The fibroblast hormone Endotrophin is a biomarker of mortality in chronic diseases
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We conducted a systematic literature review collecting evidence from original papers published between 2012 and January 2023 that reported associations between circulating endotrophin (PROsingle bondC6) and mortality. Cohorts with data available to the study authors were included in an Individual Patient Data (IPD) meta-analysis that evaluated the association of PROsingle bondC6 with mortality (PROSPERO registration number: CRD42023340215) after adjustment for age, sex and BMI, where available.
In the IPD meta-analysis including sixteen cohorts of patients with different non-communicable chronic diseases (NCCDs) (N = 15,205) the estimated summary hazard ratio for 3-years all-cause mortality was 2.10 (95 % CI 1.75—2.52) for a 2-fold increase in PROsingle bondC6, with some heterogeneity observed between the studies (I2=70 %).
This meta-analysis is the first study documenting that fibroblast activities, as quantified by circulating endotrophin, are independently associated with mortality across a broad range of NCCDs. This indicates that, irrespective of disease, interstitial tissue remodeling, and consequently fibroblast activities, has a central role in adverse clinical outcomes, and should be considered with urgency from drug developers as a target to treat.
Originalsprog | Engelsk |
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Tidsskrift | Matrix Biology |
Vol/bind | 132 |
Sider (fra-til) | 1-9 |
Antal sider | 9 |
ISSN | 0945-053X |
DOI | |
Status | Udgivet - 2024 |
Bibliografisk note
Funding Information:
RGJ is funded by an NIHR Research Professorship ( RP-2017-08-ST2-014 ). RGJ, LW and IS are funded by the MRC-NIHR Strategic Priority Fund Consortium Award \u2013 ( MR/W014491/1 ) DEMISTIFI Multi Morbidity: DEfining MechanIsms Shared across mulTI-organ FIbrotic disease to prevent the development of long-term multi-morbidity. JV was supported by the NIHR Manchester BRC. DS, MK, DL received project related support from EU Horizon 2020 under grant agreement nr. 777377 (LITMUS, Liver Investigation on Marker Utility in Steatohepatitis). DS was supported by the German Research Foundation (DFG) Collaborative Research Center (CRC) grant 1292 project B08.
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© 2024
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