The Ocular Glymphatic System—Current Understanding and Future Perspectives

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

The Ocular Glymphatic System—Current Understanding and Future Perspectives. / Delle, Christine; Wang, Xiaowei; Nedergaard, Maiken.

I: International Journal of Molecular Sciences, Bind 25, Nr. 11, 5734, 2024.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Delle, C, Wang, X & Nedergaard, M 2024, 'The Ocular Glymphatic System—Current Understanding and Future Perspectives', International Journal of Molecular Sciences, bind 25, nr. 11, 5734. https://doi.org/10.3390/ijms25115734

APA

Delle, C., Wang, X., & Nedergaard, M. (2024). The Ocular Glymphatic System—Current Understanding and Future Perspectives. International Journal of Molecular Sciences, 25(11), [5734]. https://doi.org/10.3390/ijms25115734

Vancouver

Delle C, Wang X, Nedergaard M. The Ocular Glymphatic System—Current Understanding and Future Perspectives. International Journal of Molecular Sciences. 2024;25(11). 5734. https://doi.org/10.3390/ijms25115734

Author

Delle, Christine ; Wang, Xiaowei ; Nedergaard, Maiken. / The Ocular Glymphatic System—Current Understanding and Future Perspectives. I: International Journal of Molecular Sciences. 2024 ; Bind 25, Nr. 11.

Bibtex

@article{2b699cc9123744d2a494d09baded0381,
title = "The Ocular Glymphatic System—Current Understanding and Future Perspectives",
abstract = "The ocular glymphatic system subserves the bidirectional polarized fluid transport in the optic nerve, whereby cerebrospinal fluid from the brain is directed along periarterial spaces towards the eye, and fluid from the retina is directed along perivenous spaces following upon its axonal transport across the glial lamina. Fluid homeostasis and waste removal are vital for retinal function, making the ocular glymphatic fluid pathway a potential route for targeted manipulation to combat blinding ocular diseases such as age-related macular degeneration, diabetic retinopathy, and glaucoma. Several lines of work investigating the bidirectional ocular glymphatic transport with varying methodologies have developed diverging mechanistic models, which has created some confusion about how ocular glymphatic transport should be defined. In this review, we provide a comprehensive summary of the current understanding of the ocular glymphatic system, aiming to address misconceptions and foster a cohesive understanding of the topic.",
keywords = "amyloid-beta, aquaporin-4, blood–retinal barrier, cerebrospinal fluid, diabetes, glaucoma, glymphatic–lymphatic fluid transport, intracranial pressure, intraocular pressure, meningeal lymphatics, perivascular spaces",
author = "Christine Delle and Xiaowei Wang and Maiken Nedergaard",
note = "Publisher Copyright: {\textcopyright} 2024 by the authors.",
year = "2024",
doi = "10.3390/ijms25115734",
language = "English",
volume = "25",
journal = "International Journal of Molecular Sciences (Online)",
issn = "1661-6596",
publisher = "MDPI AG",
number = "11",

}

RIS

TY - JOUR

T1 - The Ocular Glymphatic System—Current Understanding and Future Perspectives

AU - Delle, Christine

AU - Wang, Xiaowei

AU - Nedergaard, Maiken

N1 - Publisher Copyright: © 2024 by the authors.

PY - 2024

Y1 - 2024

N2 - The ocular glymphatic system subserves the bidirectional polarized fluid transport in the optic nerve, whereby cerebrospinal fluid from the brain is directed along periarterial spaces towards the eye, and fluid from the retina is directed along perivenous spaces following upon its axonal transport across the glial lamina. Fluid homeostasis and waste removal are vital for retinal function, making the ocular glymphatic fluid pathway a potential route for targeted manipulation to combat blinding ocular diseases such as age-related macular degeneration, diabetic retinopathy, and glaucoma. Several lines of work investigating the bidirectional ocular glymphatic transport with varying methodologies have developed diverging mechanistic models, which has created some confusion about how ocular glymphatic transport should be defined. In this review, we provide a comprehensive summary of the current understanding of the ocular glymphatic system, aiming to address misconceptions and foster a cohesive understanding of the topic.

AB - The ocular glymphatic system subserves the bidirectional polarized fluid transport in the optic nerve, whereby cerebrospinal fluid from the brain is directed along periarterial spaces towards the eye, and fluid from the retina is directed along perivenous spaces following upon its axonal transport across the glial lamina. Fluid homeostasis and waste removal are vital for retinal function, making the ocular glymphatic fluid pathway a potential route for targeted manipulation to combat blinding ocular diseases such as age-related macular degeneration, diabetic retinopathy, and glaucoma. Several lines of work investigating the bidirectional ocular glymphatic transport with varying methodologies have developed diverging mechanistic models, which has created some confusion about how ocular glymphatic transport should be defined. In this review, we provide a comprehensive summary of the current understanding of the ocular glymphatic system, aiming to address misconceptions and foster a cohesive understanding of the topic.

KW - amyloid-beta

KW - aquaporin-4

KW - blood–retinal barrier

KW - cerebrospinal fluid

KW - diabetes

KW - glaucoma

KW - glymphatic–lymphatic fluid transport

KW - intracranial pressure

KW - intraocular pressure

KW - meningeal lymphatics

KW - perivascular spaces

U2 - 10.3390/ijms25115734

DO - 10.3390/ijms25115734

M3 - Review

C2 - 38891923

AN - SCOPUS:85195845412

VL - 25

JO - International Journal of Molecular Sciences (Online)

JF - International Journal of Molecular Sciences (Online)

SN - 1661-6596

IS - 11

M1 - 5734

ER -

ID: 395392073