The evolutionarily conserved choroid plexus contributes to the homeostasis of brain ventricles in zebrafish
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The evolutionarily conserved choroid plexus contributes to the homeostasis of brain ventricles in zebrafish. / Jeong, Inyoung; Andreassen, Søren N.; Hoang, Linh; Poulain, Morgane; Seo, Yongbo; Park, Hae Chul; Fürthauer, Maximilian; MacAulay, Nanna; Jurisch-Yaksi, Nathalie.
I: Cell Reports, Bind 43, Nr. 6, 114331, 2024.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - The evolutionarily conserved choroid plexus contributes to the homeostasis of brain ventricles in zebrafish
AU - Jeong, Inyoung
AU - Andreassen, Søren N.
AU - Hoang, Linh
AU - Poulain, Morgane
AU - Seo, Yongbo
AU - Park, Hae Chul
AU - Fürthauer, Maximilian
AU - MacAulay, Nanna
AU - Jurisch-Yaksi, Nathalie
N1 - Publisher Copyright: © 2024 The Authors
PY - 2024
Y1 - 2024
N2 - The choroid plexus (ChP) produces cerebrospinal fluid (CSF). It also contributes to brain development and serves as the CSF-blood barrier. Prior studies have identified transporters on the epithelial cells that transport water and ions from the blood vasculature to the ventricles and tight junctions involved in the CSF-blood barrier. Yet, how the ChP epithelial cells control brain physiology remains unresolved. We use zebrafish to provide insights into the physiological roles of the ChP. Upon histological and transcriptomic analyses, we identify that the zebrafish ChP is conserved with mammals and expresses transporters involved in CSF secretion. Next, we show that the ChP epithelial cells secrete proteins into CSF. By ablating the ChP epithelial cells, we identify a reduction of the ventricular sizes without alterations of the CSF-blood barrier. Altogether, our findings reveal that the zebrafish ChP is conserved and contributes to the size and homeostasis of the brain ventricles.
AB - The choroid plexus (ChP) produces cerebrospinal fluid (CSF). It also contributes to brain development and serves as the CSF-blood barrier. Prior studies have identified transporters on the epithelial cells that transport water and ions from the blood vasculature to the ventricles and tight junctions involved in the CSF-blood barrier. Yet, how the ChP epithelial cells control brain physiology remains unresolved. We use zebrafish to provide insights into the physiological roles of the ChP. Upon histological and transcriptomic analyses, we identify that the zebrafish ChP is conserved with mammals and expresses transporters involved in CSF secretion. Next, we show that the ChP epithelial cells secrete proteins into CSF. By ablating the ChP epithelial cells, we identify a reduction of the ventricular sizes without alterations of the CSF-blood barrier. Altogether, our findings reveal that the zebrafish ChP is conserved and contributes to the size and homeostasis of the brain ventricles.
KW - brain ventricles
KW - cerebrospinal fluid
KW - choroid plexus
KW - CP: Neuroscience
KW - fabp7b
KW - zebrafish
U2 - 10.1016/j.celrep.2024.114331
DO - 10.1016/j.celrep.2024.114331
M3 - Journal article
C2 - 38843394
AN - SCOPUS:85195100599
VL - 43
JO - Cell Reports
JF - Cell Reports
SN - 2211-1247
IS - 6
M1 - 114331
ER -
ID: 394983096