The effects of cimetidine on creatinine excretion, glomerular filtration rate and tubular function in renal transplant recipients

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Standard

The effects of cimetidine on creatinine excretion, glomerular filtration rate and tubular function in renal transplant recipients. / Olsen, Niels Vidiendal; Ladefoged, S D; Feldt-Rasmussen, B; Fogh-Andersen, N; Jordening, H; Munck, O.

I: Scandinavian Journal of Clinical & Laboratory Investigation, Bind 49, Nr. 2, 04.1989, s. 155-9.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Olsen, NV, Ladefoged, SD, Feldt-Rasmussen, B, Fogh-Andersen, N, Jordening, H & Munck, O 1989, 'The effects of cimetidine on creatinine excretion, glomerular filtration rate and tubular function in renal transplant recipients', Scandinavian Journal of Clinical & Laboratory Investigation, bind 49, nr. 2, s. 155-9.

APA

Olsen, N. V., Ladefoged, S. D., Feldt-Rasmussen, B., Fogh-Andersen, N., Jordening, H., & Munck, O. (1989). The effects of cimetidine on creatinine excretion, glomerular filtration rate and tubular function in renal transplant recipients. Scandinavian Journal of Clinical & Laboratory Investigation, 49(2), 155-9.

Vancouver

Olsen NV, Ladefoged SD, Feldt-Rasmussen B, Fogh-Andersen N, Jordening H, Munck O. The effects of cimetidine on creatinine excretion, glomerular filtration rate and tubular function in renal transplant recipients. Scandinavian Journal of Clinical & Laboratory Investigation. 1989 apr.;49(2):155-9.

Author

Olsen, Niels Vidiendal ; Ladefoged, S D ; Feldt-Rasmussen, B ; Fogh-Andersen, N ; Jordening, H ; Munck, O. / The effects of cimetidine on creatinine excretion, glomerular filtration rate and tubular function in renal transplant recipients. I: Scandinavian Journal of Clinical & Laboratory Investigation. 1989 ; Bind 49, Nr. 2. s. 155-9.

Bibtex

@article{0b1175e3ab354e9f9451586bcd8f295b,
title = "The effects of cimetidine on creatinine excretion, glomerular filtration rate and tubular function in renal transplant recipients",
abstract = "The renal clearance of endogenous creatinine (CCr), sodium (CNa) and lithium (CLi) was determined before and after a single intravenous bolus of cimetidine in nine renal transplant recipients. The glomerular filtration rate (GFR) was measured with 125I-iothalamate clearance (CTh). The initial CCr of 65 ml/min (median) was reduced to a nadir of 46 ml/min (p less than 0.01) during the first 2 h after infusion of cimetidine. GFR remained unchanged, and thus the fractional clearance of creatinine (CCr/CTh) was reduced from 1.43 (median) to 1.03 (p less than 0.01). CNa and the fractional excretion of sodium decreased throughout the study (p less than 0.05); CLi was unchanged. In conclusion cimetidine, when measured during 1-h clearance periods, interferes with tubular creatinine secretion in the denervated kidney of transplant recipients without affecting the glomerular filtration rate or proximal tubular flow. This suggests that on-going cimetidine treatment must be taken into account when graft function is evaluated by the CCr alone.",
keywords = "Absorption, Adult, Cimetidine, Creatinine, Glomerular Filtration Rate, Humans, Kidney Transplantation, Kidney Tubules, Lithium, Male, Metabolic Clearance Rate, Middle Aged, Sodium",
author = "Olsen, {Niels Vidiendal} and Ladefoged, {S D} and B Feldt-Rasmussen and N Fogh-Andersen and H Jordening and O Munck",
year = "1989",
month = apr,
language = "English",
volume = "49",
pages = "155--9",
journal = "Scandinavian Journal of Clinical & Laboratory Investigation",
issn = "0036-5513",
publisher = "Taylor & Francis",
number = "2",

}

RIS

TY - JOUR

T1 - The effects of cimetidine on creatinine excretion, glomerular filtration rate and tubular function in renal transplant recipients

AU - Olsen, Niels Vidiendal

AU - Ladefoged, S D

AU - Feldt-Rasmussen, B

AU - Fogh-Andersen, N

AU - Jordening, H

AU - Munck, O

PY - 1989/4

Y1 - 1989/4

N2 - The renal clearance of endogenous creatinine (CCr), sodium (CNa) and lithium (CLi) was determined before and after a single intravenous bolus of cimetidine in nine renal transplant recipients. The glomerular filtration rate (GFR) was measured with 125I-iothalamate clearance (CTh). The initial CCr of 65 ml/min (median) was reduced to a nadir of 46 ml/min (p less than 0.01) during the first 2 h after infusion of cimetidine. GFR remained unchanged, and thus the fractional clearance of creatinine (CCr/CTh) was reduced from 1.43 (median) to 1.03 (p less than 0.01). CNa and the fractional excretion of sodium decreased throughout the study (p less than 0.05); CLi was unchanged. In conclusion cimetidine, when measured during 1-h clearance periods, interferes with tubular creatinine secretion in the denervated kidney of transplant recipients without affecting the glomerular filtration rate or proximal tubular flow. This suggests that on-going cimetidine treatment must be taken into account when graft function is evaluated by the CCr alone.

AB - The renal clearance of endogenous creatinine (CCr), sodium (CNa) and lithium (CLi) was determined before and after a single intravenous bolus of cimetidine in nine renal transplant recipients. The glomerular filtration rate (GFR) was measured with 125I-iothalamate clearance (CTh). The initial CCr of 65 ml/min (median) was reduced to a nadir of 46 ml/min (p less than 0.01) during the first 2 h after infusion of cimetidine. GFR remained unchanged, and thus the fractional clearance of creatinine (CCr/CTh) was reduced from 1.43 (median) to 1.03 (p less than 0.01). CNa and the fractional excretion of sodium decreased throughout the study (p less than 0.05); CLi was unchanged. In conclusion cimetidine, when measured during 1-h clearance periods, interferes with tubular creatinine secretion in the denervated kidney of transplant recipients without affecting the glomerular filtration rate or proximal tubular flow. This suggests that on-going cimetidine treatment must be taken into account when graft function is evaluated by the CCr alone.

KW - Absorption

KW - Adult

KW - Cimetidine

KW - Creatinine

KW - Glomerular Filtration Rate

KW - Humans

KW - Kidney Transplantation

KW - Kidney Tubules

KW - Lithium

KW - Male

KW - Metabolic Clearance Rate

KW - Middle Aged

KW - Sodium

M3 - Journal article

C2 - 2520367

VL - 49

SP - 155

EP - 159

JO - Scandinavian Journal of Clinical & Laboratory Investigation

JF - Scandinavian Journal of Clinical & Laboratory Investigation

SN - 0036-5513

IS - 2

ER -

ID: 47241146