TY - JOUR

T1 - The effect of praziquantel against Schistosoma mansoni-infections in Botswana

AU - Friis, H

AU - Byskov, Jens

PY - 1989/1

Y1 - 1989/1

N2 - Chemotherapy of all infected individuals, using praziquantel 40 mg/kg in a single dose, was the initial component of the recently introduced control programme against Schistosoma mansoni-infections in Ngamiland, Botswana. To evaluate the effect of praziquantel in Ngamiland, 81 children were selected at random from three strata of intensities of infection. Six weeks after treatment a duplicate of Kato fecal thick smear was made. When eggs of S. mansoni were found, a new stool sample was collected and a hatching test performed. Only in case of a positive hatching test was the child considered to be infected: Cure rates between 78.6 and 90.0%, and reductions in egg output among noncured between 84.6 and 98.0% were found.

AB - Chemotherapy of all infected individuals, using praziquantel 40 mg/kg in a single dose, was the initial component of the recently introduced control programme against Schistosoma mansoni-infections in Ngamiland, Botswana. To evaluate the effect of praziquantel in Ngamiland, 81 children were selected at random from three strata of intensities of infection. Six weeks after treatment a duplicate of Kato fecal thick smear was made. When eggs of S. mansoni were found, a new stool sample was collected and a hatching test performed. Only in case of a positive hatching test was the child considered to be infected: Cure rates between 78.6 and 90.0%, and reductions in egg output among noncured between 84.6 and 98.0% were found.

KW - Animals

KW - Botswana

KW - Child

KW - Child, Preschool

KW - Clinical Trials as Topic

KW - Humans

KW - Parasite Egg Count

KW - Praziquantel

KW - Random Allocation

KW - Schistosomiasis mansoni

M3 - Journal article

C2 - 2503911

VL - 41

SP - 49

EP - 51

JO - Tropical and Geographical Medicine

JF - Tropical and Geographical Medicine

SN - 0041-3232

IS - 1

ER -