The Ocular Glymphatic System—Current Understanding and Future Perspectives
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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The ocular glymphatic system subserves the bidirectional polarized fluid transport in the optic nerve, whereby cerebrospinal fluid from the brain is directed along periarterial spaces towards the eye, and fluid from the retina is directed along perivenous spaces following upon its axonal transport across the glial lamina. Fluid homeostasis and waste removal are vital for retinal function, making the ocular glymphatic fluid pathway a potential route for targeted manipulation to combat blinding ocular diseases such as age-related macular degeneration, diabetic retinopathy, and glaucoma. Several lines of work investigating the bidirectional ocular glymphatic transport with varying methodologies have developed diverging mechanistic models, which has created some confusion about how ocular glymphatic transport should be defined. In this review, we provide a comprehensive summary of the current understanding of the ocular glymphatic system, aiming to address misconceptions and foster a cohesive understanding of the topic.
Originalsprog | Engelsk |
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Artikelnummer | 5734 |
Tidsskrift | International Journal of Molecular Sciences |
Vol/bind | 25 |
Udgave nummer | 11 |
Antal sider | 12 |
ISSN | 1661-6596 |
DOI | |
Status | Udgivet - 2024 |
Bibliografisk note
Funding Information:
This project has received funding from the European Research Council (ERC) under the European Union\u2019s Horizon 2020 research and innovation programme (grant agreement No 742112), the NNF Laureate grant (NNF13OC0004258), JPND, HFSP, The Simon, Cure for Alzheimer and Adelson Foundations, the Lundbeck Foundation (R155-2016\u2013552) and NIH R01AT012312, R01AR012707, R01AT011439, U19 NS128613 and the U.S. Army under Award No. MURI W911NF1910280.
Publisher Copyright:
© 2024 by the authors.
ID: 395392073