to diseased glial progenitor cells and their derived astrocytes and oligodendrocytes. It will briefly discuss the body of data identifying the contribution of glial dysfunction to disease phenotype in rodent models of HD, and will then focus on recent studies of cell-intrinsic glial transcriptional dysregulation in HD. The review will emphasize recent studies of diseased human cells and humanized models of HD glial pathology, and on the contributions of that glial pathology to neuronal and synaptic dysfunction in HD.
OriginalsprogEngelsk
TitelHuntington's Disease : Pathogenic Mechanisms and Implications for Therapeutics
Antal sider15
ForlagElsevier
Publikationsdato2024
Sider337-351
Kapitel14
ISBN (Trykt)9780323956734
ISBN (Elektronisk)9780323956727
DOI
StatusUdgivet - 2024

Bibliografisk note

Publisher Copyright:
© 2024 Elsevier Inc. All rights reserved.

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